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| | ENSGALP00000066836 | ANK_REP_REGION domain-containing protein. (202 aa) |
| | TOM1 | Target of Myb protein 1; May be involved in intracellular trafficking. Probable association with membranes; Belongs to the TOM1 family. (515 aa) |
| | CXCR4 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (362 aa) |
| | TMEM184B | Uncharacterized protein. (410 aa) |
| | SNX4 | Sorting nexin 4. (435 aa) |
| | WDR91 | WD repeat-containing protein 91; Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport; Belongs to the WD repeat WDR91 family. (751 aa) |
| | PLD4 | Phospholipase D family member 4. (514 aa) |
| | UHRF1BP1L | UHRF1 binding protein 1 like. (1450 aa) |
| | CMTM6 | CKLF like MARVEL transmembrane domain containing 6. (183 aa) |
| | RAB5A | Uncharacterized protein. (215 aa) |
| | TBC1D5 | TBC1 domain family member 5. (834 aa) |
| | WLS | Protein wntless homolog; May play an essential role in Wnt signaling pathway. May be required for Wnt-dependent patterning processes (By similarity). Belongs to the wntless family. (541 aa) |
| | SNX13 | Uncharacterized protein. (969 aa) |
| | ZFYVE9 | Zinc finger FYVE domain-containing protein. (1416 aa) |
| | VIPAS39 | VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog. (497 aa) |
| | SLC30A2 | Solute carrier family 30 member 2. (351 aa) |
| | CLCN3 | Chloride channel protein. (866 aa) |
| | TMEM192 | Transmembrane protein 192. (279 aa) |
| | VTI1B | Vesicle transport through interaction with t-SNAREs 1B. (232 aa) |
| | FAM45A | UDENN domain-containing protein. (397 aa) |
| | STEAP2 | STEAP2 metalloreductase. (489 aa) |
| | EHD4 | EH domain containing 4; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (542 aa) |
| | TMEM9 | Transmembrane protein 9A. (191 aa) |
| | CHMP7 | Charged multivesicular body protein 7; ESCRT-III-like protein required to recruit the ESCRT-III complex to the nuclear envelope during late anaphase. Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase. Plays a role in the endosomal sorting pathway; Belongs to the SNF7 family. (448 aa) |
| | LAMTOR5 | Uncharacterized protein. (91 aa) |
| | SPPL2C | Signal peptide peptidase-like 2B; Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. (596 aa) |
| | RAB11B | Uncharacterized protein. (218 aa) |
| | STX12 | Syntaxin 12; Belongs to the syntaxin family. (272 aa) |
| | UBXN6 | UBX domain protein 6. (438 aa) |
| | MAP2K2 | Dual specificity mitogen-activated protein kinase kinase 2; Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity). (398 aa) |
| | SNF8 | Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family. (258 aa) |
| | ADRB1 | Adrenoceptor beta 1. (477 aa) |
| | PIKFYVE | Phosphoinositide kinase, FYVE-type zinc finger containing. (2118 aa) |
| | PLA2G4B | Phospholipase A2. (815 aa) |
| | CST7 | Cystatin domain-containing protein. (147 aa) |
| | HRG | Uncharacterized protein. (1078 aa) |
| | ALS2 | Alsin Rho guanine nucleotide exchange factor ALS2. (1649 aa) |
| | TPCN1 | Two pore segment channel 1. (817 aa) |
| | GRB2 | Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Belongs to the GRB2/sem-5/DRK family. (217 aa) |
| | PTPN1 | Tyrosine-protein phosphatase non-receptor type 1; May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET (By similarity). (475 aa) |
| | GGA3 | Uncharacterized protein. (754 aa) |
| | CLN6 | Uncharacterized protein. (317 aa) |
| | ZDHHC15 | Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (332 aa) |
| | RAB11A | Ras-related protein Rab-11A; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The small Rab GTPase RAB11A regulates endocytic recycling (By similarity). (216 aa) |
