STRINGSTRING
PDZD7-2 PDZD7-2 STRA6 STRA6 BBS4 BBS4 CRB1 CRB1 FRZB FRZB FASLG FASLG STAT3 STAT3 PRRX1 PRRX1 LOC427439 LOC427439 MFSD2A MFSD2A MFN2 MFN2 FBN1 FBN1 FOXN4 FOXN4 AQP1 AQP1 SOX8 SOX8 WNT9A WNT9A LHX1 LHX1 BHLHE23 BHLHE23 USH1C USH1C TBC1D20 TBC1D20 SHH SHH PDE6C PDE6C DSCAML1 DSCAML1 LHX5 LHX5 DZANK1 DZANK1 WDPCP WDPCP JAG1 JAG1 TSPAN12 TSPAN12 DLX5 DLX5 MYO3B MYO3B LRIG3 LRIG3 PROX1 PROX1 FRS2 FRS2 EDNRA EDNRA INTU INTU CLRN1 CLRN1 TSHR TSHR TTC8 TTC8 PTPRQ PTPRQ IHH IHH TDRD7 TDRD7 AGTPBP1 AGTPBP1 EDN1 EDN1 THL THL IGF1 IGF1 BCL2 BCL2 KDR KDR AHI1 AHI1 E1C1Y1_CHICK E1C1Y1_CHICK C1H12ORF57 C1H12ORF57 MSX1 MSX1 TTC39C TTC39C RORB RORB NECTIN3 NECTIN3 MYO6 MYO6 CYP26B1 CYP26B1 DSCAM DSCAM LRRC1 LRRC1 IFT172 IFT172 RS1 RS1 SIX4 SIX4 GAS1 GAS1 FGF2 FGF2 FGF8 FGF8 LRIG1 LRIG1 ATF4 ATF4 SOX9 SOX9 CRB2 CRB2 NTN1 NTN1 THY1 THY1 PTF1A PTF1A CNTF CNTF SIX2 SIX2 WNT2 WNT2 FZD3 FZD3 NAGLU NAGLU FJX1 FJX1 WNT2B WNT2B TBX3 TBX3 USH1G USH1G CTNNB1 CTNNB1 SIX1 SIX1 SP3 SP3 MFAP2 MFAP2 HOXC13 HOXC13 CHD9 CHD9 OSR2 OSR2 ENSGALP00000048186 ENSGALP00000048186 PHACTR4 PHACTR4 SOX21 SOX21 OTOP1 OTOP1 SOX1 SOX1 SEC24B SEC24B TH TH EYA1 EYA1 LOC427025 LOC427025 GBX2 GBX2 FAT3 FAT3 ZIC1 ZIC1 FOXG1 FOXG1 SOBP SOBP ALDH1A3 ALDH1A3 BAK1 BAK1 MYO3A MYO3A IGFN1 IGFN1 CHD7 CHD7 WNT3A WNT3A EPHA2 EPHA2 NECTIN1 NECTIN1 TBX2 TBX2 NBL1 NBL1 ZHX2 ZHX2 SIX3 SIX3 WDR19 WDR19 GSC GSC HDAC1 HDAC1 SLITRK6 SLITRK6 SDK1 SDK1 EEF1E1 EEF1E1 GRXCR2 GRXCR2 SDK2 SDK2 NKX3-2 NKX3-2 TPRN TPRN ENSGALP00000065224 ENSGALP00000065224 MEGF11 MEGF11 CABP4 CABP4 ENSGALP00000066624 ENSGALP00000066624 REST REST DLL1 DLL1 ENSGALP00000068651 ENSGALP00000068651 GATA3 GATA3 BCHE BCHE RPGRIP1L RPGRIP1L CTHRC1 CTHRC1 ENSGALP00000069955 ENSGALP00000069955 DLX6 DLX6 KCNQ1 KCNQ1 WHRN WHRN MFAP5 MFAP5 LOC107050371 LOC107050371 OSR1 OSR1 OTX1 OTX1 PDZD7 PDZD7 PRDM1 PRDM1 FAT1 FAT1 ACHE ACHE
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PDZD7-2Uncharacterized protein. (548 aa)
STRA6Uncharacterized protein. (671 aa)
BBS4TPR_REGION domain-containing protein. (532 aa)
CRB1Crumbs cell polarity complex component 1. (807 aa)
FRZBSecreted frizzled-related protein 3; Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development. (315 aa)
FASLGTNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (295 aa)
STAT3Signal transducer and activator of transcription 3; Transcription factor that binds to the interleukin-6 (IL-6)- responsive elements identified in the promoters of various acute-phase protein genes. (771 aa)
PRRX1Paired mesoderm homeobox protein 1; May participate in maintenance of mesenchymal cell lineages derived from both mesoderm and the neural crest and in patterning of the limbs and the face. (245 aa)
LOC427439Nipped-B protein. (2783 aa)
MFSD2AMajor facilitator superfamily domain containing 2A. (528 aa)
MFN2Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (762 aa)
FBN1Fibrillin 1. (2861 aa)
FOXN4Forkhead box N4. (513 aa)
AQP1Aquaporin-1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (270 aa)
SOX8Transcription factor SOX-8; May play a role in central nervous system, limb and facial development. May be involved in male sex determination. Binds the consensus motif 5'-[AT][AT]CAA[AT]G-3'. (470 aa)
WNT9AProtein Wnt-9a; Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt/beta-catenin signaling pathway. Plays a role in embryonic chondrocyte maturation and in embryonic bone mineralization (By similarity). (503 aa)
LHX1LIM/homeobox protein Lhx1; Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with ISL-2. (406 aa)
BHLHE23BHLH transcription factor neuroAB. (220 aa)
USH1CUSH1 protein network component harmonin. (556 aa)
TBC1D20TBC1 domain family member 20. (394 aa)
SHHSonic hedgehog protein N-product; [Sonic hedgehog protein]: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). (425 aa)
PDE6CCone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha; As cone-specific cGMP phosphodiesterase, it plays an essential role in light detection and cone phototransduction by rapidly decreasing intracellular levels of cGMP. (862 aa)
DSCAML1Down syndrome cell adhesion molecule-like protein 1 homolog; Cell adhesion molecule that plays a role in neuronal self- avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells (By similarity). Adhesion molecule that promotes lamina-specific synaptic connections in the retina: expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions. (2042 aa)
