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HOXA11 HOXA11 WNT11 WNT11 CD34 CD34 DVL1 DVL1 GDNF GDNF DKK1 DKK1 ABL1 ABL1 WNT7A WNT7A SOX8 SOX8 LHX1 LHX1 NTN4L NTN4L RYK RYK LHX5 LHX5 FRS2 FRS2 DMRT3 DMRT3 AGT AGT IHH IHH NTN4 NTN4 DACT1 DACT1 AHI1 AHI1 MSX1 MSX1 ROR2 ROR2 SIX4 SIX4 FGF8 FGF8 GREM1 GREM1 SOX9 SOX9 WNT9B WNT9B FGF7 FGF7 SIX2 SIX2 FZD3 FZD3 DVL3 DVL3 CTNNB1 CTNNB1 AR AR SIX1 SIX1 SMO SMO HGF HGF LGR4 LGR4 SEC24B SEC24B HOXB7 HOXB7 SPRY1 SPRY1 ABL2 ABL2 RSPO2 RSPO2 SULF1 SULF1 TNFRSF11B TNFRSF11B AJAP1 AJAP1 MKS1 MKS1 CSF1 CSF1 ENSGALP00000066589 ENSGALP00000066589 NKD1 NKD1 ANKRD6 ANKRD6 PKHD1 PKHD1 GATA3 GATA3 PTHLH PTHLH CTHRC1 CTHRC1 ENSGALP00000069823 ENSGALP00000069823 ENSGALP00000071132 ENSGALP00000071132 BTBD7 BTBD7 SP6 SP6 SAPCD2 SAPCD2 ENSGALP00000072166 ENSGALP00000072166 JHY JHY ENSGALP00000072609 ENSGALP00000072609 DAB2 DAB2 HOXC11 HOXC11 ENSGALP00000074194 ENSGALP00000074194
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HOXA11Homeobox protein Hox-A11; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Abd-B homeobox family. (297 aa)
WNT11Protein Wnt-11; Ligand for members of the frizzled family of seven transmembrane receptors. May play a role in the formation of dermal structure, both limb and feather buds. Is likely to signal over only few cell diameters. (354 aa)
CD34CD34 molecule. (385 aa)
DVL1Dishevelled segment polarity protein 1. (529 aa)
GDNFGlial cell derived neurotrophic factor. (209 aa)
DKK1Dickkopf WNT signaling pathway inhibitor 1. (240 aa)
ABL1Tyrosine-protein kinase. (1111 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
SOX8Transcription factor SOX-8; May play a role in central nervous system, limb and facial development. May be involved in male sex determination. Binds the consensus motif 5'-[AT][AT]CAA[AT]G-3'. (470 aa)
LHX1LIM/homeobox protein Lhx1; Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with ISL-2. (406 aa)
NTN4LUncharacterized protein. (638 aa)
RYKReceptor like tyrosine kinase. (481 aa)
LHX5LIM homeobox protein 5. (402 aa)
FRS2IRS-type PTB domain-containing protein. (508 aa)
DMRT3Doublesex and mab-3 related transcription factor 3. (466 aa)
AGTAngiotensinogen; Belongs to the serpin family. (464 aa)
IHHIndian hedgehog protein C-product; Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP); Belongs to the hedgehog family. (408 aa)
NTN4Netrin 4. (626 aa)
DACT1DAPPER1. (822 aa)
AHI1Abelson helper integration site 1. (1242 aa)
MSX1Homeobox protein GHOX-7; Probably plays a role in patterning events during embryonic limb development. May also be involved in programmed cell death. (288 aa)
ROR2Receptor tyrosine kinase-like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (934 aa)
SIX4SIX homeobox 4. (776 aa)
FGF8Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Involved in initiation, outgrowth and patterning of the limbs; Belongs to the heparin-binding growth factors family. (214 aa)
GREM1Gremlin-1; Cytokine that may play a role in the development of the medial pallium and during optic nerve and pecten development by modulating BMP signaling. (184 aa)
SOX9Transcription factor SOX-9; Transcription factor that selectively activates enhancer through its interaction with a DNA-binding partner factor. Activates enhancer of COL2A1 through its binding with DNA sequence 5'-ATTCAT-3'. In response to bone morphogenetic protein stimulus, phosphorylation is induced and then sumoylation, allowing cooperation with SNAI2 to trigger neural crest delamination. Functions at the level of mesenchymal cell condensation by inducing cartilage development in limbs and by changing the aggregation properties of limb mesenchymal cells. Regulates the cell fate dec [...] (494 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (388 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
SIX2Sine oculis-related homeobox 2 homolog. (287 aa)
FZD3Frizzled-3; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to i [...] (666 aa)
DVL3Dishevelled segment polarity protein 3. (731 aa)
CTNNB1Uncharacterized protein. (781 aa)
ARUncharacterized protein. (703 aa)
SIX1Sine oculis-related homeobox 1 homolog. (282 aa)
SMOSmoothened homolog; G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). (816 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (726 aa)
LGR4Leucine rich repeat containing G protein-coupled receptor 4. (952 aa)
SEC24BUncharacterized protein. (1234 aa)
HOXB7Homeobox B7. (217 aa)
SPRY1Protein sprouty homolog 1; May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis; Belongs to the sprouty family. (321 aa)
ABL2Tyrosine-protein kinase. (1159 aa)
RSPO2R-spondin 2. (241 aa)
SULF1Sulfatase 1. (862 aa)
TNFRSF11BTumor necrosis factor receptor superfamily member 11B; Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. (402 aa)
AJAP1Adherens junctions associated protein 1. (266 aa)
MKS1MKS transition zone complex subunit 1. (562 aa)
CSF1Uncharacterized protein. (493 aa)
ENSGALP00000066589Uncharacterized protein. (349 aa)
NKD1NKD inhibitor of WNT signaling pathway 1. (472 aa)
ANKRD6Ankyrin repeat domain 6. (793 aa)
PKHD1Uncharacterized protein. (551 aa)
GATA3GATA-binding factor 3; Transcriptional activator which probably serves as a general switch factor for cell-specific development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of genes. (444 aa)
PTHLHParathyroid hormone-related protein; Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport; Belongs to the parathyroid hormone family. (214 aa)
CTHRC1Collagen triple helix repeat containing 1. (314 aa)
ENSGALP00000069823Uncharacterized protein. (167 aa)
ENSGALP00000071132Uncharacterized protein. (386 aa)
BTBD7BTB domain containing 7. (1159 aa)
SP6Sp6 transcription factor. (357 aa)
SAPCD2Suppressor APC domain containing 2. (458 aa)
ENSGALP00000072166IPT/TIG domain-containing protein. (239 aa)
JHYJunctional cadherin complex regulator. (741 aa)
ENSGALP00000072609Uncharacterized protein. (215 aa)
DAB2DAB adaptor protein 2. (715 aa)
HOXC11Homeobox C11. (193 aa)
ENSGALP00000074194Uncharacterized protein. (401 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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