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| | POP4 | Ribonuclease P protein subunit p29; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. (238 aa) |
| | SPO11 | SPO11 initiator of meiotic double stranded breaks. (382 aa) |
| | KIAA0391 | PRORP domain-containing protein. (591 aa) |
| | RRS1 | Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family. (357 aa) |
| | DCP2 | Decapping mRNA 2. (416 aa) |
| | RAD51C | RAD51 paralog C. (360 aa) |
| | PAN3 | PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA deca [...] (687 aa) |
| | MGME1 | Mitochondrial genome maintenance exonuclease 1; Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair. Belongs to the MGME1 family. (342 aa) |
| | ZC3H12A | Zinc finger CCCH-type containing 12A. (681 aa) |
| | TTC38L | Uncharacterized protein. (279 aa) |
| | FEN1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (381 aa) |
| | CNOT6 | CCR4-NOT transcription complex subunit 6. (557 aa) |
| | EDC4 | Enhancer of mRNA decapping 4. (1403 aa) |
| | ZC3H12D | Zinc finger CCCH-type containing 12D. (615 aa) |
| | C12orf10 | Chromosome 12 open reading frame 10. (474 aa) |
| | EXOSC7 | Uncharacterized protein. (291 aa) |
| | EDC3 | Enhancer of mRNA-decapping protein 3; Binds single-stranded RNA. Involved in the process of mRNA degradation and in the positive regulation of mRNA decapping (By similarity). (506 aa) |
| | DFFB | Caspase-activated DNase. (333 aa) |
| | MEI4 | Meiotic double-stranded break formation protein 4. (400 aa) |
| | NOCT | Endo/exonuclease/phosphatase domain-containing protein. (386 aa) |
| | ENDOUL | XendoU domain-containing protein. (289 aa) |
| | AGO2 | Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include ago2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (864 aa) |
| | MARF1 | Meiosis regulator and mRNA stability factor 1; Essential regulator of oogenesis required for female meiotic progression to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. (1741 aa) |
| | NOL9 | Nucleolar protein 9. (588 aa) |
| | XPA | DNA repair protein complementing XP-A cells homolog; Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region (By similarity). Belongs to the XPA family. (270 aa) |
| | DROSHA | Uncharacterized protein. (1336 aa) |
| | ENDOG | Endonuclease G. (201 aa) |
| | ERI2 | ERI1 exoribonuclease family member 2. (682 aa) |
| | LOC422926 | Uncharacterized protein. (873 aa) |
| | RNASE6 | Angiogenin; Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs). Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo (By similarity). (139 aa) |
| | RAD50 | Zinc-hook domain-containing protein. (1313 aa) |
| | EXOSC9 | Polymyositis/scleroderma autoantigen 1. (440 aa) |
| | RNASET2 | Uncharacterized protein; Belongs to the RNase T2 family. (266 aa) |
| | DICER1 | Endoribonuclease Dicer; Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, al [...] (1921 aa) |
| | DNASE1L3 | Deoxyribonuclease; Belongs to the DNase I family. (307 aa) |
| | RPS21 | 40S ribosomal protein S21; Belongs to the eukaryotic ribosomal protein eS21 family. (83 aa) |
| | RSFR | Ribonuclease homolog. (139 aa) |
| | MEIOB | Meiosis specific with OB-fold. (344 aa) |
| | DCLRE1A | DNA cross-link repair 1A protein; May be required for DNA interstrand cross-link repair. (972 aa) |
| | CL2 | Ribonuclease CL2; Pyrimidine-specific nuclease with preference for C; Belongs to the pancreatic ribonuclease family. (145 aa) |
| | POLR3K | DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (108 aa) |