| | RUBCN | Rubicon autophagy regulator. (904 aa) |
| | RAB22A | Uncharacterized protein. (194 aa) |
| | TPCN2 | Uncharacterized protein. (753 aa) |
| | ABCC2 | Uncharacterized protein. (1538 aa) |
| | UBAP1L | Uncharacterized protein. (428 aa) |
| | RAB35 | Uncharacterized protein. (201 aa) |
| | HGS | Hepatocyte growth factor-regulated tyrosine kinase substrate. (759 aa) |
| | ATP13A4 | Probable cation-transporting ATPase 13A4; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1205 aa) |
| | SNX21 | Sorting nexin family member 21. (183 aa) |
| | EPHB1 | Ephrin type-B receptor 1; Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. May play a role in axon guidance during nervous system development. May also play an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines [...] (1003 aa) |
| | TM9SF4 | Transmembrane 9 superfamily member; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. (668 aa) |
| | ABHD17C | Alpha/beta hydrolase domain-containing protein 17C; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards NRAS. Belongs to the AB hydrolase superfamily. ABHD17 family. (310 aa) |
| | WDR53 | WD repeat domain 53. (355 aa) |
| | UEVLD | UEV domain-containing protein. (479 aa) |
| | TSG101 | Uncharacterized protein. (390 aa) |
| | PI4K2A | PI3K/PI4K domain-containing protein. (466 aa) |
| | TMEM9B | TMEM9 domain family member B. (189 aa) |
| | SGSM2 | Uncharacterized protein. (1056 aa) |
| | SLC30A4 | Uncharacterized protein. (429 aa) |
| | EPHA4 | Ephrin type-A receptor 4; Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI- anchored ephrin-A and transmembrane ephrin-B ligands including EFNA1 and EFNB3. U [...] (986 aa) |
| | WDFY1 | Uncharacterized protein. (410 aa) |
| | E1BT64_CHICK | Uncharacterized protein. (206 aa) |
| | ARFGEF2 | ADP ribosylation factor guanine nucleotide exchange factor 2. (1792 aa) |
| | CD63 | Tetraspanin. (227 aa) |
| | VPS8 | VPS8 subunit of CORVET complex. (1494 aa) |
| | MON1A | Vacuolar fusion protein MON1 homolog A; Plays an important role in membrane trafficking through the secretory apparatus. Not involved in endocytic trafficking to lysosomes. (549 aa) |
| | C7orf25 | Chromosome 7 open reading frame 25. (460 aa) |
| | SYTL4 | Synaptotagmin like 4. (690 aa) |
| | SPDEF | SAM pointed domain containing ETS transcription factor. (350 aa) |
| | ATP13A5 | Uncharacterized protein. (253 aa) |
| | ACAP2 | Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2; GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6). (823 aa) |
| | MVB12B | Uncharacterized protein. (332 aa) |
| | MARCH1 | RING-CH-type domain-containing protein. (559 aa) |
| | ENSGALP00000072903 | Uncharacterized protein. (81 aa) |
| | TPCN3 | Uncharacterized protein. (783 aa) |
| | RAB4A | RAB4A, member RAS oncogene family. (255 aa) |
| | VPS37A | VPS37A subunit of ESCRT-I. (395 aa) |
| | TLR21 | TIR domain-containing protein. (1083 aa) |
| | RIN3 | Ras and Rab interactor 3. (983 aa) |
| | ENSGALP00000071742 | Uncharacterized protein. (95 aa) |
| | RAB11FIP4 | RAB11 family interacting protein 4. (496 aa) |
| | ENSGALP00000071642 | SAM domain-containing protein. (136 aa) |
| | ANKRD13B | Ankyrin repeat domain 13B. (723 aa) |
| | ANKRD13C | Uncharacterized protein. (152 aa) |
| | USP50 | UCH domain-containing protein. (115 aa) |
| | CTNS | Cystinosin, lysosomal cystine transporter. (377 aa) |
| | SNX8 | Sorting nexin 8. (448 aa) |
| | TMEM184A | Transmembrane protein 184A. (425 aa) |
| | MICALL2 | Uncharacterized protein. (629 aa) |
| | GPER1 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (357 aa) |
| | RAB17 | RAB17, member RAS oncogene family. (213 aa) |
