STRINGSTRING
C3H6orf120 C3H6orf120 LPO LPO ENSGALP00000074046 ENSGALP00000074046 VAMP1 VAMP1 SYTL4 SYTL4 FSTL4 FSTL4 FSTL5 FSTL5 THBS2 THBS2 DNAJC5G DNAJC5G SPATA1 SPATA1 RAB4A RAB4A VPS13B VPS13B RAB44 RAB44 IQUB IQUB ENSGALP00000071604 ENSGALP00000071604 PHACTR2 PHACTR2 REXO1 REXO1 GRP GRP KIAA1210 KIAA1210 BRI3 BRI3 SYCN SYCN VPS13C VPS13C ENSGALP00000069116 ENSGALP00000069116 RRBP1 RRBP1 ENSGALP00000068902 ENSGALP00000068902 STXBP5 STXBP5 HYAL3 HYAL3 RAB15 RAB15 ENSGALP00000066467 ENSGALP00000066467 NHLRC3 NHLRC3 STK31 STK31 SFTPC SFTPC TOR4A TOR4A CCDC189 CCDC189 STXBP3 STXBP3 PRSS57 PRSS57 DNASE1L2 DNASE1L2 RAB10L RAB10L DNASE1 DNASE1 SCAMP1 SCAMP1 SPACA1 SPACA1 ABCC4 ABCC4 ABCA13 ABCA13 UVS.2L UVS.2L KNL1 KNL1 ENSGALP00000058230 ENSGALP00000058230 C1orf35 C1orf35 STX7 STX7 GMFB GMFB LRGUK LRGUK ARSA ARSA FRMPD4 FRMPD4 ENSGALP00000054692 ENSGALP00000054692 CFAP65 CFAP65 PADI2 PADI2 GALNS GALNS MYH9 MYH9 MYO5C MYO5C VPS13A VPS13A STXBP1 STXBP1 CTSH CTSH DNAJC5B DNAJC5B SYT4 SYT4 MYO5A MYO5A PTPRN PTPRN STXBP5L STXBP5L DNAJC5 DNAJC5 COMMD9 COMMD9 EPX EPX F5 F5 DBH DBH SYT2 SYT2 PTPRN2 PTPRN2 ICA1 ICA1 ASTL ASTL MYRIP MYRIP ABCA3 ABCA3 LOC425940 LOC425940 SCFD2 SCFD2 RAB12 RAB12 SCG2 SCG2 RAB37 RAB37 STK11IP STK11IP CLDN16 CLDN16 STBD1 STBD1 SYT1 SYT1 SLC17A9 SLC17A9 CYB561 CYB561 TGFB3 TGFB3 ZPBP ZPBP RAB10 RAB10 AvBD1 AvBD1 DNASE1L3 DNASE1L3 PLA2G10 PLA2G10 DEFB4A DEFB4A PLA2G10L PLA2G10L OLFM4 OLFM4 PRSS55 PRSS55 WFS1 WFS1 PENK PENK GNAQ GNAQ GNA14 GNA14 DENND4C DENND4C CRHBP CRHBP RABL3 RABL3 CLUL1 CLUL1 PCSK1 PCSK1 ING4 ING4 SPX SPX F1NT47_CHICK F1NT47_CHICK CTSV CTSV TMEM184B TMEM184B PLAC8 PLAC8 NPY NPY MEPE MEPE CHGA CHGA TRIP11 TRIP11 TMED10 TMED10 GTPBP2 GTPBP2 GLIPR1L GLIPR1L E1BZU2_CHICK E1BZU2_CHICK SCG5 SCG5 SNAP23 SNAP23 E1BU02_CHICK E1BU02_CHICK LAMP3 LAMP3 SYT8 SYT8 SYT9 SYT9 OPNP OPNP LHFPL2 LHFPL2 TMEM184A TMEM184A SPARC SPARC ABCA12 ABCA12 GNA11 GNA11 C4BPA C4BPA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
C3H6orf120UPF0669 protein C6orf120 homolog. (185 aa)
LPOUncharacterized protein. (790 aa)
ENSGALP00000074046Uncharacterized protein. (401 aa)
VAMP1V-SNARE coiled-coil homology domain-containing protein. (119 aa)
SYTL4Synaptotagmin like 4. (690 aa)
FSTL4Uncharacterized protein. (923 aa)
FSTL5Follistatin like 5. (866 aa)
THBS2Thrombospondin-2; Adhesive glycoprotein that mediates cell-to-cell and cell-to- matrix interactions; Belongs to the thrombospondin family. (1213 aa)
DNAJC5GJ domain-containing protein. (171 aa)
SPATA1SPATA1_C domain-containing protein. (163 aa)
RAB4ARAB4A, member RAS oncogene family. (255 aa)
VPS13BUncharacterized protein. (511 aa)
RAB44Uncharacterized protein. (1276 aa)
IQUBIQ motif and ubiquitin domain containing. (704 aa)
ENSGALP00000071604Uncharacterized protein. (406 aa)
PHACTR2Phosphatase and actin regulator. (642 aa)
REXO1RNA exonuclease 1 homolog. (1255 aa)
GRPGastrin-releasing peptide; Stimulates the release of gastrin and other gastrointestinal hormones (Probable). Stimulates pancreatic protein and fluid secretion, and increases acid secretion from the avian proventriculus. Belongs to the bombesin/neuromedin-B/ranatensin family. (164 aa)
KIAA1210DUF4592 domain-containing protein. (971 aa)
BRI3Brain protein I3. (149 aa)
SYCNSyncollin. (131 aa)
VPS13CVacuolar protein sorting 13 homolog C. (3587 aa)
ENSGALP00000069116Uncharacterized protein. (59 aa)
RRBP1Rib_recp_KP_reg domain-containing protein. (1041 aa)
ENSGALP00000068902Chorein_N domain-containing protein. (141 aa)
STXBP5Syntaxin binding protein 5. (1152 aa)
HYAL3Hyaluronidase. (584 aa)
RAB15RAB15, member RAS oncogene family. (211 aa)
ENSGALP00000066467Uncharacterized protein. (248 aa)
NHLRC3NHL repeat containing 3. (502 aa)
STK31Serine/threonine kinase 31. (1007 aa)
SFTPCBRICHOS domain-containing protein. (202 aa)
TOR4ATorsin family 4 member A. (531 aa)
CCDC189Uncharacterized protein. (255 aa)
STXBP3Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. (601 aa)
