(46 nodes) Cellular response to interferon-gamma network (Gallus gallus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GBP1	GB1/RHD3-type G domain-containing protein. (1020 aa)
	IL12B	Interleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily. (315 aa)
	VPS26B	VPS26, retromer complex component B. (336 aa)
	CCL20	C-C motif chemokine. (100 aa)
	IRF8	Interferon regulatory factor 8; Plays a role as a transcriptional activator or repressor. Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a regulatory role in cells of the immune system (By similarity); Belongs to the IRF family. (425 aa)
	CIITA	NACHT domain-containing protein. (874 aa)
	IRG1L	Uncharacterized protein. (463 aa)
	MMR1L3	Uncharacterized protein. (1415 aa)
	MRC1	Uncharacterized protein. (1458 aa)
	XCL1	Lymphotactin. (97 aa)
	RAB20	RAB20, member RAS oncogene family. (163 aa)
	ACOD1	Uncharacterized protein. (478 aa)
	RAB7B	RAB7B, member RAS oncogene family. (207 aa)
	VAMP3	V-SNARE coiled-coil homology domain-containing protein. (104 aa)
	CDC42EP4	CDC42 effector protein 4. (302 aa)
	CX3CL1	SCY domain-containing protein. (496 aa)
	GBP	GB1/RHD3-type G domain-containing protein. (600 aa)
	SLC26A6	STAS domain-containing protein. (752 aa)
	MMR1L4	Uncharacterized protein. (1448 aa)
	CCL19-2	SCY domain-containing protein. (99 aa)
	LOC428421	Uncharacterized protein. (1441 aa)
	CCL5	C-C motif chemokine. (90 aa)
	ADAMTS13	ADAM_CR_2 domain-containing protein. (415 aa)
	STX8	t-SNARE coiled-coil homology domain-containing protein. (273 aa)
	ENSGALP00000057424	GB1/RHD3-type G domain-containing protein. (658 aa)
	GBP4L	GB1/RHD3-type G domain-containing protein. (654 aa)
	NOS2	Nitric oxide synthase, inducible; Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. NO may serve as both a paracrine and autocrine signal for modulating osteoclast bone resorption. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2 (By similarity); Belongs to the NOS family. (1136 aa)
	CLEC17A	C-type lectin domain-containing protein. (325 aa)
	FCER2	C-type lectin domain-containing protein. (320 aa)
	NMI	N-myc and STAT interactor. (381 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are proba [...] (333 aa)
	ACTR2	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (By similarity). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (By similarity). Seems to contact the pointed end of the daughter actin filament (By similarity). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and r [...] (400 aa)
	EPRS	Uncharacterized protein. (1689 aa)
	STXBP3	Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. (601 aa)
	LOC112531454	GB1/RHD3-type G domain-containing protein. (194 aa)
	CDC42	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. Plays a role in the extension and maintenance of the formation of thin, actin- rich surface projections called filopodia. Also plays a role in phagocytos [...] (194 aa)
	IL12RB1	Fibronectin type-III domain-containing protein. (591 aa)
	LOC107051217	Gp_dh_C domain-containing protein. (307 aa)
	STXBP4	Syntaxin binding protein 4. (736 aa)
	CCL4-2	C-C motif chemokine 4 homolog; Monokine with inflammatory and chemokinetic properties. (96 aa)
	LOC107049166	Uncharacterized protein. (573 aa)
	CCL19	C-C motif chemokine. (108 aa)
	GBP7	GB1/RHD3-type G domain-containing protein. (298 aa)
	PDE12	Phosphodiesterase 12. (584 aa)
	IRF9	IRF tryptophan pentad repeat domain-containing protein. (472 aa)
	AQP4	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (417 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACOD1	CCL4-2	ENSGALP00000027300	ENSGALP00000067768	Uncharacterized protein.	C-C motif chemokine 4 homolog; Monokine with inflammatory and chemokinetic properties.	0.410
ACOD1	IRG1L	ENSGALP00000027300	ENSGALP00000012177	Uncharacterized protein.	Uncharacterized protein.	0.903
ACTR2	CDC42	ENSGALP00000065109	ENSGALP00000065867	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (By similarity). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (By similarity). Seems to contact the pointed end of the daughter actin filament (By similarity). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and r [...]	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. Plays a role in the extension and maintenance of the formation of thin, actin- rich surface projections called filopodia. Also plays a role in phagocytos [...]	0.878
ACTR2	GAPDH	ENSGALP00000065109	ENSGALP00000063325	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (By similarity). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (By similarity). Seems to contact the pointed end of the daughter actin filament (By similarity). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and r [...]	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are proba [...]	0.543
ACTR2	LOC107051217	ENSGALP00000065109	ENSGALP00000066789	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (By similarity). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (By similarity). Seems to contact the pointed end of the daughter actin filament (By similarity). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and r [...]	Gp_dh_C domain-containing protein.	0.477
AQP4	GAPDH	ENSGALP00000073366	ENSGALP00000063325	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family.	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are proba [...]	0.445
CCL19	CCL19-2	ENSGALP00000068348	ENSGALP00000043299	C-C motif chemokine.	SCY domain-containing protein.	0.841
CCL19	CCL20	ENSGALP00000068348	ENSGALP00000004738	C-C motif chemokine.	C-C motif chemokine.	0.901
CCL19	CCL4-2	ENSGALP00000068348	ENSGALP00000067768	C-C motif chemokine.	C-C motif chemokine 4 homolog; Monokine with inflammatory and chemokinetic properties.	0.819
CCL19	CCL5	ENSGALP00000068348	ENSGALP00000049143	C-C motif chemokine.	C-C motif chemokine.	0.988
CCL19	CX3CL1	ENSGALP00000068348	ENSGALP00000041151	C-C motif chemokine.	SCY domain-containing protein.	0.716
CCL19	XCL1	ENSGALP00000068348	ENSGALP00000024539	C-C motif chemokine.	Lymphotactin.	0.903
CCL19-2	CCL19	ENSGALP00000043299	ENSGALP00000068348	SCY domain-containing protein.	C-C motif chemokine.	0.841
CCL19-2	CCL20	ENSGALP00000043299	ENSGALP00000004738	SCY domain-containing protein.	C-C motif chemokine.	0.880
CCL19-2	CCL4-2	ENSGALP00000043299	ENSGALP00000067768	SCY domain-containing protein.	C-C motif chemokine 4 homolog; Monokine with inflammatory and chemokinetic properties.	0.828
CCL19-2	CCL5	ENSGALP00000043299	ENSGALP00000049143	SCY domain-containing protein.	C-C motif chemokine.	0.881
CCL19-2	CIITA	ENSGALP00000043299	ENSGALP00000011599	SCY domain-containing protein.	NACHT domain-containing protein.	0.437
CCL19-2	CX3CL1	ENSGALP00000043299	ENSGALP00000041151	SCY domain-containing protein.	SCY domain-containing protein.	0.722
CCL19-2	GBP1	ENSGALP00000043299	ENSGALP00000001014	SCY domain-containing protein.	GB1/RHD3-type G domain-containing protein.	0.436
CCL19-2	XCL1	ENSGALP00000043299	ENSGALP00000024539	SCY domain-containing protein.	Lymphotactin.	0.608