STRINGSTRING
CD79B CD79B LRRTM4 LRRTM4 KBP KBP PLXNA2 PLXNA2 GABRD GABRD ZAP70 ZAP70 GABRB2 GABRB2 GABRA1 GABRA1 GRIK3 GRIK3 BARL BARL NOTCH1 NOTCH1 TRADD TRADD GDNF GDNF OSMR OSMR RAMP1 RAMP1 GPR119 GPR119 CHRNA7 CHRNA7 AADACL3C AADACL3C NIPAL3 NIPAL3 LOC100859347 LOC100859347 GP9 GP9 AHR2 AHR2 BHLHE23 BHLHE23 FLT4 FLT4 ACVR2B ACVR2B PLXNA4 PLXNA4 GRIK4 GRIK4 TLR4 TLR4 GABRA3 GABRA3 GRIN2A GRIN2A CD3E CD3E ITGB2 ITGB2 HTR2B HTR2B ITGA11 ITGA11 FSHR FSHR CNIH3 CNIH3 TRAF5 TRAF5 HSP90AB1 HSP90AB1 ROR1 ROR1 ITGB6 ITGB6 TGFBR2 TGFBR2 NR1H4 NR1H4 CCR9 CCR9 GRIN2B GRIN2B AMHR2 AMHR2 GRM1 GRM1 CSF2RB CSF2RB VWC2 VWC2 LOXL4 LOXL4 INSRR INSRR IL7R IL7R CHRNA10 CHRNA10 AASDH AASDH GABRA2 GABRA2 GABRG1 GABRG1 CHRNA9 CHRNA9 AICDA AICDA IL6ST IL6ST E1C5R1_CHICK E1C5R1_CHICK ITGA2 ITGA2 COL10A1 COL10A1 GPR156 GPR156 GRIK2 GRIK2 SDCBP SDCBP CD247 CD247 GRIN3A GRIN3A GABRR2 GABRR2 GABRR1 GABRR1 CSF2RA CSF2RA GABRA5 GABRA5 PGR PGR GRM5 GRM5 TLR1A TLR1A LOC418667 LOC418667 CD200R1 CD200R1 TRAT1 TRAT1 TRIL TRIL ACVR2A ACVR2A GRIA2 GRIA2 TLR2B TLR2B CD40 CD40 VWC2L VWC2L GRIN1 GRIN1 RAMP2 RAMP2 TNFSF11 TNFSF11 GRIN2C GRIN2C SDCBP2 SDCBP2 LOC100858919 LOC100858919 TROJANZ TROJANZ IL5RA IL5RA CACNG4 CACNG4 GRIN3B GRIN3B MUSK MUSK LOC107054425 LOC107054425 GHR GHR MCMDC2 MCMDC2 GABBR2 GABBR2 ACVR1 ACVR1 LYN LYN LOC101747944 LOC101747944 AHR AHR ITGAV ITGAV ITGB5 ITGB5 INSR INSR CYP1B1 CYP1B1 HTR3A HTR3A LOC428967 LOC428967 GABRB3 GABRB3 RAMP3 RAMP3 IL13RA2 IL13RA2 ACVR1B ACVR1B ITGA3 ITGA3 TLR2A TLR2A NIPAL2 NIPAL2 IL7 IL7 SOST SOST GRIK1 GRIK1 ARNT2 ARNT2 CD14 CD14 IL4R IL4R ITGA4 ITGA4 GRIA3 GRIA3 GRIA4 GRIA4 GABRG2 GABRG2 TGFBR1 TGFBR1 IL10RA IL10RA TNFRSF11B TNFRSF11B CYP1C1 CYP1C1 ITGA9 ITGA9 CD5 CD5 CD44 CD44 IGF1R IGF1R IL6R IL6R GABRG3 GABRG3 CACNG2 CACNG2 BMPR2 BMPR2 AADACL3A AADACL3A ITGB8 ITGB8 IL13RA1 IL13RA1 AADACL4B AADACL4B RET RET HSP90AA1 HSP90AA1 LINGO3 LINGO3 PTPRA PTPRA GMSRAL GMSRAL ENSGALP00000064105 ENSGALP00000064105 PTCRA PTCRA LOC112532795 LOC112532795 MADCAM1 MADCAM1 ITGA8 ITGA8 CRCBL CRCBL CNTFR CNTFR ACVR1C ACVR1C IL12RB1 IL12RB1 LOC101749641 LOC101749641 PLXNB3 PLXNB3 PLXNB2 PLXNB2 ENSGALP00000066648 ENSGALP00000066648 LY96 LY96 MED28 MED28 IFNL3 IFNL3 TRAF3 TRAF3 ITGA2B ITGA2B TLR1B TLR1B GABRP GABRP ARNTL2 ARNTL2 CALCRL CALCRL IL6 IL6 ACVRL1 ACVRL1 PLXND1 PLXND1 ENSGALP00000068604 ENSGALP00000068604 IL20RA IL20RA IFNLR1 IFNLR1 LOC101750889 LOC101750889 PLXNA1 PLXNA1 BMP2 BMP2 ITGAD ITGAD AADACL3B AADACL3B LOC107051468 LOC107051468 ENSGALP00000070440 ENSGALP00000070440 GABRR3 GABRR3 ENSGALP00000070753 ENSGALP00000070753 HJV HJV IL22RA2 IL22RA2 LOC107050365 LOC107050365 ARNT ARNT CD3D CD3D TNFRSF4 TNFRSF4 PLXNC1 PLXNC1 EMILIN1 EMILIN1 TNFRSF9 TNFRSF9 GP1BB GP1BB ENSGALP00000073351 ENSGALP00000073351 LOC100858953 LOC100858953 JAK2 JAK2 ENSGALP00000074243 ENSGALP00000074243
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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CD79BB29/Ig-b. (226 aa)
LRRTM4Leucine rich repeat transmembrane neuronal 4. (590 aa)
KBPProbable glutamate receptor; Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (461 aa)
PLXNA2Plexin A2. (1893 aa)
GABRDGamma-aminobutyric acid type A receptor delta subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (451 aa)
ZAP70Tyrosine-protein kinase. (609 aa)
GABRB2Uncharacterized protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (491 aa)
GABRA1Gamma-aminobutyric acid receptor subunit alpha-1; Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (By similarity). Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (By similarity). Functions also as histamine receptor and mediates cellular responses to histamine (By similarity). Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) s [...] (455 aa)
