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NKX2-4 | NK2 homeobox 4. (337 aa) | ||||
HOXB3 | Homeobox protein Hox-B3; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Antp homeobox family. (399 aa) | ||||
HOXC8 | Homeobox protein Hox-C8; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (242 aa) | ||||
HOXB8 | Homeobox protein Hox-B8; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Antp homeobox family. (241 aa) | ||||
POU4F3 | POU domain protein. (326 aa) | ||||
HOXB7 | Homeobox B7. (217 aa) | ||||
BARX2 | Homeodomain transcription factor BARX2B. (267 aa) | ||||
HOXC12 | Homeobox C12. (267 aa) | ||||
LBX2 | Homeobox domain-containing protein. (213 aa) | ||||
GBX2 | Homeobox protein GBX-2; May act as a transcription factor for cell pluripotency and differentiation in the embryo. (339 aa) | ||||
EMX1 | Empty spiracles homeobox 1. (235 aa) | ||||
PAX5 | Pax-5 protein. (391 aa) | ||||
EN1 | Homeobox protein engrailed-1. (334 aa) | ||||
ZHX3 | Zinc fingers and homeoboxes 3. (929 aa) | ||||
PKNOX2 | TALE homeodomain transcription factor Prep2. (477 aa) | ||||
ZHX1 | Zinc fingers and homeoboxes 1. (873 aa) | ||||
GSX1 | GS homeobox 1. (247 aa) | ||||
LMX1B | LIM/homeobox protein LMX-1.2; Specifies dorsal cell fate during limb development. (400 aa) | ||||
BARHL1 | BarH like homeobox 1. (316 aa) | ||||
HOXD13 | Homeobox protein Hox-D13; Sequence-specific transcription factor that binds gene promoters and activates their transcription (By similarity). Part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (303 aa) | ||||
HOXC10 | Homeobox domain-containing protein. (354 aa) | ||||
NKX2-2 | Homeobox domain-containing protein. (272 aa) | ||||
HOXC9 | Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (262 aa) | ||||
POU4F3-2 | Brain-specific homeobox/POU domain protein 3; May play a role in specifying terminally differentiated neuronal phenotypes; Belongs to the POU transcription factor family. Class-4 subfamily. (341 aa) | ||||
ISL2 | Insulin gene enhancer protein ISL-2; Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with LIM-1, LIM-3 and ISL-1. (356 aa) | ||||
VSX1 | Visual system homeobox 1; Binds to the 37-bp core of the locus control region (LCR) of the red/green visual pigment gene cluster. May regulate the activity of the LCR and the cone opsin genes at earlier stages of development (By similarity). Dispensable in early retinal development (By similarity). Belongs to the paired homeobox family. (349 aa) | ||||
NKX6-3 | NK6 homeobox 3. (259 aa) | ||||
MTA3 | Metastasis associated 1 family member 3. (693 aa) | ||||
PROX1 | Prospero homeobox protein 1; Transcription factor which may be involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. May be essential in the development and function of the eye. May play a role in the regulation of the circadian rhythm by repressing the expression of clock genes; Belongs to the Prospero homeodomain family. (736 aa) | ||||
VAX1 | Ventral anterior homeobox 1; Transcription factor that plays a role in establishing dorsal-ventral polarity in the neural retina. (325 aa) | ||||
DLX5 | Homeobox protein DLX-5; Transcriptional factor involved in bone development. Could be involved in apical ectodermal ridge activity, pattern formation, and cartilage differentiation. Binds to DNA; Belongs to the distal-less homeobox family. (286 aa) | ||||
ZZZ3 | Uncharacterized protein. (905 aa) | ||||
HOXB5 | Homeobox protein Hox-B5; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Antp homeobox family. (264 aa) | ||||
NKX2-6 | Homeobox domain-containing protein. (193 aa) | ||||
ALX4 | Paired type homeodomain protein. (387 aa) | ||||
NKX1-2 | Homeobox protein SAX-1; Belongs to the NK-1 homeobox family. (289 aa) | ||||
HOXB4 | Homeobox protein Hox-B4; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Antp homeobox family. Deformed subfamily. (245 aa) | ||||
BARX1 | Homeobox protein BarH-like 1b; Transcription factor which is involved with the serum response factor (SRF) in the smooth muscle cell-specific transcription of the beta-tropomyosin gene in the upper digestive organs and their attached arteries; Belongs to the BAR homeobox family. (346 aa) | ||||
POU3F1 | POU domain protein. (374 aa) | ||||
