STRINGSTRING
CTXN1 CTXN1 LOXL2 LOXL2 OLFML2A OLFML2A ZP3L2 ZP3L2 MMRN2-2 MMRN2-2 OLFML2B OLFML2B COMP COMP FN1 FN1 MMP2 MMP2 SPARC SPARC ASPN ASPN FBN1 FBN1 FBLN2 FBLN2 FREM1 FREM1 F3 F3 MMP11 MMP11 RBP3 RBP3 TF TF ACAN ACAN E1C7P2_CHICK E1C7P2_CHICK LAMB1 LAMB1 CYR61 CYR61 TECTB TECTB SMOC1 SMOC1 LOC417800 LOC417800 THBS1 THBS1 COL1A2 COL1A2 COCH COCH FBLN5 FBLN5 MEPE MEPE EPYC EPYC GFOD1 GFOD1 BAG1 BAG1 HAPLN2 HAPLN2 ADAMTS6 ADAMTS6 THBS4 THBS4 COL8A1 COL8A1 RBP4 RBP4 ADAMTS5 ADAMTS5 RWDD2A RWDD2A ZPAX ZPAX LINC00954 LINC00954 SDC1 SDC1 ALG11 ALG11 SPDYA SPDYA TGFB2 TGFB2 PHOSPHO2 PHOSPHO2 ZP4 ZP4 TGFB3 TGFB3 ZP2 ZP2 PRNP PRNP OMD OMD C12orf75 C12orf75 TIMP3 TIMP3 CCBE1 CCBE1 COL6A2 COL6A2 FMOD FMOD ADAMTS10 ADAMTS10 CPZ CPZ P3H2 P3H2 EFEMP1 EFEMP1 ADAMTS4 ADAMTS4 ADNP2 ADNP2 CASK CASK ANXA2P2 ANXA2P2 PRELP PRELP C9H2ORF82 C9H2ORF82 PHOSPHO1 PHOSPHO1 COL26A1 COL26A1 SFSWAP SFSWAP ANOS1 ANOS1 LOC107049024 LOC107049024 OTOA OTOA RARRES2 RARRES2 CILP CILP ADAMTSL2 ADAMTSL2 OPTC OPTC LOC100857892 LOC100857892 ENSGALP00000057014 ENSGALP00000057014 TGFBI TGFBI MMRN2 MMRN2 AGRN AGRN MDK MDK DCN DCN ANP32B ANP32B KERA KERA MATN2 MATN2 HPSE2 HPSE2 ENSGALP00000064934 ENSGALP00000064934 ENSGALP00000065673 ENSGALP00000065673 POSTN POSTN ENSGALP00000066764 ENSGALP00000066764 LOXL3 LOXL3 BICC1 BICC1 ZPLD1 ZPLD1 EMID1 EMID1 ADAMTSL5 ADAMTSL5 LTBP2 LTBP2 ELN ELN ENSGALP00000069344 ENSGALP00000069344 SNED1 SNED1 ADAMTSL2L ADAMTSL2L LTBP1 LTBP1 GFOD2 GFOD2 ABI3BP ABI3BP FAM107B FAM107B TECTA TECTA SMOC2 SMOC2 GPLD1 GPLD1 THBS2 THBS2 SPOCK2 SPOCK2 ENSGALP00000073838 ENSGALP00000073838 ENSGALP00000074008 ENSGALP00000074008
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CTXN1Cortexin 1. (78 aa)
LOXL2Lysyl oxidase homolog 2; Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). Acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. Shows no activity against histone H3 when it is trimethylated on 'Lys- 9' (H3K9me3) or 'Lys-27' (H3K27me3) or when 'Lys-4' is monomethylated (H3K4me1) or dimethylated (H3K4me2). Also mediates deamination of methylated TAF10, a member o [...] (773 aa)
OLFML2AOlfactomedin like 2A. (640 aa)
ZP3L2ZP domain-containing protein. (472 aa)
MMRN2-2C1q domain-containing protein. (582 aa)
OLFML2BOlfactomedin like 2B. (740 aa)
COMPUncharacterized protein. (777 aa)
FN1Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. May be involved in osteoblast compaction (By similarity). (2526 aa)
MMP272 kDa type IV collagenase; Belongs to the peptidase M10A family. (663 aa)
SPARCSPARC; Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity (By similarity). (298 aa)
ASPNAsporin. (371 aa)
FBN1Fibrillin 1. (2861 aa)
FBLN2Fibulin 2. (1196 aa)
FREM1FRAS1 related extracellular matrix 1. (2184 aa)
F3Coagulation factor III, tissue factor. (283 aa)
MMP11Matrix metallopeptidase 11. (456 aa)
RBP3Uncharacterized protein. (1235 aa)
TFOvotransferrin; Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. Responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. There are two forms of hen transferrin, ovotransferrin, found in the ovoducts and, serum transferrin, secreted by the liver. Serum transferrin may also have a role in stimulating cell proliferation and is regulated by iron levels. Ovotransferrin has a bacteriostatic function and, is not controlled by iron levels. (756 aa)
ACANAggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. (2089 aa)
E1C7P2_CHICKUncharacterized protein. (264 aa)
LAMB1Laminin subunit beta-1; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. (1785 aa)
CYR61CCN family member 1; Probable secreted regulatory protein. (375 aa)
TECTBBeta-tectorin; One of the major non-collagenous components of the tectorial membrane. The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair- cell membrane potential, transducing sound into electrical signals. (329 aa)
SMOC1SPARC related modular calcium binding 1. (457 aa)
LOC417800Uncharacterized protein. (225 aa)
THBS1Uncharacterized protein. (1175 aa)
COL1A2Collagen alpha-2(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen). (1363 aa)
COCHCochlin; Plays a role in the control of cell shape and motility in the trabecular meshwork. (546 aa)
