STRINGSTRING
NKX2-4 NKX2-4 HOXB3 HOXB3 HOXC8 HOXC8 HOXB8 HOXB8 POU4F3 POU4F3 HOXB7 HOXB7 BARX2 BARX2 HOXC12 HOXC12 LBX2 LBX2 GBX2 GBX2 EMX1 EMX1 PAX5 PAX5 EN1 EN1 ZHX3 ZHX3 PKNOX2 PKNOX2 ZHX1 ZHX1 GSX1 GSX1 LMX1B LMX1B BARHL1 BARHL1 HOXD13 HOXD13 HOXC10 HOXC10 NKX2-2 NKX2-2 HOXC9 HOXC9 POU4F3-2 POU4F3-2 ISL2 ISL2 VSX1 VSX1 NKX6-3 NKX6-3 MTA3 MTA3 PROX1 PROX1 VAX1 VAX1 DLX5 DLX5 ZZZ3 ZZZ3 HOXB5 HOXB5 NKX2-6 NKX2-6 ALX4 ALX4 NKX1-2 NKX1-2 HOXB4 HOXB4 BARX1 BARX1 POU3F1 POU3F1 LHX9 LHX9 ZEB2 ZEB2 ZFHX4 ZFHX4 NPDC1 NPDC1 PAX6 PAX6 RCOR3 RCOR3 MEIS1 MEIS1 HHEX HHEX HOXA5 HOXA5 HOXD12 HOXD12 HOXA7 HOXA7 HNF1A HNF1A HESX1 HESX1 GSC GSC HOXB6 HOXB6 MEIS2 MEIS2 SIX3 SIX3 ZHX2 ZHX2 PAX3 PAX3 SATB1 SATB1 NOTO NOTO PAX1 PAX1 IRX1 IRX1 LHX5 LHX5 DNAJC2 DNAJC2 TLX1 TLX1 CDX4 CDX4 HMX3 HMX3 ZEB1 ZEB1 HDX HDX POU2F3 POU2F3 BSX BSX CDX1 CDX1 TADA2A TADA2A LHX1 LHX1 DLX1 DLX1 LEUTX LEUTX PRRX1 PRRX1 NKX2-5 NKX2-5 TLX3 TLX3 LHX3 LHX3 HOXB9 HOXB9 LHX2 LHX2 PBX3 PBX3 TERF2IP TERF2IP TERF2 TERF2 HMBOX1 HMBOX1 PKNOX1 PKNOX1 TADA2B TADA2B MSX1 MSX1 MIER3 MIER3 SHOX SHOX CERS3 CERS3 PBX1 PBX1 LHX8 LHX8 HOXA9 HOXA9 HOXA10 HOXA10 MEOX2 MEOX2 LCORL LCORL HOXA4 HOXA4 HOXD9 HOXD9 POU2F1 POU2F1 RAX2 RAX2 DMBX1 DMBX1 IRX4 IRX4 SIX6 SIX6 PHOX2B PHOX2B PAX9 PAX9 HOPX HOPX MYSM1 MYSM1 HOXD10 HOXD10 HOXD4 HOXD4 HOXD3 HOXD3 DBX2 DBX2 ALX1 ALX1 OTP OTP HOXA3 HOXA3 HOXA1 HOXA1 PRRX2 PRRX2 HOXA6 HOXA6 NANOG NANOG HOXB2 HOXB2 SATB2 SATB2 ISL1 ISL1 HOXA13 HOXA13 TTF1 TTF1 MIER1 MIER1 SIX2 SIX2 LOC426615 LOC426615 OTX5 OTX5 RAX RAX PAX7 PAX7 PITX1 PITX1 MYBL1 MYBL1 TGIF1 TGIF1 HOXA2 HOXA2 PAX2 PAX2 OTX2 OTX2 POU1F1 POU1F1 ONECUT1 ONECUT1 DMTF1 DMTF1 EN2 EN2 HOXA11 HOXA11 HOXD11 HOXD11 SIX1 SIX1 MYBL2 MYBL2 POU4F1 POU4F1 PITX2 PITX2 MSX2 MSX2 HOXC13 HOXC13 MYB MYB GBX1 GBX1 VSX2 VSX2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NKX2-4NK2 homeobox 4. (337 aa)
HOXB3Homeobox protein Hox-B3; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Antp homeobox family. (399 aa)
HOXC8Homeobox protein Hox-C8; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (242 aa)
HOXB8Homeobox protein Hox-B8; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Antp homeobox family. (241 aa)
POU4F3POU domain protein. (326 aa)
HOXB7Homeobox B7. (217 aa)
BARX2Homeodomain transcription factor BARX2B. (267 aa)
HOXC12Homeobox C12. (267 aa)
LBX2Homeobox domain-containing protein. (213 aa)
GBX2Homeobox protein GBX-2; May act as a transcription factor for cell pluripotency and differentiation in the embryo. (339 aa)
EMX1Empty spiracles homeobox 1. (235 aa)
PAX5Pax-5 protein. (391 aa)
EN1Homeobox protein engrailed-1. (334 aa)
ZHX3Zinc fingers and homeoboxes 3. (929 aa)
PKNOX2TALE homeodomain transcription factor Prep2. (477 aa)
ZHX1Zinc fingers and homeoboxes 1. (873 aa)
GSX1GS homeobox 1. (247 aa)
LMX1BLIM/homeobox protein LMX-1.2; Specifies dorsal cell fate during limb development. (400 aa)
BARHL1BarH like homeobox 1. (316 aa)
HOXD13Homeobox protein Hox-D13; Sequence-specific transcription factor that binds gene promoters and activates their transcription (By similarity). Part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (303 aa)
HOXC10Homeobox domain-containing protein. (354 aa)
NKX2-2Homeobox domain-containing protein. (272 aa)
HOXC9Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (262 aa)
POU4F3-2Brain-specific homeobox/POU domain protein 3; May play a role in specifying terminally differentiated neuronal phenotypes; Belongs to the POU transcription factor family. Class-4 subfamily. (341 aa)
ISL2Insulin gene enhancer protein ISL-2; Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with LIM-1, LIM-3 and ISL-1. (356 aa)
VSX1Visual system homeobox 1; Binds to the 37-bp core of the locus control region (LCR) of the red/green visual pigment gene cluster. May regulate the activity of the LCR and the cone opsin genes at earlier stages of development (By similarity). Dispensable in early retinal development (By similarity). Belongs to the paired homeobox family. (349 aa)
NKX6-3NK6 homeobox 3. (259 aa)
MTA3Metastasis associated 1 family member 3. (693 aa)
PROX1Prospero homeobox protein 1; Transcription factor which may be involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. May be essential in the development and function of the eye. May play a role in the regulation of the circadian rhythm by repressing the expression of clock genes; Belongs to the Prospero homeodomain family. (736 aa)
