(12 nodes) Platelet aggregation network (Gallus gallus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SLC7A11	Solute carrier family 7 member 11 xCT. (501 aa)
	PTPN6	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (639 aa)
	LOC101750889	LRRCT domain-containing protein. (714 aa)
	PLEK	Uncharacterized protein. (353 aa)
	STXBP3	Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. (601 aa)
	PEAR1	Uncharacterized protein. (602 aa)
	UBASH3B	Ubiquitin associated and SH3 domain containing B. (651 aa)
	FGB	Fibrinogen beta chain; Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. (488 aa)
	BLOC1S4	Biogenesis of lysosomal organelles complex 1 subunit 4. (214 aa)
	CGTL	Uncharacterized protein. (474 aa)
	FGG	Fibrinogen C-terminal domain-containing protein. (438 aa)
	ITGB3	Integrin beta; Belongs to the integrin beta chain family. (781 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CGTL	SLC7A11	ENSGALP00000020919	ENSGALP00000015861	Uncharacterized protein.	Solute carrier family 7 member 11 xCT.	0.902
FGB	FGG	ENSGALP00000038105	ENSGALP00000015063	Fibrinogen beta chain; Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots.	Fibrinogen C-terminal domain-containing protein.	0.999
FGB	ITGB3	ENSGALP00000038105	ENSGALP00000000518	Fibrinogen beta chain; Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots.	Integrin beta; Belongs to the integrin beta chain family.	0.493
FGG	FGB	ENSGALP00000015063	ENSGALP00000038105	Fibrinogen C-terminal domain-containing protein.	Fibrinogen beta chain; Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots.	0.999
FGG	ITGB3	ENSGALP00000015063	ENSGALP00000000518	Fibrinogen C-terminal domain-containing protein.	Integrin beta; Belongs to the integrin beta chain family.	0.581
ITGB3	FGB	ENSGALP00000000518	ENSGALP00000038105	Integrin beta; Belongs to the integrin beta chain family.	Fibrinogen beta chain; Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots.	0.493
ITGB3	FGG	ENSGALP00000000518	ENSGALP00000015063	Integrin beta; Belongs to the integrin beta chain family.	Fibrinogen C-terminal domain-containing protein.	0.581
ITGB3	LOC101750889	ENSGALP00000000518	ENSGALP00000069216	Integrin beta; Belongs to the integrin beta chain family.	LRRCT domain-containing protein.	0.508
LOC101750889	ITGB3	ENSGALP00000069216	ENSGALP00000000518	LRRCT domain-containing protein.	Integrin beta; Belongs to the integrin beta chain family.	0.508
PLEK	PTPN6	ENSGALP00000065639	ENSGALP00000073072	Uncharacterized protein.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.457
PTPN6	PLEK	ENSGALP00000073072	ENSGALP00000065639	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	Uncharacterized protein.	0.457
SLC7A11	CGTL	ENSGALP00000015861	ENSGALP00000020919	Solute carrier family 7 member 11 xCT.	Uncharacterized protein.	0.902