STRINGSTRING
ITGB2 ITGB2 ITGA11 ITGA11 CNIH3 CNIH3 TRAF5 TRAF5 ITGB6 ITGB6 TGFBR2 TGFBR2 CCR9 CCR9 GRIN2B GRIN2B AMHR2 AMHR2 GRM1 GRM1 CSF2RB CSF2RB VWC2 VWC2 GABBR2 GABBR2 INSRR INSRR CHRNA10 CHRNA10 AASDH AASDH CHRNA9 CHRNA9 AICDA AICDA IL6ST IL6ST ITGA2 ITGA2 GPR156 GPR156 GRIK2 GRIK2 SDCBP SDCBP CD247 CD247 GRIN3A GRIN3A CSF2RA CSF2RA GRM5 GRM5 TLR1A TLR1A LOC418667 LOC418667 TRAT1 TRAT1 ACVR2A ACVR2A GRIA2 GRIA2 TLR2B TLR2B CD40 CD40 VWC2L VWC2L GRIN1 GRIN1 RAMP2 RAMP2 GRIN2C GRIN2C SDCBP2 SDCBP2 IL5RA IL5RA ENSGALP00000074243 ENSGALP00000074243 JAK2 JAK2 ENSGALP00000073351 ENSGALP00000073351 GP1BB GP1BB EMILIN1 EMILIN1 CD3D CD3D LOC107050365 LOC107050365 IL22RA2 IL22RA2 HJV HJV ENSGALP00000070753 ENSGALP00000070753 ENSGALP00000070440 ENSGALP00000070440 LOC107051468 LOC107051468 AADACL3B AADACL3B ITGAD ITGAD BMP2 BMP2 LOC101750889 LOC101750889 IFNLR1 IFNLR1 IL20RA IL20RA ENSGALP00000068604 ENSGALP00000068604 ACVRL1 ACVRL1 IL6 IL6 CALCRL CALCRL TLR1B TLR1B ITGA2B ITGA2B TRAF3 TRAF3 IFNL3 IFNL3 ENSGALP00000066648 ENSGALP00000066648 LOC101749641 LOC101749641 IL12RB1 IL12RB1 ACVR1C ACVR1C CNTFR CNTFR CRCBL CRCBL ITGA8 ITGA8 MADCAM1 MADCAM1 LOC112532795 LOC112532795 PTCRA PTCRA ENSGALP00000064105 ENSGALP00000064105 GMSRAL GMSRAL AADACL4B AADACL4B IL13RA1 IL13RA1 ITGB8 ITGB8 AADACL3A AADACL3A BMPR2 BMPR2 CACNG2 CACNG2 IL6R IL6R IGF1R IGF1R CD5 CD5 ITGA9 ITGA9 TGFBR1 TGFBR1 GRIA4 GRIA4 GRIA3 GRIA3 ITGA4 ITGA4 IL4R IL4R GRIK1 GRIK1 NIPAL2 NIPAL2 TLR2A TLR2A ITGA3 ITGA3 ACVR1B ACVR1B IL13RA2 IL13RA2 RAMP3 RAMP3 HTR3A HTR3A INSR INSR ITGB5 ITGB5 ITGAV ITGAV LYN LYN ACVR1 ACVR1 CACNG4 CACNG4 GRIN3B GRIN3B LOC107054425 LOC107054425 MCMDC2 MCMDC2 CD79B CD79B LRRTM4 LRRTM4 KBP KBP ZAP70 ZAP70 GRIK3 GRIK3 OSMR OSMR RAMP1 RAMP1 CHRNA7 CHRNA7 AADACL3C AADACL3C NIPAL3 NIPAL3 GP9 GP9 BHLHE23 BHLHE23 ACVR2B ACVR2B GRIK4 GRIK4 GRIN2A GRIN2A CD3E CD3E
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ITGB2Integrin beta. (773 aa)
ITGA11Integrin subunit alpha 11; Belongs to the integrin alpha chain family. (1240 aa)
CNIH3Protein cornichon homolog 2; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs) (By similarity). Plays an important role in the proper development of cranial nerves by facilitating the secretion of HBEGF; Belongs to the cornichon family. (160 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (557 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (789 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (671 aa)
CCR9G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (382 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1504 aa)
AMHR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (678 aa)
GRM1Glutamate metabotropic receptor 1. (1152 aa)
CSF2RBUncharacterized protein. (678 aa)
VWC2Von Willebrand factor C domain containing 2. (383 aa)
GABBR2Gamma-aminobutyric acid type B receptor subunit 2. (936 aa)
INSRRTyrosine-protein kinase receptor. (1333 aa)
CHRNA10Neuronal acetylcholine receptor subunit alpha-10; Ionotropic receptor with a probable role in the modulation of auditory stimuli. (452 aa)
AASDHAminoadipate-semialdehyde dehydrogenase. (1128 aa)
CHRNA9Neuronal acetylcholine receptor subunit alpha-9; Ionotropic receptor that may play a role in the modulation of auditory stimuli. Agonist binding induces a conformation change that leads to the opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. (484 aa)
AICDACMP/dCMP-type deaminase domain-containing protein. (198 aa)
IL6STGlycoprotein 130. (918 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1175 aa)
GPR156G protein-coupled receptor 156. (691 aa)
GRIK2Glutamate ionotropic receptor kainate type subunit 2. (917 aa)
SDCBPUncharacterized protein. (294 aa)
CD247Uncharacterized protein. (166 aa)
GRIN3AGlutamate ionotropic receptor NMDA type subunit 3A; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1126 aa)
