STRINGSTRING
IFNW1 IFNW1 GH GH IL10 IL10 IL19 IL19 IL13 IL13 IFNG IFNG IL22 IL22 KITLG KITLG IL21 IL21 IL2 IL2 LOC768614 LOC768614 PRL PRL IL4 IL4 IL5 IL5 THPO THPO CNTF CNTF CSF3 CSF3 LOC100858506 LOC100858506 IL6 IL6 LOC100858177 LOC100858177
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IFNW1Interferon type B; Has antiviral activities; Belongs to the alpha/beta interferon family. (203 aa)
GHSomatotropin; Growth hormone plays an important role in growth control. (216 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (175 aa)
IL19Interleukin 19. (176 aa)
IL13Interleukin-13. (138 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity). (164 aa)
IL22Uncharacterized protein. (197 aa)
KITLGProcessed kit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Acts synergistically with other cytokines, probably interleukins (By similarity). (287 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (145 aa)
IL2Interleukin; Belongs to the IL-15/IL-21 family. (143 aa)
LOC768614Interferon type A3; Has antiviral activities; Belongs to the alpha/beta interferon family. (193 aa)
PRLProlactin. (229 aa)
IL4Interleukin 4. (136 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (136 aa)
THPOThrombopoietin. (177 aa)
CNTFCiliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy. (195 aa)
CSF3Myelomonocytic growth factor; Hematopoietic growth factor that stimulates the proliferation and colony formation of normal and transformed avian cells of the myeloid lineage; Belongs to the IL-6 superfamily. (201 aa)
LOC100858506Interferon alpha. (193 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily. (307 aa)
LOC100858177Interferon type A1/A2; Has antiviral activities. (193 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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