LHX5LIM homeobox protein 5. (402 aa)
DZANK1ANK_REP_REGION domain-containing protein. (767 aa)
WDPCPWD repeat containing planar cell polarity effector. (807 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1216 aa)
TSPAN12Tetraspanin-12; Regulator of cell surface receptor signal transduction. Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activate the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt- dependent activation of FZD4, suggesting the existence of a Wnt- independent signaling that also [...] (305 aa)
DLX5Homeobox protein DLX-5; Transcriptional factor involved in bone development. Could be involved in apical ectodermal ridge activity, pattern formation, and cartilage differentiation. Binds to DNA; Belongs to the distal-less homeobox family. (286 aa)
MYO3BMyosin IIIB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1287 aa)
LRIG3Uncharacterized protein. (1099 aa)
PROX1Prospero homeobox protein 1; Transcription factor which may be involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. May be essential in the development and function of the eye. May play a role in the regulation of the circadian rhythm by repressing the expression of clock genes; Belongs to the Prospero homeodomain family. (736 aa)
FRS2IRS-type PTB domain-containing protein. (508 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (421 aa)
INTUUncharacterized protein. (322 aa)
CLRN1Clarin 1. (232 aa)
TSHRThyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (761 aa)
TTC8Tetratricopeptide repeat domain 8. (567 aa)
PTPRQProtein tyrosine phosphatase receptor type Q. (2308 aa)
IHHIndian hedgehog protein C-product; Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP); Belongs to the hedgehog family. (408 aa)
TDRD7Tudor domain-containing protein 7; Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. Required for lens transparency during lens development, by regulating translation of specific genes in the developing lens. Also required during spermatogenesis. (1095 aa)
AGTPBP1Cytosolic carboxypeptidase 1; Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate. (1225 aa)
EDN1Endothelin 1. (194 aa)
THLBH4_AAA_HYDROXYL_2 domain-containing protein. (443 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins. Its binding to integrins and subsequent ternary complex fo [...] (153 aa)
BCL2Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). (233 aa)
KDRUncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1348 aa)
AHI1Abelson helper integration site 1. (1242 aa)
E1C1Y1_CHICKUncharacterized protein. (351 aa)
C1H12ORF57Uncharacterized protein. (126 aa)
MSX1Homeobox protein GHOX-7; Probably plays a role in patterning events during embryonic limb development. May also be involved in programmed cell death. (288 aa)
TTC39CTetratricopeptide repeat domain 39C. (576 aa)
RORBNuclear orphan receptor ROR-beta. (459 aa)
NECTIN3Nectin cell adhesion molecule 3. (559 aa)
MYO6Unconventional myosin-VI; Myosins are actin-based motor molecules with ATPase activity (By similarity). Unconventional myosins serve in intracellular movements (By similarity). Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments (By similarity). Has slow rate of actin-activated ADP release due to weak ATP binding (By similarity). Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration (By similarity). Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-su [...] (1276 aa)
CYP26B1Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (511 aa)
DSCAMDown syndrome cell adhesion molecule homolog; Cell adhesion molecule that plays a role in neuronal self- avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Mediates within retinal amacrine and ganglion cell subtypes both isoneuronal self- avoidance for creating an orderly dendritic arborization and heteroneuronal self-avoidance to maintain the mosaic spacing between amacrine and ganglion cell bodies (By similarity). Receptor for netrin required for axon guidance independently of and in collaboration with the receptor [...] (2034 aa)
LRRC1Leucine rich repeat containing 1. (797 aa)
IFT172Intraflagellar transport 172. (1749 aa)
RS1F5/8 type C domain-containing protein. (224 aa)
SIX4SIX homeobox 4. (776 aa)
GAS1Growth arrest specific 1. (159 aa)
