STRINGSTRING
SRP54 SRP54 RAB3GAP2 RAB3GAP2 SEC62 SEC62 EDEM1 EDEM1 BCAP29 BCAP29 SRPRB SRPRB SEC61A1 SEC61A1 GBF1 GBF1 GET4 GET4 GABARAPL2 GABARAPL2 ZFAND2A ZFAND2A SEC16A SEC16A SRP68 SRP68 MFSD11 MFSD11 SPCS1 SPCS1 HERPUD1 HERPUD1 SSR3 SSR3 HSPA5 HSPA5 SRP19 SRP19 INSIG2 INSIG2 RER1 RER1 ENSGALP00000044402 ENSGALP00000044402 SEC61A2 SEC61A2 BCAP31 BCAP31 KDELR2 KDELR2 SEC16B SEC16B SGTA SGTA GLP1R GLP1R ENSGALP00000051793 ENSGALP00000051793 TRAM1L1 TRAM1L1 KDELR3 KDELR3 LRRK2 LRRK2 VAPA VAPA LOC100858626 LOC100858626 TAPT1 TAPT1 SEC61G SEC61G ENSGALP00000066836 ENSGALP00000066836 TTC33 TTC33 ANKRD13C ANKRD13C SRPRA SRPRA GET3 GET3 SRP9 SRP9 RAB10 RAB10 INSIG1 INSIG1 TRAM2 TRAM2 DDRGK1 DDRGK1 SEC63 SEC63 SGTB SGTB SEC61B SEC61B RAB3GAP1 RAB3GAP1 SRP72 SRP72 SPCS3 SPCS3 SRP14 SRP14
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SRP54Signal recognition particle 54 kDa protein; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein). Belongs to the GTP-binding SRP family. SRP54 subfamily. (504 aa)
RAB3GAP2Uncharacterized protein. (1382 aa)
SEC62Translocation protein SEC62; Required for preprotein translocation. (398 aa)
EDEM1alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (616 aa)
BCAP29Uncharacterized protein. (243 aa)
SRPRBUncharacterized protein. (258 aa)
SEC61A1SEC61 translocon alpha 1 subunit. (476 aa)
GBF1Golgi brefeldin A resistant guanine nucleotide exchange factor 1. (1863 aa)
GET4Golgi to ER traffic protein 4 homolog; As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches- containing proteins in a soluble state and participates to their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of [...] (327 aa)
GABARAPL2GABA type A receptor associated protein like 2. (178 aa)
ZFAND2AZinc finger AN1-type containing 2A. (175 aa)
SEC16AProtein transport protein sec16; Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. (2201 aa)
SRP68Signal recognition particle subunit SRP68; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane; Belongs to the SRP68 family. (602 aa)
MFSD11Major facilitator superfamily domain containing 11. (448 aa)
SPCS1Uncharacterized protein. (166 aa)
HERPUD1Homocysteine inducible ER protein with ubiquitin like domain 1. (401 aa)
SSR3Uncharacterized protein. (187 aa)
HSPA5Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to dis [...] (652 aa)
SRP19Signal recognition particle 19. (144 aa)
INSIG2Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (225 aa)
RER1Protein RER1; Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment; Belongs to the RER1 family. (196 aa)
ENSGALP00000044402ANK_REP_REGION domain-containing protein. (216 aa)
SEC61A2Plug_translocon domain-containing protein. (476 aa)
BCAP31B cell receptor associated protein 31. (240 aa)
KDELR2ER lumen protein-retaining receptor 2; Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Golgi back to the endoplasmic reticulum (By similarity). Binding is pH dependent, and is optimal at pH 5-5.4. (212 aa)
SEC16BProtein transport protein Sec16B; Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. Involved in peroxisome biogenesis. Regulates the transport of peroxisomal biogenesis factors PEX3 and PEX16 from the ER to peroxisomes. (1084 aa)
SGTATPR_REGION domain-containing protein. (312 aa)
GLP1RGlucagon-like peptide 1 receptor; Belongs to the G-protein coupled receptor 2 family. (459 aa)
ENSGALP00000051793Uncharacterized protein. (360 aa)
TRAM1L1TLC domain-containing protein. (518 aa)
KDELR3ER lumen protein-retaining receptor. (203 aa)
LRRK2Uncharacterized protein. (2557 aa)
VAPAMSP domain-containing protein. (284 aa)
LOC100858626Zinc finger AN1-type containing 2B. (488 aa)
TAPT1Transmembrane anterior posterior transformation protein 1 homolog; Plays a role in primary cilia formation. May act as a downstream effector of HOXC8 during development. May be involved in cartilage and bone development. May play a role in the differentiation of cranial neural crest cells; Belongs to the TAPT1 family. (657 aa)
SEC61GUncharacterized protein. (68 aa)
ENSGALP00000066836ANK_REP_REGION domain-containing protein. (202 aa)
TTC33Tetratricopeptide repeat domain 33. (304 aa)
ANKRD13CUncharacterized protein. (152 aa)
SRPRAUncharacterized protein. (676 aa)
GET3Guided entry of tail-anchored proteins factor 3, ATPase. (331 aa)
SRP9Signal recognition particle 9 kDa protein; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding. (86 aa)
RAB10Ras-related protein Rab-10; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane. Plays also a specific role in asymmetric protein transport to the plasma mem [...] (200 aa)
INSIG1Insulin-induced gene 1 protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (252 aa)
TRAM2Translocation associated membrane protein 2. (506 aa)
DDRGK1DDRGK domain containing 1. (221 aa)
SEC63SEC63 homolog, protein translocation regulator. (755 aa)
SGTBTPR_REGION domain-containing protein. (304 aa)
SEC61BProtein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum. (96 aa)
RAB3GAP1RAB3 GTPase activating protein catalytic subunit 1. (1014 aa)
SRP72Signal recognition particle subunit SRP72; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane; Belongs to the SRP72 family. (671 aa)
SPCS3Signal peptidase complex subunit 3; Component of the microsomal signal peptidase complex which removes signal peptides and other N-terminal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. (180 aa)
SRP14Uncharacterized protein. (110 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.