| | RPS3 | KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (243 aa) |
| | PCF11 | PCF11 cleavage and polyadenylation factor subunit. (1690 aa) |
| | MRE11 | Double-strand break repair protein MRE11; Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restr [...] (709 aa) |
| | ENDOD1 | Endonuclease domain containing 1. (480 aa) |
| | ZC3H12C | Zinc finger CCCH-type containing 12C. (857 aa) |
| | EXOSC8 | Exosome component 8. (283 aa) |
| | N4BP2L1 | Uncharacterized protein. (217 aa) |
| | DIS3 | DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease; Belongs to the RNR ribonuclease family. (997 aa) |
| | BIVM | Uncharacterized protein. (505 aa) |
| | ERCC5 | Uncharacterized protein. (1118 aa) |
| | GEN1 | GEN1 Holliday junction 5' flap endonuclease. (941 aa) |
| | DDX1 | ATP-dependent RNA helicase DDX1; Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5' single-stranded RNA overhang nuclease activity. Acts as a positive regulator of transcription. May be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. Binds DNA and RNA. Component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of catalytic subunit RTCB (By similarity). Binds (via helicase ATP-binding domain) on both short and long poly(I:C) dsRNA (By similarity). (740 aa) |
| | CPSF3 | Cleavage and polyadenylation specific factor 3. (691 aa) |
| | RNASEH1 | Ribonuclease H1; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (293 aa) |
| | NUDT12 | Nudix hydrolase 12. (465 aa) |
| | RCL1 | RNA terminal phosphate cyclase like 1. (374 aa) |
| | RBBP8 | RB binding protein 8, endonuclease. (912 aa) |
| | PELO | Integrin alpha-1; Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth (By similarity). (1175 aa) |
| | FIP1L1 | Fip1 domain-containing protein. (545 aa) |
| | DCLRE1C | Protein artemis; Required for V(D)J recombination, the process by which exons encoding the antigen-binding domains of immunoglobulins and T-cell receptor proteins are assembled from individual V, (D), and J gene segments. V(D)J recombination is initiated by the lymphoid specific RAG endonuclease complex, which generates site specific DNA double strand breaks (DSBs). These DSBs present two types of DNA end structures: hairpin sealed coding ends and phosphorylated blunt signal ends. These ends are independently repaired by the non homologous end joining (NHEJ) pathway to form coding and [...] (714 aa) |
| | CNOT7 | CCR4-NOT transcription complex subunit 7; Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA- mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence [...] (285 aa) |
| | B4GALNT3 | Beta-1,4-N-acetylgalactosaminyltransferase; Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'- diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans. (1064 aa) |
| | ZRANB3 | Zinc finger RANBP2-type containing 3. (420 aa) |
| | E1BQD2_CHICK | AAA_12 domain-containing protein. (229 aa) |
| | TSN | Translin; DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots (By similarity). Belongs to the translin family. (229 aa) |
| | PLD4 | Phospholipase D family member 4. (514 aa) |
| | PNLDC1 | PARN like, ribonuclease domain containing 1. (509 aa) |
| | ERCC3 | General transcription and DNA repair factor IIH helicase subunit XPB; ATP-dependent 3'-5' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATPase activity of XPB/ERCC3, but not its helicase activity, is required fo [...] (780 aa) |
| | CPSF2 | Cleavage and polyadenylation specificity factor subunit 2. (782 aa) |