LHX9 | LIM/homeobox protein Lhx9; May be involved in gonadal development. (455 aa) | ||||
ZEB2 | Smad-interacting protein 1. (1214 aa) | ||||
ZFHX4 | Zinc finger homeobox protein 4; May play a role in neural and muscle differentiation (By similarity). May be involved in transcriptional regulation. Belongs to the krueppel C2H2-type zinc-finger protein family. (3595 aa) | ||||
NPDC1 | POU domain, class 5, transcription factor 3; Required for the maintenance of pluripotency and self-renewal of embryonic stem cells. Transcriptional activator that binds the DNA consensus sequence 5'-ATGCAAAT-3'; Belongs to the POU transcription factor family. (427 aa) | ||||
PAX6 | Paired box protein Pax-6; May be a transcription factor with important functions in eye and nasal development. (500 aa) | ||||
RCOR3 | REST corepressor 3; May act as a component of a corepressor complex that represses transcription; Belongs to the CoREST family. (542 aa) | ||||
MEIS1 | Homeobox domain-containing protein. (465 aa) | ||||
HHEX | Hematopoietically-expressed homeobox protein HHEX; Recognizes the DNA sequence 5'-ATTAA-3'. Transcriptional repressor. May play a role in hematopoietic differentiation. (320 aa) | ||||
HOXA5 | Homeobox protein Hox-A5; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5'-CYYNATTA[TG]Y-3' (By similarity); Belongs to the Antp homeobox family. (318 aa) | ||||
HOXD12 | Homeobox protein Hox-D12; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (266 aa) | ||||
HOXA7 | Homeobox protein Hox-A7; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Antp homeobox family. (219 aa) | ||||
HNF1A | Hepatocyte nuclear factor 1-alpha; Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver. May participate in the control of the hormone-dependent expression of the lysozyme gene in the oviduct and liver. In liver it could repress the gene while in oviduct it may act as an activator. Belongs to the HNF1 homeobox family. (634 aa) | ||||
HESX1 | Homeobox protein ANF-1; May be involved in the early patterning of the most anterior region of the main embryonic body axis. (210 aa) | ||||
GSC | Homeobox protein goosecoid; Involved in the development of the organizer region in the gastrula (Hensen node in chicken). (346 aa) | ||||
HOXB6 | Homeobox protein Hox-B6; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Antp homeobox family. (222 aa) | ||||
MEIS2 | Homeoprotein Meis2a.2. (394 aa) | ||||
SIX3 | Homeobox protein SIX3; Transcriptional regulator which can act as both a transcriptional repressor and activator by binding a ATTA homeodomain core recognition sequence on these target genes. During forebrain development represses WNT1 expression allowing zona limitans intrathalamica formation and thereby ensuring proper anterio-posterior patterning of the diencephalon and formation of the rostral diencephalon. Acts as a direct upstream activator of SHH expression in the rostral diencephalon ventral midline and that in turn SHH maintains its expression. In addition, Six3 activity is re [...] (314 aa) | ||||
ZHX2 | Zinc fingers and homeoboxes 2. (830 aa) | ||||
PAX3 | Paired-box transcription factor protein PAX3. (484 aa) | ||||
SATB1 | DNA-binding protein SATB. (786 aa) | ||||
NOTO | Gnot1 homeodomain protein. (171 aa) | ||||
PAX1 | Paired box protein Pax-1; This protein is a transcriptional activator. It may play a role in the formation of segmented structures of the embryo. May play an important role in the normal development of the vertebral column (By similarity). (426 aa) | ||||
IRX1 | Homeobox domain-containing protein. (467 aa) | ||||
LHX5 | LIM homeobox protein 5. (402 aa) | ||||
DNAJC2 | Uncharacterized protein. (619 aa) | ||||
TLX1 | T-cell leukemia homeobox protein 1; Seems to be involved in the development of cranial sensory innervation from peripheral ganglia. (297 aa) | ||||
CDX4 | Homeobox protein CHOX-CAD2; Belongs to the Caudal homeobox family. (263 aa) | ||||
HMX3 | Homeobox protein HMX3; Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development. Binds to the 5'-CAAGTG-3' core sequence (By similarity). Belongs to the HMX homeobox family. (308 aa) | ||||
