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| | ANKRD9 | Ankyrin repeat domain 9. (292 aa) |
| | FEM1A | Fem-1 homolog A. (765 aa) |
| | ANAPC5 | Anaphase-promoting complex subunit 5; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). (756 aa) |
| | CBX2 | Chromobox 2. (528 aa) |
| | RCHY1 | RING finger and CHY zinc finger domain-containing protein 1. (256 aa) |
| | AMBRA1 | Autophagy and beclin 1 regulator 1. (872 aa) |
| | BCOR | BCL6 corepressor. (1759 aa) |
| | FZR1 | WD_REPEATS_REGION domain-containing protein. (493 aa) |
| | UBE2D1 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (147 aa) |
| | RNF7 | RING-type domain-containing protein. (114 aa) |
| | KLHDC2 | Uncharacterized protein. (407 aa) |
| | LOC419074 | Uncharacterized protein. (765 aa) |
| | KLHL35 | Kelch like family member 35. (503 aa) |
| | KLHL42 | Kelch like family member 42. (503 aa) |
| | CUL4A | Cullin 4A; Belongs to the cullin family. (767 aa) |
| | CDC16 | TPR_REGION domain-containing protein. (623 aa) |
| | KLHL34 | Kelch like family member 34. (595 aa) |
| | FBXO9 | F-box domain-containing protein. (435 aa) |
| | F1NU19_CHICK | WD_REPEATS_REGION domain-containing protein. (306 aa) |
| | ATG3 | Autophagy-related protein 3. (313 aa) |
| | ENC1 | Ectodermal-neural cortex 1. (589 aa) |
| | ZSWIM6 | SWIM-type domain-containing protein. (1157 aa) |
| | FBXL5 | F-box and leucine rich repeat protein 5. (837 aa) |
| | PHC1 | Uncharacterized protein. (990 aa) |
| | GAN | Gigaxonin. (590 aa) |
| | PDCD6 | Programmed cell death 6. (178 aa) |
| | RANBP9 | RAN binding protein 9. (244 aa) |
| | RNF144B | RBR-type E3 ubiquitin transferase. (302 aa) |
| | RBX1 | RING-type domain-containing protein. (108 aa) |
| | KLHL8 | Kelch like family member 8. (617 aa) |
| | KLHL7 | Kelch-like protein 7; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL7) complex acts by mediating ubiquitination and subsequent degradation of substrate proteins. Probably mediates 'Lys-48'-linked ubiquitination (By similarity). (586 aa) |
| | ASB2 | Ankyrin repeat and SOCS box containing 2. (645 aa) |
| | FBXO8 | Uncharacterized protein. (319 aa) |
| | ZYG11A | Zyg-11 family member B, cell cycle regulator. (735 aa) |
| | SEL1L | SEL1L adaptor subunit of ERAD E3 ubiquitin ligase. (791 aa) |
| | RNF11 | RING-type domain-containing protein. (154 aa) |
| | ZSWIM5 | Zinc finger SWIM-type containing 5. (1321 aa) |
| | FBXO33 | F-box protein 33. (526 aa) |
| | DTL | Denticleless protein homolog; Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1), KMT5A and SDE2. CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. [...] (720 aa) |
| | ASB4 | Ankyrin repeat and SOCS box containing 4. (425 aa) |
| | KLHL2 | BTB domain-containing protein. (599 aa) |
| | DCAF5 | DDB1 and CUL4 associated factor 5. (959 aa) |
| | PHC3 | Polyhomeotic homolog 3. (973 aa) |
| | DCAF4L2 | WD_REPEATS_REGION domain-containing protein. (501 aa) |
| | ANKRD9L | ANK_REP_REGION domain-containing protein. (293 aa) |
| | COMMD1 | Copper metabolism domain containing 1. (215 aa) |
| | DCUN1D1 | DCN1-like protein 1; Part of an E3 ubiquitin ligase complex for neddylation. Promotes neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes. Acts by binding to cullin-RBX1 complexes in the cytoplasm and promoting their nuclear translocation, enhancing recruitment of E2-NEDD8 (UBE2M-NEDD8) thioester to the complex, and optimizing the orientation of proteins in the complex to allow efficient transfer of NEDD8 from the E2 to the cullin substrates. (259 aa) |
| | RAD18 | Uncharacterized protein. (672 aa) |
| | CRBN | Protein cereblon; Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8. May also play a role in the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning. (445 aa) |
| | FBXW8 | F-box and WD repeat domain containing 8. (582 aa) |
| | FEM1C | Fem-1 homolog C. (617 aa) |
| | FBXO21 | F-box protein 21. (610 aa) |
| | ATXN7L1 | Ataxin 7 like 1. (834 aa) |
| | KLHDC10 | Kelch domain containing 10. (409 aa) |