PRSS57Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (488 aa)
DNASE1L2Deoxyribonuclease; Belongs to the DNase I family. (278 aa)
RAB10LUncharacterized protein. (208 aa)
DNASE1Deoxyribonuclease-1; Serum endocuclease secreted into body fluids by a wide variety of exocrine and endocrine organs. Expressed by non-hematopoietic tissues and preferentially cleaves protein-free DNA (By similarity). Among other functions, seems to be involved in cell death by apoptosis (By similarity). Binds specifically to G-actin and blocks actin polymerization (By similarity). (282 aa)
SCAMP1Secretory carrier-associated membrane protein. (481 aa)
SPACA1Sperm acrosome associated 1. (197 aa)
ABCC4Multidrug resistance protein 4. (1349 aa)
ABCA13Uncharacterized protein. (646 aa)
UVS.2LMetalloendopeptidase. (281 aa)
KNL1Knl1_RWD_C domain-containing protein. (399 aa)
ENSGALP00000058230Uncharacterized protein. (317 aa)
C1orf35Chromosome 1 open reading frame 35. (310 aa)
STX7t-SNARE coiled-coil homology domain-containing protein; Belongs to the syntaxin family. (258 aa)
GMFBGlia maturation factor; Belongs to the actin-binding proteins ADF family. GMF subfamily. (141 aa)
LRGUKLeucine rich repeats and guanylate kinase domain containing. (740 aa)
ARSAArylsulfatase A. (506 aa)
FRMPD4FERM and PDZ domain containing 4. (1314 aa)
ENSGALP00000054692ABC transporter domain-containing protein. (434 aa)
CFAP65Cilia- and flagella-associated protein 65; May play a role in sperm motility. (1775 aa)
PADI2Peptidylarginine deiminase type II. (663 aa)
GALNSGalactosamine (N-acetyl)-6-sulfatase. (513 aa)
MYH9Myosin-9; Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. (1960 aa)
MYO5CMyosin VC; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1737 aa)
VPS13AUncharacterized protein. (3193 aa)
STXBP1Syntaxin-binding protein 1; May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxins, components of the synaptic vesicle fusion machinery. May play a role in determining the specificity of intracellular fusion reactions (By similarity). Belongs to the STXBP/unc-18/SEC1 family. (603 aa)
CTSHUncharacterized protein; Belongs to the peptidase C1 family. (403 aa)
DNAJC5BDnaJ heat shock protein family (Hsp40) member C5 beta. (196 aa)
SYT4Synaptotagmin 4. (425 aa)
MYO5AUnconventional myosin-Va; Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarization process involved in dendrite formation (By similarity). (1830 aa)
PTPRNProtein tyrosine phosphatase receptor type N. (946 aa)
STXBP5LSyntaxin binding protein 5 like. (1184 aa)
DNAJC5J domain-containing protein. (198 aa)
COMMD9COMM domain containing 9. (199 aa)
EPXEosinophil peroxidase. (941 aa)
F5Coagulation factor V; Belongs to the multicopper oxidase family. (2025 aa)
DBHDopamine beta-hydroxylase. (584 aa)
SYT2Synaptotagmin 2. (490 aa)
PTPRN2Protein tyrosine phosphatase receptor type N2. (1030 aa)
ICA1Islet cell autoantigen 1. (676 aa)
ASTLAstacin-like metalloendopeptidase; Probable oocyte-specific oolemmal receptor involved in sperm and egg adhesion and fertilization. May act as a protease (By similarity). (409 aa)
MYRIPRab_eff_C domain-containing protein. (666 aa)
ABCA3ATP binding cassette subfamily A member 3. (1708 aa)
LOC425940Uncharacterized protein. (1491 aa)
SCFD2Sec1 family domain containing 2; Belongs to the STXBP/unc-18/SEC1 family. (652 aa)
RAB12RAB12, member RAS oncogene family. (290 aa)
SCG2Secretogranin II. (629 aa)
RAB37RAB37, member RAS oncogene family. (371 aa)
STK11IPSerine/threonine-protein kinase 11-interacting protein. (1141 aa)
CLDN16Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (226 aa)
STBD1Starch binding domain 1. (290 aa)
SYT1Synaptotagmin-1; Calcium sensor that participates in triggering neurotransmitter release at the synapse (By similarity). May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. May play a role in dendrite formation by melanocytes; Belongs to the synaptotagmin family. (430 aa)
SLC17A9MFS domain-containing protein. (606 aa)