| | SRC | Proto-oncogene tyrosine-protein kinase Src; Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy bet [...] (539 aa) |
| | VPS37B | VPS37B subunit of ESCRT-I. (283 aa) |
| | SLC46A1 | Uncharacterized protein. (473 aa) |
| | CCZ1 | Vacuolar fusion protein CCZ1 homolog. (475 aa) |
| | RILP | Rab interacting lysosomal protein. (400 aa) |
| | RND2 | Uncharacterized protein. (227 aa) |
| | VPS50 | Syndetin; Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane. (997 aa) |
| | KIF16B | Kinesin family member 16B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (2059 aa) |
| | CHMP3 | Uncharacterized protein. (241 aa) |
| | SLC29A3 | Solute carrier family 29 member 3. (458 aa) |
| | PDCD1LG2 | Uncharacterized protein. (334 aa) |
| | SLC15A4 | Solute carrier family 15 member 4. (581 aa) |
| | UNC13D | Unc-13 homolog D. (708 aa) |
| | CHMP4B | Charged multivesicular body protein 4b; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids (By similarity). (227 aa) |
| | SCAMP2 | Secretory carrier-associated membrane protein. (333 aa) |
| | ANKFY1 | Ankyrin repeat and FYVE domain containing 1. (1076 aa) |
| | HTR4 | 5-hydroxytryptamine receptor 4; Belongs to the G-protein coupled receptor 1 family. (386 aa) |
| | SCAMP3 | Uncharacterized protein. (459 aa) |
| | GRIPAP1 | Uncharacterized protein. (764 aa) |
| | ACAP1 | ArfGAP with coiled-coil, ankyrin repeat and PH domains 1. (618 aa) |
| | VPS37D | VPS37D subunit of ESCRT-I. (358 aa) |
| | TRAPPC5 | Trafficking protein particle complex subunit 5; May play a role in vesicular transport from endoplasmic reticulum to Golgi. (211 aa) |
| | RAB11FIP3 | RAB11 family interacting protein 3. (689 aa) |
| | MARCH8 | RING-CH-type domain-containing protein. (581 aa) |
| | MXD3 | FYVE domain-containing protein. (619 aa) |
| | ATP11A | Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1174 aa) |
| | ENSGALP00000068244 | PLD phosphodiesterase domain-containing protein. (380 aa) |
| | USP8-2 | Rhodanese domain-containing protein. (602 aa) |
| | ATP13A3 | Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1283 aa) |
| | CLCN5 | Chloride channel protein. (826 aa) |
| | TGFBRAP1 | Transforming growth factor beta receptor associated protein 1. (863 aa) |
| | SLC39A9 | Zinc transporter ZIP9; May act as a zinc-influx transporter; Belongs to the ZIP transporter (TC 2.A.5) family. (324 aa) |
| | RPS6KC1 | Ribosomal protein S6 kinase C1. (1078 aa) |
| | MICALL1 | Uncharacterized protein. (991 aa) |
| | PLD3 | PLD phosphodiesterase domain-containing protein. (204 aa) |
| | SMPD1 | Sphingomyelin phosphodiesterase 1. (679 aa) |
| | SORT1 | Sortilin. (954 aa) |
| | WASH1 | WASH complex subunit 1; Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. Its assembly in the WASH core complex seems to inhibit its NPF activity and is required for its membrane targeting; Belongs to the WASH1 family. (485 aa) |
| | TOM1L2 | Uncharacterized protein. (571 aa) |
| | LITAF | Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog; Plays a role in endosomal protein trafficking and in targeting proteins for lysosomal degradation. May also contribute to the regulation of gene expression in the nucleus. Binds DNA (in vitro) and may play a synergistic role in the nucleus in regulating the expression of numerous cytokines. (148 aa) |
| | LAMTOR1 | Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1. (161 aa) |
| | ENSGALP00000066581 | Uncharacterized protein. (532 aa) |
| | ENSGALP00000066560 | Uncharacterized protein. (172 aa) |
| | DOP1B | DOP1 leucine zipper like protein B. (2282 aa) |
| | NEU2 | Neuraminidase 2. (413 aa) |
| | SLA2 | Uncharacterized protein. (279 aa) |
| | RUSC1 | RUN and SH3 domain containing 1. (1092 aa) |