| | ZC3HC1 | Uncharacterized protein. (484 aa) |
| | DCX | Doublecortin. (361 aa) |
| | KCTD2 | BTB domain-containing protein. (332 aa) |
| | CDC23 | Cell division cycle 23. (595 aa) |
| | KLHL25 | Kelch like family member 25. (589 aa) |
| | DET1 | Uncharacterized protein. (551 aa) |
| | PCGF5 | RING-type domain-containing protein. (256 aa) |
| | SKP1 | S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1 (By similarity). (163 aa) |
| | MKLN1 | Uncharacterized protein. (733 aa) |
| | GLMN | Glomulin, FKBP associated protein. (628 aa) |
| | ZFAND4 | Zinc finger AN1-type containing 4. (716 aa) |
| | DCAF12L2 | DDB1- and CUL4-associated factor 12; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. (427 aa) |
| | SGSM2 | Uncharacterized protein. (1056 aa) |
| | FBXL15 | F-box and leucine rich repeat protein 15. (299 aa) |
| | DCAF10 | DDB1 and CUL4 associated factor 10. (390 aa) |
| | APPBP2 | TPR_REGION domain-containing protein. (586 aa) |
| | FBXL17 | F-box and leucine rich repeat protein 17. (442 aa) |
| | DCAF7 | WD_REPEATS_REGION domain-containing protein. (460 aa) |
| | KLHL12 | Kelch like family member 12. (565 aa) |
| | CDC27 | Uncharacterized protein. (833 aa) |
| | RANBP10 | RAN binding protein 10. (608 aa) |
| | KLHL6 | BTB domain-containing protein. (610 aa) |
| | NCBP3 | Nuclear cap-binding protein subunit 3; Associates with NCBP1/CBP80 to form an alternative cap- binding complex (CBC) which plays a key role in mRNA export. NCBP3 serves as adapter protein linking the capped RNAs (m7GpppG-capped RNA) to NCBP1/CBP80. Unlike the conventional CBC with NCBP2 which binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus, the alternative CBC with NCBP3 does not bind snRNA and associates only with mRNA thereby playing a role in only mRNA export. (604 aa) |
| | BRCA1 | Uncharacterized protein. (1749 aa) |
| | AMFR | Autocrine motility factor receptor. (622 aa) |
| | TRPC4AP | Uncharacterized protein. (771 aa) |
| | BARD1 | Uncharacterized protein. (795 aa) |
| | SKP2 | F-box domain-containing protein. (520 aa) |
| | SMURF2 | SMAD specific E3 ubiquitin protein ligase 2. (717 aa) |
| | FBXO42 | F-box protein 42. (764 aa) |
| | ANAPC7 | Anaphase promoting complex subunit 7. (565 aa) |
| | BCORL1 | BCL6 corepressor like 1. (1651 aa) |
| | ASB1 | Ankyrin repeat and SOCS box containing 1. (309 aa) |
| | ANAPC16 | Anaphase promoting complex subunit 16. (134 aa) |
| | BRAP | Uncharacterized protein. (556 aa) |
| | ZER1 | Zyg-11 related cell cycle regulator. (766 aa) |
| | ZSWIM8 | SWIM-type domain-containing protein. (1833 aa) |
| | KCTD10 | Potassium channel tetramerization domain containing 10. (313 aa) |
| | ANKRD46 | Ankyrin repeat domain 46. (228 aa) |
| | RNF168 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...] (605 aa) |
| | RNF20 | E3 ubiquitin-protein ligase BRE1A; Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). (1028 aa) |
| | ENSGALP00000073605 | Uncharacterized protein. (253 aa) |
| | ENSGALP00000073564 | Uncharacterized protein. (243 aa) |
| | FBXO41 | F-box protein 41. (795 aa) |
| | ENSGALP00000073240 | Uncharacterized protein. (430 aa) |
| | KLHDC3 | Kelch domain containing 3. (382 aa) |
| | ASB6 | Uncharacterized protein. (475 aa) |
| | ANKRD39 | Ankyrin repeat domain 39. (181 aa) |
| | COP1 | COP1 E3 ubiquitin ligase. (723 aa) |
| | CBX8 | Chromobox 8. (388 aa) |
| | ENSGALP00000072290 | WD_REPEATS_REGION domain-containing protein. (89 aa) |
| | CDC26 | Uncharacterized protein. (84 aa) |
| | DDA1 | DET1- and DDB1-associated protein 1; May be involved in ubiquitination and subsequent proteasomal degradation of target proteins. Component of the DDD-E2 complexes which may provide a platform for interaction with CUL4A and WD repeat proteins (By similarity); Belongs to the DDA1 family. (166 aa) |
| | ENSGALP00000071775 | RING-type domain-containing protein. (343 aa) |
