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LOC107049024 LOC107049024 LOXL2 LOXL2 P3H2 P3H2 EFEMP1 EFEMP1 LAMB2 LAMB2 PVALB PVALB CASK CASK ANXA2P2 ANXA2P2 COL4A1 COL4A1 C9H2ORF82 C9H2ORF82 COL3A1 COL3A1 TNR TNR SPARCL1 SPARCL1 MUC1 MUC1 DCN DCN BCAN BCAN MDK MDK COL11A1 COL11A1 AGRN AGRN MMRN2 MMRN2 TNC TNC COL1A1 COL1A1 COL22A1 COL22A1 TGFBI TGFBI ENSGALP00000069232 ENSGALP00000069232 ENSGALP00000069758 ENSGALP00000069758 RELL2 RELL2 COL5A1 COL5A1 HSPG2 HSPG2 LAMB1 LAMB1 KAZALD1 KAZALD1 ACAN ACAN NTN4L NTN4L RBP3 RBP3 FREM1 FREM1 FBLN2 FBLN2 COL4A4 COL4A4 ENSGALP00000057063 ENSGALP00000057063 ECM2 ECM2 USHBP1 USHBP1 COL14A1 COL14A1 NID1 NID1 ENSGALP00000052829 ENSGALP00000052829 COL2A1 COL2A1 COL4A3 COL4A3 SPARC SPARC MATN4 MATN4 NTNG2 NTNG2 MMP2 MMP2 LUM LUM NTN4 NTN4 FN1 FN1 LAMC3 LAMC3 ENSGALP00000071474 ENSGALP00000071474 COL5A2 COL5A2 ENSGALP00000067353 ENSGALP00000067353 ENSGALP00000067392 ENSGALP00000067392 ABI3BP ABI3BP ENSGALP00000071836 ENSGALP00000071836 SMOC2 SMOC2 COL4A6 COL4A6 EMILIN1 EMILIN1 LOC769726 LOC769726 F1NSR4_CHICK F1NSR4_CHICK COMP COMP MMRN2-2 MMRN2-2 ENSGALP00000066134 ENSGALP00000066134 POSTN POSTN ZPLD1 ZPLD1 COL25A1-2 COL25A1-2 COL28A1 COL28A1 VIT VIT MMRN1 MMRN1 COCH COCH USH2A USH2A COL1A2 COL1A2 VWA1 VWA1 ANP32B ANP32B CHADL CHADL ADAMTS6 ADAMTS6 THBS4 THBS4 LAMA4 LAMA4 LOC417800 LOC417800 SMOC1 SMOC1 VWA2 VWA2 CYR61 CYR61 THBS2 THBS2 ENSGALP00000073358 ENSGALP00000073358 ENSGALP00000073688 ENSGALP00000073688 LAMA5 LAMA5 LOXL3 LOXL3 CCDC80 CCDC80 COL8A1 COL8A1 RBP4 RBP4 VCAN VCAN IMPG1 IMPG1 ENSGALP00000066520 ENSGALP00000066520 ENSGALP00000066764 ENSGALP00000066764 LAMB4 LAMB4 LAMA1 LAMA1 IMPG2 IMPG2 TGFB3 TGFB3 LAMA2 LAMA2 ENSGALP00000065958 ENSGALP00000065958 MEGF9 MEGF9 COL4A2 COL4A2 ENSGALP00000065355 ENSGALP00000065355 NID2 NID2 ENSGALP00000064934 ENSGALP00000064934 ENSGALP00000064853 ENSGALP00000064853 FRAS1 FRAS1 LAMC1 LAMC1 COL4A5 COL4A5 FBLN5 FBLN5 MATN2 MATN2 LAMB3 LAMB3 PRNP PRNP TIMP3 TIMP3 OTOL1 OTOL1 C1QTNF3 C1QTNF3 LAMA3 LAMA3 NTNG1 NTNG1 ADAMTS10 ADAMTS10 MATN1 MATN1 CILP CILP RARRES2 RARRES2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC107049024Epidermal differentiation protein. (316 aa)
LOXL2Lysyl oxidase homolog 2; Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). Acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. Shows no activity against histone H3 when it is trimethylated on 'Lys- 9' (H3K9me3) or 'Lys-27' (H3K27me3) or when 'Lys-4' is monomethylated (H3K4me1) or dimethylated (H3K4me2). Also mediates deamination of methylated TAF10, a member o [...] (773 aa)
P3H2Prolyl 3-hydroxylase 2; Prolyl 3-hydroxylase that catalyzes the post-translational formation of 3-hydroxyproline on collagens (By similarity). Contributes to proline 3-hydroxylation of collagen COL4A1 and COL1A1 in tendons, the eye sclera and in the eye lens capsule (By similarity). Has high activity with the type IV collagen COL4A1, and lower activity with COL1A1. Catalyzes hydroxylation of the first Pro in Gly-Pro-Hyp sequences where Hyp is 4-hydroxyproline. Has no activity on substrates that lack 4-hydroxyproline in the third position (By similarity). (694 aa)
EFEMP1EGF containing fibulin extracellular matrix protein 1. (451 aa)
LAMB2Uncharacterized protein. (1802 aa)
PVALBParvalbumin, muscle; In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions (By similarity); Belongs to the parvalbumin family. (134 aa)
CASKCalcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family. (944 aa)
ANXA2P2Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. (339 aa)
COL4A1Collagen IV NC1 domain-containing protein. (1669 aa)
C9H2ORF82Uncharacterized protein. (121 aa)
COL3A1Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. (1460 aa)
TNRTenascin-R; Neural extracellular matrix (ECM) protein involved in interactions with different cells and matrix components. Involved in cell attachment and neurite formation. Interaction with CNTN1 enhances the neurite outgrowth. (1353 aa)
SPARCL1SPARC like 1. (658 aa)
MUC1Uncharacterized protein. (583 aa)
DCNDecorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. (357 aa)
BCANBrevican. (968 aa)