GRIK3Glutamate ionotropic receptor kainate type subunit 3. (919 aa)
BARLUncharacterized protein. (503 aa)
NOTCH1Uncharacterized protein. (2561 aa)
TRADDTNFRSF1A associated via death domain. (461 aa)
GDNFGlial cell derived neurotrophic factor. (209 aa)
OSMRUncharacterized protein. (622 aa)
RAMP1Receptor activity modifying protein 1. (125 aa)
GPR119G protein-coupled receptor 119. (320 aa)
CHRNA7Neuronal acetylcholine receptor subunit alpha-7; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane; Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-7/CHRNA7 sub- subfamily. (502 aa)
AADACL3CUncharacterized protein. (411 aa)
NIPAL3NIPA like domain containing 3. (408 aa)
LOC100859347Uncharacterized protein. (964 aa)
GP9Glycoprotein IX platelet. (208 aa)
AHR2Aryl hydrocarbon receptor 2. (882 aa)
BHLHE23BHLH transcription factor neuroAB. (220 aa)
FLT4Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1378 aa)
ACVR2BActivin receptor type-2B; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. May modulate neuropeptide expression in dorsal root ganglia (DRG) neurons and ovarian follicle development. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (512 aa)
PLXNA4Plexin A4. (1892 aa)
GRIK4Glutamate ionotropic receptor kainate type subunit 4. (959 aa)
TLR4Toll-like receptor 4; Belongs to the Toll-like receptor family. (843 aa)
GABRA3Gamma-aminobutyric acid type A receptor alpha3 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (464 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1458 aa)
CD3ET-cell surface glycoprotein CD3 epsilon chain; The CD3 complex mediates signal transduction, resulting in T- cell activation and proliferation. Required for normal immune responses. (175 aa)
ITGB2Integrin beta. (773 aa)
HTR2BSerotonin receptor subtype 2b. (462 aa)
ITGA11Integrin subunit alpha 11; Belongs to the integrin alpha chain family. (1240 aa)
FSHRFollicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (704 aa)
CNIH3Protein cornichon homolog 2; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs) (By similarity). Plays an important role in the proper development of cranial nerves by facilitating the secretion of HBEGF; Belongs to the cornichon family. (160 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (557 aa)
HSP90AB1Heat shock cognate protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its [...] (725 aa)
ROR1Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (896 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (789 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (671 aa)
NR1H4Farnesoid X receptor. (473 aa)
CCR9G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (382 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1504 aa)
AMHR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (678 aa)
GRM1Glutamate metabotropic receptor 1. (1152 aa)
CSF2RBUncharacterized protein. (678 aa)
VWC2Von Willebrand factor C domain containing 2. (383 aa)
LOXL4Lysyl oxidase like 4. (761 aa)
INSRRTyrosine-protein kinase receptor. (1333 aa)
IL7RInterleukin-7 receptor alpha chain. (460 aa)
CHRNA10Neuronal acetylcholine receptor subunit alpha-10; Ionotropic receptor with a probable role in the modulation of auditory stimuli. (452 aa)
AASDHAminoadipate-semialdehyde dehydrogenase. (1128 aa)
GABRA2Gamma-aminobutyric acid type A receptor alpha2 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (455 aa)
GABRG1Gamma-aminobutyric acid type A receptor gamma1 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (464 aa)
