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ZFPM2 ZFPM2 RASAL3 RASAL3 GFI1 GFI1 LOC425347 LOC425347 ZBTB8AL ZBTB8AL ZIC1 ZIC1 ZIC2 ZIC2 PATZ1 PATZ1 AEBP2 AEBP2 BCL11A BCL11A SP4 SP4 HIC1 HIC1 KLF15 KLF15 ZNF319 ZNF319 ZBTB43 ZBTB43 SF3A2 SF3A2 ZNF593 ZNF593 ZNF276 ZNF276 SP2 SP2 ZFP91 ZFP91 ZBTB34 ZBTB34 GLIS1 GLIS1 ZBTB1 ZBTB1 ATF2 ATF2 YY2 YY2 ZHX3 ZHX3 ZBTB17 ZBTB17 SP1 SP1 JAZF1 JAZF1 ZNF622 ZNF622 BNC2 BNC2 KLF6 KLF6 ZFP64 ZFP64 GLI1 GLI1 MECOM MECOM ZNF521 ZNF521 ZBTB32 ZBTB32 GLI3 GLI3 ZNF692 ZNF692 SP8 SP8 SP3 SP3 SALL4 SALL4 ZNF143 ZNF143 PLAGL2 PLAGL2 FEZF2 FEZF2 ZEB1 ZEB1 KLF3 KLF3 ZHX1 ZHX1 SCRT2 SCRT2 KLF13 KLF13 ZBTB25 ZBTB25 VEZF1 VEZF1 ZMAT2 ZMAT2 BCL11B BCL11B IKZF5 IKZF5 ZMAT3 ZMAT3 RAG1 RAG1 ZIC3 ZIC3 ZNF652 ZNF652 ZBTB44 ZBTB44 ZBTB41 ZBTB41 SNRPC SNRPC ZBTB8A ZBTB8A GFI1B GFI1B TRIT1 TRIT1 PRDM12 PRDM12 KLF2 KLF2 BCL6 BCL6 LOC430697 LOC430697 EGR1 EGR1 SNAI1 SNAI1 ZMAT5 ZMAT5 ZBTB18 ZBTB18 GLI2 GLI2 ZNF367 ZNF367 IKZF3 IKZF3 ZBTB20 ZBTB20 ZFX ZFX WBP4 WBP4 EGR2 EGR2 ZBTB14 ZBTB14 ZBTB26 ZBTB26 KLF9 KLF9 BZFP1 BZFP1 PRMT3 PRMT3 ZBTB5 ZBTB5 ZNF385D ZNF385D ZBED1 ZBED1 PRDM1 PRDM1 HIC2 HIC2 OSR1 OSR1 ZEB2 ZEB2 HIVEP3 HIVEP3 LOC420992 LOC420992 ZFHX4 ZFHX4 RREB1 RREB1 ZBTB7A ZBTB7A DPF1 DPF1 ZNF644 ZNF644 IKZF1 IKZF1 PRDM16 PRDM16 RP1-27O5.3 RP1-27O5.3 ZBTB46 ZBTB46 KLF12 KLF12 ZNF821 ZNF821 PLAG1 PLAG1 LOC107057099 LOC107057099 MTF1 MTF1 DPF3 DPF3 ZNF410 ZNF410 LOC101747670 LOC101747670 ZHX2 ZHX2 ZIC5 ZIC5 CTCF CTCF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ZFPM2Zinc finger protein, FOG family member 2. (1151 aa)
RASAL3Uncharacterized protein. (1938 aa)
GFI1Growth factor independent 1 transcriptional repressor. (405 aa)
LOC425347Uncharacterized protein. (1292 aa)
ZBTB8ALUncharacterized protein. (483 aa)
ZIC1Zinc finger protein ZIC 1; Acts as a transcriptional activator. Involved in neurogenesis. Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3' (By similarity). (444 aa)
ZIC2Zinc finger protein Zic2. (478 aa)
PATZ1POZ/BTB and AT hook containing zinc finger 1. (714 aa)
AEBP2AE binding protein 2. (494 aa)
BCL11AUncharacterized protein. (796 aa)
SP4Sp4 transcription factor. (780 aa)
HIC1Hypermethylated in cancer 1 protein; Binds specifically to the gamma F-1-binding motif of the gamma F-crystallin promoter. May have a regulatory role in sclerotome specification and/or differentiation. Isoform 2 functions as a transcriptional repressor in lens cells; Belongs to the krueppel C2H2-type zinc-finger protein family. Hic subfamily. (665 aa)
KLF15Kruppel like factor 15. (403 aa)
ZNF319Zinc finger protein 319. (554 aa)
ZBTB43Zinc finger and BTB domain containing 43. (464 aa)
SF3A2Splicing factor 3a subunit 2. (315 aa)
ZNF593C2H2-type domain-containing protein. (133 aa)
ZNF276Zinc finger protein 276. (632 aa)
SP2Sp2 transcription factor. (626 aa)
ZFP91Uncharacterized protein. (256 aa)
ZBTB34Uncharacterized protein. (499 aa)
GLIS1GLIS family zinc finger 1. (851 aa)
ZBTB1Zinc finger and BTB domain containing 1. (711 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3') (By similarity); Belongs to the bZIP family. ATF subfamily. (486 aa)
YY2Uncharacterized protein. (420 aa)
ZHX3Zinc fingers and homeoboxes 3. (929 aa)
ZBTB17Zinc finger and BTB domain-containing protein 17; Transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. Plays a critical role in early lymphocyte development, where it is essential to prevent apoptosis in lymphoid precursors, allowing them to survive in response to IL7 and undergo proper lineage commitment. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Required for early embryonic development during gastrul [...] (817 aa)
SP1Transcription factor. (760 aa)
JAZF1Uncharacterized protein. (243 aa)
ZNF622Zinc finger protein 622; May behave as an activator of the bound transcription factor, MYBL2, and be involved in embryonic development. (469 aa)
BNC2Basonuclin 2. (1059 aa)
KLF6KLF6. (283 aa)
ZFP64Uncharacterized protein. (689 aa)
GLI1Zinc finger protein GLI1; Acts as a transcriptional activator. Binds to the DNA consensus sequence 5'-GACCACCCA-3' (By similarity). May regulate the transcription of specific genes during normal development. May play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling. Plays a role in cell proliferation and differentiation via its role in SHH signaling. Belongs to the GLI C2H2-type zinc-finger protein family. (1281 aa)
