(7 nodes) ClpP/crotonase-like domain superfamily network (Gallus gallus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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a 3D structure is known or predicted

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Your Input:
	MCCC2	Methylcrotonoyl-CoA carboxylase 2. (560 aa)
	ECHDC2	Enoyl-CoA hydratase domain containing 2; Belongs to the enoyl-CoA hydratase/isomerase family. (286 aa)
	ACACA	Acetyl-CoA carboxylase; Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. (2355 aa)
	PCCB	Propionyl-CoA carboxylase subunit beta. (529 aa)
	HIBCH	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA (By similarity); Belongs to the enoyl-CoA hydratase/isomerase family. (385 aa)
	AUH	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family. (350 aa)
	ECHDC1	Ethylmalonyl-CoA decarboxylase; Decarboxylates ethylmalonyl-CoA, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading. Also has methylmalonyl-CoA decarboxylase activity at lower level; Belongs to the enoyl-CoA hydratase/isomerase family. (300 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACACA	ECHDC1	ENSGALP00000043760	ENSGALP00000070409	Acetyl-CoA carboxylase; Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.	Ethylmalonyl-CoA decarboxylase; Decarboxylates ethylmalonyl-CoA, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading. Also has methylmalonyl-CoA decarboxylase activity at lower level; Belongs to the enoyl-CoA hydratase/isomerase family.	0.429
ACACA	MCCC2	ENSGALP00000043760	ENSGALP00000003974	Acetyl-CoA carboxylase; Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.	Methylcrotonoyl-CoA carboxylase 2.	0.491
ACACA	PCCB	ENSGALP00000043760	ENSGALP00000045840	Acetyl-CoA carboxylase; Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.	Propionyl-CoA carboxylase subunit beta.	0.544
AUH	ECHDC1	ENSGALP00000069282	ENSGALP00000070409	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family.	Ethylmalonyl-CoA decarboxylase; Decarboxylates ethylmalonyl-CoA, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading. Also has methylmalonyl-CoA decarboxylase activity at lower level; Belongs to the enoyl-CoA hydratase/isomerase family.	0.501
AUH	HIBCH	ENSGALP00000069282	ENSGALP00000052042	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family.	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA (By similarity); Belongs to the enoyl-CoA hydratase/isomerase family.	0.524
AUH	MCCC2	ENSGALP00000069282	ENSGALP00000003974	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family.	Methylcrotonoyl-CoA carboxylase 2.	0.950
AUH	PCCB	ENSGALP00000069282	ENSGALP00000045840	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family.	Propionyl-CoA carboxylase subunit beta.	0.521
ECHDC1	ACACA	ENSGALP00000070409	ENSGALP00000043760	Ethylmalonyl-CoA decarboxylase; Decarboxylates ethylmalonyl-CoA, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading. Also has methylmalonyl-CoA decarboxylase activity at lower level; Belongs to the enoyl-CoA hydratase/isomerase family.	Acetyl-CoA carboxylase; Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.	0.429
ECHDC1	AUH	ENSGALP00000070409	ENSGALP00000069282	Ethylmalonyl-CoA decarboxylase; Decarboxylates ethylmalonyl-CoA, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading. Also has methylmalonyl-CoA decarboxylase activity at lower level; Belongs to the enoyl-CoA hydratase/isomerase family.	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family.	0.501
ECHDC1	HIBCH	ENSGALP00000070409	ENSGALP00000052042	Ethylmalonyl-CoA decarboxylase; Decarboxylates ethylmalonyl-CoA, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading. Also has methylmalonyl-CoA decarboxylase activity at lower level; Belongs to the enoyl-CoA hydratase/isomerase family.	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA (By similarity); Belongs to the enoyl-CoA hydratase/isomerase family.	0.886
ECHDC1	MCCC2	ENSGALP00000070409	ENSGALP00000003974	Ethylmalonyl-CoA decarboxylase; Decarboxylates ethylmalonyl-CoA, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading. Also has methylmalonyl-CoA decarboxylase activity at lower level; Belongs to the enoyl-CoA hydratase/isomerase family.	Methylcrotonoyl-CoA carboxylase 2.	0.532
ECHDC1	PCCB	ENSGALP00000070409	ENSGALP00000045840	Ethylmalonyl-CoA decarboxylase; Decarboxylates ethylmalonyl-CoA, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading. Also has methylmalonyl-CoA decarboxylase activity at lower level; Belongs to the enoyl-CoA hydratase/isomerase family.	Propionyl-CoA carboxylase subunit beta.	0.957
ECHDC2	HIBCH	ENSGALP00000017301	ENSGALP00000052042	Enoyl-CoA hydratase domain containing 2; Belongs to the enoyl-CoA hydratase/isomerase family.	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA (By similarity); Belongs to the enoyl-CoA hydratase/isomerase family.	0.511
ECHDC2	MCCC2	ENSGALP00000017301	ENSGALP00000003974	Enoyl-CoA hydratase domain containing 2; Belongs to the enoyl-CoA hydratase/isomerase family.	Methylcrotonoyl-CoA carboxylase 2.	0.535
ECHDC2	PCCB	ENSGALP00000017301	ENSGALP00000045840	Enoyl-CoA hydratase domain containing 2; Belongs to the enoyl-CoA hydratase/isomerase family.	Propionyl-CoA carboxylase subunit beta.	0.539
HIBCH	AUH	ENSGALP00000052042	ENSGALP00000069282	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA (By similarity); Belongs to the enoyl-CoA hydratase/isomerase family.	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family.	0.524
HIBCH	ECHDC1	ENSGALP00000052042	ENSGALP00000070409	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA (By similarity); Belongs to the enoyl-CoA hydratase/isomerase family.	Ethylmalonyl-CoA decarboxylase; Decarboxylates ethylmalonyl-CoA, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading. Also has methylmalonyl-CoA decarboxylase activity at lower level; Belongs to the enoyl-CoA hydratase/isomerase family.	0.886
HIBCH	ECHDC2	ENSGALP00000052042	ENSGALP00000017301	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA (By similarity); Belongs to the enoyl-CoA hydratase/isomerase family.	Enoyl-CoA hydratase domain containing 2; Belongs to the enoyl-CoA hydratase/isomerase family.	0.511
HIBCH	MCCC2	ENSGALP00000052042	ENSGALP00000003974	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA (By similarity); Belongs to the enoyl-CoA hydratase/isomerase family.	Methylcrotonoyl-CoA carboxylase 2.	0.462
HIBCH	PCCB	ENSGALP00000052042	ENSGALP00000045840	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA (By similarity); Belongs to the enoyl-CoA hydratase/isomerase family.	Propionyl-CoA carboxylase subunit beta.	0.748