CSF2RAFibronectin type-III domain-containing protein. (384 aa)
GRM5G_PROTEIN_RECEP_F3_4 domain-containing protein. (1242 aa)
TLR1ATIR domain-containing protein; Belongs to the Toll-like receptor family. (818 aa)
LOC418667Fibronectin type-III domain-containing protein. (298 aa)
TRAT1T cell receptor associated transmembrane adaptor 1. (175 aa)
ACVR2AActivin receptor type-2A; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. May modulate neuropeptide expression in dorsal root ganglia (DRG) neurons and ovarian follicle development. (513 aa)
GRIA2Uncharacterized protein. (883 aa)
TLR2BToll-like receptor 2 type-2; Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Mediates the response to mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2). (781 aa)
CD40Uncharacterized protein. (299 aa)
VWC2LVon Willebrand factor C domain containing 2 like. (229 aa)
GRIN1N-methyl-D-aspartate receptor type 1 subunit. (965 aa)
RAMP2Receptor activity modifying protein 2. (176 aa)
GRIN2CGlutamate ionotropic receptor NMDA type subunit 2C. (1301 aa)
SDCBP2Syndecan binding protein 2. (352 aa)
IL5RAIL6Ra-bind domain-containing protein. (424 aa)
ENSGALP00000074243Uncharacterized protein. (1200 aa)
JAK2Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with cytokine receptors. Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recru [...] (1165 aa)
ENSGALP00000073351Integrin_alpha2 domain-containing protein. (465 aa)
GP1BBGlycoprotein Ib platelet subunit beta. (202 aa)
EMILIN1EMI domain-containing protein. (610 aa)
CD3DIg_4 domain-containing protein. (179 aa)
LOC107050365Ig-like domain-containing protein. (367 aa)
IL22RA2Interleukin 22 receptor subunit alpha 2. (239 aa)
HJVHemojuvelin BMP co-receptor. (514 aa)
ENSGALP00000070753ANF_receptor domain-containing protein. (1472 aa)
ENSGALP00000070440Uncharacterized protein. (167 aa)
LOC107051468Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (416 aa)
AADACL3BUncharacterized protein. (410 aa)
ITGADVWFA domain-containing protein; Belongs to the integrin alpha chain family. (1068 aa)
BMP2Bone morphogenetic protein 2; Negatively regulates the structure and function of the limb apical ectodermal ridge. (392 aa)
LOC101750889LRRCT domain-containing protein. (714 aa)
IFNLR1Interferon lambda receptor 1; The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, [...] (567 aa)
IL20RAInterleukin 20 receptor subunit alpha. (547 aa)
ENSGALP00000068604Uncharacterized protein. (186 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (796 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily. (307 aa)
CALCRLCalcitonin receptor-like receptor; Belongs to the G-protein coupled receptor 2 family. (457 aa)
TLR1BToll-like receptor 1 type 2; Belongs to the Toll-like receptor family. (652 aa)
ITGA2BIntegrin subunit alpha 2b; Belongs to the integrin alpha chain family. (866 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (567 aa)
IFNL3Interferon lambda 3. (186 aa)
ENSGALP00000066648VWFA domain-containing protein. (590 aa)
LOC101749641Fibronectin type-III domain-containing protein. (415 aa)
IL12RB1Fibronectin type-III domain-containing protein. (591 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (495 aa)
CNTFRCiliary neurotrophic factor receptor subunit alpha; Binds to CNTF (GPA). The alpha subunit provides the receptor specificity. (497 aa)
CRCBLFibronectin type-III domain-containing protein. (674 aa)
ITGA8Integrin alpha-8 heavy chain; Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1, TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis (By similarity). Neuronal receptor for TNC it mediates cell- cell interactions and regulates neurite outgrowth of sensory and motor neurons. (1076 aa)
MADCAM1Uncharacterized protein. (456 aa)
LOC112532795Interferon lambda-3-like. (186 aa)
PTCRAUncharacterized protein. (169 aa)
ENSGALP00000064105Ig-like domain-containing protein. (342 aa)
