(53 nodes) Protein transmembrane transport network (Gallus gallus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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protein homology

Your Input:
	TIMM17B	Mitochondrial import inner membrane translocase subunit TIM17; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. (166 aa)
	TIMM44	Mitochondrial import inner membrane translocase subunit TIM44; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner; Belongs to the Tim44 family. (451 aa)
	HSPA5	Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to dis [...] (652 aa)
	TIMM23B	Mitochondrial import inner membrane translocase subunit TIM23; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. (208 aa)
	PEX12	Peroxisome assembly protein 12; Required for protein import into peroxisomes. Belongs to the pex2/pex10/pex12 family. (356 aa)
	AIFM1	Uncharacterized protein. (689 aa)
	TIMM22	Translocase of inner mitochondrial membrane 22. (190 aa)
	SEC61A1	SEC61 translocon alpha 1 subunit. (476 aa)
	CHCHD4	CHCH domain-containing protein. (138 aa)
	PEX13	SH3 domain-containing protein. (397 aa)
	HSPD1	60 kDa heat shock protein, mitochondrial; Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per rin [...] (573 aa)
	FAM185A	Family with sequence similarity 185 member A. (374 aa)
	DNAJC19	DnaJ heat shock protein family (Hsp40) member C19. (115 aa)
	SEC62	Translocation protein SEC62; Required for preprotein translocation. (398 aa)
	PEX1	Peroxisomal biogenesis factor 1. (1290 aa)
	EDNRA	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (421 aa)
	SRP54	Signal recognition particle 54 kDa protein; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein). Belongs to the GTP-binding SRP family. SRP54 subfamily. (504 aa)
	TMED10	GOLD domain-containing protein. (219 aa)
	SEC61B	Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum. (96 aa)
	TIMM21	Translocase of inner mitochondrial membrane 21. (327 aa)
	PEX7	WD_REPEATS_REGION domain-containing protein. (360 aa)
	TOMM70	Translocase of outer mitochondrial membrane 70. (583 aa)
	SEC63	SEC63 homolog, protein translocation regulator. (755 aa)
	TRAM2	Translocation associated membrane protein 2. (506 aa)
	DNAJC15	J domain-containing protein. (148 aa)
	PEX26	Peroxisomal biogenesis factor 26. (319 aa)
	EDNRB	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (560 aa)
	ROMO1	Uncharacterized protein. (79 aa)
	PEX5	Peroxisomal targeting signal 1 receptor; Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import. (644 aa)
	SEC61A2	Plug_translocon domain-containing protein. (476 aa)
	GLP1R	Glucagon-like peptide 1 receptor; Belongs to the G-protein coupled receptor 2 family. (459 aa)
	ENSGALP00000051793	Uncharacterized protein. (360 aa)
	TRAM1L1	TLC domain-containing protein. (518 aa)
	SAMD15	Uncharacterized protein. (98 aa)
	TOMM20	Translocase of outer mitochondrial membrane 20. (146 aa)
	TOMM40L	Translocase of outer mitochondrial membrane 40 like. (303 aa)
	PEX2	RING-type domain-containing protein. (304 aa)
	PEX5L	Peroxisomal biogenesis factor 5 like. (605 aa)
	SEC61G	Uncharacterized protein. (68 aa)
	PEX14	Peroxisomal biogenesis factor 14. (363 aa)
	PEX10	RING-type domain-containing protein. (325 aa)
	PEX6	Peroxisomal biogenesis factor 6; Belongs to the AAA ATPase family. (535 aa)
	TOMM7	Uncharacterized protein. (55 aa)
	GRPEL1	GrpE protein homolog; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner; Belongs to the GrpE family. (237 aa)
	TIMM50	Mitochondrial import inner membrane translocase subunit TIM50; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. (230 aa)
	PEX16	Peroxisomal membrane protein PEX16. (241 aa)
	C3orf18	Chromosome 3 open reading frame 18. (156 aa)
	ENSGALP00000068754	Uncharacterized protein. (89 aa)
	GRPEL2	GrpE like 2, mitochondrial. (149 aa)