| | EXO1 | Uncharacterized protein. (800 aa) |
| | CNOT6L | CCR4-NOT transcription complex subunit 6 like. (607 aa) |
| | TOE1 | Target of EGR1, exonuclease. (534 aa) |
| | ERI3 | ERI1 exoribonuclease family member 3. (244 aa) |
| | CNOT2 | NOT2_3_5 domain-containing protein. (520 aa) |
| | ANGEL2 | Endo/exonuclease/phosphatase domain-containing protein. (681 aa) |
| | EXD2 | 3'-5' exonuclease domain-containing protein. (621 aa) |
| | DNASE2B | Uncharacterized protein. (381 aa) |
| | XRN2 | 5'-3' exoribonuclease 2; Possesses 5'->3' exoribonuclease activity. May promote the termination of transcription by RNA polymerase II (By similarity). Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily. (949 aa) |
| | HARBI1 | Harbinger transposase derived 1. (348 aa) |
| | DIS3L2 | DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase. Essential for correct mitosis, and negatively regulates cell proliferation. Belongs to the RNR ribonuclease family. DIS3L2 subfamily. (1128 aa) |
| | EME1 | Essential meiotic structure-specific endonuclease 1. (568 aa) |
| | POLE | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2290 aa) |
| | DIS3L | DIS3 like exosome 3'-5' exoribonuclease; Belongs to the RNR ribonuclease family. (1054 aa) |
| | EXOG | Exo/endonuclease G. (382 aa) |
| | NTHL1 | Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family. (281 aa) |
| | TBL3 | WD_REPEATS_REGION domain-containing protein. (812 aa) |
| | CPSF4 | Uncharacterized protein. (243 aa) |
| | CPSF4L | Uncharacterized protein. (193 aa) |
| | G3BP1 | Uncharacterized protein. (472 aa) |
| | DNA2 | DNA replication ATP-dependent helicase/nuclease DNA2; Key enzyme involved in DNA replication and DNA repair in nucleus and mitochondrion. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA, while the 3'-ssDNA cleavage is prevented by [...] (992 aa) |
| | N4BP1 | NEDD4-binding protein 1; Inhibitor of the E3 ubiquitin-protein ligase ITCH. Belongs to the N4BP1 family. (930 aa) |
| | ERN1 | Uncharacterized protein. (968 aa) |
| | PMS2 | Mismatch repair endonuclease PMS2; Component of the post-replicative DNA mismatch repair system (MMR). Involved in B cell growth by positively regulating B cell proliferation and controlling replication efficiency. Controls cell cycle to prevent re-replication and defects in DNA damage-induced G2 checkpoint. Doesn't seem to counteract or control the immunoglobulin gene conversion (Ig GC) and to contribute to guanine/uracil mismatch repair. (869 aa) |
| | ATAD5 | AAA domain-containing protein. (1816 aa) |
| | SMG6 | SMG6 nonsense mediated mRNA decay factor. (1452 aa) |
| | PARN | R3H domain-containing protein. (635 aa) |
| | EXOSC10 | HRDC domain-containing protein. (910 aa) |
| | MRPL44 | Uncharacterized protein. (326 aa) |
| | ERCC4 | ERCC4 domain-containing protein. (903 aa) |
| | XRN1 | 5'-3' exoribonuclease 1. (1770 aa) |
| | PIWIL1 | Piwi-like protein 1; Endoribonuclease that plays a central role in postnatal germ cells by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds methylated piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived fro [...] (867 aa) |
| | BMS1 | Bms1-type G domain-containing protein. (1299 aa) |
| | CNOT1 | Uncharacterized protein. (2376 aa) |
| | EME2 | Essential meiotic structure-specific endonuclease subunit 2. (273 aa) |
| | REXO5 | Uncharacterized protein. (773 aa) |
