STRINGSTRING
ITGB7 ITGB7 ENSGALP00000073351 ENSGALP00000073351 PTPN6 PTPN6 GP1BB GP1BB CACNG7 CACNG7 EMILIN1 EMILIN1 SKAP1 SKAP1 CD3D CD3D HJV HJV ENSGALP00000070753 ENSGALP00000070753 ENSGALP00000070440 ENSGALP00000070440 CHRNB2 CHRNB2 LOC107051468 LOC107051468 ITGAD ITGAD LOC101750889 LOC101750889 PORCN PORCN ENSGALP00000068604 ENSGALP00000068604 ACVRL1 ACVRL1 TRAF6 TRAF6 IL6 IL6 CALCRL CALCRL ITGA2B ITGA2B TRAF3 TRAF3 CHRNB1 CHRNB1 IL12RB1 IL12RB1 ACVR1C ACVR1C CNTFR CNTFR CRCBL CRCBL ITGA8 ITGA8 SHISA8 SHISA8 LOC107051192 LOC107051192 ITGB8 ITGB8 CACNG2 CACNG2 IL6R IL6R IGF1R IGF1R ITGA6 ITGA6 CACNG3 CACNG3 ITGA9 ITGA9 CHRND CHRND ITGB1 ITGB1 TGFBR1 TGFBR1 GRIA4 GRIA4 GRIA3 GRIA3 ITGA4 ITGA4 GRIA1 GRIA1 HTRA2 HTRA2 IKBKB IKBKB ITGA7 ITGA7 ITGA3 ITGA3 ACVR1B ACVR1B RAMP3 RAMP3 HTR3A HTR3A INSR INSR ITGB5 ITGB5 ITGAV ITGAV LYN LYN CHRNA1 CHRNA1 ACVR1 ACVR1 GABBR2 GABBR2 SHISA9 SHISA9 GRIN3B GRIN3B CACNG4 CACNG4 GRIN2C GRIN2C RAMP2 RAMP2 GRIN1 GRIN1 VWC2L VWC2L CHRNB4 CHRNB4 CD40 CD40 GRIA2 GRIA2 ACVR2A ACVR2A CHRNA6 CHRNA6 TRAT1 TRAT1 IL18RAP IL18RAP CHRNA2 CHRNA2 GRIN3A GRIN3A CD247 CD247 CHRNA8 CHRNA8 GPR156 GPR156 ITGA2 ITGA2 PELO PELO IL6ST IL6ST CHRNA9 CHRNA9 CHRNA10 CHRNA10 INSRR INSRR VWC2 VWC2 CSF2RB CSF2RB AMHR2 AMHR2 GRIN2B GRIN2B TGFBR2 TGFBR2 ITGB6 ITGB6 TRAF5 TRAF5 ITGA11 ITGA11 CHRNG CHRNG ITGB2 ITGB2 CD3E CD3E GRIN2A GRIN2A GRIK4 GRIK4 ACVR2B ACVR2B CHRNA4 CHRNA4 ABHD6 ABHD6 GP9 GP9 CHRNA7 CHRNA7 CACNG5 CACNG5 RAMP1 RAMP1 OSMR OSMR CHRNA5 CHRNA5 CHRNA3 CHRNA3 CD79B CD79B ITGB3 ITGB3 KBP KBP ZAP70 ZAP70 STOML2 STOML2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ITGB7Integrin beta; Belongs to the integrin beta chain family. (538 aa)
ENSGALP00000073351Integrin_alpha2 domain-containing protein. (465 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (639 aa)
GP1BBGlycoprotein Ib platelet subunit beta. (202 aa)
CACNG7Calcium voltage-gated channel auxiliary subunit gamma 7. (126 aa)
EMILIN1EMI domain-containing protein. (610 aa)
SKAP1Src kinase associated phosphoprotein 1. (355 aa)
CD3DIg_4 domain-containing protein. (179 aa)
HJVHemojuvelin BMP co-receptor. (514 aa)
ENSGALP00000070753ANF_receptor domain-containing protein. (1472 aa)
ENSGALP00000070440Uncharacterized protein. (167 aa)
CHRNB2Neuronal acetylcholine receptor subunit beta-2; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane; Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Beta-2/CHRNB2 sub- subfamily. (835 aa)
LOC107051468Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (416 aa)
ITGADVWFA domain-containing protein; Belongs to the integrin alpha chain family. (1068 aa)
LOC101750889LRRCT domain-containing protein. (714 aa)
PORCNPorcupine O-acyltransferase. (291 aa)
ENSGALP00000068604Uncharacterized protein. (186 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (796 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (545 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily. (307 aa)
CALCRLCalcitonin receptor-like receptor; Belongs to the G-protein coupled receptor 2 family. (457 aa)
ITGA2BIntegrin subunit alpha 2b; Belongs to the integrin alpha chain family. (866 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (567 aa)
CHRNB1Acetylcholine receptor subunit beta; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. (228 aa)
IL12RB1Fibronectin type-III domain-containing protein. (591 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (495 aa)
CNTFRCiliary neurotrophic factor receptor subunit alpha; Binds to CNTF (GPA). The alpha subunit provides the receptor specificity. (497 aa)
CRCBLFibronectin type-III domain-containing protein. (674 aa)
