STRINGSTRING
GREB1 GREB1 GREB1L GREB1L AHI1 AHI1 BCL2 BCL2 BMP4 BMP4 WT1 WT1 KIF26B KIF26B EDNRA EDNRA JAG1 JAG1 COMMD5 COMMD5 LHX5 LHX5 PKD1 PKD1 HNF1B HNF1B LHX1 LHX1 SOX8 SOX8 AQP1 AQP1 NPHS2 NPHS2 GDNF GDNF WNT11 WNT11 IRX3 IRX3 HOXA11 HOXA11 CTNNB1 CTNNB1 CHTOP CHTOP MTSS1 MTSS1 CD24 CD24 GZF1 GZF1 TCF21 TCF21 PKD2 PKD2 ILK ILK SMO SMO LGR4 LGR4 AQP11 AQP11 GZF1-2 GZF1-2 IRX1 IRX1 MILR1 MILR1 DLL1 DLL1 GATA3 GATA3 PECAM1 PECAM1 FGF1 FGF1 EDNRB2 EDNRB2 HS2ST1 HS2ST1 WNT9B WNT9B SOX9 SOX9 LAMB2 LAMB2 CTNNBIP1 CTNNBIP1 MAGI2 MAGI2 HOXC11 HOXC11 BASP1 BASP1 WNT6 WNT6 GREM1 GREM1 PTPRO PTPRO EDNRB EDNRB TMEM59L TMEM59L FGF8 FGF8 FGF2 FGF2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GREB1Uncharacterized protein. (1937 aa)
GREB1LGREB1 like retinoic acid receptor coactivator. (1930 aa)
AHI1Abelson helper integration site 1. (1242 aa)
BCL2Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). (233 aa)
BMP4Bone morphogenetic protein 4; Negatively regulates the structure and function of the limb apical ectodermal ridge. (404 aa)
WT1Uncharacterized protein. (417 aa)
KIF26BKinesin family member 26B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (2119 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (421 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1216 aa)
COMMD5COMM domain-containing protein. (226 aa)
LHX5LIM homeobox protein 5. (402 aa)
PKD1Polycystin 1, transient receptor potential channel interacting. (4382 aa)
HNF1BHNF1 homeobox B. (531 aa)
LHX1LIM/homeobox protein Lhx1; Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with ISL-2. (406 aa)
SOX8Transcription factor SOX-8; May play a role in central nervous system, limb and facial development. May be involved in male sex determination. Binds the consensus motif 5'-[AT][AT]CAA[AT]G-3'. (470 aa)
AQP1Aquaporin-1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (270 aa)
NPHS2NPHS2 stomatin family member, podocin. (384 aa)
GDNFGlial cell derived neurotrophic factor. (209 aa)
WNT11Protein Wnt-11; Ligand for members of the frizzled family of seven transmembrane receptors. May play a role in the formation of dermal structure, both limb and feather buds. Is likely to signal over only few cell diameters. (354 aa)
IRX3Iroquois homeobox 3. (445 aa)
HOXA11Homeobox protein Hox-A11; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Abd-B homeobox family. (297 aa)
CTNNB1Uncharacterized protein. (781 aa)
CHTOPMothers against decapentaplegic homolog. (445 aa)
MTSS1Uncharacterized protein. (701 aa)
CD24Uncharacterized protein. (87 aa)
GZF1Uncharacterized protein. (707 aa)
TCF21BHLH domain-containing protein. (179 aa)
PKD2Uncharacterized protein. (881 aa)
ILKIntegrin-linked kinase. (452 aa)
SMOSmoothened homolog; G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). (816 aa)
LGR4Leucine rich repeat containing G protein-coupled receptor 4. (952 aa)
AQP11Aquaporin 11; Belongs to the MIP/aquaporin (TC 1.A.8) family. (260 aa)
GZF1-2Uncharacterized protein. (520 aa)
IRX1Homeobox domain-containing protein. (467 aa)
MILR1Uncharacterized protein. (357 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (893 aa)
GATA3GATA-binding factor 3; Transcriptional activator which probably serves as a general switch factor for cell-specific development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of genes. (444 aa)
PECAM1Platelet and endothelial cell adhesion molecule 1. (712 aa)
FGF1Endothelial cell growth factor alpha; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with [...] (155 aa)
EDNRB2G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (479 aa)
HS2ST1Heparan sulfate 2-O-sulfotransferase 1; Catalyzes the transfer of sulfate to the C2-position of selected hexuronic acid residues within the maturing heparan sulfate (HS). 2-O-sulfation within HS, particularly of iduronate residues, is essential for HS to participate in a variety of high-affinity ligand- binding interactions and signaling processes. (356 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (388 aa)
SOX9Transcription factor SOX-9; Transcription factor that selectively activates enhancer through its interaction with a DNA-binding partner factor. Activates enhancer of COL2A1 through its binding with DNA sequence 5'-ATTCAT-3'. In response to bone morphogenetic protein stimulus, phosphorylation is induced and then sumoylation, allowing cooperation with SNAI2 to trigger neural crest delamination. Functions at the level of mesenchymal cell condensation by inducing cartilage development in limbs and by changing the aggregation properties of limb mesenchymal cells. Regulates the cell fate dec [...] (494 aa)
LAMB2Uncharacterized protein. (1802 aa)
CTNNBIP1ICAT domain-containing protein. (81 aa)
MAGI2Uncharacterized protein. (1510 aa)
HOXC11Homeobox C11. (193 aa)
BASP1Brain acid soluble protein 1 homolog; May play a specific role in the development of tissues. (244 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
GREM1Gremlin-1; Cytokine that may play a role in the development of the medial pallium and during optic nerve and pecten development by modulating BMP signaling. (184 aa)
PTPROUncharacterized protein. (1268 aa)
EDNRBG_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (560 aa)
TMEM59LTransmembrane protein 59 like. (329 aa)
FGF8Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Involved in initiation, outgrowth and patterning of the limbs; Belongs to the heparin-binding growth factors family. (214 aa)
FGF2Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis; Belongs to the heparin-binding growth factors family. (158 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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