| | APTX | Aprataxin; DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'- monophosphoramidate (AMP-NH(2)) and diadenosine tetraphosphate (AppppA), b [...] (350 aa) |
| | ELAC2 | ElaC ribonuclease Z 2. (842 aa) |
| | NOB1 | RNA-binding protein NOB1; May play a role in mRNA degradation. Belongs to the NOB1 family. (426 aa) |
| | ENSGALP00000074161 | Uncharacterized protein. (696 aa) |
| | K123 | K123 protein. (276 aa) |
| | PNPT1 | Polyribonucleotide nucleotidyltransferase 1. (896 aa) |
| | ENSGALP00000073911 | Uncharacterized protein. (1017 aa) |
| | ENSGALP00000073877 | Uncharacterized protein. (1017 aa) |
| | ENSGALP00000073842 | Uncharacterized protein. (711 aa) |
| | RIDA | Reactive intermediate imine deaminase A homolog. (286 aa) |
| | ENSGALP00000073783 | Uncharacterized protein. (744 aa) |
| | RNASEK | Ribonuclease K. (130 aa) |
| | REXO4 | REX4 homolog, 3'-5' exonuclease. (172 aa) |
| | TSEN2 | tRNA-splicing endonuclease subunit Sen2; Constitutes one of the two catalytic subunit of the tRNA- splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural [...] (461 aa) |
| | ENSGALP00000073693 | Uncharacterized protein. (1017 aa) |
| | ANKLE1 | Ankyrin repeat and LEM domain containing 1. (609 aa) |
| | ENSGALP00000073491 | Uncharacterized protein. (827 aa) |
| | ANGEL1 | Endo/exonuclease/phosphatase domain-containing protein. (704 aa) |
| | LOC101751955 | DDE Tnp4 domain-containing protein. (736 aa) |
| | NUDT21 | Nudix hydrolase domain-containing protein. (473 aa) |
| | ENSGALP00000072652 | Uncharacterized protein. (438 aa) |
| | ENSGALP00000072585 | Uncharacterized protein. (236 aa) |
| | MBLAC1 | Metallo-beta-lactamase domain containing 1. (369 aa) |
| | SETMAR | Uncharacterized protein. (297 aa) |
| | ENDOV | Endonuclease V. (202 aa) |
| | CSTF2 | RRM domain-containing protein. (573 aa) |
| | ISG20L2 | Interferon stimulated exonuclease gene 20 like 2. (303 aa) |
| | FAN1 | Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1034 aa) |
| | ENSGALP00000072078 | Uncharacterized protein. (927 aa) |
| | C19orf43 | Uncharacterized protein. (232 aa) |
| | ENSGALP00000071693 | Uncharacterized protein. (697 aa) |
| | ENSGALP00000071601 | Reverse transcriptase domain-containing protein. (127 aa) |
| | PLD6 | Phospholipase D family member 6. (218 aa) |
| | YBEY | YbeY metalloendoribonuclease. (164 aa) |
| | ENSGALP00000071349 | AAA_11 domain-containing protein. (258 aa) |
| | PDE12 | Phosphodiesterase 12. (584 aa) |
| | HELZ2 | Helicase with zinc finger 2. (2818 aa) |
| | ENSGALP00000071169 | Smr domain-containing protein. (223 aa) |
| | ENSGALP00000071149 | annotation not available (1017 aa) |
| | ENSGALP00000071051 | Uncharacterized protein. (696 aa) |
| | ENSGALP00000070953 | Uncharacterized protein. (1017 aa) |
| | DCP1B | Decapping mRNA 1B. (606 aa) |
| | ENSGALP00000070777 | Uncharacterized protein. (191 aa) |
| | ENSGALP00000070549 | Uncharacterized protein. (696 aa) |
| | ENSGALP00000070412 | Reverse transcriptase domain-containing protein. (297 aa) |
| | ENSGALP00000070408 | Reverse transcriptase domain-containing protein. (347 aa) |
| | FANCM | Fanconi anemia group M protein; DNA-dependent ATPase component of the Fanconi anemia (FA) core complex (By similarity). Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double- stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates (By similarity). Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a mova [...] (2101 aa) |
| | ENSGALP00000070057 | Reverse transcriptase domain-containing protein. (915 aa) |