MECOMMDS1 and EVI1 complex locus. (1245 aa)
ZNF521Zinc finger protein 521. (1419 aa)
ZBTB32Uncharacterized protein. (665 aa)
GLI3Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. (1576 aa)
ZNF692Uncharacterized protein. (522 aa)
SP8Transcription factor Sp8; Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos. Belongs to the Sp1 C2H2-type zinc-finger protein family. (480 aa)
SP3Transcription factor Sp3; Transcriptional factor that can act as an activator or repressor depending on post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box promoters. Weak activator of transcription (By similarity). Required for activation of SPARC transcription; Belongs to the Sp1 C2H2-type zinc-finger protein family. (771 aa)
SALL4Uncharacterized protein. (1108 aa)
ZNF143Zinc finger protein 143. (637 aa)
PLAGL2PLAG1 like zinc finger 2. (494 aa)
FEZF2FEZ family zinc finger 2. (441 aa)
ZEB1Zinc finger E-box-binding homeobox 1; Acts as a transcriptional repressor. Positively regulates neuronal differentiation. Represses transcription by binding to the E box-containing promoter (By similarity). Binds to delta 1-crystallin enhancer core and represses lens-specific transcription. It binds as well many other non-lens specific DNA sequences. (1114 aa)
KLF3Kruppel like factor 3. (347 aa)
ZHX1Zinc fingers and homeoboxes 1. (873 aa)
SCRT2Zinc finger transcription factor. (276 aa)
KLF13Kruppel like factor 13. (277 aa)
ZBTB25Zinc finger and BTB domain containing 25. (434 aa)
VEZF1Uncharacterized protein. (555 aa)
ZMAT2U1-type domain-containing protein. (199 aa)
BCL11BBAF chromatin remodeling complex subunit BCL11B. (884 aa)
IKZF5Zinc finger protein Pegasus; DNA-binding protein that binds to the 5'GNNTGTNG-3' core sequence. Transcriptional repressor (By similarity); Belongs to the Ikaros C2H2-type zinc-finger protein family. (421 aa)
ZMAT3Zinc finger matrin-type 3. (289 aa)
RAG1V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break b [...] (1041 aa)
ZIC3Zinc finger protein Zic3. (464 aa)
ZNF652Zinc finger protein 652. (609 aa)
ZBTB44Zinc finger and BTB domain containing 44. (627 aa)
ZBTB41Zinc finger and BTB domain containing 41. (905 aa)
SNRPCU1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. (160 aa)
ZBTB8AZinc finger and BTB domain containing 8A. (600 aa)
GFI1BZinc finger protein Gfi-1b; Essential transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages. Alters histone methylation by recruiting histone methyltransferase to target genes promoters. Plays a role in heterochromatin formation. (337 aa)
TRIT1tRNA dimethylallyltransferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37; Belongs to the IPP transferase family. (458 aa)
PRDM12PR domain zinc finger protein 12; Involved in the positive regulation of histone H3-K9 dimethylation; Belongs to the class V-like SAM-binding methyltransferase superfamily. (351 aa)
KLF2Kruppel-like factor 2. (380 aa)
BCL6B-cell lymphoma 6 protein homolog; Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, repres [...] (708 aa)
LOC430697Uncharacterized protein. (393 aa)
EGR1Early growth response protein 1; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (By similarity). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Mediates responses to ischemia and hypoxia; regulates the express [...] (510 aa)
SNAI1Snail like protein. (256 aa)
ZMAT5C3H1-type domain-containing protein. (170 aa)
ZBTB18Zinc finger and BTB domain containing 18. (531 aa)
GLI2Zinc finger protein GLI2; Functions as transcription regulator in the hedgehog (Hh) pathway. Functions as transcriptional activator. May also function as transcriptional repressor. Binds to the DNA sequence 5'-GAACCACCCA-3' (By similarity). Is involved in the smoothened (SHH) signaling pathway. Required for normal skeleton development (By similarity). (1528 aa)
ZNF367Zinc finger protein 367. (333 aa)
IKZF3Uncharacterized protein. (509 aa)
ZBTB20Zinc finger and BTB domain containing 20. (669 aa)
ZFXUncharacterized protein. (794 aa)
WBP4WW domain-binding protein 4; Involved in pre-mRNA splicing as a component of the spliceosome. May play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex. (398 aa)