| | ENSGALP00000065349 | Uncharacterized protein. (159 aa) |
| | VPS33B | Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. (667 aa) |
| | NEU3 | Sialidase domain-containing protein. (636 aa) |
| | SCAMP1 | Secretory carrier-associated membrane protein. (481 aa) |
| | PLA2G4EL6 | PLA2c domain-containing protein. (554 aa) |
| | CXorf21 | Chromosome X open reading frame 21. (289 aa) |
| | VTA1 | Vesicle trafficking 1. (391 aa) |
| | SYT11 | Synaptotagmin 11. (432 aa) |
| | LAMP5 | Lysosomal associated membrane protein family member 5. (344 aa) |
| | LAMTOR3 | Ragulator complex protein LAMTOR3; Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids. Adapter protein that may regulate the MAP kinase cascade (By similarity). (182 aa) |
| | M6PR | Mannose-6-phosphate receptor, cation dependent. (328 aa) |
| | RET | Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1105 aa) |
| | VPS33A | Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. (601 aa) |
| | TMEM230 | Transmembrane protein 230; Involved in trafficking and recycling of synaptic vesicles. Belongs to the TMEM134/TMEM230 family. (120 aa) |
| | TMEM108 | Transmembrane protein 108. (476 aa) |
| | RABEP1 | Uncharacterized protein. (782 aa) |
| | LAMTOR2 | Late endosomal/lysosomal adaptor, MAPK and MTOR activator 2. (312 aa) |
| | VPS35L | VPS35 endosomal protein sorting factor like. (963 aa) |
| | SPRYD3 | SPRY domain containing 3. (581 aa) |
| | ANKRD13A | Ankyrin repeat domain 13A. (501 aa) |
| | AP3D1 | AP-3 complex subunit delta; Belongs to the adaptor complexes large subunit family. (887 aa) |
| | RAB5B | Ras-related protein Rab-5B; Protein transport. Probably involved in vesicular traffic (By similarity); Belongs to the small GTPase superfamily. Rab family. (215 aa) |
| | USP10 | Ubiquitin carboxyl-terminal hydrolase 10; Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteracts MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels (By similarity). (785 aa) |
| | CHMP1B | Charged multivesicular body protein 1b; Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. (199 aa) |
| | CARMIL1 | Uncharacterized protein. (1429 aa) |
| | ARHGAP1 | Rho GTPase activating protein 1. (447 aa) |
| | RAP2B | RAP2B, member of RAS oncogene family. (118 aa) |
| | SMAD7 | Mothers against decapentaplegic homolog. (388 aa) |
| | GRN | Uncharacterized protein. (287 aa) |
| | RAB2B | Uncharacterized protein. (428 aa) |
| | VPS45 | Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. (397 aa) |
| | WDR81 | WD repeat domain 81. (1946 aa) |
| | STEAP3 | STEAP3 metalloreductase. (514 aa) |
| | ATP13A2 | Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1180 aa) |
| | LAMP1 | Lysosome-associated membrane glycoprotein 1; Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis; Belongs to the LAMP family. (406 aa) |
| | MLC1 | Modulator of VRAC current 1. (379 aa) |
| | VAMP4 | Vesicle associated membrane protein 4. (141 aa) |
| | YKT6 | Uncharacterized protein; Belongs to the synaptobrevin family. (198 aa) |
| | STX8 | t-SNARE coiled-coil homology domain-containing protein. (273 aa) |
| | CDIP1 | LITAF domain-containing protein. (200 aa) |
| | USP8 | Ubiquitin specific peptidase 8; Belongs to the peptidase C19 family. (331 aa) |
| | ENSGALP00000051391 | FYVE-type domain-containing protein. (201 aa) |
| | VPS37C | VPS37 C-terminal domain-containing protein. (370 aa) |
| | TBC1D16 | TBC1 domain family member 16. (728 aa) |
| | PPP1R21 | Protein phosphatase 1 regulatory subunit 21; Putative regulator of protein phosphatase 1 (PP1) activity. May play a role in the endosomal sorting process or in endosome maturation pathway. (814 aa) |