| | ENSGALP00000070027 | Uncharacterized protein. (523 aa) |
| | ENSGALP00000069880 | Uncharacterized protein. (948 aa) |
| | ENSGALP00000069848 | Uncharacterized protein. (481 aa) |
| | ENSGALP00000069784 | Uncharacterized protein. (1017 aa) |
| | ENSGALP00000069775 | Uncharacterized protein. (1024 aa) |
| | ENSGALP00000069752 | Uncharacterized protein. (371 aa) |
| | ENSGALP00000069664 | Uncharacterized protein. (696 aa) |
| | RPP38 | Ribosomal_L7Ae domain-containing protein. (332 aa) |
| | ASTE1 | Uncharacterized protein. (215 aa) |
| | ISG20 | Interferon stimulated exonuclease gene 20. (258 aa) |
| | ENSGALP00000069413 | Uncharacterized protein. (930 aa) |
| | ENSGALP00000069360 | annotation not available (1017 aa) |
| | RPP30 | Ribonuclease P/MRP subunit p30. (363 aa) |
| | ENSGALP00000068909 | Uncharacterized protein. (355 aa) |
| | ENSGALP00000068883 | Uncharacterized protein. (552 aa) |
| | ENSGALP00000068826 | annotation not available (1017 aa) |
| | RNASEH2A | Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (477 aa) |
| | WRN | Uncharacterized protein. (1622 aa) |
| | ENSGALP00000068712 | Uncharacterized protein. (1017 aa) |
| | ENSGALP00000068331 | Uncharacterized protein. (387 aa) |
| | ENSGALP00000068288 | Uncharacterized protein. (65 aa) |
| | ENSGALP00000068244 | PLD phosphodiesterase domain-containing protein. (380 aa) |
| | TDP1 | Tyrosyl-DNA phosphodiesterase 1. (617 aa) |
| | ENSGALP00000068125 | annotation not available (1017 aa) |
| | ENSGALP00000068066 | TNase-like domain-containing protein. (231 aa) |
| | RPP25 | Ribonuclease P and MRP subunit p25. (203 aa) |
| | ENSGALP00000067823 | Integrase catalytic domain-containing protein. (123 aa) |
| | ENDOV-2 | Uncharacterized protein. (238 aa) |
| | ENSGALP00000067774 | Uncharacterized protein. (696 aa) |
| | EXOSC3 | KH_dom_type_1 domain-containing protein. (288 aa) |
| | ENSGALP00000067720 | annotation not available (523 aa) |
| | ENDOU | Endonuclease, poly(U) specific. (356 aa) |
| | EXD3 | Exonuclease 3'-5' domain containing 3. (872 aa) |
| | ENSGALP00000067483 | Uncharacterized protein. (1017 aa) |
| | ENSGALP00000067351 | Uncharacterized protein. (1017 aa) |
| | ZGRF1 | DUF2439 domain-containing protein. (1061 aa) |
| | PLD3 | PLD phosphodiesterase domain-containing protein. (204 aa) |
| | POL | Retrovirus-related Pol polyprotein. (809 aa) |
| | ENSGALP00000066651 | Uncharacterized protein. (696 aa) |
| | ENSGALP00000066368 | Uncharacterized protein. (521 aa) |
| | ENSGALP00000066301 | Uncharacterized protein. (573 aa) |
| | ENSGALP00000066147 | Uncharacterized protein. (1017 aa) |
| | ENSGALP00000065485 | GIY-YIG domain-containing protein. (71 aa) |
| | ENSGALP00000065219 | Uncharacterized protein. (1017 aa) |
| | APLF | Uncharacterized protein. (531 aa) |
| | RPP14 | Ribonuclease P/MRP subunit p14. (134 aa) |
| | ENSGALP00000065021 | Reverse transcriptase domain-containing protein. (604 aa) |
| | ENSGALP00000064923 | Reverse transcriptase domain-containing protein. (360 aa) |
| | ENSGALP00000064916 | Uncharacterized protein. (726 aa) |
| | DNASE1L2 | Deoxyribonuclease; Belongs to the DNase I family. (278 aa) |
| | TDP2 | Tyrosyl-DNA phosphodiesterase 2; DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead- end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DNA double-strand breaks (DSBs) due to DNA damage by radiation and free radicals. The 5'-tyrosyl DNA phosphodiesterase activity can enable the repair of TOP2-induced DSBs without the need for nuclease activity, crea [...] (369 aa) |
