(43 nodes) Cellular response to amino acid stimulus network (Gallus gallus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LAMTOR1	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1. (161 aa)
	PDGFD	Uncharacterized protein; Belongs to the PDGF/VEGF growth factor family. (389 aa)
	UBR2	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1758 aa)
	HNRNPAB	Uncharacterized protein. (479 aa)
	NSMF	NMDA receptor synaptonuclear signaling and neuronal migration factor. (513 aa)
	HNRNPD	Uncharacterized protein. (324 aa)
	RPTOR	Regulatory associated protein of MTOR complex 1. (1374 aa)
	AMIGO1	Adhesion molecule with Ig like domain 1. (492 aa)
	RRAGB	Ras related GTP binding B. (313 aa)
	SESN3	Sestrin 3. (492 aa)
	RRAGC	Uncharacterized protein. (409 aa)
	SLC7A5	Large neutral amino acids transporter small subunit 1. (526 aa)
	SESN2	Uncharacterized protein. (474 aa)
	SESN1	Sestrin 1. (564 aa)
	IPO5	Importin 5. (790 aa)
	CPEB4	Cytoplasmic polyadenylation element binding protein 4. (711 aa)
	BAIAP2	BAI1 associated protein 2. (573 aa)
	RRAGD	Ras related GTP binding D. (555 aa)
	GCLC	Glutamate-cysteine ligase catalytic subunit. (636 aa)
	SLC38A9	Solute carrier family 38 member 9. (559 aa)
	AMIGO2	Ig-like domain-containing protein. (521 aa)
	CAPN2	Calpain-2 catalytic subunit; Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. (700 aa)
	UBR1	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1809 aa)
	NEURL1	Uncharacterized protein. (555 aa)
	CEBPB	CCAAT/enhancer-binding protein beta; Important transcriptional activator regulating the expression of genes involved in immune and inflammatory responses. Binds to regulatory regions of several acute-phase and cytokines genes and probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'- T[TG]NNGNAA[TG]-3'. Functions in brown adipose tissue (BAT) differentiation. Regulates the transcriptional induction of peroxisome proliferator-activated receptor gamma (PPARG). Binds to the MGF and MIM-1 promoters and activates [...] (328 aa)
	CASTOR1	Cytosolic arginine sensor for mTORC1 subunit 1. (292 aa)
	LARS1	Leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (1177 aa)
	SOCS1	Suppressor of cytokine signaling 1. (207 aa)
	KLHL22	BTB domain-containing protein. (638 aa)
	XBP1	BZIP domain-containing protein. (372 aa)
	SESN2-2	Uncharacterized protein. (450 aa)
	SH3BP4	SH3 domain binding protein 4. (964 aa)
	MMP2	72 kDa type IV collagenase; Belongs to the peptidase M10A family. (663 aa)
	MTOR	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2521 aa)
	CPEB1	RRM domain-containing protein. (561 aa)
	LAMTOR5	Uncharacterized protein. (91 aa)
	LAMTOR2	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 2. (312 aa)
	COL1A1	Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen). (1453 aa)
	GATSL2	Uncharacterized protein. (329 aa)
	CPEB3	Cytoplasmic polyadenylation element binding protein 3. (680 aa)
	BCL2L1	Bcl-2-like protein 1; Dominant regulator of apoptotic cell death. The long form displays cell death repressor activity, whereas the short isoform promotes apoptosis. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis (By similarity). (229 aa)
	BCL11A	Uncharacterized protein. (796 aa)
	LAMTOR3	Ragulator complex protein LAMTOR3; Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids. Adapter protein that may regulate the MAP kinase cascade (By similarity). (182 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCL2L1	MTOR	ENSGALP00000054103	ENSGALP00000005274	Bcl-2-like protein 1; Dominant regulator of apoptotic cell death. The long form displays cell death repressor activity, whereas the short isoform promotes apoptosis. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis (By similarity).	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.	0.474