| | RAPGEF2 | Rap guanine nucleotide exchange factor 2. (1652 aa) |
| | CHMP2A | Charged multivesicular body protein 2a; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids (By similarity). (220 aa) |
| | CLEC16A | C-type lectin domain containing 16A. (895 aa) |
| | MAP2K1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (395 aa) |
| | CFTR | Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1485 aa) |
| | PHETA1 | PH domain containing endocytic trafficking adaptor 1. (238 aa) |
| | SNX7 | Sorting nexin 7. (445 aa) |
| | SMAD6 | Mothers against decapentaplegic homolog 6; Acts as a mediator of TGF-beta and BMP antiflammatory activity. Suppresses IL1R-TLR signaling, preventing NF-kappa-B activation, and BMP-SMAD1 signaling pathway. Binds to regulatory elements in target promoter regions (By similarity). (431 aa) |
| | UNC93B1 | Unc-93 homolog B1, TLR signaling regulator. (571 aa) |
| | PSAP | Prosaposin; The lysosomal degradation of sphingolipids takes place by the sequential action of specific hydrolases. Some of these enzymes require specific low-molecular mass, non-enzymic proteins: the sphingolipids activator proteins (coproteins). Saposin-B stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A (EC 3.1.6.8), GM1 gangliosides by beta- galactosidase (EC 3.2.1.23) and globotriaosylceramide by alpha- galactosidase A (EC 3.2.1.22). Saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases. (538 aa) |
| | TMEM19 | Transmembrane protein 19. (336 aa) |
| | PDLIM4 | PDZ and LIM domain protein 4; Suppresses SRC activation by recognizing and binding to active SRC and facilitating PTPN13-mediated dephosphorylation of SRC 'Tyr-419' leading to its inactivation. Inactivated SRC dissociates from this protein allowing the initiation of a new SRC inactivation cycle. Involved in reorganization of the actin cytoskeleton (By similarity). In nonmuscle cells, binds to ACTN1 (alpha-actinin-1), increases the affinity of ACTN1 to F-actin (filamentous actin), and promotes formation of actin stress fibers. Involved in regulation of the synaptic AMPA receptor transpo [...] (330 aa) |
| | ZFYVE21 | FYVE-type domain-containing protein. (250 aa) |
| | SNX27 | Uncharacterized protein. (550 aa) |
| | ABHD17A | Abhydrolase domain containing 17A. (304 aa) |
| | ADRB2 | Adrenoceptor beta 2. (402 aa) |
| | TBC1D12 | TBC1 domain family member 12. (779 aa) |
| | CCR8 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (342 aa) |
| | PICK1 | Protein interacting with PRKCA 1. (408 aa) |
| | SNX20 | PX domain-containing protein. (328 aa) |
| | CHMP4C | Uncharacterized protein. (220 aa) |
| | RMC1 | Regulator of MON1-CCZ1. (689 aa) |
| | PMEPA1 | Uncharacterized protein. (286 aa) |
| | ZDHHC20 | Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (363 aa) |
| | TPP1 | Tripeptidyl peptidase 1. (575 aa) |
| | SORL1 | Sortilin-related receptor; Sorting receptor that directs numerous proteins to their correct location within the cell. Along with AP-1 complex, involved Golgi apparatus - endosome sorting (By similarity). Sorting receptor for APP, regulating its intracellular trafficking and processing into amyloidogenic-beta peptides. Retains APP in the trans-Golgi network, hence preventing its transit through late endosomes where amyloid beta peptides Abeta40 and Abeta42 are generated (By similarity). Sorting receptor for the BDNF receptor NTRK2/TRKB that facilitates NTRK2 trafficking between synaptic [...] (2205 aa) |
| | LZTR1 | Leucine zipper like transcription regulator 1. (786 aa) |
| | CYB561A3 | Cytochrome b561 domain-containing protein. (272 aa) |
| | AVL9 | AVL9 cell migration associated. (644 aa) |
| | LAPTM4B | Lysosomal protein transmembrane 4 beta. (224 aa) |