| | FBXO18 | F-box DNA helicase 1; 3'-5' DNA helicase and substrate-recognition component of the SCF(FBH1) E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks (By similarity). Involved in genome maintenance by acting as an anti-recombinogenic helicase and preventing extensive strand exchange during homologous recombination: promotes RAD51 filament dissolution from stalled forks, thereby inhibiting homologous recombination and preventing excessive recombination. Also promotes cell death and DNA double-strand breakage in response to replication stress: p [...] (1021 aa) |
| | RNF4 | RING-type domain-containing protein. (194 aa) |
| | DERL1 | Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (299 aa) |
| | ANAPC10 | DOC domain-containing protein. (255 aa) |
| | FBXO25 | F-box protein 25. (370 aa) |
| | ANAPC2 | Anaphase promoting complex subunit 2; Belongs to the cullin family. (884 aa) |
| | CKS1B | Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa) |
| | KCTD17 | Potassium channel tetramerization domain containing 17. (223 aa) |
| | PCGF1 | Polycomb group ring finger 1. (318 aa) |
| | ENSGALP00000066311 | Uncharacterized protein. (180 aa) |
| | SPOPL | Speckle type BTB/POZ protein like. (392 aa) |
| | LSM7 | Uncharacterized protein. (201 aa) |
| | OTULIN | OTU deubiquitinase with linear linkage specificity. (319 aa) |
| | ENSGALP00000067567 | Laminin IV type B domain-containing protein. (312 aa) |
| | ANAPC1 | Anaphase promoting complex subunit 1. (1948 aa) |
| | DCUN1D2 | DCN1-like protein. (259 aa) |
| | FBXW9 | F-box domain-containing protein. (337 aa) |
| | DCAF11 | Uncharacterized protein. (92 aa) |
| | UBE2S | Ubiquitin conjugating enzyme E2 S; Belongs to the ubiquitin-conjugating enzyme family. (268 aa) |
| | FBXL22 | F-box and leucine rich repeat protein 22. (226 aa) |
| | FBXL3 | F-box and leucine rich repeat protein 3. (433 aa) |
| | PCGF2 | RING-type domain-containing protein. (674 aa) |
| | FBXO31 | F-box protein 31. (573 aa) |
| | SHARPIN | SHANK associated RH domain interactor. (481 aa) |
| | KLHL24 | BTB domain-containing protein. (600 aa) |
| | DCAF6 | WD_REPEATS_REGION domain-containing protein. (486 aa) |
| | KLHL9 | Kelch-like protein 13; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis (By similarity). (655 aa) |
| | ENSGALP00000069923 | Uncharacterized protein. (357 aa) |
| | FBXL12 | Uncharacterized protein. (471 aa) |
| | ENSGALP00000070347 | Uncharacterized protein. (229 aa) |
| | FBXO32 | Uncharacterized protein. (355 aa) |
| | PCGF6 | Polycomb group ring finger 6. (365 aa) |
| | GID4 | GID complex subunit 4 homolog. (399 aa) |
| | ASB12 | ANK_REP_REGION domain-containing protein. (327 aa) |
| | CUL1 | Cullin 1; Belongs to the cullin family. (776 aa) |
| | BTRC | Beta-transducin repeat containing E3 ubiquitin protein ligase. (793 aa) |
| | PHC2 | Polyhomeotic homolog 2. (312 aa) |
| | KLHL30 | Kelch like family member 30. (591 aa) |
| | PEF1 | Penta-EF-hand domain containing 1. (223 aa) |
| | KLHL3 | Kelch like family member 3. (593 aa) |
| | CUL4B | Cullin 4B; Belongs to the cullin family. (883 aa) |
| | DCAF17 | DDB1 and CUL4 associated factor 17. (544 aa) |
| | RHBDD2 | Rhomboid domain-containing protein. (375 aa) |
| | UBE2A | Ubiquitin-conjugating enzyme; Belongs to the ubiquitin-conjugating enzyme family. (152 aa) |
| | DDB1 | DNA damage-binding protein 1; Required for DNA repair. Binds to DDB2 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair (By similarity). Also appears to function as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the DCX E3 ubiquitin-protein li [...] (1139 aa) |
| | FBXW7 | Uncharacterized protein. (586 aa) |
| | CUL2 | CULLIN_2 domain-containing protein; Belongs to the cullin family. (774 aa) |
| | UBE2D3 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (147 aa) |
| | FAM8A1 | Family with sequence similarity 8 member A1. (160 aa) |
| | CKS2 | Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa) |
| | BMI1 | Polycomb complex protein BMI-1; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2. (326 aa) |
