STRINGSTRING
GPR143 GPR143 DTNBP1 DTNBP1 SYTL1 SYTL1 GCHFR GCHFR LOC776376 LOC776376 LOC422353 LOC422353 GSN GSN CNP CNP PMEL PMEL SEC22B SEC22B CAPG CAPG SYTL2 SYTL2 ABCB6 ABCB6 SLC45A4 SLC45A4 RAB38 RAB38 TYRP1 TYRP1 DCT DCT MLANA MLANA TYR TYR MMP1 MMP1 OCA2 OCA2 PDIA6 PDIA6 TMEM33 TMEM33 RAB32 RAB32 TFRC TFRC ABCC2 ABCC2 PLSCR5 PLSCR5 CTNS CTNS MREG MREG SLC45A2 SLC45A2 MFSD12 MFSD12
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GPR143Uncharacterized protein. (391 aa)
DTNBP1Dysbindin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. Plays a role in intracellular vesicle trafficking. Plays a role in synaptic vesicle trafficking and in neurotransmitter release. May be required for normal dopamine homeostasis in the cerebral cortex, hippocampus, and hypothalamus. Plays a role in the regulation of cell surface exposure of DRD2. Contributes to the regulation of dopamine signaling. May play a role in actin cytoskeleton reorganization and neuri [...] (369 aa)
SYTL1Uncharacterized protein. (806 aa)
GCHFRUncharacterized protein. (84 aa)
LOC776376Ig-like domain-containing protein. (310 aa)
LOC422353Uncharacterized protein. (968 aa)
GSNGelsolin; Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis (By similarity). (833 aa)
CNPUncharacterized protein. (534 aa)
PMELMelanocyte protein PMEL; Might be required for polymerization of melanin onto the core structure of melanosomes with enzymic function of tyrosinase; Belongs to the PMEL/NMB family. (740 aa)
SEC22BVesicle-trafficking protein SEC22b; SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER. (215 aa)
CAPGCapping actin protein, gelsolin like. (327 aa)
SYTL2Synaptotagmin like 2. (863 aa)
ABCB6ATP binding cassette subfamily B member 6 (Langereis blood group). (894 aa)
SLC45A4Solute carrier family 45 member 4. (787 aa)
RAB38RAB38, member RAS oncogene family. (212 aa)
TYRP15,6-dihydroxyindole-2-carboxylic acid oxidase; Plays a role in melanin biosynthesis. Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6- quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized. Also to a lower extent, capable of hydroxylating tyrosine and producing melanin. (536 aa)
DCTL-dopachrome tautomerase; Catalyzes the conversion of L-dopachrome into 5,6- dihydroxyindole-2-carboxylic acid (DHICA). Involved in regulating eumelanin and phaeomelanin levels. (521 aa)
MLANAMelan-A. (113 aa)
TYRTyrosinase; This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone. (537 aa)
MMP1Matrix metallopeptidase 1. (466 aa)
OCA2OCA2 melanosomal transmembrane protein. (726 aa)
PDIA6Protein disulfide isomerase family A member 6; Belongs to the protein disulfide isomerase family. (447 aa)
TMEM33Transmembrane protein 33. (251 aa)
RAB32Uncharacterized protein. (218 aa)
TFRCTransferrin receptor protein 1; Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Belongs to the peptidase M28 family. M28B subfamily. (776 aa)
ABCC2Uncharacterized protein. (1538 aa)
PLSCR5Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family. (263 aa)
CTNSCystinosin, lysosomal cystine transporter. (377 aa)
MREGMelanoregulin. (208 aa)
SLC45A2Uncharacterized protein. (543 aa)
MFSD12Major facilitator superfamily domain containing 12. (494 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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