CHRNA9Neuronal acetylcholine receptor subunit alpha-9; Ionotropic receptor that may play a role in the modulation of auditory stimuli. Agonist binding induces a conformation change that leads to the opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. (484 aa)
AICDACMP/dCMP-type deaminase domain-containing protein. (198 aa)
IL6STGlycoprotein 130. (918 aa)
E1C5R1_CHICKUncharacterized protein. (512 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1175 aa)
COL10A1Collagen alpha-1(X) chain; Type X collagen is a product of hypertrophic chondrocytes and has been localized to presumptive mineralization zones of hyaline cartilage. (674 aa)
GPR156G protein-coupled receptor 156. (691 aa)
GRIK2Glutamate ionotropic receptor kainate type subunit 2. (917 aa)
SDCBPUncharacterized protein. (294 aa)
CD247Uncharacterized protein. (166 aa)
GRIN3AGlutamate ionotropic receptor NMDA type subunit 3A; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1126 aa)
GABRR2Gamma-aminobutyric acid type A receptor rho2 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (488 aa)
GABRR1Gamma-aminobutyric acid type A receptor rho1 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (439 aa)
CSF2RAFibronectin type-III domain-containing protein. (384 aa)
GABRA5Gamma-aminobutyric acid type A receptor alpha5 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (373 aa)
PGRProgesterone receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (787 aa)
GRM5G_PROTEIN_RECEP_F3_4 domain-containing protein. (1242 aa)
TLR1ATIR domain-containing protein; Belongs to the Toll-like receptor family. (818 aa)
LOC418667Fibronectin type-III domain-containing protein. (298 aa)
CD200R1Cell surface glycoprotein CD200 receptor 1-A; Belongs to the CD200R family. (306 aa)
TRAT1T cell receptor associated transmembrane adaptor 1. (175 aa)
TRILTLR4 interactor with leucine rich repeats. (757 aa)
ACVR2AActivin receptor type-2A; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. May modulate neuropeptide expression in dorsal root ganglia (DRG) neurons and ovarian follicle development. (513 aa)
GRIA2Uncharacterized protein. (883 aa)
TLR2BToll-like receptor 2 type-2; Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Mediates the response to mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2). (781 aa)
CD40Uncharacterized protein. (299 aa)
VWC2LVon Willebrand factor C domain containing 2 like. (229 aa)
GRIN1N-methyl-D-aspartate receptor type 1 subunit. (965 aa)
RAMP2Receptor activity modifying protein 2. (176 aa)
TNFSF11TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (400 aa)
GRIN2CGlutamate ionotropic receptor NMDA type subunit 2C. (1301 aa)
SDCBP2Syndecan binding protein 2. (352 aa)
LOC100858919Uncharacterized protein. (580 aa)
TROJANZUncharacterized protein. (494 aa)
IL5RAIL6Ra-bind domain-containing protein. (424 aa)
CACNG4Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (328 aa)
GRIN3BGlutamate ionotropic receptor NMDA type subunit 3B; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1022 aa)
MUSKMuscle, skeletal receptor tyrosine protein kinase; Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle. Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskel [...] (947 aa)
LOC107054425Uncharacterized protein; Belongs to the beta/gamma-crystallin family. (543 aa)
GHRGrowth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway; Belongs to the type I cytokine receptor family. Type 1 subfamily. (646 aa)
MCMDC2Uncharacterized protein. (356 aa)
GABBR2Gamma-aminobutyric acid type B receptor subunit 2. (936 aa)
ACVR1Activin receptor type-1; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin (By similarity). (524 aa)
LYNTyrosine-protein kinase. (491 aa)
