(4 nodes) Ripoptosome network (Gallus gallus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PCSK1	Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family. (748 aa)
	MLKL	Mixed lineage kinase domain like pseudokinase. (486 aa)
	CFLAR	Uncharacterized protein; Belongs to the peptidase C14A family. (493 aa)
	RIPK1	Uncharacterized protein. (682 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CFLAR	RIPK1	ENSGALP00000013394	ENSGALP00000036418	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.830
MLKL	RIPK1	ENSGALP00000004360	ENSGALP00000036418	Mixed lineage kinase domain like pseudokinase.	Uncharacterized protein.	0.545
PCSK1	RIPK1	ENSGALP00000023612	ENSGALP00000036418	Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family.	Uncharacterized protein.	0.507
RIPK1	CFLAR	ENSGALP00000036418	ENSGALP00000013394	Uncharacterized protein.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.830
RIPK1	MLKL	ENSGALP00000036418	ENSGALP00000004360	Uncharacterized protein.	Mixed lineage kinase domain like pseudokinase.	0.545
RIPK1	PCSK1	ENSGALP00000036418	ENSGALP00000023612	Uncharacterized protein.	Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family.	0.507