VAX1Ventral anterior homeobox 1; Transcription factor that plays a role in establishing dorsal-ventral polarity in the neural retina. (325 aa)
DLX5Homeobox protein DLX-5; Transcriptional factor involved in bone development. Could be involved in apical ectodermal ridge activity, pattern formation, and cartilage differentiation. Binds to DNA; Belongs to the distal-less homeobox family. (286 aa)
ZZZ3Uncharacterized protein. (905 aa)
HOXB5Homeobox protein Hox-B5; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Antp homeobox family. (264 aa)
NKX2-6Homeobox domain-containing protein. (193 aa)
ALX4Paired type homeodomain protein. (387 aa)
NKX1-2Homeobox protein SAX-1; Belongs to the NK-1 homeobox family. (289 aa)
HOXB4Homeobox protein Hox-B4; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Antp homeobox family. Deformed subfamily. (245 aa)
BARX1Homeobox protein BarH-like 1b; Transcription factor which is involved with the serum response factor (SRF) in the smooth muscle cell-specific transcription of the beta-tropomyosin gene in the upper digestive organs and their attached arteries; Belongs to the BAR homeobox family. (346 aa)
POU3F1POU domain protein. (374 aa)
LHX9LIM/homeobox protein Lhx9; May be involved in gonadal development. (455 aa)
ZEB2Smad-interacting protein 1. (1214 aa)
ZFHX4Zinc finger homeobox protein 4; May play a role in neural and muscle differentiation (By similarity). May be involved in transcriptional regulation. Belongs to the krueppel C2H2-type zinc-finger protein family. (3595 aa)
NPDC1POU domain, class 5, transcription factor 3; Required for the maintenance of pluripotency and self-renewal of embryonic stem cells. Transcriptional activator that binds the DNA consensus sequence 5'-ATGCAAAT-3'; Belongs to the POU transcription factor family. (427 aa)
PAX6Paired box protein Pax-6; May be a transcription factor with important functions in eye and nasal development. (500 aa)
RCOR3REST corepressor 3; May act as a component of a corepressor complex that represses transcription; Belongs to the CoREST family. (542 aa)
MEIS1Homeobox domain-containing protein. (465 aa)
HHEXHematopoietically-expressed homeobox protein HHEX; Recognizes the DNA sequence 5'-ATTAA-3'. Transcriptional repressor. May play a role in hematopoietic differentiation. (320 aa)
HOXA5Homeobox protein Hox-A5; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5'-CYYNATTA[TG]Y-3' (By similarity); Belongs to the Antp homeobox family. (318 aa)
HOXD12Homeobox protein Hox-D12; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (266 aa)
HOXA7Homeobox protein Hox-A7; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Antp homeobox family. (219 aa)
HNF1AHepatocyte nuclear factor 1-alpha; Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver. May participate in the control of the hormone-dependent expression of the lysozyme gene in the oviduct and liver. In liver it could repress the gene while in oviduct it may act as an activator. Belongs to the HNF1 homeobox family. (634 aa)
HESX1Homeobox protein ANF-1; May be involved in the early patterning of the most anterior region of the main embryonic body axis. (210 aa)
GSCHomeobox protein goosecoid; Involved in the development of the organizer region in the gastrula (Hensen node in chicken). (346 aa)
HOXB6Homeobox protein Hox-B6; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Antp homeobox family. (222 aa)
MEIS2Homeoprotein Meis2a.2. (394 aa)
SIX3Homeobox protein SIX3; Transcriptional regulator which can act as both a transcriptional repressor and activator by binding a ATTA homeodomain core recognition sequence on these target genes. During forebrain development represses WNT1 expression allowing zona limitans intrathalamica formation and thereby ensuring proper anterio-posterior patterning of the diencephalon and formation of the rostral diencephalon. Acts as a direct upstream activator of SHH expression in the rostral diencephalon ventral midline and that in turn SHH maintains its expression. In addition, Six3 activity is re [...] (314 aa)
ZHX2Zinc fingers and homeoboxes 2. (830 aa)
PAX3Paired-box transcription factor protein PAX3. (484 aa)
