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CACNB4 CACNB4 LRRK2 LRRK2 ADCY1 ADCY1 GIPC3 GIPC3 ADORA2B ADORA2B SNAPIN SNAPIN CASK CASK GIPC1 GIPC1 RAP1B RAP1B GIT1 GIT1 STXBP5L STXBP5L DTNBP1 DTNBP1 RAP1A RAP1A P2RX7 P2RX7 RIMS4 RIMS4 DRD2 DRD2 VPS18 VPS18 GIPC2 GIPC2 FMR1 FMR1 RAB3GAP1 RAB3GAP1 ATP2A2 ATP2A2 APBA1 APBA1 STXBP5 STXBP5 CHRM2 CHRM2 CDK5 CDK5 GRIN3A GRIN3A SLC4A8 SLC4A8 SYT4 SYT4 GIT2 GIT2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CACNB4SH3 domain-containing protein. (480 aa)
LRRK2Uncharacterized protein. (2557 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1098 aa)
GIPC3GIPC PDZ domain containing family member 3. (539 aa)
ADORA2BAdenosine receptor A2b; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family. (340 aa)
SNAPINSNARE-associated protein Snapin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling; Belongs to t [...] (126 aa)
CASKCalcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family. (944 aa)
GIPC1GIPC PDZ domain containing family member 1. (552 aa)
RAP1BRas-related protein Rap-1b. (268 aa)
GIT1ANK_REP_REGION domain-containing protein. (791 aa)
STXBP5LSyntaxin binding protein 5 like. (1184 aa)
DTNBP1Dysbindin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. Plays a role in intracellular vesicle trafficking. Plays a role in synaptic vesicle trafficking and in neurotransmitter release. May be required for normal dopamine homeostasis in the cerebral cortex, hippocampus, and hypothalamus. Plays a role in the regulation of cell surface exposure of DRD2. Contributes to the regulation of dopamine signaling. May play a role in actin cytoskeleton reorganization and neuri [...] (369 aa)
RAP1ARas-related protein Rap-1b; Probable GTP-binding protein that possesses GTPase activity. May play a role in endothelial cell polarity and endothelial barrier function (By similarity); Belongs to the small GTPase superfamily. Ras family. (184 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (574 aa)
RIMS4Regulating synaptic membrane exocytosis 4. (446 aa)
DRD2Dopamine receptor 2 protein transcript variant 1; Belongs to the G-protein coupled receptor 1 family. (437 aa)
VPS18Pep3_Vps18 domain-containing protein. (974 aa)
GIPC2GIPC PDZ domain containing family member 2. (318 aa)
FMR1Fragile X mental retardation 1. (548 aa)
RAB3GAP1RAB3 GTPase activating protein catalytic subunit 1. (1014 aa)
ATP2A2Sarcoplasmic/endoplasmic reticulum calcium ATPase 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform SERCA2A is involved in the regulation of the contraction/relaxation cycle. May act as a regulator of TNFSF11-mediated Ca(2+) signaling during osteoclastogenesis. (1042 aa)
APBA1Amyloid beta precursor protein binding family A member 1. (824 aa)
STXBP5Syntaxin binding protein 5. (1152 aa)
CHRM2Muscarinic acetylcholine receptor M2; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol. (466 aa)
CDK5Protein kinase domain-containing protein. (522 aa)
GRIN3AGlutamate ionotropic receptor NMDA type subunit 3A; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1126 aa)
SLC4A8Anion exchange protein. (1068 aa)
SYT4Synaptotagmin 4. (425 aa)
GIT2Uncharacterized protein. (757 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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