	LONP2	Lon protease homolog 2, peroxisomal; ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import; Belongs to the peptidase S16 family. ECO:0000256\|PROSITE-. (856 aa)
	EDNRB2	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (479 aa)
	C2CD5	C2 calcium dependent domain containing 5. (1219 aa)
	DNLZ	DNL-type zinc finger. (117 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C3orf18	SAMD15	ENSGALP00000067495	ENSGALP00000053228	Chromosome 3 open reading frame 18.	Uncharacterized protein.	0.440
C3orf18	SEC63	ENSGALP00000067495	ENSGALP00000024664	Chromosome 3 open reading frame 18.	SEC63 homolog, protein translocation regulator.	0.463
C3orf18	TIMM17B	ENSGALP00000067495	ENSGALP00000000122	Chromosome 3 open reading frame 18.	Mitochondrial import inner membrane translocase subunit TIM17; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.	0.610
C3orf18	TIMM21	ENSGALP00000067495	ENSGALP00000022251	Chromosome 3 open reading frame 18.	Translocase of inner mitochondrial membrane 21.	0.453
C3orf18	TIMM23B	ENSGALP00000067495	ENSGALP00000003252	Chromosome 3 open reading frame 18.	Mitochondrial import inner membrane translocase subunit TIM23; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.	0.678
C3orf18	TIMM44	ENSGALP00000067495	ENSGALP00000000471	Chromosome 3 open reading frame 18.	Mitochondrial import inner membrane translocase subunit TIM44; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner; Belongs to the Tim44 family.	0.538
C3orf18	TIMM50	ENSGALP00000067495	ENSGALP00000065130	Chromosome 3 open reading frame 18.	Mitochondrial import inner membrane translocase subunit TIM50; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.	0.430
C3orf18	TOMM7	ENSGALP00000067495	ENSGALP00000063944	Chromosome 3 open reading frame 18.	Uncharacterized protein.	0.409
CHCHD4	GRPEL1	ENSGALP00000010217	ENSGALP00000064381	CHCH domain-containing protein.	GrpE protein homolog; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner; Belongs to the GrpE family.	0.425
CHCHD4	SAMD15	ENSGALP00000010217	ENSGALP00000053228	CHCH domain-containing protein.	Uncharacterized protein.	0.466
CHCHD4	TIMM17B	ENSGALP00000010217	ENSGALP00000000122	CHCH domain-containing protein.	Mitochondrial import inner membrane translocase subunit TIM17; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.	0.673
CHCHD4	TIMM21	ENSGALP00000010217	ENSGALP00000022251	CHCH domain-containing protein.	Translocase of inner mitochondrial membrane 21.	0.644
CHCHD4	TIMM22	ENSGALP00000010217	ENSGALP00000006979	CHCH domain-containing protein.	Translocase of inner mitochondrial membrane 22.	0.588
CHCHD4	TIMM23B	ENSGALP00000010217	ENSGALP00000003252	CHCH domain-containing protein.	Mitochondrial import inner membrane translocase subunit TIM23; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.	0.493
CHCHD4	TIMM44	ENSGALP00000010217	ENSGALP00000000471	CHCH domain-containing protein.	Mitochondrial import inner membrane translocase subunit TIM44; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner; Belongs to the Tim44 family.	0.495
CHCHD4	TIMM50	ENSGALP00000010217	ENSGALP00000065130	CHCH domain-containing protein.	Mitochondrial import inner membrane translocase subunit TIM50; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.	0.650
CHCHD4	TOMM20	ENSGALP00000010217	ENSGALP00000053446	CHCH domain-containing protein.	Translocase of outer mitochondrial membrane 20.	0.529
CHCHD4	TOMM40L	ENSGALP00000010217	ENSGALP00000055223	CHCH domain-containing protein.	Translocase of outer mitochondrial membrane 40 like.	0.675
CHCHD4	TOMM7	ENSGALP00000010217	ENSGALP00000063944	CHCH domain-containing protein.	Uncharacterized protein.	0.438
CHCHD4	TOMM70	ENSGALP00000010217	ENSGALP00000024624	CHCH domain-containing protein.	Translocase of outer mitochondrial membrane 70.	0.567