6 items (Gallus gallus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GHRL	Preproghrelin. (116 aa)
	GALR1	Galanin receptor; Belongs to the G-protein coupled receptor 1 family. (357 aa)
	CRH	Corticotropin releasing hormone. (167 aa)
	POMC	Uncharacterized protein. (251 aa)
	CRHR2	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (427 aa)
	CRHR1	Corticotropin-releasing factor receptor 1; G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. (420 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CRH	CRHR1	ENSGALP00000050250	ENSGALP00000000502	Corticotropin releasing hormone.	Corticotropin-releasing factor receptor 1; G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels.	0.992
CRH	CRHR2	ENSGALP00000050250	ENSGALP00000068874	Corticotropin releasing hormone.	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	0.992
CRH	GHRL	ENSGALP00000050250	ENSGALP00000013685	Corticotropin releasing hormone.	Preproghrelin.	0.484
CRH	POMC	ENSGALP00000050250	ENSGALP00000063133	Corticotropin releasing hormone.	Uncharacterized protein.	0.904
CRHR1	CRH	ENSGALP00000000502	ENSGALP00000050250	Corticotropin-releasing factor receptor 1; G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels.	Corticotropin releasing hormone.	0.992
CRHR1	CRHR2	ENSGALP00000000502	ENSGALP00000068874	Corticotropin-releasing factor receptor 1; G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels.	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	0.904
CRHR1	GHRL	ENSGALP00000000502	ENSGALP00000013685	Corticotropin-releasing factor receptor 1; G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels.	Preproghrelin.	0.406
CRHR1	POMC	ENSGALP00000000502	ENSGALP00000063133	Corticotropin-releasing factor receptor 1; G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels.	Uncharacterized protein.	0.776
CRHR2	CRH	ENSGALP00000068874	ENSGALP00000050250	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	Corticotropin releasing hormone.	0.992
CRHR2	CRHR1	ENSGALP00000068874	ENSGALP00000000502	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	Corticotropin-releasing factor receptor 1; G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels.	0.904
CRHR2	POMC	ENSGALP00000068874	ENSGALP00000063133	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	Uncharacterized protein.	0.632
GALR1	POMC	ENSGALP00000041025	ENSGALP00000063133	Galanin receptor; Belongs to the G-protein coupled receptor 1 family.	Uncharacterized protein.	0.677
GHRL	CRH	ENSGALP00000013685	ENSGALP00000050250	Preproghrelin.	Corticotropin releasing hormone.	0.484
GHRL	CRHR1	ENSGALP00000013685	ENSGALP00000000502	Preproghrelin.	Corticotropin-releasing factor receptor 1; G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels.	0.406
GHRL	POMC	ENSGALP00000013685	ENSGALP00000063133	Preproghrelin.	Uncharacterized protein.	0.908
POMC	CRH	ENSGALP00000063133	ENSGALP00000050250	Uncharacterized protein.	Corticotropin releasing hormone.	0.904
POMC	CRHR1	ENSGALP00000063133	ENSGALP00000000502	Uncharacterized protein.	Corticotropin-releasing factor receptor 1; G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels.	0.776
POMC	CRHR2	ENSGALP00000063133	ENSGALP00000068874	Uncharacterized protein.	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	0.632
POMC	GALR1	ENSGALP00000063133	ENSGALP00000041025	Uncharacterized protein.	Galanin receptor; Belongs to the G-protein coupled receptor 1 family.	0.677
POMC	GHRL	ENSGALP00000063133	ENSGALP00000013685	Uncharacterized protein.	Preproghrelin.	0.908