EGR2Zinc-finger transcription factor KROX20. (462 aa)
ZBTB14Zinc finger and BTB domain-containing protein 14; Transcriptional activator of the dopamine transporter (DAT), binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA- 3'. Binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. Transcriptional repressor of MYC and thymidine kinase promoters (By similarity); Belongs to the krueppel C2H2-type zinc-finger protein family. (448 aa)
ZBTB26Uncharacterized protein. (438 aa)
KLF9Kruppel like factor 9. (235 aa)
BZFP1Zinc finger protein CKR1. (471 aa)
PRMT3Uncharacterized protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (526 aa)
ZBTB5Zinc finger and BTB domain containing 5. (673 aa)
ZNF385DUncharacterized protein. (512 aa)
ZBED1Zinc finger BED-type containing 1. (695 aa)
PRDM1PR/SET domain 1. (789 aa)
HIC2Uncharacterized protein. (570 aa)
OSR1Uncharacterized protein. (260 aa)
ZEB2Smad-interacting protein 1. (1214 aa)
HIVEP3Human immunodeficiency virus type I enhancer binding protein 3. (2448 aa)
LOC420992Uncharacterized protein. (479 aa)
ZFHX4Zinc finger homeobox protein 4; May play a role in neural and muscle differentiation (By similarity). May be involved in transcriptional regulation. Belongs to the krueppel C2H2-type zinc-finger protein family. (3595 aa)
RREB1Ras-responsive element-binding protein 1; Transcription factor that binds specifically to the RAS- responsive elements (RRE) of gene promoters. (1698 aa)
ZBTB7AZinc finger and BTB domain-containing protein 7A; Transcription factor that represses the transcription of a wide range of genes involved in cell proliferation and differentiation. Directly and specifically binds to the consensus sequence 5'- [GA][CA]GACCCCCCCCC-3' and represses transcription both by regulating the organization of chromatin and through the direct recruitment of transcription factors to gene regulatory regions (By similarity). May also play a role, independently of its transcriptional activity, in double-strand break repair via classical non-homologous end joining/cNHEJ [...] (753 aa)
DPF1Zinc finger protein neuro-d4; May have an important role in developing neurons by participating in regulation of cell survival, possibly as a neurospecific transcription factor. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex) and plays a role in neural development. (315 aa)
ZNF644Zinc finger protein 644. (1198 aa)
IKZF1DNA-binding protein Ikaros; Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Functions in the specification and the maturation of the T-lymphocyte. Also interacts with a critical control element in the TDT (terminal deoxynucleotidyltransferase) promoter as well as with the promoters for other genes expressed during early stages of B- and T- cell development. Function is isoform-specific and is modulated by dominant-negative inactive isoforms (By similarity). (508 aa)
PRDM16PR/SET domain 16. (1266 aa)
RP1-27O5.3Uncharacterized protein. (475 aa)
ZBTB46Zinc finger and BTB domain containing 46. (799 aa)
KLF12Kruppel like factor 12. (396 aa)
ZNF821Zinc finger protein 821. (411 aa)
PLAG1Zinc finger protein PLAG1; Transcription factor and proto-oncogene whose activation results in up-regulation of target genes, such as IGFII, leading to uncontrolled cell proliferation. (501 aa)
LOC107057099Uncharacterized protein. (534 aa)
MTF1Uncharacterized protein. (729 aa)
DPF3Zinc finger protein DPF3; Muscle-specific component of the BAF complex, a multiprotein complex involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Specifically binds acetylated lysines on histone 3 and 4. In the complex, it acts as a tissue-specific anchor between histone acetylations and methylations and chromatin remodeling. It thereby probably plays an essential role in heart and skeletal muscle development. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex) and plays a role in [...] (391 aa)
ZNF410Uncharacterized protein. (445 aa)
LOC101747670Uncharacterized protein. (557 aa)
ZHX2Zinc fingers and homeoboxes 2. (830 aa)
ZIC5Zic family member 5. (495 aa)
CTCFTranscriptional repressor CTCF; Acts as both a transcriptional activator and repressor of the MYC gene. (739 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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