(35 nodes) Negative regulation of signaling receptor activity network (Gallus gallus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

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protein homology

Your Input:
	LOC112531107	Uncharacterized protein. (245 aa)
	MXD3	FYVE domain-containing protein. (619 aa)
	PSEN1	Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins. Belongs to the peptidase A22A family. (468 aa)
	PCSK9	Proprotein convertase subtilisin/kexin type 9; Belongs to the peptidase S8 family. (643 aa)
	ENSGALP00000070862	Ig-like domain-containing protein. (280 aa)
	WFIKKN1	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1. (539 aa)
	ERRFI1	ERBB receptor feedback inhibitor 1. (465 aa)
	FAM72A	Uncharacterized protein. (120 aa)
	DKK1	Dickkopf WNT signaling pathway inhibitor 1. (240 aa)
	DKK3	Dickkopf-related protein 3; Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity). (350 aa)
	ZGPAT	Uncharacterized protein. (542 aa)
	TSG101	Uncharacterized protein. (390 aa)
	NCAPG2	Non-SMC condensin II complex subunit G2. (1144 aa)
	CBL	Uncharacterized protein. (903 aa)
	WFIKKN2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2. (570 aa)
	CNRIP1	Uncharacterized protein. (162 aa)
	SOCS5	Suppressor of cytokine signaling 5. (536 aa)
	GPRC5A	G_PROTEIN_RECEP_F3_4 domain-containing protein. (354 aa)
	LYPD6	LY6/PLAUR domain containing 6. (186 aa)
	CRHBP	Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (345 aa)
	CBLB	Cbl proto-oncogene B. (1025 aa)
	LRPAP1	Uncharacterized protein. (348 aa)
	ZFYVE28	Uncharacterized protein. (354 aa)
	LYPD6B	LY6/PLAUR domain containing 6B. (194 aa)
	DKK2	Dickkopf_N domain-containing protein. (270 aa)
	VPS25	Vacuolar protein sorting 25 homolog. (174 aa)
	LY6E	Lymphocyte antigen 6E. (126 aa)
	RAMP3	Receptor activity modifying protein 3. (156 aa)
	CHIR-B3	Ig-like domain-containing protein. (323 aa)
	ENSGALP00000051391	FYVE-type domain-containing protein. (201 aa)
	PPARA	Uncharacterized protein. (468 aa)
	IGSF1	Uncharacterized protein. (475 aa)
	SOCS4	Uncharacterized protein. (436 aa)
	LYPD1	LY6/PLAUR domain containing 1. (141 aa)
	LOC101747995	UPAR/Ly6 domain-containing protein. (127 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CBL	CBLB	ENSGALP00000010935	ENSGALP00000024726	Uncharacterized protein.	Cbl proto-oncogene B.	0.903
CBLB	CBL	ENSGALP00000024726	ENSGALP00000010935	Cbl proto-oncogene B.	Uncharacterized protein.	0.903
CBLB	SOCS4	ENSGALP00000024726	ENSGALP00000064656	Cbl proto-oncogene B.	Uncharacterized protein.	0.437
DKK1	DKK2	ENSGALP00000006037	ENSGALP00000041711	Dickkopf WNT signaling pathway inhibitor 1.	Dickkopf_N domain-containing protein.	0.943
DKK1	DKK3	ENSGALP00000006037	ENSGALP00000008890	Dickkopf WNT signaling pathway inhibitor 1.	Dickkopf-related protein 3; Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).	0.850
DKK2	DKK1	ENSGALP00000041711	ENSGALP00000006037	Dickkopf_N domain-containing protein.	Dickkopf WNT signaling pathway inhibitor 1.	0.943
DKK2	DKK3	ENSGALP00000041711	ENSGALP00000008890	Dickkopf_N domain-containing protein.	Dickkopf-related protein 3; Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).	0.875
DKK3	DKK1	ENSGALP00000008890	ENSGALP00000006037	Dickkopf-related protein 3; Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).	Dickkopf WNT signaling pathway inhibitor 1.	0.850
DKK3	DKK2	ENSGALP00000008890	ENSGALP00000041711	Dickkopf-related protein 3; Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).	Dickkopf_N domain-containing protein.	0.875
ENSGALP00000051391	ZFYVE28	ENSGALP00000051391	ENSGALP00000025254	FYVE-type domain-containing protein.	Uncharacterized protein.	0.900
MXD3	ZFYVE28	ENSGALP00000068567	ENSGALP00000025254	FYVE domain-containing protein.	Uncharacterized protein.	0.805
SOCS4	CBLB	ENSGALP00000064656	ENSGALP00000024726	Uncharacterized protein.	Cbl proto-oncogene B.	0.437
SOCS4	SOCS5	ENSGALP00000064656	ENSGALP00000016250	Uncharacterized protein.	Suppressor of cytokine signaling 5.	0.638
SOCS5	SOCS4	ENSGALP00000016250	ENSGALP00000064656	Suppressor of cytokine signaling 5.	Uncharacterized protein.	0.638
TSG101	VPS25	ENSGALP00000010193	ENSGALP00000044578	Uncharacterized protein.	Vacuolar protein sorting 25 homolog.	0.936
VPS25	TSG101	ENSGALP00000044578	ENSGALP00000010193	Vacuolar protein sorting 25 homolog.	Uncharacterized protein.	0.936
ZFYVE28	ENSGALP00000051391	ENSGALP00000025254	ENSGALP00000051391	Uncharacterized protein.	FYVE-type domain-containing protein.	0.900
ZFYVE28	MXD3	ENSGALP00000025254	ENSGALP00000068567	Uncharacterized protein.	FYVE domain-containing protein.	0.805