MDKMidkine; Has mitogenic activity, and neurite extension activity for PC12 cells; Belongs to the pleiotrophin family. (239 aa)
COL11A1Fibrillar collagen NC1 domain-containing protein. (888 aa)
AGRNAgrin C-terminal 110 kDa subunit; [Isoform 1]: heparan sulfate basal lamina glycoprotein that plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ) and directs key events in postsynaptic differentiation. Component of the AGRN-LRP4 receptor complex that induces the phosphorylation and activation of MUSK. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Calcium ions are required for maximal AChR clu [...] (2076 aa)
MMRN2EMI domain-containing protein. (208 aa)
TNCTenascin; Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. (2130 aa)
COL1A1Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen). (1453 aa)
COL22A1VWFA domain-containing protein. (1599 aa)
TGFBIUncharacterized protein. (680 aa)
ENSGALP00000069232Uncharacterized protein. (626 aa)
ENSGALP00000069758Uncharacterized protein. (176 aa)
RELL2RELT like 2. (350 aa)
COL5A1Fibrillar collagen NC1 domain-containing protein. (1835 aa)
HSPG2Heparan sulfate proteoglycan 2. (3948 aa)
LAMB1Laminin subunit beta-1; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. (1785 aa)
KAZALD1Kazal type serine peptidase inhibitor domain 1. (296 aa)
ACANAggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. (2089 aa)
NTN4LUncharacterized protein. (638 aa)
RBP3Uncharacterized protein. (1235 aa)
FREM1FRAS1 related extracellular matrix 1. (2184 aa)
FBLN2Fibulin 2. (1196 aa)
COL4A4Collagen IV NC1 domain-containing protein. (1307 aa)
ENSGALP00000057063LAM_G_DOMAIN domain-containing protein. (263 aa)
ECM2Extracellular matrix protein 2. (704 aa)
USHBP1MCC-bdg_PDZ domain-containing protein. (770 aa)
COL14A1Collagen alpha-1(XIV) chain; An adhesive role by integrating collagen bundles. It is probably associated with the surface of interstitial collagen fibrils via COL1. The COL2 domain may then serve as a rigid arm which sticks out from the fibril and protrudes the large N-terminal globular domain into the extracellular space, where it might interact with other matrix molecules or cell surface receptors. (1888 aa)
NID1Nidogen 1. (1153 aa)
ENSGALP00000052829Uncharacterized protein. (384 aa)
COL2A1Collagen alpha-1(II) chain; Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces. (1420 aa)
COL4A3Collagen IV NC1 domain-containing protein. (440 aa)
SPARCSPARC; Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity (By similarity). (298 aa)
MATN4Matrilin 4. (605 aa)
NTNG2Netrin G2. (527 aa)
MMP272 kDa type IV collagenase; Belongs to the peptidase M10A family. (663 aa)
LUMLumican; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily. (343 aa)
NTN4Netrin 4. (626 aa)
FN1Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. May be involved in osteoblast compaction (By similarity). (2526 aa)
LAMC3Uncharacterized protein. (332 aa)
ENSGALP00000071474Uncharacterized protein. (499 aa)
COL5A2Collagen type V alpha 2 chain. (1496 aa)
ENSGALP00000067353Uncharacterized protein. (154 aa)
ENSGALP00000067392Uncharacterized protein. (171 aa)
ABI3BPFibronectin type-III domain-containing protein. (511 aa)
ENSGALP00000071836Uncharacterized protein. (558 aa)
SMOC2SPARC related modular calcium binding 2. (441 aa)
COL4A6Collagen IV NC1 domain-containing protein. (170 aa)
EMILIN1EMI domain-containing protein. (610 aa)
LOC769726Uncharacterized protein. (295 aa)
F1NSR4_CHICKUncharacterized protein. (375 aa)
COMPUncharacterized protein. (777 aa)
MMRN2-2C1q domain-containing protein. (582 aa)
ENSGALP00000066134Laminin N-terminal domain-containing protein. (533 aa)
POSTNUncharacterized protein. (857 aa)
ZPLD1Zona pellucida like domain containing 1. (414 aa)
COL25A1-2Uncharacterized protein. (188 aa)
COL28A1Collagen type XXVIII alpha 1 chain. (1140 aa)
VITUncharacterized protein. (748 aa)
MMRN1Multimerin 1. (1192 aa)
COCHCochlin; Plays a role in the control of cell shape and motility in the trabecular meshwork. (546 aa)
USH2AUsherin. (5190 aa)
COL1A2Collagen alpha-2(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen). (1363 aa)
VWA1Von Willebrand factor A domain containing 1. (499 aa)