ZEB1 | Zinc finger E-box-binding homeobox 1; Acts as a transcriptional repressor. Positively regulates neuronal differentiation. Represses transcription by binding to the E box-containing promoter (By similarity). Binds to delta 1-crystallin enhancer core and represses lens-specific transcription. It binds as well many other non-lens specific DNA sequences. (1114 aa) | ||||
HDX | Highly divergent homeobox. (695 aa) | ||||
POU2F3 | POU domain protein. (533 aa) | ||||
BSX | Brain-specific homeobox protein homolog; DNA binding protein that function as transcriptional activator. May play a role in the determination and function of cell types in the brain; Belongs to the distal-less homeobox family. (233 aa) | ||||
CDX1 | Homeobox protein CDX-1; Plays a role in transcriptional regulation. Involved in activated KRAS-mediated transcriptional activation of PRKD1. Binds to the PRKD1 promoter. Could play a role in the terminal differentiation of the intestine. Binds preferentially to methylated DNA. Belongs to the Caudal homeobox family. (260 aa) | ||||
TADA2A | Transcriptional adapter 2-alpha; Component of some complex with histone acetyltransferase activity. Required for the function of some acidic activation domains, which activate transcription from a distant site (By similarity). Binds double-stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling (By similarity). (443 aa) | ||||
LHX1 | LIM/homeobox protein Lhx1; Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with ISL-2. (406 aa) | ||||
DLX1 | Homeodomain transcription factor DLX1. (255 aa) | ||||
LEUTX | Homeobox domain-containing protein. (403 aa) | ||||
PRRX1 | Paired mesoderm homeobox protein 1; May participate in maintenance of mesenchymal cell lineages derived from both mesoderm and the neural crest and in patterning of the limbs and the face. (245 aa) | ||||
NKX2-5 | Homeobox protein Nkx-2.5; Implicated in commitment to and/or differentiation of the myocardial lineage. Binds to the core DNA motif of promoter. Belongs to the NK-2 homeobox family. (294 aa) | ||||
TLX3 | T-cell leukemia homeobox protein 3; Seems to be involved in the development of cranial sensory innervation from peripheral ganglia. (296 aa) | ||||
LHX3 | LIM/homeobox protein Lhx3; Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with LIM-1, ISL-1 and ISL-2. (395 aa) | ||||
HOXB9 | Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (273 aa) | ||||
LHX2 | LIM homeodomain. (400 aa) | ||||
PBX3 | Homeobox domain-containing protein. (433 aa) | ||||
TERF2IP | Telomeric repeat-binding factor 2-interacting protein 1; Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). Does not bind DNA directly: recruited to telomeric double-stranded 5'- TTAGGG-3' repeats via its interaction with terf2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with terf2 or other factors, and regulates gene expression (By similar [...] (409 aa) | ||||
TERF2 | Telomeric repeat-binding factor 2; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'- TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA r [...] (718 aa) | ||||
HMBOX1 | Homeobox domain-containing protein. (454 aa) | ||||
PKNOX1 | PBX/knotted 1 homeobox 1. (436 aa) | ||||
TADA2B | Transcriptional adaptor 2B. (328 aa) | ||||
MSX1 | Homeobox protein GHOX-7; Probably plays a role in patterning events during embryonic limb development. May also be involved in programmed cell death. (288 aa) | ||||
MIER3 | Uncharacterized protein. (549 aa) | ||||
SHOX | Shox. (291 aa) | ||||
CERS3 | Ceramide synthase 3. (380 aa) | ||||
PBX1 | PBX1A. (430 aa) | ||||
LHX8 | Uncharacterized protein. (347 aa) | ||||
HOXA9 | Homeobox protein Hox-A9; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Abd-B homeobox family. (260 aa) | ||||
HOXA10 | Homeobox domain-containing protein. (364 aa) | ||||
MEOX2 | Homeobox domain-containing protein. (302 aa) | ||||
LCORL | Ligand-dependent nuclear receptor corepressor-like protein; May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3'. (600 aa) | ||||
HOXA4 | Homeobox protein Hox-A4; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to sites in the 5'-flanking sequence of its coding region with various affinities. The consensus sequences of the high and low affinity binding sites are 5'-TAATGA[CG]-3' and 5'-CTAATTTT-3'. (457 aa) | ||||