| | DNAJC13 | DnaJ heat shock protein family (Hsp40) member C13. (2245 aa) |
| | VPS53 | Vacuolar protein sorting-associated protein 53 homolog; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). Acts as component of the EARP complex that is involved in endocytic recycling. (831 aa) |
| | VPS4A | Uncharacterized protein; Belongs to the AAA ATPase family. (437 aa) |
| | SNX16 | PX domain-containing protein. (347 aa) |
| | SLC9A7 | Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (813 aa) |
| | DENND6A | Protein DENND6A; Guanine nucleotide exchange factor (GEF) for RAB14. Belongs to the DENND6 family. (584 aa) |
| | ABCB6 | ATP binding cassette subfamily B member 6 (Langereis blood group). (894 aa) |
| | FYCO1 | Uncharacterized protein. (1540 aa) |
| | TMEM59 | Uncharacterized protein. (325 aa) |
| | TRAPPC9 | Trafficking protein particle complex 9. (996 aa) |
| | VPS25 | Vacuolar protein sorting 25 homolog. (174 aa) |
| | ENSGALP00000044402 | ANK_REP_REGION domain-containing protein. (216 aa) |
| | MVB12A | Multivesicular body subunit 12A; Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (By similarity). (267 aa) |
| | SNX17 | Sorting nexin 17. (470 aa) |
| | LOC100859020 | Uncharacterized protein. (397 aa) |
| | CAV1 | Caveolin-1; May act as a positive regulator of T-cell coactivation. May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). (178 aa) |
| | STAM | Signal transducing adaptor molecule. (522 aa) |
| | ANKRD27 | Uncharacterized protein. (1087 aa) |
| | CXCR7 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (364 aa) |
| | C9orf85 | Chromosome 9 open reading frame 85. (166 aa) |
| | ZFYVE27 | Protrudin; Key regulator of RAB11-dependent vesicular trafficking during neurite extension through polarized membrane transport. Promotes axonal elongation and contributes to the establishment of neuronal cell polarity. Involved in nerve growth factor-induced neurite formation in VAPA-dependent manner. Contributes to both the formation and stabilization of the tubular ER network. Involved in ER morphogenesis by regulating the sheet-to-tubule balance and possibly the density of tubule interconnections. (413 aa) |
| | CLEC18B | Uncharacterized protein. (435 aa) |
| | ARF6 | ADP-ribosylation factor 6; GTP-binding protein involved in protein trafficking; regulates endocytic recycling and cytoskeleton remodeling. May contribute to the regulation of dendritic branching, filopodia extension and dendritic spine development (By similarity). (175 aa) |
| | PLA2G4EL2 | Phospholipase A2. (812 aa) |
| | CHMP6 | Charged multivesicular body protein 6; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In the ESCRT-III complex, it probably serves as an accepto [...] (200 aa) |
| | PLA2G4EL5 | Phospholipase A2. (867 aa) |
| | AP1AR | Adaptor related protein complex 1 associated regulatory protein. (301 aa) |
| | PLA2G4EL3 | PLA2c domain-containing protein. (313 aa) |
| | SLC9A9 | Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (642 aa) |
| | VPS51 | Vacuolar protein sorting-associated protein 51 homolog; Involved in retrograde transport from early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. Acts as component of the EARP complex that is involved in endocytic recycling. (787 aa) |
| | RAP2C | Uncharacterized protein. (183 aa) |
| | FETUB | Uncharacterized protein. (399 aa) |
| | MON2 | Uncharacterized protein. (1719 aa) |
| | OVAL | Ovalbumin; Non-inhibitory serpin. Storage protein of egg white. (386 aa) |
| | RAB10 | Ras-related protein Rab-10; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane. Plays also a specific role in asymmetric protein transport to the plasma mem [...] (200 aa) |
