STRINGSTRING
KCNIP1 KCNIP1 PVALB PVALB PEF1 PEF1 CALM2 CALM2 PLCB1 PLCB1 NCALD NCALD S100A6 S100A6 MYL3 MYL3 CETN2 CETN2 CALB2 CALB2 S100A10 S100A10 RHBDL1 RHBDL1 CALML3 CALML3 RCN1 RCN1 NUCB2 NUCB2 GUCA1B GUCA1B MYL2 MYL2 EFHD1 EFHD1 LOC427654 LOC427654 S100B S100B CHP1 CHP1 PPEF1 PPEF1 EFHC2 EFHC2 LETM1 LETM1 CBLB CBLB S100Z S100Z S100A12 S100A12 SCGN SCGN PDCD6 PDCD6 PLCZ1 PLCZ1 FKBP14 FKBP14 RASGRP3 RASGRP3 MCFD2 MCFD2 CAPN8 CAPN8 CAPN2 CAPN2 EHD3 EHD3 TBC1D8B TBC1D8B EHD4 EHD4 PPP3R1 PPP3R1 DYTN DYTN TESC TESC CETN1 CETN1 SNTN SNTN TNNC2 TNNC2 PLCD1 PLCD1 SWAP70 SWAP70 SPARC SPARC SDF4 SDF4 TNNC1 TNNC1 GUCA1A GUCA1A MYL4 MYL4 HPCAL4 HPCAL4 HPCA HPCA OCM OCM RHOT1 RHOT1 NECAB3 NECAB3 MYL1 MYL1 RHOT2 RHOT2 MYL6 MYL6 MICU3 MICU3 PLS3 PLS3 ACTN1 ACTN1 S100A11 S100A11 CAPSL CAPSL DMD DMD LOC776273 LOC776273 CABP1 CABP1 LCP1 LCP1 GPD2 GPD2 PLCB4 PLCB4 MYLPF MYLPF NKD1 NKD1 SPTAN1 SPTAN1 OCM2 OCM2 SLC25A24 SLC25A24 MYL9 MYL9 RASGRP1 RASGRP1 MYL12A MYL12A MYL12B MYL12B AIF1L AIF1L KCNIP4 KCNIP4 CALB1 CALB1 PLS1 PLS1 ACTN2 ACTN2 DGKB DGKB CAPN3 CAPN3 S100A1 S100A1 ACTN4 ACTN4 PLCG2 PLCG2 CAPN11 CAPN11 MYL10 MYL10 SPOCK3 SPOCK3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KCNIP1Potassium voltage-gated channel interacting protein 1. (232 aa)
PVALBParvalbumin, muscle; In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions (By similarity); Belongs to the parvalbumin family. (134 aa)
PEF1Penta-EF-hand domain containing 1. (223 aa)
CALM2Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. (151 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1219 aa)
NCALDNeurocalcin-delta; May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium ions (By similarity). (193 aa)
S100A6Protein S100-A6; May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative (By similarity). (92 aa)
MYL3Myosin light chain 1, cardiac muscle. (194 aa)
CETN2Uncharacterized protein. (171 aa)
CALB2Calretinin; Calretinin is a calcium-binding protein which is abundant in auditory neurons. (311 aa)
S100A10Protein S100-A10; Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase. (97 aa)
RHBDL1Rhomboid-related protein 1; May be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors; Belongs to the peptidase S54 family. (372 aa)
CALML3Calmodulin, striated muscle; Belongs to the calmodulin family. (149 aa)
RCN1Uncharacterized protein. (325 aa)
NUCB2Uncharacterized protein. (455 aa)
GUCA1BGuanylyl cyclase-activating protein 2; Stimulates synthesis of cGMP in photoreceptors. Thought to mediate Ca(2+)-sensitive regulation of retinal guanylyl cyclase (GC), a key event in recovery of the dark state of rod photoreceptors following light exposure (By similarity). (307 aa)
MYL2Myosin regulatory light chain 2A, cardiac muscle isoform. (202 aa)
EFHD1EF hand-containing protein 1. (238 aa)
LOC427654Uncharacterized protein; Belongs to the parvalbumin family. (129 aa)
S100BEF-hand domain-containing protein; Belongs to the S-100 family. (92 aa)
CHP1Calcineurin B homologous protein 1; Calcium-binding protein involved in different processes such as regulation of vesicular trafficking, plasma membrane Na(+)/H(+) exchanger and gene transcription. Involved in the constitutive exocytic membrane traffic. Mediates the association between microtubules and membrane-bound organelles of the endoplasmic reticulum and Golgi apparatus and is also required for the targeting and fusion of transcytotic vesicles (TCV) with the plasma membrane. Functions as an integral cofactor in cell pH regulation by controlling plasma membrane- type Na(+)/H(+) ex [...] (195 aa)
PPEF1Serine/threonine-protein phosphatase. (632 aa)
EFHC2EF-hand domain-containing family member C2. (746 aa)
LETM1Mitochondrial proton/calcium exchanger protein; Mitochondrial proton/calcium antiporter that mediates proton- dependent calcium efflux from mitochondrion (By similarity). Required for the maintenance of the tubular shape and cristae organization (By similarity). (755 aa)
CBLBCbl proto-oncogene B. (1025 aa)
S100ZProtein S100; Belongs to the S-100 family. (98 aa)
S100A12Protein MRP-126. (119 aa)
SCGNSecretagogin, EF-hand calcium binding protein. (273 aa)
PDCD6Programmed cell death 6. (178 aa)
PLCZ11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is t [...] (637 aa)
FKBP14Peptidylprolyl isomerase. (210 aa)
RASGRP3Uncharacterized protein. (691 aa)
MCFD2Uncharacterized protein. (143 aa)
CAPN8Calpain 8; Belongs to the peptidase C2 family. (702 aa)
CAPN2Calpain-2 catalytic subunit; Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. (700 aa)
EHD3Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (535 aa)
TBC1D8BTBC1 domain family member 8B. (1126 aa)
EHD4EH domain containing 4; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (542 aa)
PPP3R1Protein phospatase 3 regulatory subunit B alpha isoform type 1. (170 aa)
DYTNDystrotelin. (672 aa)
TESCCalcineurin B homologous protein 3; Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Promotes the induction of hematopoietic stem cell differentiation toward megakaryocytic lineage. Essential for the coupling of ERK cascade activation with the expression of ETS family genes in megakaryocytic differentiation. Also involved in granulocytic differentiation in a ERK-dependent manner. Inhibits the phosphatase activity of calcineurin (By similarity). (214 aa)