HOXD9 | Homeobox protein Hox-D9; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (302 aa) | ||||
POU2F1 | POU domain, class 2, transcription factor 1; Transcription factor that binds to the octamer motif (5'- ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR (By similarity). (766 aa) | ||||
RAX2 | Retinal homeobox protein Rx1; Plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation; Belongs to the paired homeobox family. Bicoid subfamily. (228 aa) | ||||
DMBX1 | Diencephalon/mesencephalon homeobox protein 1; Functions as a transcriptional repressor. Required for brain development. (367 aa) | ||||
IRX4 | Iroquois-class homeodomain protein IRX-4; Regulates the chamber-specific expression of myosin isoforms by activating the expression of the ventricle myosin heavy chain-1 (Vmhc1) and suppressing the expression of the atrial myosin heavy chain-1 (Amhc1) in the ventricles. May play a critical role in establishing chamber-specific gene expression in the developing heart; Belongs to the TALE/IRO homeobox family. (485 aa) | ||||
SIX6 | Homeobox protein SIX6; May be involved in eye development. Belongs to the SIX/Sine oculis homeobox family. (447 aa) | ||||
PHOX2B | Paired like homeobox 2B. (292 aa) | ||||
PAX9 | Paired box protein Pax-9. (341 aa) | ||||
HOPX | Homeodomain-only protein; Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. May act via an interaction with SRF, leading to modulate the expression of SRF- dependent cardiac-specific genes and cardiac development. May act as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and assist in chaperone-mediated protein refolding. (73 aa) | ||||
MYSM1 | Histone H2A deubiquitinase MYSM1; Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation (By similarity). (857 aa) | ||||
HOXD10 | Homeobox protein Hox-D10; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (339 aa) | ||||
HOXD4 | Homeobox protein Hox-D4; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to sites in the 5'-flanking sequence of its coding region with various affinities. The consensus sequences of the high and low affinity binding sites are 5'-TAATGA[CG]-3' and 5'-CTAATTTT-3'; Belongs to the Antp homeobox family. Deformed subfamily. (237 aa) | ||||
HOXD3 | Homeobox D3. (413 aa) | ||||
DBX2 | Homeobox protein DBX2; Appears to perform a very early function in establishing the identity of a subset of cells that originate in the region of the ventricular zone in the developing spinal cord and in the hindbrain; Belongs to the H2.0 homeobox family. (366 aa) | ||||
ALX1 | ALX homeobox 1. (328 aa) | ||||
OTP | Orthopedia homeobox. (325 aa) | ||||
HOXA3 | Homeobox protein Hox-A3; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Antp homeobox family. (413 aa) | ||||
HOXA1 | Homeobox A1. (320 aa) | ||||
PRRX2 | Paired mesoderm homeobox protein 2; May play a role in development of the heart; Belongs to the paired homeobox family. (247 aa) | ||||
HOXA6 | Homeobox protein Hox-A6; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Antp homeobox family. (231 aa) | ||||
NANOG | Homeobox protein NANOG; Transcription factor required for the maintenance of pluripotency and self-renewal of embryonic stem cells. Belongs to the Nanog homeobox family. (308 aa) | ||||
HOXB2 | Homeobox B2. (323 aa) | ||||
SATB2 | DNA-binding protein SATB. (731 aa) | ||||
ISL1 | Insulin gene enhancer protein ISL-1; Acts as a transcriptional regulator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA- 3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Binds to insulin gene enhancer sequences (By similarity). Defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with LHX1, LHX3 and ISL2. Binds to insulin gene enhancer sequences (By similarity). Essential for heart d [...] (349 aa) | ||||
HOXA13 | Homeobox protein Hox-A13; Sequence-specific, AT-rich binding transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (305 aa) | ||||
TTF1 | Transcription termination factor 1. (712 aa) | ||||
MIER1 | Mesoderm induction early response protein 1; Transcriptional repressor regulating the expression of a number of genes. Probably functions through recruitment of histone deacetylases involved in chromatin silencing (By similarity). (530 aa) | ||||