SATB1DNA-binding protein SATB. (786 aa)
NOTOGnot1 homeodomain protein. (171 aa)
PAX1Paired box protein Pax-1; This protein is a transcriptional activator. It may play a role in the formation of segmented structures of the embryo. May play an important role in the normal development of the vertebral column (By similarity). (426 aa)
IRX1Homeobox domain-containing protein. (467 aa)
LHX5LIM homeobox protein 5. (402 aa)
DNAJC2Uncharacterized protein. (619 aa)
TLX1T-cell leukemia homeobox protein 1; Seems to be involved in the development of cranial sensory innervation from peripheral ganglia. (297 aa)
CDX4Homeobox protein CHOX-CAD2; Belongs to the Caudal homeobox family. (263 aa)
HMX3Homeobox protein HMX3; Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development. Binds to the 5'-CAAGTG-3' core sequence (By similarity). Belongs to the HMX homeobox family. (308 aa)
ZEB1Zinc finger E-box-binding homeobox 1; Acts as a transcriptional repressor. Positively regulates neuronal differentiation. Represses transcription by binding to the E box-containing promoter (By similarity). Binds to delta 1-crystallin enhancer core and represses lens-specific transcription. It binds as well many other non-lens specific DNA sequences. (1114 aa)
HDXHighly divergent homeobox. (695 aa)
POU2F3POU domain protein. (533 aa)
BSXBrain-specific homeobox protein homolog; DNA binding protein that function as transcriptional activator. May play a role in the determination and function of cell types in the brain; Belongs to the distal-less homeobox family. (233 aa)
CDX1Homeobox protein CDX-1; Plays a role in transcriptional regulation. Involved in activated KRAS-mediated transcriptional activation of PRKD1. Binds to the PRKD1 promoter. Could play a role in the terminal differentiation of the intestine. Binds preferentially to methylated DNA. Belongs to the Caudal homeobox family. (260 aa)
TADA2ATranscriptional adapter 2-alpha; Component of some complex with histone acetyltransferase activity. Required for the function of some acidic activation domains, which activate transcription from a distant site (By similarity). Binds double-stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling (By similarity). (443 aa)
LHX1LIM/homeobox protein Lhx1; Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with ISL-2. (406 aa)
DLX1Homeodomain transcription factor DLX1. (255 aa)
LEUTXHomeobox domain-containing protein. (403 aa)
PRRX1Paired mesoderm homeobox protein 1; May participate in maintenance of mesenchymal cell lineages derived from both mesoderm and the neural crest and in patterning of the limbs and the face. (245 aa)
NKX2-5Homeobox protein Nkx-2.5; Implicated in commitment to and/or differentiation of the myocardial lineage. Binds to the core DNA motif of promoter. Belongs to the NK-2 homeobox family. (294 aa)
TLX3T-cell leukemia homeobox protein 3; Seems to be involved in the development of cranial sensory innervation from peripheral ganglia. (296 aa)
LHX3LIM/homeobox protein Lhx3; Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with LIM-1, ISL-1 and ISL-2. (395 aa)
HOXB9Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (273 aa)
LHX2LIM homeodomain. (400 aa)
PBX3Homeobox domain-containing protein. (433 aa)
TERF2IPTelomeric repeat-binding factor 2-interacting protein 1; Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). Does not bind DNA directly: recruited to telomeric double-stranded 5'- TTAGGG-3' repeats via its interaction with terf2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with terf2 or other factors, and regulates gene expression (By similar [...] (409 aa)
TERF2Telomeric repeat-binding factor 2; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'- TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA r [...] (718 aa)
HMBOX1Homeobox domain-containing protein. (454 aa)
PKNOX1PBX/knotted 1 homeobox 1. (436 aa)
TADA2BTranscriptional adaptor 2B. (328 aa)
MSX1Homeobox protein GHOX-7; Probably plays a role in patterning events during embryonic limb development. May also be involved in programmed cell death. (288 aa)
MIER3Uncharacterized protein. (549 aa)
SHOXShox. (291 aa)
CERS3Ceramide synthase 3. (380 aa)
PBX1PBX1A. (430 aa)
LHX8Uncharacterized protein. (347 aa)