ITGA8Integrin alpha-8 heavy chain; Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1, TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis (By similarity). Neuronal receptor for TNC it mediates cell- cell interactions and regulates neurite outgrowth of sensory and motor neurons. (1076 aa)
SHISA8Uncharacterized protein. (359 aa)
LOC107051192RanBP2-type domain-containing protein. (1255 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (787 aa)
CACNG2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (323 aa)
IL6RUncharacterized protein. (445 aa)
IGF1RTyrosine-protein kinase receptor. (1363 aa)
ITGA6Integrin alpha-6 heavy chain; Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion. Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome. (1072 aa)
CACNG3Uncharacterized protein. (315 aa)
ITGA9Integrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. (1031 aa)
CHRNDAcetylcholine receptor subunit delta; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. (525 aa)
ITGB1Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-1 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] (822 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
GRIA4Uncharacterized protein. (943 aa)
GRIA3Uncharacterized protein. (888 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1021 aa)
GRIA1Uncharacterized protein. (902 aa)
HTRA2HtrA serine peptidase 2. (200 aa)
IKBKBProtein kinase domain-containing protein. (753 aa)
ITGA7Integrin subunit alpha 7; Belongs to the integrin alpha chain family. (1180 aa)
ITGA3Uncharacterized protein; Belongs to the integrin alpha chain family. (1108 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (519 aa)
RAMP3Receptor activity modifying protein 3. (156 aa)
HTR3ANeur_chan_memb domain-containing protein. (209 aa)
INSRTyrosine-protein kinase receptor. (1324 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (811 aa)
ITGAVIntegrin alpha-V heavy chain; The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase- 2, osteopontin, osteomodulin, prothrombin, thrombospondin, TGFB1 and vWF. They recognize the sequence R-G-D in a wide array of ligands. Alpha-V integrins may play a role in embryo implantation, angiogenesis and wound healing (By similarity). ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling. ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential [...] (1048 aa)
LYNTyrosine-protein kinase. (491 aa)
CHRNA1Acetylcholine receptor subunit alpha; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. (474 aa)
ACVR1Activin receptor type-1; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin (By similarity). (524 aa)
GABBR2Gamma-aminobutyric acid type B receptor subunit 2. (936 aa)
SHISA9Shisa family member 9. (274 aa)
GRIN3BGlutamate ionotropic receptor NMDA type subunit 3B; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1022 aa)
CACNG4Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (328 aa)
GRIN2CGlutamate ionotropic receptor NMDA type subunit 2C. (1301 aa)
RAMP2Receptor activity modifying protein 2. (176 aa)
GRIN1N-methyl-D-aspartate receptor type 1 subunit. (965 aa)
VWC2LVon Willebrand factor C domain containing 2 like. (229 aa)
CHRNB4Neuronal acetylcholine receptor subunit beta-4; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. (489 aa)
CD40Uncharacterized protein. (299 aa)
GRIA2Uncharacterized protein. (883 aa)
ACVR2AActivin receptor type-2A; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. May modulate neuropeptide expression in dorsal root ganglia (DRG) neurons and ovarian follicle development. (513 aa)
CHRNA6Neuronal acetylcholine receptor subunit alpha-6; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. (494 aa)