CYB561Cytochrome b561. (252 aa)
TGFB3Transforming growth factor beta-3 proprotein; Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively. Transforming growth factor beta-3: Multifunctional protein that regulates embryogenesis and cell differentiation and is required in various processes such as secondary palate development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi appa [...] (535 aa)
ZPBPZona pellucida-binding protein 1; Plays a role in sperm morphogenesis and in sperm-oocyte interaction during fertilization; Belongs to the zona pellucida-binding protein Sp38 family. (344 aa)
RAB10Ras-related protein Rab-10; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane. Plays also a specific role in asymmetric protein transport to the plasma mem [...] (200 aa)
AvBD1Gallinacin-1; Has bactericidal activity. Potent activity against E.coli ML- 35, L.monocytogenes EGD and C.albicans. (65 aa)
DNASE1L3Deoxyribonuclease; Belongs to the DNase I family. (307 aa)
PLA2G10Phospholipase A(2). (155 aa)
DEFB4AGallinacin-2; Potent antibacterial activity against the Gram-negative bacterium E.coli ML-35, and against the Gram-positive bacterium L.monocytogenes EGD. Lacks antifungal activity against C.albicans. (64 aa)
PLA2G10LPhospholipase A(2). (158 aa)
OLFM4Olfactomedin-like domain-containing protein. (489 aa)
PRSS55Peptidase S1 domain-containing protein. (214 aa)
WFS1Wolframin ER transmembrane glycoprotein. (874 aa)
PENKProenkephalin. (267 aa)
GNAQUncharacterized protein. (359 aa)
GNA14Uncharacterized protein. (187 aa)
DENND4CDENN domain containing 4C. (1950 aa)
CRHBPCorticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (345 aa)
RABL3Rab-like protein 3; Belongs to the small GTPase superfamily. Rab family. (236 aa)
CLUL1Clusterin; Belongs to the clusterin family. (461 aa)
PCSK1Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family. (748 aa)
ING4Inhibitor of growth protein 4; Through chromatin acetylation it may function in DNA replication. May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation (By similarity); Belongs to the ING family. (249 aa)
SPXSpexin hormone. (116 aa)
F1NT47_CHICKUncharacterized protein. (112 aa)
CTSVCathepsin L1 heavy chain; Important for the overall degradation of proteins in lysosomes; Belongs to the peptidase C1 family. (353 aa)
TMEM184BUncharacterized protein. (410 aa)
PLAC8Uncharacterized protein. (145 aa)
NPYC-flanking peptide of NPY; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone; Belongs to the NPY family. (97 aa)
MEPEOvocleidin-116; Major component of the eggshell matrix. May play an important role in the regulation of calcite growth during eggshell calcification. May also regulate the mineralization process in developing and growing bones. (743 aa)
CHGAChromogranin A. (466 aa)
TRIP11Thyroid hormone receptor interactor 11. (1980 aa)
TMED10GOLD domain-containing protein. (219 aa)
GTPBP2GTP binding protein 2. (605 aa)
GLIPR1LSCP domain-containing protein; Belongs to the CRISP family. (265 aa)
E1BZU2_CHICKSCP domain-containing protein; Belongs to the CRISP family. (264 aa)
SCG5Uncharacterized protein. (208 aa)
SNAP23Synaptosomal-associated protein; Belongs to the SNAP-25 family. (209 aa)
E1BU02_CHICKSpermatogenesis associated 1. (335 aa)
LAMP3Uncharacterized protein. (471 aa)
SYT8Synaptotagmin 8. (396 aa)
SYT9Synaptotagmin 9. (528 aa)
OPNPPinopsin; Produces a slow and prolonged phototransduction response consistent with the non-visual function of pineal photoreception. (351 aa)
LHFPL2LHFPL tetraspan subfamily member 2. (228 aa)
TMEM184ATransmembrane protein 184A. (425 aa)
SPARCSPARC; Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity (By similarity). (298 aa)
ABCA12ATP binding cassette subfamily A member 12. (3348 aa)
GNA11Guanine nucleotide-binding protein G11 alpha-subunit. (359 aa)
C4BPAUncharacterized protein. (451 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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