FGF2Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis; Belongs to the heparin-binding growth factors family. (158 aa)
FGF8Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Involved in initiation, outgrowth and patterning of the limbs; Belongs to the heparin-binding growth factors family. (214 aa)
LRIG1Leucine rich repeats and immunoglobulin like domains 1. (1206 aa)
ATF4ATF4. (354 aa)
SOX9Transcription factor SOX-9; Transcription factor that selectively activates enhancer through its interaction with a DNA-binding partner factor. Activates enhancer of COL2A1 through its binding with DNA sequence 5'-ATTCAT-3'. In response to bone morphogenetic protein stimulus, phosphorylation is induced and then sumoylation, allowing cooperation with SNAI2 to trigger neural crest delamination. Functions at the level of mesenchymal cell condensation by inducing cartilage development in limbs and by changing the aggregation properties of limb mesenchymal cells. Regulates the cell fate dec [...] (494 aa)
CRB2Uncharacterized protein. (1469 aa)
NTN1Netrin-1; Netrins control guidance of CNS commissural axons and peripheral motor axons. Promotes neurite outgrowth from commissural axons but acts as a chemorepellent for trochlear motor axons. These effects are mediated by distinct receptors. (688 aa)
THY1Thy-1 membrane glycoprotein; May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain. (161 aa)
PTF1APancreas associated transcription factor 1a. (275 aa)
CNTFCiliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy. (195 aa)
SIX2Sine oculis-related homeobox 2 homolog. (287 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (376 aa)
FZD3Frizzled-3; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to i [...] (666 aa)
NAGLUN-acetyl-alpha-glucosaminidase. (751 aa)
FJX1Four jointed box 1. (384 aa)
WNT2BProtein Wnt-2b; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt/beta-catenin signaling pathway. Acts as an upstream regulator of FGF10 in the lateral plate mesoderm during limb initiation in the embryo. (385 aa)
TBX3T-box transcription factor TBX3; Transcriptional repressor involved in developmental processes. Probably plays a role in limb pattern formation. (732 aa)
USH1GUSH1 protein network component sans. (457 aa)
CTNNB1Uncharacterized protein. (781 aa)
SIX1Sine oculis-related homeobox 1 homolog. (282 aa)
SP3Transcription factor Sp3; Transcriptional factor that can act as an activator or repressor depending on post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box promoters. Weak activator of transcription (By similarity). Required for activation of SPARC transcription; Belongs to the Sp1 C2H2-type zinc-finger protein family. (771 aa)
MFAP2Microfibril associated protein 2. (187 aa)
HOXC13Homeobox C13. (295 aa)
CHD9Chromodomain helicase DNA binding protein 9. (2820 aa)
OSR2Uncharacterized protein. (412 aa)
ENSGALP00000048186Uncharacterized protein. (528 aa)
PHACTR4Phosphatase and actin regulator 4; Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to repression of the integrin signaling through the RHO/ROCK pathway (By similarity). (199 aa)
SOX21Transcription factor SOX-21; Acts as a negative regulator of transcription. (280 aa)
OTOP1Otopetrin 1. (609 aa)
SOX1Transcription factor SOX-1; Transcriptional activator. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural protein and suppresses neuronal differentiation. (373 aa)
SEC24BUncharacterized protein. (1234 aa)
THTyrosine hydroxylase. (491 aa)
EYA1Eyes absent homolog 1; Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for other transcription factors of this family. Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Its function as histone phosphatase may contribute to its function i [...] (625 aa)
LOC427025Nipped-B protein. (2769 aa)
GBX2Homeobox protein GBX-2; May act as a transcription factor for cell pluripotency and differentiation in the embryo. (339 aa)
FAT3Uncharacterized protein. (4598 aa)
ZIC1Zinc finger protein ZIC 1; Acts as a transcriptional activator. Involved in neurogenesis. Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3' (By similarity). (444 aa)
FOXG1Forkhead box protein G1; May determine the nasotemporal axis of the retina, and consequently specify the topographical projection of the retinal ganglion-cell axons to the tectum by controlling expression of their target genes. (451 aa)