LOC101747944Interleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily. (257 aa)
AHRUncharacterized protein. (877 aa)
ITGAVIntegrin alpha-V heavy chain; The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase- 2, osteopontin, osteomodulin, prothrombin, thrombospondin, TGFB1 and vWF. They recognize the sequence R-G-D in a wide array of ligands. Alpha-V integrins may play a role in embryo implantation, angiogenesis and wound healing (By similarity). ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling. ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential [...] (1048 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (811 aa)
INSRTyrosine-protein kinase receptor. (1324 aa)
CYP1B1Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (536 aa)
HTR3ANeur_chan_memb domain-containing protein. (209 aa)
LOC428967Uncharacterized protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (284 aa)
GABRB3Gamma-aminobutyric acid receptor subunit beta-3; Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (By similarity). Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA- gated ion channel (By similarity). (476 aa)
RAMP3Receptor activity modifying protein 3. (156 aa)
IL13RA2Uncharacterized protein. (391 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (519 aa)
ITGA3Uncharacterized protein; Belongs to the integrin alpha chain family. (1108 aa)
TLR2AToll-like receptor 2 type-1; Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). Does not respond to LPS and responds with less ability than TLR2-2 to mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2). (955 aa)
NIPAL2NIPA like domain containing 2. (222 aa)
IL7Interleukin-7. (146 aa)
SOSTSclerostin. (213 aa)
GRIK1Glutamate ionotropic receptor kainate type subunit 1. (926 aa)
ARNT2Aryl hydrocarbon receptor nuclear translocator 2. (723 aa)
CD14Uncharacterized protein. (465 aa)
IL4RFibronectin type-III domain-containing protein. (996 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1021 aa)
GRIA3Uncharacterized protein. (888 aa)
GRIA4Uncharacterized protein. (943 aa)
GABRG2Gamma-aminobutyric acid receptor subunit gamma-2; Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (By similarity). Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (By similarity). Functions also as histamine receptor and mediates cellular responses to histamine (By similarity). Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) s [...] (474 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
IL10RAFibronectin type-III domain-containing protein. (558 aa)
TNFRSF11BTumor necrosis factor receptor superfamily member 11B; Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. (402 aa)
CYP1C1Uncharacterized protein; Belongs to the cytochrome P450 family. (516 aa)
ITGA9Integrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. (1031 aa)
CD5Uncharacterized protein. (473 aa)
CD44Link domain-containing protein. (696 aa)
IGF1RTyrosine-protein kinase receptor. (1363 aa)
IL6RUncharacterized protein. (445 aa)
GABRG3Gamma-aminobutyric acid type A receptor gamma3 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (456 aa)
CACNG2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (323 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1031 aa)
AADACL3AAbhydrolase_3 domain-containing protein. (369 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (787 aa)
IL13RA1Interleukin 13 receptor subunit alpha 1. (424 aa)
AADACL4BUncharacterized protein. (404 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1105 aa)
HSP90AA1Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...] (771 aa)
LINGO3Leucine rich repeat and Ig domain containing 3. (605 aa)
PTPRAUncharacterized protein. (867 aa)