HOXA9Homeobox protein Hox-A9; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Abd-B homeobox family. (260 aa)
HOXA10Homeobox domain-containing protein. (364 aa)
MEOX2Homeobox domain-containing protein. (302 aa)
LCORLLigand-dependent nuclear receptor corepressor-like protein; May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3'. (600 aa)
HOXA4Homeobox protein Hox-A4; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to sites in the 5'-flanking sequence of its coding region with various affinities. The consensus sequences of the high and low affinity binding sites are 5'-TAATGA[CG]-3' and 5'-CTAATTTT-3'. (457 aa)
HOXD9Homeobox protein Hox-D9; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (302 aa)
POU2F1POU domain, class 2, transcription factor 1; Transcription factor that binds to the octamer motif (5'- ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR (By similarity). (766 aa)
RAX2Retinal homeobox protein Rx1; Plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation; Belongs to the paired homeobox family. Bicoid subfamily. (228 aa)
DMBX1Diencephalon/mesencephalon homeobox protein 1; Functions as a transcriptional repressor. Required for brain development. (367 aa)
IRX4Iroquois-class homeodomain protein IRX-4; Regulates the chamber-specific expression of myosin isoforms by activating the expression of the ventricle myosin heavy chain-1 (Vmhc1) and suppressing the expression of the atrial myosin heavy chain-1 (Amhc1) in the ventricles. May play a critical role in establishing chamber-specific gene expression in the developing heart; Belongs to the TALE/IRO homeobox family. (485 aa)
SIX6Homeobox protein SIX6; May be involved in eye development. Belongs to the SIX/Sine oculis homeobox family. (447 aa)
PHOX2BPaired like homeobox 2B. (292 aa)
PAX9Paired box protein Pax-9. (341 aa)
HOPXHomeodomain-only protein; Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. May act via an interaction with SRF, leading to modulate the expression of SRF- dependent cardiac-specific genes and cardiac development. May act as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and assist in chaperone-mediated protein refolding. (73 aa)
MYSM1Histone H2A deubiquitinase MYSM1; Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation (By similarity). (857 aa)
HOXD10Homeobox protein Hox-D10; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (339 aa)
HOXD4Homeobox protein Hox-D4; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to sites in the 5'-flanking sequence of its coding region with various affinities. The consensus sequences of the high and low affinity binding sites are 5'-TAATGA[CG]-3' and 5'-CTAATTTT-3'; Belongs to the Antp homeobox family. Deformed subfamily. (237 aa)
HOXD3Homeobox D3. (413 aa)
DBX2Homeobox protein DBX2; Appears to perform a very early function in establishing the identity of a subset of cells that originate in the region of the ventricular zone in the developing spinal cord and in the hindbrain; Belongs to the H2.0 homeobox family. (366 aa)
ALX1ALX homeobox 1. (328 aa)
OTPOrthopedia homeobox. (325 aa)
HOXA3Homeobox protein Hox-A3; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Antp homeobox family. (413 aa)
HOXA1Homeobox A1. (320 aa)
PRRX2Paired mesoderm homeobox protein 2; May play a role in development of the heart; Belongs to the paired homeobox family. (247 aa)
HOXA6Homeobox protein Hox-A6; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Antp homeobox family. (231 aa)
NANOGHomeobox protein NANOG; Transcription factor required for the maintenance of pluripotency and self-renewal of embryonic stem cells. Belongs to the Nanog homeobox family. (308 aa)
HOXB2Homeobox B2. (323 aa)
SATB2DNA-binding protein SATB. (731 aa)
ISL1Insulin gene enhancer protein ISL-1; Acts as a transcriptional regulator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA- 3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Binds to insulin gene enhancer sequences (By similarity). Defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with LHX1, LHX3 and ISL2. Binds to insulin gene enhancer sequences (By similarity). Essential for heart d [...] (349 aa)
HOXA13Homeobox protein Hox-A13; Sequence-specific, AT-rich binding transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (305 aa)
TTF1Transcription termination factor 1. (712 aa)
