STRINGSTRING
PSMD9 PSMD9 GHRHR GHRHR TRPM2 TRPM2 RBP4A RBP4A DRD2 DRD2 ACSL4 ACSL4 GHRL GHRL TRH TRH SRI SRI FGG FGG SELENOT SELENOT AIMP1 AIMP1 NR1H4 NR1H4 PLA2G6 PLA2G6 IGF1 IGF1 VIP VIP RFX6 RFX6 MPC2 MPC2 BLK BLK GCG GCG TNFSF11 TNFSF11 FFAR4 FFAR4 GLUD2 GLUD2 LRRC8A LRRC8A MYRIP MYRIP SEC11A SEC11A CFTR CFTR CRH CRH C2CD2L C2CD2L PDX1 PDX1 ADCY8 ADCY8 SEC11C SEC11C CAPN10 CAPN10 SIRT6 SIRT6 ADCYAP1 ADCYAP1 GRP GRP TM7SF3 TM7SF3 UCN UCN GPLD1 GPLD1 RPH3AL RPH3AL NR0B2 NR0B2 C1QTNF12 C1QTNF12 AACS AACS GHRH GHRH GPER1 GPER1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PSMD9PDZ domain-containing protein. (207 aa)
GHRHRG protein-coupled pituitary GHRH receptor; Belongs to the G-protein coupled receptor 2 family. (419 aa)
TRPM2Transient receptor potential cation channel subfamily M member 2. (1508 aa)
RBP4ARetinol-binding protein 4; Retinol-binding protein that mediates retinol transport in blood plasma. Delivers retinol from the liver stores to the peripheral tissues. Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane. Belongs to the calycin superfamily. Lipocalin family. (196 aa)
DRD2Dopamine receptor 2 protein transcript variant 1; Belongs to the G-protein coupled receptor 1 family. (437 aa)
ACSL4Acyl-CoA synthetase long chain family member 4. (670 aa)
GHRLPreproghrelin. (116 aa)
TRHPro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems; Belongs to the TRH family. (260 aa)
SRIUncharacterized protein. (297 aa)
FGGFibrinogen C-terminal domain-containing protein. (438 aa)
SELENOTThioredoxin reductase-like selenoprotein T; Selenoprotein with thioredoxin reductase-like oxidoreductase activity; Belongs to the SelWTH family. Selenoprotein T subfamily. (199 aa)
AIMP1Aminoacyl tRNA synthetase complex interacting multifunctional protein 1. (317 aa)
NR1H4Farnesoid X receptor. (473 aa)
PLA2G6Uncharacterized protein. (796 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins. Its binding to integrins and subsequent ternary complex fo [...] (153 aa)
VIPIntestinal peptide PHI-27-like; VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder; Belongs to the glucagon family. (200 aa)
RFX6Regulatory factor X6. (916 aa)
MPC2Mitochondrial pyruvate carrier; Mediates the uptake of pyruvate into mitochondria. Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family. (133 aa)
BLKTyrosine-protein kinase. (526 aa)
GCGGlicentin-related polypeptide; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. (206 aa)
TNFSF11TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (400 aa)
FFAR4Free fatty acid receptor 4. (349 aa)
GLUD2Glutamate dehydrogenase 1, mitochondrial; Mitochondrial glutamate dehydrogenase that converts L- glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle (By similarity). (553 aa)
LRRC8ALeucine rich repeat containing 8 VRAC subunit A. (810 aa)
MYRIPRab_eff_C domain-containing protein. (666 aa)
SEC11ASignal peptidase complex catalytic subunit SEC11. (179 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1485 aa)
CRHCorticotropin releasing hormone. (167 aa)
C2CD2LSMP_C2CD2L domain-containing protein. (707 aa)
PDX1Homeobox domain-containing protein. (259 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1240 aa)
SEC11CSignal peptidase complex catalytic subunit SEC11. (177 aa)
CAPN10Calpain 10; Belongs to the peptidase C2 family. (672 aa)
SIRT6Deacetylase sirtuin-type domain-containing protein. (378 aa)
ADCYAP1Pituitary adenylate cyclase-activating polypeptide 27; Primary role of GRF is to release GH from the pituitary; Belongs to the glucagon family. (172 aa)
GRPGastrin-releasing peptide; Stimulates the release of gastrin and other gastrointestinal hormones (Probable). Stimulates pancreatic protein and fluid secretion, and increases acid secretion from the avian proventriculus. Belongs to the bombesin/neuromedin-B/ranatensin family. (164 aa)
TM7SF3Transmembrane 7 superfamily member 3. (563 aa)
UCNUrocortin. (100 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (856 aa)
RPH3ALUncharacterized protein. (295 aa)
NR0B2NR LBD domain-containing protein. (262 aa)
C1QTNF12C1q and TNF related 12. (320 aa)
AACSAcetoacetyl-CoA synthetase; Activates acetoacetate to acetoacetyl-CoA. May be involved in utilizing ketone body for the fatty acid-synthesis during adipose tissue development (By similarity). (743 aa)
GHRHGHRH/PACAP-like. (172 aa)
GPER1G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (357 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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