SIX2 | Sine oculis-related homeobox 2 homolog. (287 aa) | ||||
LOC426615 | Uncharacterized protein. (640 aa) | ||||
OTX5 | Orthodenticle-related homeobox 5. (287 aa) | ||||
RAX | Retinal homeobox protein Rx2; Plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation. (317 aa) | ||||
PAX7 | PAX7 protein. (524 aa) | ||||
PITX1 | Pituitary homeobox 1; Sequence-specific transcription factor that binds gene promoters and activates their transcription. May play a role in the development of anterior structures, and in particular, the brain and facies and in specifying the identity or structure of hindlimb. Acts as a transcriptional activator by binding to promoter sequences with a TAAT/GCC core motif; Belongs to the paired homeobox family. Bicoid subfamily. (311 aa) | ||||
MYBL1 | Myb-related protein A; Strong transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Could have a role in the proliferation and/or differentiation of neurogenic, spermatogenic and B-lymphoid cells. (757 aa) | ||||
TGIF1 | Homeobox protein AKR; Binds to the F' element of the APOVLDLII gene and represses its transcription; Belongs to the TALE/TGIF homeobox family. (277 aa) | ||||
HOXA2 | Homeobox protein Hox-A2; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Antp homeobox family. Proboscipedia subfamily. (375 aa) | ||||
PAX2 | Paired-box containing protein Pax-2. (394 aa) | ||||
OTX2 | Homeodomain transcription factor. (289 aa) | ||||
POU1F1 | Pituitary-specific positive transcription factor 1; Transcription factor that activates growth hormone and prolactin genes. Specifically binds to the consensus sequence 5'-TAAAT- 3'; Belongs to the POU transcription factor family. Class-1 subfamily. (363 aa) | ||||
ONECUT1 | One cut domain family member. (450 aa) | ||||
DMTF1 | Uncharacterized protein. (767 aa) | ||||
EN2 | Homeobox protein engrailed-2. (289 aa) | ||||
HOXA11 | Homeobox protein Hox-A11; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Abd-B homeobox family. (297 aa) | ||||
HOXD11 | Homeobox protein Hox-D11; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (280 aa) | ||||
SIX1 | Sine oculis-related homeobox 1 homolog. (282 aa) | ||||
MYBL2 | Myb-related protein B; Represses v-myb- and c-myb-mediated activation of the mim-1 gene, probably by competing with other myb proteins for binding sites. It is an inhibitory member of the myb family. (820 aa) | ||||
POU4F1 | POU domain, class 4, transcription factor 1; Multifunctional transcription factor with different regions mediating its different effects. Acts by binding (via its C-terminal domain) to sequences related to the consensus octamer motif 5'- ATGCAAAT-3' in the regulatory regions of its target genes. Regulates the expression of specific genes involved in differentiation and survival within a subset of neuronal lineages. It has been shown that activation of some of these genes requires its N-terminal domain, maybe through a neuronal-specific cofactor; Belongs to the POU transcription factor [...] (389 aa) | ||||
PITX2 | Pituitary homeobox 2; May play an important role in development and maintenance of anterior structures. May play a role in determining left-right asymmetry and in vasculogenesis during avian embryogenesis. (333 aa) | ||||
MSX2 | Homeobox protein MSX-2; Acts as a transcriptional regulator in bone development. Binds to DNA (By similarity). Morphogenetic role; Belongs to the Msh homeobox family. (259 aa) | ||||
HOXC13 | Homeobox C13. (295 aa) | ||||
MYB | Transcriptional activator Myb; Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells. (785 aa) | ||||
GBX1 | Gastrulation brain homeobox 1. (243 aa) | ||||
VSX2 | Visual system homeobox 2; Acts as a transcriptional regulator (By similarity). Plays a significant role in the specification and morphogenesis of the sensory retina (By similarity). Mediates differentiation of V2a interneurons by repression of motor neuron gene transcription, via competitively binding to response elements that are activated by the ISL1-LHX3 complex. May also participate in the development of the cells of the inner nuclear layer, particularly bipolar cells (By similarity); Belongs to the paired homeobox family. (377 aa) |