(14 nodes) Extrinsic apoptotic signaling pathway in absence of ligand network (Gallus gallus)

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Your Input:
	BCL2L11	BCL2 like 11. (179 aa)
	BAG3	BCL2 associated athanogene 3. (560 aa)
	BCL2	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). (233 aa)
	CASP2	Caspase-2 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival. (441 aa)
	CX3CL1	SCY domain-containing protein. (496 aa)
	EYA2	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (631 aa)
	BCL2L10	Anti-apoptotic protein NR13; Shows anti-apoptotic properties. Counteract the pro-apoptotic activity of BAX; Belongs to the Bcl-2 family. (177 aa)
	BCL2L1	Bcl-2-like protein 1; Dominant regulator of apoptotic cell death. The long form displays cell death repressor activity, whereas the short isoform promotes apoptosis. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis (By similarity). (229 aa)
	BAK1	Uncharacterized protein. (216 aa)
	MCL1	Uncharacterized protein. (335 aa)
	GSK3B	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (420 aa)
	BOK	Bcl-2-related ovarian killer protein; May play a role in apoptosis; Belongs to the Bcl-2 family. (213 aa)
	BCL2A1	Protein A1. (174 aa)
	FADD	Fas associated via death domain. (195 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BAG3	BCL2	ENSGALP00000015342	ENSGALP00000020984	BCL2 associated athanogene 3.	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).	0.845
BAK1	BCL2	ENSGALP00000055311	ENSGALP00000020984	Uncharacterized protein.	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).	0.985
BAK1	BCL2A1	ENSGALP00000055311	ENSGALP00000010509	Uncharacterized protein.	Protein A1.	0.937
BAK1	BCL2L1	ENSGALP00000055311	ENSGALP00000054103	Uncharacterized protein.	Bcl-2-like protein 1; Dominant regulator of apoptotic cell death. The long form displays cell death repressor activity, whereas the short isoform promotes apoptosis. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis (By similarity).	0.996
BAK1	BCL2L10	ENSGALP00000055311	ENSGALP00000053183	Uncharacterized protein.	Anti-apoptotic protein NR13; Shows anti-apoptotic properties. Counteract the pro-apoptotic activity of BAX; Belongs to the Bcl-2 family.	0.639
BAK1	BCL2L11	ENSGALP00000055311	ENSGALP00000070659	Uncharacterized protein.	BCL2 like 11.	0.916
BAK1	MCL1	ENSGALP00000055311	ENSGALP00000062575	Uncharacterized protein.	Uncharacterized protein.	0.931
BCL2	BAG3	ENSGALP00000020984	ENSGALP00000015342	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).	BCL2 associated athanogene 3.	0.845
BCL2	BAK1	ENSGALP00000020984	ENSGALP00000055311	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).	Uncharacterized protein.	0.985
BCL2	BCL2L1	ENSGALP00000020984	ENSGALP00000054103	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).	Bcl-2-like protein 1; Dominant regulator of apoptotic cell death. The long form displays cell death repressor activity, whereas the short isoform promotes apoptosis. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis (By similarity).	0.972
BCL2	BCL2L10	ENSGALP00000020984	ENSGALP00000053183	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).	Anti-apoptotic protein NR13; Shows anti-apoptotic properties. Counteract the pro-apoptotic activity of BAX; Belongs to the Bcl-2 family.	0.566
BCL2	BCL2L11	ENSGALP00000020984	ENSGALP00000070659	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).	BCL2 like 11.	0.997
BCL2	BOK	ENSGALP00000020984	ENSGALP00000071746	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).	Bcl-2-related ovarian killer protein; May play a role in apoptosis; Belongs to the Bcl-2 family.	0.628
BCL2	CASP2	ENSGALP00000020984	ENSGALP00000029853	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).	Caspase-2 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival.	0.767
BCL2	FADD	ENSGALP00000020984	ENSGALP00000012326	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).	Fas associated via death domain.	0.741
BCL2	GSK3B	ENSGALP00000020984	ENSGALP00000066184	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily.	0.580
BCL2	MCL1	ENSGALP00000020984	ENSGALP00000062575	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).	Uncharacterized protein.	0.626
BCL2A1	BAK1	ENSGALP00000010509	ENSGALP00000055311	Protein A1.	Uncharacterized protein.	0.937
BCL2A1	BCL2L10	ENSGALP00000010509	ENSGALP00000053183	Protein A1.	Anti-apoptotic protein NR13; Shows anti-apoptotic properties. Counteract the pro-apoptotic activity of BAX; Belongs to the Bcl-2 family.	0.495
BCL2A1	BCL2L11	ENSGALP00000010509	ENSGALP00000070659	Protein A1.	BCL2 like 11.	0.975