| | EXOSC2 | S1 domain-containing protein. (294 aa) |
| | CNOT8 | Uncharacterized protein. (292 aa) |
| | USB1 | U6 snRNA phosphodiesterase; Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA; Belongs to the 2H phosphoesterase superfamily. USB1 family. (398 aa) |
| | POP5 | POP5 homolog, ribonuclease P/MRP subunit. (281 aa) |
| | DNASE1 | Deoxyribonuclease-1; Serum endocuclease secreted into body fluids by a wide variety of exocrine and endocrine organs. Expressed by non-hematopoietic tissues and preferentially cleaves protein-free DNA (By similarity). Among other functions, seems to be involved in cell death by apoptosis (By similarity). Binds specifically to G-actin and blocks actin polymerization (By similarity). (282 aa) |
| | POLG | DNA polymerase subunit gamma-1; Involved in the replication of mitochondrial DNA. Associates with mitochondrial DNA (By similarity). (1191 aa) |
| | ENSGALP00000061451 | Uncharacterized protein. (255 aa) |
| | TATDN3 | TatD DNase domain containing 3. (261 aa) |
| | REXO2 | Exonuclease domain-containing protein. (233 aa) |
| | AGO4 | Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs; Belongs to the argonaute family. Ago subfamily. (861 aa) |
| | N4BP2 | Uncharacterized protein. (261 aa) |
| | UTP23 | UTP23 small subunit processome component. (246 aa) |
| | SWT1 | SWT1 RNA endoribonuclease homolog. (861 aa) |
| | ENPP3 | Ectonucleotide pyrophosphatase/phosphodiesterase 3. (886 aa) |
| | AGO1 | Uncharacterized protein; Belongs to the argonaute family. (857 aa) |
| | LAS1L | LAS1 like, ribosome biogenesis factor. (626 aa) |
| | TTC38 | Uncharacterized protein. (466 aa) |
| | ZRANB3-2 | HNH domain-containing protein. (442 aa) |
| | RAG1 | V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break b [...] (1041 aa) |
| | PAN2 | PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent [...] (1439 aa) |
| | ENPP1 | Uncharacterized protein. (354 aa) |
| | RAD1 | RAD1 checkpoint DNA exonuclease. (281 aa) |
| | DBR1 | Lariat debranching enzyme; Cleaves the 2'-5' phosphodiester linkage at the branch point of lariat intron pre-mRNAs after splicing and converts them into linear molecules that are subsequently degraded. It thereby facilitates ribonucleotide turnover. It may also participate in retrovirus replication via an RNA lariat intermediate in cDNA synthesis (By similarity); Belongs to the lariat debranching enzyme family. (486 aa) |
| | RPP40 | Ribonuclease P/MRP subunit p40. (362 aa) |
| | DCP1A | Decapping mRNA 1A. (582 aa) |
| | ENPP2 | Uncharacterized protein. (859 aa) |
| | LACTB2 | Lactamase_B domain-containing protein. (264 aa) |
| | TATDN1 | TatD DNase domain containing 1. (297 aa) |
| | CPSF7 | Cleavage and polyadenylation specific factor 7. (533 aa) |
| | POLR2I | DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (130 aa) |
| | ERI1 | SAP domain-containing protein. (327 aa) |
| | RNASEL | Uncharacterized protein. (686 aa) |
| | ZC3H12B | Zinc finger CCCH-type containing 12B. (837 aa) |
| | AGO3 | Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Possesses RNA slicer activity but only on select RNAs bearing 5'- and 3'-flanking sequences to the region of guide-target complementarity. (860 aa) |
| | RRP36 | Uncharacterized protein. (202 aa) |
| | CPSF6 | Cleavage and polyadenylation specificity factor subunit 6; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The [...] (582 aa) |
