node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CNTF | IL6 | ENSGALP00000042605 | ENSGALP00000068117 | Ciliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy. | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily. | 0.780 |
CSF3 | IFNG | ENSGALP00000044330 | ENSGALP00000016086 | Myelomonocytic growth factor; Hematopoietic growth factor that stimulates the proliferation and colony formation of normal and transformed avian cells of the myeloid lineage; Belongs to the IL-6 superfamily. | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity). | 0.905 |
CSF3 | IL10 | ENSGALP00000044330 | ENSGALP00000001310 | Myelomonocytic growth factor; Hematopoietic growth factor that stimulates the proliferation and colony formation of normal and transformed avian cells of the myeloid lineage; Belongs to the IL-6 superfamily. | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] | 0.835 |
CSF3 | IL2 | ENSGALP00000044330 | ENSGALP00000019308 | Myelomonocytic growth factor; Hematopoietic growth factor that stimulates the proliferation and colony formation of normal and transformed avian cells of the myeloid lineage; Belongs to the IL-6 superfamily. | Interleukin; Belongs to the IL-15/IL-21 family. | 0.595 |
CSF3 | IL22 | ENSGALP00000044330 | ENSGALP00000016087 | Myelomonocytic growth factor; Hematopoietic growth factor that stimulates the proliferation and colony formation of normal and transformed avian cells of the myeloid lineage; Belongs to the IL-6 superfamily. | Uncharacterized protein. | 0.503 |
CSF3 | IL4 | ENSGALP00000044330 | ENSGALP00000039130 | Myelomonocytic growth factor; Hematopoietic growth factor that stimulates the proliferation and colony formation of normal and transformed avian cells of the myeloid lineage; Belongs to the IL-6 superfamily. | Interleukin 4. | 0.631 |
CSF3 | IL6 | ENSGALP00000044330 | ENSGALP00000068117 | Myelomonocytic growth factor; Hematopoietic growth factor that stimulates the proliferation and colony formation of normal and transformed avian cells of the myeloid lineage; Belongs to the IL-6 superfamily. | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily. | 0.940 |
CSF3 | KITLG | ENSGALP00000044330 | ENSGALP00000018246 | Myelomonocytic growth factor; Hematopoietic growth factor that stimulates the proliferation and colony formation of normal and transformed avian cells of the myeloid lineage; Belongs to the IL-6 superfamily. | Processed kit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Acts synergistically with other cytokines, probably interleukins (By similarity). | 0.722 |
CSF3 | THPO | ENSGALP00000044330 | ENSGALP00000041285 | Myelomonocytic growth factor; Hematopoietic growth factor that stimulates the proliferation and colony formation of normal and transformed avian cells of the myeloid lineage; Belongs to the IL-6 superfamily. | Thrombopoietin. | 0.603 |
GH | IFNG | ENSGALP00000000327 | ENSGALP00000016086 | Somatotropin; Growth hormone plays an important role in growth control. | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity). | 0.449 |
GH | PRL | ENSGALP00000000327 | ENSGALP00000020651 | Somatotropin; Growth hormone plays an important role in growth control. | Prolactin. | 0.924 |
IFNG | CSF3 | ENSGALP00000016086 | ENSGALP00000044330 | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity). | Myelomonocytic growth factor; Hematopoietic growth factor that stimulates the proliferation and colony formation of normal and transformed avian cells of the myeloid lineage; Belongs to the IL-6 superfamily. | 0.905 |
IFNG | GH | ENSGALP00000016086 | ENSGALP00000000327 | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity). | Somatotropin; Growth hormone plays an important role in growth control. | 0.449 |
IFNG | IFNW1 | ENSGALP00000016086 | ENSGALP00000038687 | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity). | Interferon type B; Has antiviral activities; Belongs to the alpha/beta interferon family. | 0.675 |
IFNG | IL10 | ENSGALP00000016086 | ENSGALP00000001310 | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity). | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] | 0.992 |
IFNG | IL13 | ENSGALP00000016086 | ENSGALP00000010986 | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity). | Interleukin-13. | 0.763 |
IFNG | IL19 | ENSGALP00000016086 | ENSGALP00000001338 | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity). | Interleukin 19. | 0.479 |
IFNG | IL2 | ENSGALP00000016086 | ENSGALP00000019308 | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity). | Interleukin; Belongs to the IL-15/IL-21 family. | 0.958 |
IFNG | IL21 | ENSGALP00000016086 | ENSGALP00000019301 | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity). | Interleukin; Belongs to the IL-15/IL-21 family. | 0.858 |
IFNG | IL22 | ENSGALP00000016086 | ENSGALP00000016087 | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity). | Uncharacterized protein. | 0.907 |