ANP32BAcidic leucine-rich nuclear phosphoprotein 32 family member B; Multifunctional protein working as a cell cycle progression factor as well as a cell survival factor. Required for the progression from the G1 to the S phase. Anti-apoptotic protein which functions as a caspase-3 inhibitor. Has no phosphatase 2A (PP2A) inhibitor activity. Exhibits histone chaperone properties, stimulating core histones to assemble into a nucleosome (By similarity). (262 aa)
CHADLUncharacterized protein. (733 aa)
ADAMTS6ADAM metallopeptidase with thrombospondin type 1 motif 6. (1119 aa)
THBS4Uncharacterized protein. (953 aa)
LAMA4Laminin subunit alpha 4. (1827 aa)
LOC417800Uncharacterized protein. (225 aa)
SMOC1SPARC related modular calcium binding 1. (457 aa)
VWA2Von Willebrand factor A domain containing 2. (788 aa)
CYR61CCN family member 1; Probable secreted regulatory protein. (375 aa)
THBS2Thrombospondin-2; Adhesive glycoprotein that mediates cell-to-cell and cell-to- matrix interactions; Belongs to the thrombospondin family. (1213 aa)
ENSGALP00000073358Uncharacterized protein. (653 aa)
ENSGALP00000073688annotation not available (478 aa)
LAMA5Laminin subunit alpha 5. (3725 aa)
LOXL3Lysyl oxidase like 3. (755 aa)
CCDC80Coiled-coil domain-containing protein 80; Promotes cell adhesion and matrix assembly (By similarity). May play a role in eye formation. (958 aa)
COL8A1Collagen alpha-1(VIII) chain; Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis (By similarity). (739 aa)
RBP4Purpurin; May be involved in the transport of retinol between the photoreceptors and the pigmented epithelium; Belongs to the calycin superfamily. Lipocalin family. (196 aa)
VCANVersican core protein; May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid. (3559 aa)
IMPG1Interphotoreceptor matrix proteoglycan 1; May be involved in a novel system mediating adhesion between neural retina and retinal pigment epithelium. (928 aa)
ENSGALP00000066520Uncharacterized protein. (411 aa)
ENSGALP00000066764Fibronectin type-III domain-containing protein. (334 aa)
LAMB4Uncharacterized protein. (1831 aa)
LAMA1Uncharacterized protein. (3091 aa)
IMPG2Interphotoreceptor matrix proteoglycan 2; Chondroitin sulfate- and hyaluronan-binding proteoglycan involved in the organization of interphotoreceptor matrix. (1420 aa)
TGFB3Transforming growth factor beta-3 proprotein; Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively. Transforming growth factor beta-3: Multifunctional protein that regulates embryogenesis and cell differentiation and is required in various processes such as secondary palate development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi appa [...] (535 aa)
LAMA2Uncharacterized protein. (598 aa)
ENSGALP00000065958annotation not available (276 aa)
MEGF9Multiple EGF like domains 9. (219 aa)
COL4A2Collagen IV NC1 domain-containing protein. (1847 aa)
ENSGALP00000065355Uncharacterized protein. (535 aa)
NID2Uncharacterized protein. (1170 aa)
ENSGALP00000064934Uncharacterized protein. (2030 aa)
ENSGALP00000064853Uncharacterized protein. (165 aa)
FRAS1Uncharacterized protein. (3989 aa)
LAMC1Laminin subunit gamma 1. (1603 aa)
COL4A5Collagen IV NC1 domain-containing protein. (540 aa)
FBLN5Uncharacterized protein. (444 aa)
MATN2Matrilin 2. (1297 aa)
LAMB3Laminin subunit beta 3. (1168 aa)
PRNPMajor prion protein homolog; Its primary physiological function is unclear. Has cytoprotective activity against internal or environmental stresses. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its h [...] (273 aa)
TIMP3Metalloproteinase inhibitor 3; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli; Belongs to the protease inhibitor I35 (TIMP) family. (212 aa)
OTOL1Otolin 1. (415 aa)
C1QTNF3C1q domain-containing protein. (314 aa)
LAMA3Laminin subunit alpha 3. (3448 aa)
NTNG1Netrin G1. (483 aa)
ADAMTS10ADAM metallopeptidase with thrombospondin type 1 motif 10. (1109 aa)
MATN1Cartilage matrix protein; Cartilage matrix protein is a major component of the extracellular matrix of non-articular cartilage. It binds to collagen. (493 aa)
CILPCartilage intermediate layer protein. (1104 aa)
RARRES2Chemerin. (162 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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