| | FAM89A | Family with sequence similarity 89 member A. (136 aa) |
| | DCAF1 | DDB1 and CUL4 associated factor 1. (1505 aa) |
| | RBFOX3 | RNA binding fox-1 homolog 3. (486 aa) |
| | FBXL7 | F-box and leucine rich repeat protein 7. (491 aa) |
| | ANAPC15 | Anaphase promoting complex subunit 15. (121 aa) |
| | KLHL21 | Kelch like family member 21. (600 aa) |
| | AUP1 | AUP1 lipid droplet regulating VLDL assembly factor. (406 aa) |
| | UBE2D2 | Ubiquitin conjugating enzyme E2 D2; Belongs to the ubiquitin-conjugating enzyme family. (238 aa) |
| | FBXO2 | F-box protein 2. (247 aa) |
| | ENSGALP00000054501 | Uncharacterized protein. (152 aa) |
| | TMEM183A | Uncharacterized protein. (368 aa) |
| | CACUL1 | Cullin domain-containing protein; Belongs to the cullin family. (377 aa) |
| | CBX7 | Chromobox 7. (146 aa) |
| | FBXO4 | F-box protein 4. (354 aa) |
| | ENSGALP00000055781 | Cullin_Nedd8 domain-containing protein. (146 aa) |
| | ANAPC13 | Uncharacterized protein. (74 aa) |
| | DERL2 | Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (239 aa) |
| | WDR76 | WD repeat-containing protein 76; Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. Belongs to the WD repeat DDB2/WDR76 family. (397 aa) |
| | LOC100859602 | SWIM-type domain-containing protein. (1005 aa) |
| | KBTBD8 | Kelch repeat and BTB domain containing 8. (601 aa) |
| | STUB1 | STIP1 homology and U box-containing protein 1; E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. Ubiquitinates NOS1 in concert with Hsp70 and Hsp40. Mediates polyubiquitination of DNA polymerase beta (POLB), thereby playing a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF-BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome. Mediates polyubiquitination of CYP3A4. May ubiquitinate EPHA2 and regulate the receptor stability and activity through proteasomal degradation. (314 aa) |
| | ERCC8 | ERCC excision repair 8, CSA ubiquitin ligase complex subunit. (399 aa) |
| | KLHL20 | Kelch-like protein 20; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. The BCR(KLHL20) E3 ubiquitin ligase complex mediates the ubiquitination of target proteins, leading to their degradation by the proteasome. It also specifically mediates 'Lys-33'-linked ubiquitination (By similarity). (613 aa) |
| | FBXL21 | F-box domain-containing protein. (437 aa) |
| | PHC2-2 | Uncharacterized protein. (234 aa) |
| | FBXL14 | F-box and leucine rich repeat protein 14. (400 aa) |
| | CBX4 | Chromo domain-containing protein. (522 aa) |
| | DCAF13 | DDB1- and CUL4-associated factor 13; Possible role in ribosomal RNA processing. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex (By similarity). (566 aa) |
| | ENSGALP00000059206 | Uncharacterized protein. (64 aa) |
| | DERL3 | Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (279 aa) |
| | LOC107051192 | RanBP2-type domain-containing protein. (1255 aa) |
| | KLHDC1 | Kelch domain containing 1. (404 aa) |
| | TRAF7 | Uncharacterized protein. (670 aa) |
| | LZTR1 | Leucine zipper like transcription regulator 1. (786 aa) |
| | KLHL26 | BTB domain-containing protein. (603 aa) |
| | CUL5 | Cullin 5; Belongs to the cullin family. (662 aa) |
| | FBXW11 | Uncharacterized protein. (531 aa) |
| | FBXW5 | Uncharacterized protein. (588 aa) |
| | SPOP | Speckle type BTB/POZ protein. (374 aa) |
| | UBE2B | Ubiquitin conjugating enzyme E2 B; Belongs to the ubiquitin-conjugating enzyme family. (152 aa) |
| | LOC100859020 | Uncharacterized protein. (397 aa) |
| | LOC425795 | BTB domain-containing protein. (589 aa) |
| | VHL | Uncharacterized protein. (161 aa) |
| | UBE2C | Ubiquitin conjugating enzyme E2 C; Belongs to the ubiquitin-conjugating enzyme family. (179 aa) |
| | FEM1B | Protein fem-1 homolog B; Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis (By similarity); Belongs to the fem-1 family. (627 aa) |
| | USP47 | Ubiquitin carboxyl-terminal hydrolase 47; Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizing POLB thereby playing a role in base-excision repair (BER). (1376 aa) |