BCL2L1	XBP1	ENSGALP00000054103	ENSGALP00000009296	Bcl-2-like protein 1; Dominant regulator of apoptotic cell death. The long form displays cell death repressor activity, whereas the short isoform promotes apoptosis. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis (By similarity).	BZIP domain-containing protein.	0.506
CASTOR1	GATSL2	ENSGALP00000012918	ENSGALP00000056752	Cytosolic arginine sensor for mTORC1 subunit 1.	Uncharacterized protein.	0.901
CASTOR1	LAMTOR1	ENSGALP00000012918	ENSGALP00000066667	Cytosolic arginine sensor for mTORC1 subunit 1.	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1.	0.417
CASTOR1	LAMTOR2	ENSGALP00000012918	ENSGALP00000058190	Cytosolic arginine sensor for mTORC1 subunit 1.	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 2.	0.417
CASTOR1	LAMTOR3	ENSGALP00000012918	ENSGALP00000060460	Cytosolic arginine sensor for mTORC1 subunit 1.	Ragulator complex protein LAMTOR3; Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids. Adapter protein that may regulate the MAP kinase cascade (By similarity).	0.445
CASTOR1	LAMTOR5	ENSGALP00000012918	ENSGALP00000000571	Cytosolic arginine sensor for mTORC1 subunit 1.	Uncharacterized protein.	0.421
CASTOR1	MTOR	ENSGALP00000012918	ENSGALP00000005274	Cytosolic arginine sensor for mTORC1 subunit 1.	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.	0.400
CASTOR1	RPTOR	ENSGALP00000012918	ENSGALP00000071940	Cytosolic arginine sensor for mTORC1 subunit 1.	Regulatory associated protein of MTOR complex 1.	0.400
CASTOR1	RRAGB	ENSGALP00000012918	ENSGALP00000073101	Cytosolic arginine sensor for mTORC1 subunit 1.	Ras related GTP binding B.	0.427
CASTOR1	RRAGC	ENSGALP00000012918	ENSGALP00000053707	Cytosolic arginine sensor for mTORC1 subunit 1.	Uncharacterized protein.	0.410
CASTOR1	RRAGD	ENSGALP00000012918	ENSGALP00000042542	Cytosolic arginine sensor for mTORC1 subunit 1.	Ras related GTP binding D.	0.410
CEBPB	XBP1	ENSGALP00000012991	ENSGALP00000009296	CCAAT/enhancer-binding protein beta; Important transcriptional activator regulating the expression of genes involved in immune and inflammatory responses. Binds to regulatory regions of several acute-phase and cytokines genes and probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'- T[TG]NNGNAA[TG]-3'. Functions in brown adipose tissue (BAT) differentiation. Regulates the transcriptional induction of peroxisome proliferator-activated receptor gamma (PPARG). Binds to the MGF and MIM-1 promoters and activates [...]	BZIP domain-containing protein.	0.439
COL1A1	MMP2	ENSGALP00000058148	ENSGALP00000005656	Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen).	72 kDa type IV collagenase; Belongs to the peptidase M10A family.	0.448
CPEB1	CPEB3	ENSGALP00000003366	ENSGALP00000056491	RRM domain-containing protein.	Cytoplasmic polyadenylation element binding protein 3.	0.667
CPEB1	CPEB4	ENSGALP00000003366	ENSGALP00000046649	RRM domain-containing protein.	Cytoplasmic polyadenylation element binding protein 4.	0.672
CPEB3	CPEB1	ENSGALP00000056491	ENSGALP00000003366	Cytoplasmic polyadenylation element binding protein 3.	RRM domain-containing protein.	0.667
CPEB3	CPEB4	ENSGALP00000056491	ENSGALP00000046649	Cytoplasmic polyadenylation element binding protein 3.	Cytoplasmic polyadenylation element binding protein 4.	0.559
CPEB4	CPEB1	ENSGALP00000046649	ENSGALP00000003366	Cytoplasmic polyadenylation element binding protein 4.	RRM domain-containing protein.	0.672
CPEB4	CPEB3	ENSGALP00000046649	ENSGALP00000056491	Cytoplasmic polyadenylation element binding protein 4.	Cytoplasmic polyadenylation element binding protein 3.	0.559