(41 nodes) Midbody network (Gallus gallus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SPART	Spartin. (631 aa)
	NUDC	Nuclear migration protein nudC; Plays a role in neurogenesis and neuronal migration. Necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Necessary for cytokinesis and cell proliferation (By similarity). (341 aa)
	KIF14	Kinesin family member 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1616 aa)
	KIF4B	Chromosome-associated kinesin KIF4; Required for mitotic chromosomal positioning and bipolar spindle stabilization. (1226 aa)
	PLK1	Serine/threonine-protein kinase PLK. (595 aa)
	IL16	Pro-interleukin-16; Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. (1454 aa)
	CEP55	Centrosomal protein 55. (465 aa)
	ARL3	ADP ribosylation factor like GTPase 3; Belongs to the small GTPase superfamily. Arf family. (182 aa)
	ZFYVE19	FYVE-type domain-containing protein. (420 aa)
	CENPF	Uncharacterized protein. (2935 aa)
	BIRC6	Baculoviral IAP repeat containing 6. (4856 aa)
	TBCK	TBC domain-containing protein kinase-like protein; Involved in the modulation of mTOR signaling and expression of mTOR complex components. Involved in the regulation of cell proliferation and growth. Involved in the control of actin-cytoskeleton organization. (893 aa)
	SPAST	Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Go [...] (613 aa)
	SCCPDH	Sacchrp_dh_NADP domain-containing protein. (434 aa)
	URB2	URB2 ribosome biogenesis homolog. (1543 aa)
	ANKRD54	Ankyrin repeat domain 54. (168 aa)
	KATNA1	Katanin p60 ATPase-containing subunit A1; Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. (495 aa)
	CHMP5	Uncharacterized protein. (219 aa)
	MITD1	Microtubule interacting and trafficking domain containing 1. (250 aa)
	C26H6orf89	Uncharacterized protein. (328 aa)
	BIRC5	Uncharacterized protein. (142 aa)
	ZFYVE26	Zinc finger FYVE-type containing 26. (2561 aa)
	ARF6	ADP-ribosylation factor 6; GTP-binding protein involved in protein trafficking; regulates endocytic recycling and cytoskeleton remodeling. May contribute to the regulation of dendritic branching, filopodia extension and dendritic spine development (By similarity). (175 aa)
	GNAI1	Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...] (354 aa)
	SIRT2	Deacetylase sirtuin-type domain-containing protein. (485 aa)
	CRMP1	Collapsin response mediator protein-1A. (683 aa)
	LOC768589	Uncharacterized protein. (173 aa)
	MPLKIP	M-phase specific PLK1 interacting protein. (179 aa)
	AGBL5	ATP/GTP binding protein like 5. (635 aa)
	TTC28	Tetratricopeptide repeat domain 28. (2428 aa)
	PDCD6IP	BRO1 domain-containing protein. (887 aa)
	IST1	IST1 factor associated with ESCRT-III. (366 aa)
	GNAI3	G protein alpha subunit. (354 aa)
	CDC42	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. Plays a role in the extension and maintenance of the formation of thin, actin- rich surface projections called filopodia. Also plays a role in phagocytos [...] (194 aa)
	YPEL5	Protein yippee-like; Belongs to the yippee family. (121 aa)
	ENSGALP00000066824	Uncharacterized protein. (105 aa)
	ANXA11	Annexin. (496 aa)
	ENSGALP00000068764	Uncharacterized protein. (495 aa)
	DDX11	DEAD/H-box helicase 11. (908 aa)
	SSNA1	Uncharacterized protein. (114 aa)