GMSRALFibronectin type-III domain-containing protein. (401 aa)
AADACL4BUncharacterized protein. (404 aa)
IL13RA1Interleukin 13 receptor subunit alpha 1. (424 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (787 aa)
AADACL3AAbhydrolase_3 domain-containing protein. (369 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1031 aa)
CACNG2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (323 aa)
IL6RUncharacterized protein. (445 aa)
IGF1RTyrosine-protein kinase receptor. (1363 aa)
CD5Uncharacterized protein. (473 aa)
ITGA9Integrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. (1031 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
GRIA4Uncharacterized protein. (943 aa)
GRIA3Uncharacterized protein. (888 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1021 aa)
IL4RFibronectin type-III domain-containing protein. (996 aa)
GRIK1Glutamate ionotropic receptor kainate type subunit 1. (926 aa)
NIPAL2NIPA like domain containing 2. (222 aa)
TLR2AToll-like receptor 2 type-1; Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). Does not respond to LPS and responds with less ability than TLR2-2 to mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2). (955 aa)
ITGA3Uncharacterized protein; Belongs to the integrin alpha chain family. (1108 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (519 aa)
IL13RA2Uncharacterized protein. (391 aa)
RAMP3Receptor activity modifying protein 3. (156 aa)
HTR3ANeur_chan_memb domain-containing protein. (209 aa)
INSRTyrosine-protein kinase receptor. (1324 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (811 aa)
ITGAVIntegrin alpha-V heavy chain; The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase- 2, osteopontin, osteomodulin, prothrombin, thrombospondin, TGFB1 and vWF. They recognize the sequence R-G-D in a wide array of ligands. Alpha-V integrins may play a role in embryo implantation, angiogenesis and wound healing (By similarity). ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling. ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential [...] (1048 aa)
LYNTyrosine-protein kinase. (491 aa)
ACVR1Activin receptor type-1; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin (By similarity). (524 aa)
CACNG4Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (328 aa)
GRIN3BGlutamate ionotropic receptor NMDA type subunit 3B; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1022 aa)
LOC107054425Uncharacterized protein; Belongs to the beta/gamma-crystallin family. (543 aa)
MCMDC2Uncharacterized protein. (356 aa)
CD79BB29/Ig-b. (226 aa)
LRRTM4Leucine rich repeat transmembrane neuronal 4. (590 aa)
KBPProbable glutamate receptor; Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (461 aa)
ZAP70Tyrosine-protein kinase. (609 aa)
GRIK3Glutamate ionotropic receptor kainate type subunit 3. (919 aa)
OSMRUncharacterized protein. (622 aa)
RAMP1Receptor activity modifying protein 1. (125 aa)
CHRNA7Neuronal acetylcholine receptor subunit alpha-7; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane; Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-7/CHRNA7 sub- subfamily. (502 aa)
AADACL3CUncharacterized protein. (411 aa)
NIPAL3NIPA like domain containing 3. (408 aa)
GP9Glycoprotein IX platelet. (208 aa)
BHLHE23BHLH transcription factor neuroAB. (220 aa)
ACVR2BActivin receptor type-2B; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. May modulate neuropeptide expression in dorsal root ganglia (DRG) neurons and ovarian follicle development. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (512 aa)
GRIK4Glutamate ionotropic receptor kainate type subunit 4. (959 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1458 aa)
CD3ET-cell surface glycoprotein CD3 epsilon chain; The CD3 complex mediates signal transduction, resulting in T- cell activation and proliferation. Required for normal immune responses. (175 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.