GMSRALFibronectin type-III domain-containing protein. (401 aa)
ENSGALP00000064105Ig-like domain-containing protein. (342 aa)
PTCRAUncharacterized protein. (169 aa)
LOC112532795Interferon lambda-3-like. (186 aa)
MADCAM1Uncharacterized protein. (456 aa)
ITGA8Integrin alpha-8 heavy chain; Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1, TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis (By similarity). Neuronal receptor for TNC it mediates cell- cell interactions and regulates neurite outgrowth of sensory and motor neurons. (1076 aa)
CRCBLFibronectin type-III domain-containing protein. (674 aa)
CNTFRCiliary neurotrophic factor receptor subunit alpha; Binds to CNTF (GPA). The alpha subunit provides the receptor specificity. (497 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (495 aa)
IL12RB1Fibronectin type-III domain-containing protein. (591 aa)
LOC101749641Fibronectin type-III domain-containing protein. (415 aa)
PLXNB3Sema domain-containing protein. (2202 aa)
PLXNB2Plexin B2. (1781 aa)
ENSGALP00000066648VWFA domain-containing protein. (590 aa)
LY96Lymphocyte antigen 96. (155 aa)
MED28Mediator complex subunit 28. (178 aa)
IFNL3Interferon lambda 3. (186 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (567 aa)
ITGA2BIntegrin subunit alpha 2b; Belongs to the integrin alpha chain family. (866 aa)
TLR1BToll-like receptor 1 type 2; Belongs to the Toll-like receptor family. (652 aa)
GABRPGamma-aminobutyric acid type A receptor pi subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (445 aa)
ARNTL2Aryl hydrocarbon receptor nuclear translocator-like protein 2; Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressur [...] (686 aa)
CALCRLCalcitonin receptor-like receptor; Belongs to the G-protein coupled receptor 2 family. (457 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily. (307 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (796 aa)
PLXND1Plexin D1. (1928 aa)
ENSGALP00000068604Uncharacterized protein. (186 aa)
IL20RAInterleukin 20 receptor subunit alpha. (547 aa)
IFNLR1Interferon lambda receptor 1; The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, [...] (567 aa)
LOC101750889LRRCT domain-containing protein. (714 aa)
PLXNA1Plexin A1. (1903 aa)
BMP2Bone morphogenetic protein 2; Negatively regulates the structure and function of the limb apical ectodermal ridge. (392 aa)
ITGADVWFA domain-containing protein; Belongs to the integrin alpha chain family. (1068 aa)
AADACL3BUncharacterized protein. (410 aa)
LOC107051468Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (416 aa)
ENSGALP00000070440Uncharacterized protein. (167 aa)
GABRR3Neur_chan_memb domain-containing protein. (159 aa)
ENSGALP00000070753ANF_receptor domain-containing protein. (1472 aa)
HJVHemojuvelin BMP co-receptor. (514 aa)
IL22RA2Interleukin 22 receptor subunit alpha 2. (239 aa)
LOC107050365Ig-like domain-containing protein. (367 aa)
ARNTUncharacterized protein. (936 aa)
CD3DIg_4 domain-containing protein. (179 aa)
TNFRSF4Uncharacterized protein. (287 aa)
PLXNC1Plexin C1. (1279 aa)
EMILIN1EMI domain-containing protein. (610 aa)
TNFRSF9TNF receptor superfamily member 9. (269 aa)
GP1BBGlycoprotein Ib platelet subunit beta. (202 aa)
ENSGALP00000073351Integrin_alpha2 domain-containing protein. (465 aa)
LOC100858953Fibronectin type-III domain-containing protein. (572 aa)
JAK2Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with cytokine receptors. Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recru [...] (1165 aa)
ENSGALP00000074243Uncharacterized protein. (1200 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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