STRINGSTRING
ID2 ID2 LRRK2 LRRK2 FOXG1 FOXG1 PTPRZ1 PTPRZ1 KIAA1524 KIAA1524 ZNF335 ZNF335 CDH2 CDH2 VEGFC VEGFC VAX1 VAX1 DLL4 DLL4 SPINT1 SPINT1 LHX5 LHX5 DRD2 DRD2 SHH SHH LHX1 LHX1 DISP3 DISP3 SHCBP1 SHCBP1 TRIM71 TRIM71 ID4 ID4 CX3CR1 CX3CR1 SIX3 SIX3 ENSGALP00000058848 ENSGALP00000058848 ENSGALP00000060974 ENSGALP00000060974 KIFAP3 KIFAP3 ENSGALP00000062901 ENSGALP00000062901 ENSGALP00000064942 ENSGALP00000064942 TOX TOX ENSGALP00000068660 ENSGALP00000068660 TAFA3 TAFA3 NF2L NF2L LIMS2 LIMS2 TAFA1 TAFA1 BTG2 BTG2 PTBP2 PTBP2 NF2 NF2 DCT DCT CX3CL1 CX3CL1 OTP OTP APPL2 APPL2 FZD3 FZD3 ENSGALP00000044096 ENSGALP00000044096 SIRT2 SIRT2 CTNNB1 CTNNB1 CEND1 CEND1 LYN LYN LIMS1 LIMS1 CDH15 CDH15 KDM1A KDM1A DISC1 DISC1 ILK ILK SMO SMO ADGRG1 ADGRG1 SMAD6 SMAD6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ID2Transcriptional regulator Id2. (134 aa)
LRRK2Uncharacterized protein. (2557 aa)
FOXG1Forkhead box protein G1; May determine the nasotemporal axis of the retina, and consequently specify the topographical projection of the retinal ganglion-cell axons to the tectum by controlling expression of their target genes. (451 aa)
PTPRZ1Protein-tyrosine-phosphatase. (2343 aa)
KIAA1524Protein CIP2A homolog. (924 aa)
ZNF335Uncharacterized protein. (1473 aa)
CDH2Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion. Cadherins may thus contribute to the sorting of heterogeneous cell types, and thereby play an important role during embryonic development (By similarity). (912 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (586 aa)
VAX1Ventral anterior homeobox 1; Transcription factor that plays a role in establishing dorsal-ventral polarity in the neural retina. (325 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (709 aa)
SPINT1Uncharacterized protein. (509 aa)
LHX5LIM homeobox protein 5. (402 aa)
DRD2Dopamine receptor 2 protein transcript variant 1; Belongs to the G-protein coupled receptor 1 family. (437 aa)
SHHSonic hedgehog protein N-product; [Sonic hedgehog protein]: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). (425 aa)
LHX1LIM/homeobox protein Lhx1; Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with ISL-2. (406 aa)
DISP3Protein dispatched homolog 3; Plays a role in neuronal proliferation and differentiation (By similarity). Plays a role in the accumulation of cellular cholesterol. Involved in intracellular lipid droplet formation. May contribute to cholesterol homeostasis in neuronal cells. (1338 aa)
SHCBP1SHC binding and spindle associated 1. (650 aa)
TRIM71E3 ubiquitin-protein ligase TRIM71; E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance. Binds to miRNAs and participates in post-transcriptional repression of transcripts. Required to maintain proliferation and prevent premature differentiation of neural progenitor cells during early neural development. Belongs to the TRIM/RBCC family. (877 aa)
ID4BHLH domain-containing protein. (139 aa)
CX3CR1C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (354 aa)
SIX3Homeobox protein SIX3; Transcriptional regulator which can act as both a transcriptional repressor and activator by binding a ATTA homeodomain core recognition sequence on these target genes. During forebrain development represses WNT1 expression allowing zona limitans intrathalamica formation and thereby ensuring proper anterio-posterior patterning of the diencephalon and formation of the rostral diencephalon. Acts as a direct upstream activator of SHH expression in the rostral diencephalon ventral midline and that in turn SHH maintains its expression. In addition, Six3 activity is re [...] (314 aa)
ENSGALP00000058848Uncharacterized protein. (236 aa)
ENSGALP00000060974LIM zinc-binding domain-containing protein. (209 aa)
KIFAP3Kinesin associated protein 3. (793 aa)
ENSGALP00000062901Uncharacterized protein. (229 aa)
ENSGALP00000064942Uncharacterized protein. (152 aa)
TOXThymocyte selection associated high mobility group box. (525 aa)
ENSGALP00000068660Uncharacterized protein. (221 aa)
TAFA3TAFA chemokine like family member 3. (136 aa)
NF2LFERM domain-containing protein. (648 aa)
LIMS2LIM zinc finger domain containing 2. (252 aa)
TAFA1TAFA chemokine like family member 1. (145 aa)
BTG2BTG anti-proliferation factor 2. (164 aa)
PTBP2Polypyrimidine tract binding protein 2. (675 aa)
NF2FERM domain-containing protein. (595 aa)
DCTL-dopachrome tautomerase; Catalyzes the conversion of L-dopachrome into 5,6- dihydroxyindole-2-carboxylic acid (DHICA). Involved in regulating eumelanin and phaeomelanin levels. (521 aa)
CX3CL1SCY domain-containing protein. (496 aa)
OTPOrthopedia homeobox. (325 aa)
APPL2Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (671 aa)
FZD3Frizzled-3; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to i [...] (666 aa)
ENSGALP00000044096Uncharacterized protein. (239 aa)
SIRT2Deacetylase sirtuin-type domain-containing protein. (485 aa)
CTNNB1Uncharacterized protein. (781 aa)
CEND1Uncharacterized protein. (130 aa)
LYNTyrosine-protein kinase. (491 aa)
LIMS1LIM domain-containing protein. (362 aa)
CDH15Cadherin 15; Cadherins are calcium-dependent cell adhesion proteins. (792 aa)
KDM1ALysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (826 aa)
DISC1DISC1 scaffold protein. (856 aa)
ILKIntegrin-linked kinase. (452 aa)
SMOSmoothened homolog; G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). (816 aa)
ADGRG1Adhesion G protein-coupled receptor G1; Belongs to the G-protein coupled receptor 2 family. (695 aa)
SMAD6Mothers against decapentaplegic homolog 6; Acts as a mediator of TGF-beta and BMP antiflammatory activity. Suppresses IL1R-TLR signaling, preventing NF-kappa-B activation, and BMP-SMAD1 signaling pathway. Binds to regulatory elements in target promoter regions (By similarity). (431 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
Server load: low (24%) [HD]