CETN1Uncharacterized protein. (172 aa)
SNTNSentan; May be a component of the linker structure that bridges the ciliary membrane and peripheral singlet microtubules. (144 aa)
TNNC2Troponin C, skeletal muscle; Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments. (163 aa)
PLCD1Phosphoinositide phospholipase C. (781 aa)
SWAP70Switch-associated protein 70; Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion (By similarity). (586 aa)
SPARCSPARC; Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity (By similarity). (298 aa)
SDF445 kDa calcium-binding protein; May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment; Belongs to the CREC family. (356 aa)
TNNC1Troponin C, slow skeletal and cardiac muscles; Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments. (215 aa)
GUCA1AGuanylyl cyclase-activating protein 1; Stimulates retinal guanylyl cyclase when free calcium ions concentration is low and inhibits guanylyl cyclase when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of retinal guanylyl cyclase is a key event in recovery of the dark state of rod photoreceptors following light exposure. (199 aa)
MYL4Myosin light chain, embryonic. (185 aa)
HPCAL4Visinin-like protein 1; Regulates (in vitro) the inhibition of rhodopsin phosphorylation in a calcium-dependent manner. (191 aa)
HPCAHippocalcin. (193 aa)
OCMParvalbumin, thymic CPV3; Binds two calcium ions. (109 aa)
RHOT1Mitochondrial Rho GTPase 1; Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (By similarity). (618 aa)
NECAB3Uncharacterized protein. (350 aa)
MYL1Myosin light chain 1, skeletal muscle isoform. (192 aa)
RHOT2Mitochondrial Rho GTPase 2; Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (By similarity). (618 aa)
MYL6Myosin light polypeptide 6; Regulatory light chain of myosin. Does not bind calcium. (275 aa)
MICU3Mitochondrial calcium uptake family member 3. (511 aa)
PLS3Uncharacterized protein. (637 aa)
ACTN1Alpha-actinin-1; F-actin cross-linking protein is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. (915 aa)
S100A11Protein S100-A11. (101 aa)
CAPSLCalcyphosine like. (211 aa)
DMDDystrophin; May play a role in anchoring the cytoskeleton to the plasma membrane. (3700 aa)
LOC7762731-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1303 aa)
CABP1Calcium binding protein 1. (411 aa)
LCP1Uncharacterized protein. (633 aa)
GPD2Glycerol-3-phosphate dehydrogenase; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. (727 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1210 aa)
MYLPFMyosin regulatory light chain 2, skeletal muscle isoform. (87 aa)
NKD1NKD inhibitor of WNT signaling pathway 1. (472 aa)
SPTAN1Spectrin alpha chain, non-erythrocytic 1; Morphologically, spectrin-like proteins appear to be related to spectrin, showing a flexible rod-like structure. They can bind actin but seem to differ in their calmodulin-binding activity. In nonerythroid tissues, spectrins, in association with some other proteins, may play an important role in membrane organization. (2497 aa)
OCM2Parvalbumin, thymic; Appears to promote immune maturation in bone marrow cells in culture. Binds two calcium ions; Belongs to the parvalbumin family. (109 aa)
SLC25A24Solute carrier family 25 member 24; Belongs to the mitochondrial carrier (TC 2.A.29) family. (475 aa)
MYL9Myosin regulatory light chain 2, smooth muscle major isoform; Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity. Implicated in cytokinesis, receptor capping, and cell locomotion (By similarity). (172 aa)
RASGRP1RAS guanyl releasing protein 1. (480 aa)
MYL12AMyosin regulatory light chain 2, smooth muscle minor isoform; Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity. Implicated in cytokinesis, receptor capping, and cell locomotion (By similarity). (198 aa)
MYL12BUncharacterized protein. (172 aa)
AIF1LAllograft inflammatory factor 1-like protein. (145 aa)
KCNIP4Uncharacterized protein. (233 aa)
CALB1Calbindin; Buffers cytosolic calcium. May stimulate a membrane Ca(2+)- ATPase and a 3',5'-cyclic nucleotide phosphodiesterase. (262 aa)
PLS1Plastin-1; Actin-bundling protein found in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia. (630 aa)
ACTN2Alpha-actinin-2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity). (923 aa)
DGKBDiacylglycerol kinase. (814 aa)
CAPN3Calpain-3; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family. (810 aa)
S100A1Protein S100; Belongs to the S-100 family. (94 aa)
ACTN4Alpha-actinin-4; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Probably involved in vesicular trafficking via its association with the CART complex. Involved in tight junction assembly in epithelial cells. May also function as a transcriptional coactivator, stimulating transcription mediated by nuclear hormone receptors. Belongs to the alpha-actinin family. (1045 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
CAPN11Calpain-1 catalytic subunit; Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction; Belongs to the peptidase C2 family. (705 aa)
MYL10Myosin regulatory light chain 2B, cardiac muscle isoform. (187 aa)
SPOCK3SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3. (431 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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