	GNAI2	Guanine nucleotide-binding protein G(i) subunit alpha-2. (460 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARF6	CDC42	ENSGALP00000041604	ENSGALP00000065867	ADP-ribosylation factor 6; GTP-binding protein involved in protein trafficking; regulates endocytic recycling and cytoskeleton remodeling. May contribute to the regulation of dendritic branching, filopodia extension and dendritic spine development (By similarity).	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. Plays a role in the extension and maintenance of the formation of thin, actin- rich surface projections called filopodia. Also plays a role in phagocytos [...]	0.759
BIRC5	CENPF	ENSGALP00000038330	ENSGALP00000015880	Uncharacterized protein.	Uncharacterized protein.	0.831
BIRC5	CEP55	ENSGALP00000038330	ENSGALP00000010710	Uncharacterized protein.	Centrosomal protein 55.	0.663
BIRC5	KIF4B	ENSGALP00000038330	ENSGALP00000006656	Uncharacterized protein.	Chromosome-associated kinesin KIF4; Required for mitotic chromosomal positioning and bipolar spindle stabilization.	0.804
BIRC5	NUDC	ENSGALP00000038330	ENSGALP00000001315	Uncharacterized protein.	Nuclear migration protein nudC; Plays a role in neurogenesis and neuronal migration. Necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Necessary for cytokinesis and cell proliferation (By similarity).	0.502
BIRC5	PLK1	ENSGALP00000038330	ENSGALP00000009850	Uncharacterized protein.	Serine/threonine-protein kinase PLK.	0.905
BIRC6	PDCD6IP	ENSGALP00000017138	ENSGALP00000053723	Baculoviral IAP repeat containing 6.	BRO1 domain-containing protein.	0.507
CDC42	ARF6	ENSGALP00000065867	ENSGALP00000041604	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. Plays a role in the extension and maintenance of the formation of thin, actin- rich surface projections called filopodia. Also plays a role in phagocytos [...]	ADP-ribosylation factor 6; GTP-binding protein involved in protein trafficking; regulates endocytic recycling and cytoskeleton remodeling. May contribute to the regulation of dendritic branching, filopodia extension and dendritic spine development (By similarity).	0.759
CENPF	BIRC5	ENSGALP00000015880	ENSGALP00000038330	Uncharacterized protein.	Uncharacterized protein.	0.831
CENPF	CEP55	ENSGALP00000015880	ENSGALP00000010710	Uncharacterized protein.	Centrosomal protein 55.	0.856
CENPF	KIF14	ENSGALP00000015880	ENSGALP00000003403	Uncharacterized protein.	Kinesin family member 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.863
CENPF	KIF4B	ENSGALP00000015880	ENSGALP00000006656	Uncharacterized protein.	Chromosome-associated kinesin KIF4; Required for mitotic chromosomal positioning and bipolar spindle stabilization.	0.766
CENPF	LOC768589	ENSGALP00000015880	ENSGALP00000045439	Uncharacterized protein.	Uncharacterized protein.	0.628
CENPF	NUDC	ENSGALP00000015880	ENSGALP00000001315	Uncharacterized protein.	Nuclear migration protein nudC; Plays a role in neurogenesis and neuronal migration. Necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Necessary for cytokinesis and cell proliferation (By similarity).	0.805
CENPF	PLK1	ENSGALP00000015880	ENSGALP00000009850	Uncharacterized protein.	Serine/threonine-protein kinase PLK.	0.951
CEP55	BIRC5	ENSGALP00000010710	ENSGALP00000038330	Centrosomal protein 55.	Uncharacterized protein.	0.663
CEP55	CENPF	ENSGALP00000010710	ENSGALP00000015880	Centrosomal protein 55.	Uncharacterized protein.	0.856
CEP55	KIF14	ENSGALP00000010710	ENSGALP00000003403	Centrosomal protein 55.	Kinesin family member 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.725
CEP55	KIF4B	ENSGALP00000010710	ENSGALP00000006656	Centrosomal protein 55.	Chromosome-associated kinesin KIF4; Required for mitotic chromosomal positioning and bipolar spindle stabilization.	0.892
CEP55	LOC768589	ENSGALP00000010710	ENSGALP00000045439	Centrosomal protein 55.	Uncharacterized protein.	0.631