TRAT1T cell receptor associated transmembrane adaptor 1. (175 aa)
IL18RAPInterleukin 18 receptor accessory protein. (652 aa)
CHRNA2Neuronal acetylcholine receptor subunit alpha-2; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. (528 aa)
GRIN3AGlutamate ionotropic receptor NMDA type subunit 3A; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1126 aa)
CD247Uncharacterized protein. (166 aa)
CHRNA8Alpha8 subunit of nicotinic acetylcholine receptor. (511 aa)
GPR156G protein-coupled receptor 156. (691 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1175 aa)
PELOIntegrin alpha-1; Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth (By similarity). (1175 aa)
IL6STGlycoprotein 130. (918 aa)
CHRNA9Neuronal acetylcholine receptor subunit alpha-9; Ionotropic receptor that may play a role in the modulation of auditory stimuli. Agonist binding induces a conformation change that leads to the opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. (484 aa)
CHRNA10Neuronal acetylcholine receptor subunit alpha-10; Ionotropic receptor with a probable role in the modulation of auditory stimuli. (452 aa)
INSRRTyrosine-protein kinase receptor. (1333 aa)
VWC2Von Willebrand factor C domain containing 2. (383 aa)
CSF2RBUncharacterized protein. (678 aa)
AMHR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (678 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1504 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (671 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (789 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (557 aa)
ITGA11Integrin subunit alpha 11; Belongs to the integrin alpha chain family. (1240 aa)
CHRNGAcetylcholine receptor subunit gamma; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. (514 aa)
ITGB2Integrin beta. (773 aa)
CD3ET-cell surface glycoprotein CD3 epsilon chain; The CD3 complex mediates signal transduction, resulting in T- cell activation and proliferation. Required for normal immune responses. (175 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1458 aa)
GRIK4Glutamate ionotropic receptor kainate type subunit 4. (959 aa)
ACVR2BActivin receptor type-2B; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. May modulate neuropeptide expression in dorsal root ganglia (DRG) neurons and ovarian follicle development. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (512 aa)
CHRNA4Neuronal acetylcholine receptor subunit alpha-4; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane; Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-4/CHRNA4 sub- subfamily. (622 aa)
ABHD6Abhydrolase domain containing 6. (338 aa)
GP9Glycoprotein IX platelet. (208 aa)
CHRNA7Neuronal acetylcholine receptor subunit alpha-7; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane; Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-7/CHRNA7 sub- subfamily. (502 aa)
CACNG5Calcium voltage-gated channel auxiliary subunit gamma 5. (279 aa)
RAMP1Receptor activity modifying protein 1. (125 aa)
OSMRUncharacterized protein. (622 aa)
CHRNA5Neuronal acetylcholine receptor subunit alpha-5; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane; Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-5/CHRNA5 sub- subfamily. (472 aa)
CHRNA3Neuronal acetylcholine receptor subunit alpha-3; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. (496 aa)
CD79BB29/Ig-b. (226 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (781 aa)
KBPProbable glutamate receptor; Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (461 aa)
ZAP70Tyrosine-protein kinase. (609 aa)
STOML2Stomatin like 2. (382 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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