STRINGSTRING
LRRC57 LRRC57 LINGO3 LINGO3 LRRC28 LRRC28 LRRC59 LRRC59 LRRN1 LRRN1 LRRC30 LRRC30 TLR2A TLR2A LGR4 LGR4 PRELP PRELP PPP1R7 PPP1R7 RXFP2 RXFP2 LRFN3 LRFN3 LRRC20 LRRC20 LRRC8A LRRC8A FMOD FMOD OGN OGN LRTM2 LRTM2 TLR2B TLR2B PHLPP1 PHLPP1 LRRC8D LRRC8D CHAD CHAD SLITRK1 SLITRK1 LRRC1 LRRC1 E1C5R1_CHICK E1C5R1_CHICK ASPN ASPN LRRTM4 LRRTM4 LRRC18 LRRC18 KERA KERA RSU1 RSU1 DCN DCN OMG OMG LRRC8B LRRC8B TLR4 TLR4 ADGRA1 ADGRA1 RTN4R RTN4R FLRT3 FLRT3 SHOC2 SHOC2 SLITRK2 SLITRK2 TLR5 TLR5 RXFP1 RXFP1 LRFN2 LRFN2 LGR5 LGR5 CNOT6L CNOT6L FLRT2 FLRT2 EPYC EPYC LUM LUM LRRC40 LRRC40 ELFN2 ELFN2 TLR3 TLR3 LRRC2 LRRC2 LRRC38 LRRC38 LINGO1 LINGO1 LRRTM2 LRRTM2 TSKU TSKU TLR7 TLR7 LRRC8C LRRC8C LRRC4C LRRC4C LRRC17 LRRC17 LRRC3B LRRC3B TLR1B TLR1B LGI1 LGI1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LRRC57Uncharacterized protein. (238 aa)
LINGO3Leucine rich repeat and Ig domain containing 3. (605 aa)
LRRC28Uncharacterized protein. (388 aa)
LRRC59Leucine-rich repeat-containing protein 59; Required for nuclear import of FGF1. (361 aa)
LRRN1Leucine-rich repeat neuronal 1. (716 aa)
LRRC30Uncharacterized protein. (298 aa)
TLR2AToll-like receptor 2 type-1; Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). Does not respond to LPS and responds with less ability than TLR2-2 to mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2). (955 aa)
LGR4Leucine rich repeat containing G protein-coupled receptor 4. (952 aa)
PRELPProline and arginine rich end leucine rich repeat protein. (430 aa)
PPP1R7LRRcap domain-containing protein. (354 aa)
RXFP2G_PROTEIN_RECEP_F1_2 domain-containing protein. (709 aa)
LRFN3Uncharacterized protein. (626 aa)
LRRC20Uncharacterized protein. (183 aa)
LRRC8ALeucine rich repeat containing 8 VRAC subunit A. (810 aa)
FMODFibromodulin; Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity); Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily. (380 aa)
OGNMimecan; Induces bone formation in conjunction with TGF-beta-1 or TGF- beta-2; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily. (294 aa)
LRTM2Leucine rich repeats and transmembrane domains 2. (460 aa)
TLR2BToll-like receptor 2 type-2; Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Mediates the response to mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2). (781 aa)
PHLPP1PH domain and leucine rich repeat protein phosphatase 1. (1552 aa)
LRRC8DLeucine rich repeat containing 8 VRAC subunit D. (856 aa)
CHADUncharacterized protein. (361 aa)
SLITRK1SLIT and NTRK like family member 1. (692 aa)
LRRC1Leucine rich repeat containing 1. (797 aa)
E1C5R1_CHICKUncharacterized protein. (512 aa)
ASPNAsporin. (371 aa)
LRRTM4Leucine rich repeat transmembrane neuronal 4. (590 aa)
LRRC18Leucine rich repeat containing 18. (259 aa)
KERAKeratocan; Plays an important role in generating and maintaining a transparent matrix within the corneal stroma. (353 aa)
RSU1Uncharacterized protein. (277 aa)
DCNDecorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. (357 aa)
OMGOligodendrocyte myelin glycoprotein. (434 aa)
LRRC8BLeucine rich repeat containing 8 VRAC subunit B. (800 aa)
TLR4Toll-like receptor 4; Belongs to the Toll-like receptor family. (843 aa)
ADGRA1Adhesion G protein-coupled receptor A1; Belongs to the G-protein coupled receptor 2 family. (1303 aa)
RTN4RReticulon 4 receptor. (483 aa)
FLRT3Leucine-rich repeat transmembrane protein FLRT3; Modulates the structure and function of the apical ectodermal ridge (AER) that controls embryonic limb development. Functions in cell-cell adhesion, cell migration and axon guidance, exerting an attractive or repulsive role depending on its interaction partners. Plays a role in the spatial organization of brain neurons. Plays a role in vascular development. Plays a role in cell-cell adhesion via its interaction with latrophilins that are expressed at the surface of adjacent cells. Mediates axon attraction towards cells expressing NTN1. M [...] (647 aa)
SHOC2Leucine-rich repeat protein SHOC-2; Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes (By similarity); Belongs to the SHOC2 family. (582 aa)
SLITRK2SLIT and NTRK like family member 2. (857 aa)
TLR5TLR5; Belongs to the Toll-like receptor family. (861 aa)
RXFP1Relaxin family peptide receptor 1. (763 aa)
LRFN2Leucine rich repeat and fibronectin type III domain containing 2. (763 aa)
LGR5Leucine rich repeat containing G protein-coupled receptor 5. (909 aa)
CNOT6LCCR4-NOT transcription complex subunit 6 like. (607 aa)
FLRT2Fibronectin leucine rich transmembrane protein 2. (662 aa)
EPYCEpiphycan; May have a role in bone formation and also in establishing the ordered structure of cartilage through matrix organization; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily. (316 aa)
LUMLumican; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily. (343 aa)
LRRC40Leucine-rich repeat-containing protein 40. (603 aa)
ELFN2Extracellular leucine rich repeat and fibronectin type III domain containing 2. (808 aa)
TLR3Toll-like receptor 3; Belongs to the Toll-like receptor family. (896 aa)
LRRC2Leucine rich repeat containing 2. (372 aa)
LRRC38Leucine rich repeat containing 38. (293 aa)
LINGO1Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1; Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination (By similarity). (558 aa)
LRRTM2Leucine rich repeat transmembrane neuronal 2. (515 aa)
TSKUTsukushin; Dorsalizing factor involved in the induction of Hensen node. Functions as an inhibitor of bone morphogenetic proteins (BMP) during gastrulation. (369 aa)
TLR7Toll-like receptor 7; Belongs to the Toll-like receptor family. (1059 aa)
LRRC8CLeucine rich repeat containing 8 VRAC subunit C. (802 aa)
LRRC4CLeucine rich repeat containing 4C. (638 aa)
LRRC17p37NB protein. (437 aa)
LRRC3BLeucine rich repeat containing 3B. (259 aa)
TLR1BToll-like receptor 1 type 2; Belongs to the Toll-like receptor family. (652 aa)
LGI1LRRCT domain-containing protein. (543 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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