(24 nodes) Cellular senescence network (Gallus gallus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
	HRAS	GTPase HRas, N-terminally processed; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)
	NPM2	Nucleophosmin/nucleoplasmin 2. (250 aa)
	WRN	Uncharacterized protein. (1622 aa)
	PMLL	Uncharacterized protein. (464 aa)
	NPM1	Nucleophosmin; Acts as a chaperonin for the core histones H3, H2B and H4. Associated with nucleolar ribonucleoprotein structures and bind single- stranded nucleic acids. It may function in the assembly and/or transport of ribosome. May stimulate endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA. May inhibit endonuclease activity on AP single-stranded RNA (By similarity). Belongs to the nucleoplasmin family. (404 aa)
	TBX2	T-box transcription factor 2. (693 aa)
	WNT16	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (507 aa)
	SRF	Serum response factor; SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Together with MRTFA transcription coactivator, controls expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration. (492 aa)
	OPA1	Dynamin-like 120 kDa protein, mitochondrial; Dynamin-related GTPase that is essential for normal mitochondrial morphology by regulating the equilibrium between mitochondrial fusion and mitochondrial fission. Binds lipid membranes enriched in negatively charged phospholipids, such as cardiolipin, and promotes membrane tubulation. The intrinsic GTPase activity is low, and is strongly increased by interaction with lipid membranes (By similarity). Plays a role in remodeling cristae and the release of cytochrome c during apoptosis (By similarity). Belongs to the TRAFAC class dynamin-like GT [...] (1014 aa)
	NSMCE2	SP-RING-type domain-containing protein. (239 aa)
	HMGA1	High mobility group A1b. (96 aa)
	ECRG4	ECRG4 augurin precursor. (112 aa)
	PRELP	Proline and arginine rich end leucine rich repeat protein. (430 aa)
	TBX3	T-box transcription factor TBX3; Transcriptional repressor involved in developmental processes. Probably plays a role in limb pattern formation. (732 aa)
	CDKN2B	p15INK4b tumor suppressor. (139 aa)
	PLA2R1	Uncharacterized protein. (1459 aa)
	BRCA2	Tower domain-containing protein. (3397 aa)
	SMC6	SMC_N domain-containing protein. (1096 aa)
	SMC5	Structural maintenance of chromosomes protein 5; Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components. Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; [...] (1065 aa)
	HMGA2	High mobility group protein I-C. (109 aa)
	MNT	MAX network transcriptional repressor. (562 aa)
	MAPKAPK5	Protein kinase domain-containing protein. (465 aa)
	SIRT1	Deacetylase sirtuin-type domain-containing protein. (881 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BRCA2	SMC5	ENSGALP00000027524	ENSGALP00000024348	Tower domain-containing protein.	Structural maintenance of chromosomes protein 5; Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components. Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; [...]	0.457
BRCA2	TP63	ENSGALP00000027524	ENSGALP00000062182	Tower domain-containing protein.	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.	0.533
BRCA2	WRN	ENSGALP00000027524	ENSGALP00000068726	Tower domain-containing protein.	Uncharacterized protein.	0.949
CDKN2B	NPM1	ENSGALP00000042709	ENSGALP00000058806	p15INK4b tumor suppressor.	Nucleophosmin; Acts as a chaperonin for the core histones H3, H2B and H4. Associated with nucleolar ribonucleoprotein structures and bind single- stranded nucleic acids. It may function in the assembly and/or transport of ribosome. May stimulate endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA. May inhibit endonuclease activity on AP single-stranded RNA (By similarity). Belongs to the nucleoplasmin family.	0.544
CDKN2B	NPM2	ENSGALP00000042709	ENSGALP00000070388	p15INK4b tumor suppressor.	Nucleophosmin/nucleoplasmin 2.	0.501
NPM1	CDKN2B	ENSGALP00000058806	ENSGALP00000042709	Nucleophosmin; Acts as a chaperonin for the core histones H3, H2B and H4. Associated with nucleolar ribonucleoprotein structures and bind single- stranded nucleic acids. It may function in the assembly and/or transport of ribosome. May stimulate endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA. May inhibit endonuclease activity on AP single-stranded RNA (By similarity). Belongs to the nucleoplasmin family.	p15INK4b tumor suppressor.	0.544
NPM2	CDKN2B	ENSGALP00000070388	ENSGALP00000042709	Nucleophosmin/nucleoplasmin 2.	p15INK4b tumor suppressor.	0.501
NSMCE2	SMC5	ENSGALP00000053530	ENSGALP00000024348	SP-RING-type domain-containing protein.	Structural maintenance of chromosomes protein 5; Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components. Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; [...]	0.999
NSMCE2	SMC6	ENSGALP00000053530	ENSGALP00000026518	SP-RING-type domain-containing protein.	SMC_N domain-containing protein.	0.999
NSMCE2	WRN	ENSGALP00000053530	ENSGALP00000068726	SP-RING-type domain-containing protein.	Uncharacterized protein.	0.705
SIRT1	WRN	ENSGALP00000004350	ENSGALP00000068726	Deacetylase sirtuin-type domain-containing protein.	Uncharacterized protein.	0.802
SMC5	BRCA2	ENSGALP00000024348	ENSGALP00000027524	Structural maintenance of chromosomes protein 5; Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components. Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; [...]	Tower domain-containing protein.	0.457
SMC5	NSMCE2	ENSGALP00000024348	ENSGALP00000053530	Structural maintenance of chromosomes protein 5; Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components. Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; [...]	SP-RING-type domain-containing protein.	0.999
SMC5	SMC6	ENSGALP00000024348	ENSGALP00000026518	Structural maintenance of chromosomes protein 5; Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components. Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; [...]	SMC_N domain-containing protein.	0.999
SMC5	WRN	ENSGALP00000024348	ENSGALP00000068726	Structural maintenance of chromosomes protein 5; Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components. Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; [...]	Uncharacterized protein.	0.848
SMC6	NSMCE2	ENSGALP00000026518	ENSGALP00000053530	SMC_N domain-containing protein.	SP-RING-type domain-containing protein.	0.999
SMC6	SMC5	ENSGALP00000026518	ENSGALP00000024348	SMC_N domain-containing protein.	Structural maintenance of chromosomes protein 5; Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components. Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; [...]	0.999
SMC6	WRN	ENSGALP00000026518	ENSGALP00000068726	SMC_N domain-containing protein.	Uncharacterized protein.	0.800
TP63	BRCA2	ENSGALP00000062182	ENSGALP00000027524	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.	Tower domain-containing protein.	0.533
TP63	WRN	ENSGALP00000062182	ENSGALP00000068726	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.	Uncharacterized protein.	0.641