MIER1Mesoderm induction early response protein 1; Transcriptional repressor regulating the expression of a number of genes. Probably functions through recruitment of histone deacetylases involved in chromatin silencing (By similarity). (530 aa)
SIX2Sine oculis-related homeobox 2 homolog. (287 aa)
LOC426615Uncharacterized protein. (640 aa)
OTX5Orthodenticle-related homeobox 5. (287 aa)
RAXRetinal homeobox protein Rx2; Plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation. (317 aa)
PAX7PAX7 protein. (524 aa)
PITX1Pituitary homeobox 1; Sequence-specific transcription factor that binds gene promoters and activates their transcription. May play a role in the development of anterior structures, and in particular, the brain and facies and in specifying the identity or structure of hindlimb. Acts as a transcriptional activator by binding to promoter sequences with a TAAT/GCC core motif; Belongs to the paired homeobox family. Bicoid subfamily. (311 aa)
MYBL1Myb-related protein A; Strong transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Could have a role in the proliferation and/or differentiation of neurogenic, spermatogenic and B-lymphoid cells. (757 aa)
TGIF1Homeobox protein AKR; Binds to the F' element of the APOVLDLII gene and represses its transcription; Belongs to the TALE/TGIF homeobox family. (277 aa)
HOXA2Homeobox protein Hox-A2; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Antp homeobox family. Proboscipedia subfamily. (375 aa)
PAX2Paired-box containing protein Pax-2. (394 aa)
OTX2Homeodomain transcription factor. (289 aa)
POU1F1Pituitary-specific positive transcription factor 1; Transcription factor that activates growth hormone and prolactin genes. Specifically binds to the consensus sequence 5'-TAAAT- 3'; Belongs to the POU transcription factor family. Class-1 subfamily. (363 aa)
ONECUT1One cut domain family member. (450 aa)
DMTF1Uncharacterized protein. (767 aa)
EN2Homeobox protein engrailed-2. (289 aa)
HOXA11Homeobox protein Hox-A11; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Abd-B homeobox family. (297 aa)
HOXD11Homeobox protein Hox-D11; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (280 aa)
SIX1Sine oculis-related homeobox 1 homolog. (282 aa)
MYBL2Myb-related protein B; Represses v-myb- and c-myb-mediated activation of the mim-1 gene, probably by competing with other myb proteins for binding sites. It is an inhibitory member of the myb family. (820 aa)
POU4F1POU domain, class 4, transcription factor 1; Multifunctional transcription factor with different regions mediating its different effects. Acts by binding (via its C-terminal domain) to sequences related to the consensus octamer motif 5'- ATGCAAAT-3' in the regulatory regions of its target genes. Regulates the expression of specific genes involved in differentiation and survival within a subset of neuronal lineages. It has been shown that activation of some of these genes requires its N-terminal domain, maybe through a neuronal-specific cofactor; Belongs to the POU transcription factor [...] (389 aa)
PITX2Pituitary homeobox 2; May play an important role in development and maintenance of anterior structures. May play a role in determining left-right asymmetry and in vasculogenesis during avian embryogenesis. (333 aa)
MSX2Homeobox protein MSX-2; Acts as a transcriptional regulator in bone development. Binds to DNA (By similarity). Morphogenetic role; Belongs to the Msh homeobox family. (259 aa)
HOXC13Homeobox C13. (295 aa)
MYBTranscriptional activator Myb; Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells. (785 aa)
GBX1Gastrulation brain homeobox 1. (243 aa)
VSX2Visual system homeobox 2; Acts as a transcriptional regulator (By similarity). Plays a significant role in the specification and morphogenesis of the sensory retina (By similarity). Mediates differentiation of V2a interneurons by repression of motor neuron gene transcription, via competitively binding to response elements that are activated by the ISL1-LHX3 complex. May also participate in the development of the cells of the inner nuclear layer, particularly bipolar cells (By similarity); Belongs to the paired homeobox family. (377 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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