| | TRAPPC10 | Foie-gras_1 domain-containing protein. (1267 aa) |
| | RAB7B | RAB7B, member RAS oncogene family. (207 aa) |
| | CARMIL2 | Capping protein regulator and myosin 1 linker 2. (1435 aa) |
| | UBAP1 | Ubiquitin associated protein 1. (515 aa) |
| | CHMP1A | Uncharacterized protein. (196 aa) |
| | RAB31 | RAB31, member RAS oncogene family. (195 aa) |
| | ANXA1 | Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (By similarity). Contribut [...] (342 aa) |
| | PLA2G4EL7 | PLA2c domain-containing protein. (580 aa) |
| | VAMP7 | Vesicle-associated membrane protein 7; Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for focal exocytosis of late endocytic vesicles during phagosome formation (By similarity); Belongs to the synaptobrevin family. (220 aa) |
| | VPS36 | Vacuolar protein sorting 36 homolog. (541 aa) |
| | WDFY2 | Uncharacterized protein. (400 aa) |
| | RAP2A | RAP2A, member of RAS oncogene family. (183 aa) |
| | LAPTM4A | Lysosomal-associated transmembrane protein 4A; May function in the transport of nucleosides and/or nucleoside derivatives between the cytosol and the lumen of an intracellular membrane-bound compartment. (229 aa) |
| | SNX14 | Uncharacterized protein. (963 aa) |
| | ECPAS | Ecm29 proteasome adaptor and scaffold. (1872 aa) |
| | ZFYVE28 | Uncharacterized protein. (354 aa) |
| | SNX30 | Sorting nexin family member 30. (438 aa) |
| | EPHA7 | Ephrin type-A receptor 7; Receptor tyrosine kinase which binds promiscuously GPI- anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repel [...] (993 aa) |
| | ZFYVE16 | Zinc finger FYVE domain-containing protein. (1366 aa) |
| | TBC1D14 | Rab-GAP TBC domain-containing protein. (711 aa) |
| | CHMP2B | Charged multivesicular body protein 2b; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids (By similarity). (214 aa) |
| | EPHA3 | Ephrin type-A receptor 3; Receptor tyrosine kinase which binds promiscuously membrane- bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in ca [...] (983 aa) |
| | TMEM175 | Endosomal/lysosomal potassium channel TMEM175; Organelle-specific potassium channel specifically responsible for potassium conductance in endosomes and lysosomes. Forms a potassium-permeable leak-like channel; Belongs to the TMEM175 family. (501 aa) |
| | GPR161 | G protein-coupled receptor 161; Belongs to the G-protein coupled receptor 1 family. (535 aa) |
| | FIG4 | SAC domain-containing protein. (903 aa) |
| | CD274 | Uncharacterized protein. (471 aa) |
| | NSG1 | Neuronal vesicle trafficking-associated protein 1; Plays a role in the recycling mechanism in neurons of multiple receptors and acts at the level of early endosomes to promote sorting of receptors toward a recycling pathway. Belongs to the NSG family. (185 aa) |
| | CRHBP | Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (345 aa) |
| | TPD52L1 | Tumor protein D53 homolog. (210 aa) |
| | SLC38A9 | Solute carrier family 38 member 9. (559 aa) |
| | LLGL1 | LLGL scribble cell polarity complex component 1. (1234 aa) |
| | PACSIN2 | Protein kinase C and casein kinase substrate in neurons protein 2; Regulates the morphogenesis and endocytosis of caveolae (By similarity). Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle-mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus. (485 aa) |
| | KDR | Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1348 aa) |
| | ZDHHC2 | Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (445 aa) |
| | CHMP5 | Uncharacterized protein. (219 aa) |
| | RELCH | RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1363 aa) |
| | VPS4B | Uncharacterized protein; Belongs to the AAA ATPase family. (438 aa) |