SOBPSine oculis-binding protein homolog; Implicated in development of the cochlea. (873 aa)
ALDH1A3Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (512 aa)
BAK1Uncharacterized protein. (216 aa)
MYO3AMyosin IIIA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1632 aa)
IGFN1Uncharacterized protein. (2363 aa)
CHD7Chromodomain-helicase-DNA-binding protein 7; Probable transcription regulator. Maybe involved in the in 45S precursor rRNA production (By similarity). (3009 aa)
WNT3AProtein Wnt-3a; [Isoform 1]: Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. Regulates chick apical ectodermal ridge formation. Required for normal embryonic mesoderm development and formation of caudal somites. Required for normal morphogenesis of the developing neural tube (By similarity). ECO:0000250|UniProtKB:P56704. (376 aa)
EPHA2EPH receptor A2. (1288 aa)
NECTIN1Nectin cell adhesion molecule 1. (523 aa)
TBX2T-box transcription factor 2. (693 aa)
NBL1Neuroblastoma suppressor of tumorigenicity 1; May act as a tumor suppressor. (194 aa)
ZHX2Zinc fingers and homeoboxes 2. (830 aa)
SIX3Homeobox protein SIX3; Transcriptional regulator which can act as both a transcriptional repressor and activator by binding a ATTA homeodomain core recognition sequence on these target genes. During forebrain development represses WNT1 expression allowing zona limitans intrathalamica formation and thereby ensuring proper anterio-posterior patterning of the diencephalon and formation of the rostral diencephalon. Acts as a direct upstream activator of SHH expression in the rostral diencephalon ventral midline and that in turn SHH maintains its expression. In addition, Six3 activity is re [...] (314 aa)
WDR19WD_REPEATS_REGION domain-containing protein. (470 aa)
GSCHomeobox protein goosecoid; Involved in the development of the organizer region in the gastrula (Hensen node in chicken). (346 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity); Belongs to the histone deacetylase family. HD type 1 subfamily. (480 aa)
SLITRK6SLIT and NTRK like family member 6. (840 aa)
SDK1Protein sidekick-1; Adhesion molecule that promotes lamina-specific synaptic connections in the retina. Expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions ; Belongs to the sidekick family. (2275 aa)
EEF1E1Biogenesis of lysosome-related organelles complex 1 subunit 5; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. Plays a role in intracellular vesicle trafficking (By similarity); Belongs to the BLOC1S5 family. (221 aa)
GRXCR2Glutaredoxin and cysteine rich domain containing 2. (132 aa)
SDK2Protein sidekick-2; Adhesion molecule that promotes lamina-specific synaptic connections in the retina. Expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions. (2205 aa)
NKX3-2Homeobox domain-containing protein. (275 aa)
TPRNPhostensin domain-containing protein. (125 aa)
ENSGALP00000065224Uncharacterized protein. (381 aa)
MEGF11Multiple EGF like domains 11. (1084 aa)
CABP4Calcium binding protein 4. (173 aa)
ENSGALP00000066624Uncharacterized protein. (187 aa)
RESTUncharacterized protein. (339 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (893 aa)
ENSGALP00000068651Uncharacterized protein. (150 aa)
GATA3GATA-binding factor 3; Transcriptional activator which probably serves as a general switch factor for cell-specific development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of genes. (444 aa)
BCHECarboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (603 aa)
RPGRIP1LRPGRIP1 like. (1273 aa)
CTHRC1Collagen triple helix repeat containing 1. (314 aa)
ENSGALP00000069955Uncharacterized protein. (496 aa)
DLX6Homeobox domain-containing protein. (283 aa)
KCNQ1Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (863 aa)
WHRNWhirlin. (926 aa)
MFAP5Microfibril associated protein 5. (154 aa)
LOC107050371Uncharacterized protein. (1015 aa)
OSR1Uncharacterized protein. (260 aa)
OTX1Orthodenticle homeobox 1. (335 aa)
PDZD7PDZ domain-containing protein. (413 aa)
PRDM1PR/SET domain 1. (789 aa)
FAT1FAT atypical cadherin 1. (4645 aa)
ACHEAcetylcholinesterase; Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft; Belongs to the type-B carboxylesterase/lipase family. (767 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
Server load: low (20%) [HD]