FBLN5Uncharacterized protein. (444 aa)
MEPEOvocleidin-116; Major component of the eggshell matrix. May play an important role in the regulation of calcite growth during eggshell calcification. May also regulate the mineralization process in developing and growing bones. (743 aa)
EPYCEpiphycan; May have a role in bone formation and also in establishing the ordered structure of cartilage through matrix organization; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily. (316 aa)
GFOD1Glucose-fructose oxidoreductase domain containing 1. (390 aa)
BAG1Uncharacterized protein. (209 aa)
HAPLN2Hyaluronan and proteoglycan link protein 2. (374 aa)
ADAMTS6ADAM metallopeptidase with thrombospondin type 1 motif 6. (1119 aa)
THBS4Uncharacterized protein. (953 aa)
COL8A1Collagen alpha-1(VIII) chain; Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis (By similarity). (739 aa)
RBP4Purpurin; May be involved in the transport of retinol between the photoreceptors and the pigmented epithelium; Belongs to the calycin superfamily. Lipocalin family. (196 aa)
ADAMTS5ADAM metallopeptidase with thrombospondin type 1 motif 5. (877 aa)
RWDD2ARWD domain containing 2A. (291 aa)
ZPAXZona pellucida protein. (837 aa)
LINC00954ZP domain-containing protein. (911 aa)
SDC1Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (308 aa)
ALG11Uncharacterized protein. (518 aa)
SPDYASpeedy/RINGO cell cycle regulator family member A. (324 aa)
TGFB2Transforming growth factor beta-2 proprotein; Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. Transforming growth factor beta-2: Multifunctional protein that regulates various processes such as angiogenesis and heart development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transfor [...] (412 aa)
PHOSPHO2Phosphatase, orphan 2. (244 aa)
ZP4Uncharacterized protein. (542 aa)
TGFB3Transforming growth factor beta-3 proprotein; Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively. Transforming growth factor beta-3: Multifunctional protein that regulates embryogenesis and cell differentiation and is required in various processes such as secondary palate development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi appa [...] (535 aa)
ZP2ZP domain-containing protein. (829 aa)
PRNPMajor prion protein homolog; Its primary physiological function is unclear. Has cytoprotective activity against internal or environmental stresses. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its h [...] (273 aa)
OMDOsteomodulin. (413 aa)
C12orf75Overexpressed in colon carcinoma 1 protein homolog; Belongs to the OCC1 family. (39 aa)
TIMP3Metalloproteinase inhibitor 3; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli; Belongs to the protease inhibitor I35 (TIMP) family. (212 aa)
CCBE1Collagen and calcium binding EGF domains 1. (329 aa)
COL6A2Collagen alpha-2(VI) chain; Collagen VI acts as a cell-binding protein. (1022 aa)
FMODFibromodulin; Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity); Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily. (380 aa)
ADAMTS10ADAM metallopeptidase with thrombospondin type 1 motif 10. (1109 aa)
CPZCarboxypeptidase Z; Cleaves substrates with C-terminal arginine residues. Modulates the Wnt signaling pathway, probably by cleaving some undefined protein. Regulates the development of skeletal elements during development, probably by activating WNT4. Belongs to the peptidase M14 family. (647 aa)
P3H2Prolyl 3-hydroxylase 2; Prolyl 3-hydroxylase that catalyzes the post-translational formation of 3-hydroxyproline on collagens (By similarity). Contributes to proline 3-hydroxylation of collagen COL4A1 and COL1A1 in tendons, the eye sclera and in the eye lens capsule (By similarity). Has high activity with the type IV collagen COL4A1, and lower activity with COL1A1. Catalyzes hydroxylation of the first Pro in Gly-Pro-Hyp sequences where Hyp is 4-hydroxyproline. Has no activity on substrates that lack 4-hydroxyproline in the third position (By similarity). (694 aa)
EFEMP1EGF containing fibulin extracellular matrix protein 1. (451 aa)
ADAMTS4ADAM metallopeptidase with thrombospondin type 1 motif 4. (644 aa)
ADNP2ADNP homeobox 2. (1055 aa)
CASKCalcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family. (944 aa)
ANXA2P2Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. (339 aa)
PRELPProline and arginine rich end leucine rich repeat protein. (430 aa)
C9H2ORF82Uncharacterized protein. (121 aa)
PHOSPHO1Phosphoethanolamine/phosphocholine phosphatase; Phosphatase that has a high activity toward phosphoethanolamine (PEA) and phosphocholine (PCho). Involved in the generation of inorganic phosphate for bone mineralization. Belongs to the HAD-like hydrolase superfamily. PHOSPHO family. (268 aa)
COL26A1Collagen type XXVI alpha 1 chain. (406 aa)
SFSWAPSplicing factor SWAP. (1001 aa)
ANOS1Anosmin-1; May be an adhesion-like molecule with anti-protease activity. (675 aa)
LOC107049024Epidermal differentiation protein. (316 aa)
OTOAUncharacterized protein. (524 aa)
RARRES2Chemerin. (162 aa)
CILPCartilage intermediate layer protein. (1104 aa)
ADAMTSL2ADAMTS like 2. (1037 aa)
OPTCLRRNT domain-containing protein. (338 aa)
LOC100857892NIDO domain-containing protein. (271 aa)
ENSGALP00000057014Uncharacterized protein. (511 aa)
TGFBIUncharacterized protein. (680 aa)
MMRN2EMI domain-containing protein. (208 aa)
AGRNAgrin C-terminal 110 kDa subunit; [Isoform 1]: heparan sulfate basal lamina glycoprotein that plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ) and directs key events in postsynaptic differentiation. Component of the AGRN-LRP4 receptor complex that induces the phosphorylation and activation of MUSK. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Calcium ions are required for maximal AChR clu [...] (2076 aa)
MDKMidkine; Has mitogenic activity, and neurite extension activity for PC12 cells; Belongs to the pleiotrophin family. (239 aa)
DCNDecorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. (357 aa)
ANP32BAcidic leucine-rich nuclear phosphoprotein 32 family member B; Multifunctional protein working as a cell cycle progression factor as well as a cell survival factor. Required for the progression from the G1 to the S phase. Anti-apoptotic protein which functions as a caspase-3 inhibitor. Has no phosphatase 2A (PP2A) inhibitor activity. Exhibits histone chaperone properties, stimulating core histones to assemble into a nucleosome (By similarity). (262 aa)
KERAKeratocan; Plays an important role in generating and maintaining a transparent matrix within the corneal stroma. (353 aa)
MATN2Matrilin 2. (1297 aa)
HPSE2Heparanase 2 (inactive). (675 aa)
ENSGALP00000064934Uncharacterized protein. (2030 aa)
ENSGALP00000065673Uncharacterized protein. (899 aa)
POSTNUncharacterized protein. (857 aa)
ENSGALP00000066764Fibronectin type-III domain-containing protein. (334 aa)
LOXL3Lysyl oxidase like 3. (755 aa)
BICC1SAM domain-containing protein. (1058 aa)
ZPLD1Zona pellucida like domain containing 1. (414 aa)
EMID1EMI domain containing 1. (698 aa)
ADAMTSL5ADAMTS like 5. (692 aa)
LTBP2Latent transforming growth factor beta binding protein 2. (1851 aa)
ELNElastin; Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. (811 aa)
ENSGALP00000069344Uncharacterized protein. (176 aa)
SNED1Sushi, nidogen and EGF like domains 1. (1491 aa)
ADAMTSL2LPLAC domain-containing protein. (362 aa)
LTBP1Uncharacterized protein. (1656 aa)
GFOD2GFO_IDH_MocA domain-containing protein. (385 aa)
ABI3BPFibronectin type-III domain-containing protein. (511 aa)
FAM107BFamily with sequence similarity 107 member B. (334 aa)
TECTAAlpha-tectorin; One of the major non-collagenous components of the tectorial membrane. The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair- cell membrane potential, transducing sound into electrical signals. (2158 aa)
SMOC2SPARC related modular calcium binding 2. (441 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (856 aa)
THBS2Thrombospondin-2; Adhesive glycoprotein that mediates cell-to-cell and cell-to- matrix interactions; Belongs to the thrombospondin family. (1213 aa)
SPOCK2SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2. (406 aa)
ENSGALP00000073838EGF-like domain-containing protein. (269 aa)
ENSGALP00000074008Uncharacterized protein. (520 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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