STRINGSTRING
LDHB LDHB HIBADH HIBADH ADH1C ADH1C NMRAL1 NMRAL1 RDH14 RDH14 ACLY ACLY QDPR QDPR MTHFD2 MTHFD2 HSD17B7 HSD17B7 HTATIP2 HTATIP2 LOC415661 LOC415661 UGDH UGDH HSD17B3 HSD17B3 KCNMA1 KCNMA1 GAPDH GAPDH CTBP1 CTBP1 LOC100858664 LOC100858664 FAR2 FAR2 LOC771069 LOC771069 GLUD2 GLUD2 BLVRA BLVRA GLYR1 GLYR1 FASN FASN SORD SORD HSD11B1b HSD11B1b LOC100857820 LOC100857820 MDH2 MDH2 HSD17B4 HSD17B4 DECR2 DECR2 PGD PGD DCXR DCXR HSDL1 HSDL1 DHRS7B DHRS7B WWOX WWOX DHRS11 DHRS11 BDH1A BDH1A SDR42E2 SDR42E2 SUCLG1 SUCLG1 HPGD HPGD NSDHL NSDHL PTGR2 PTGR2 ERD2L ERD2L KDSR KDSR LOC101748254 LOC101748254 LDHA LDHA CTBPL CTBPL MDH1B MDH1B MDH1 MDH1 STEAP2 STEAP2 RDH11 RDH11 SCCPDH SCCPDH DHRS9 DHRS9 GPD1L GPD1L BDH2 BDH2 GFOD1 GFOD1 HSDL2 HSDL2 TP53I3 TP53I3 FAR1 FAR1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LDHBL-lactate dehydrogenase B chain; Belongs to the LDH/MDH superfamily. LDH family. (333 aa)
HIBADH3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family. (335 aa)
ADH1CAlcohol dehydrogenase 1. (376 aa)
NMRAL1NmrA-like family domain-containing protein 1; Redox sensor protein. Undergoes restructuring and subcellular redistribution in response to changes in intracellular NADPH/NADP(+) levels (By similarity). (296 aa)
RDH14Retinol dehydrogenase 14; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (326 aa)
ACLYATP-citrate synthase; In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family. (1101 aa)
QDPRUncharacterized protein. (238 aa)
MTHFD2Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial; Although its dehydrogenase activity is NAD-specific, it can also utilize NADP at a reduced efficiency. (337 aa)
HSD17B7Uncharacterized protein. (332 aa)
HTATIP2NAD(P)-bd_dom domain-containing protein. (231 aa)
LOC415661NADB-LER3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (259 aa)
UGDHUDP-glucose 6-dehydrogenase; Catalyzes the formation of UDP-alpha-D-glucuronate, a constituent of complex glycosaminoglycans (By similarity). Required for the biosynthesis of chondroitin sulfate and heparan sulfate. Required for embryonic development via its role in the biosynthesis of glycosaminoglycans (By similarity). (494 aa)
HSD17B3Hydroxysteroid 17-beta dehydrogenase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (276 aa)
KCNMA1Calcium-activated potassium channel subunit alpha-1; Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in t [...] (1247 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are proba [...] (333 aa)
CTBP1Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (447 aa)
LOC100858664Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (331 aa)
FAR2Fatty acyl-CoA reductase; Catalyzes the reduction of fatty acyl-CoA to fatty alcohols. (515 aa)
LOC771069NADB-LER2; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (253 aa)
GLUD2Glutamate dehydrogenase 1, mitochondrial; Mitochondrial glutamate dehydrogenase that converts L- glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle (By similarity). (553 aa)
BLVRABiliverdin reductase A; Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor; Belongs to the Gfo/Idh/MocA family. Biliverdin reductase subfamily. (296 aa)
GLYR1Putative oxidoreductase GLYR1; Nucleosome-destabilizing factor that is recruited to genes during transcriptional activation. Facilitates Pol II transcription through nucleosomes. Binds DNA (in vitro). Recognizes and binds trimethylated 'Lys-36' of histone H3 (H3K36me3). Promotes KDM1B demethylase activity. Stimulates the acetylation of 'Lys-56' of nucleosomal histone H3 (H3K56ac) by EP300. Regulates p38 MAP kinase activity by mediating stress activation of p38alpha/MAPK14 and specifically regulating MAPK14 signaling. Indirectly promotes phosphorylation of MAPK14 and activation of ATF2. [...] (553 aa)
FASN3-hydroxyacyl-[acyl-carrier-protein] dehydratase; Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein. (2512 aa)
SORDSorbitol dehydrogenase; Polyol dehydrogenase that catalyzes the reversible NAD(+)- dependent oxidation of various sugar alcohols. Is active with D- sorbitol (D-glucitol) as substrate, leading to the C2-oxidized product D-fructose. Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism (By similarity). (355 aa)
HSD11B1bUncharacterized protein. (301 aa)
LOC100857820NADB-LER1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (259 aa)
MDH2Malate dehydrogenase. (337 aa)
HSD17B417-beta-hydroxysteroid dehydrogenase type IV. (735 aa)
DECR22,4-dienoyl-CoA reductase 2. (348 aa)
PGD6-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (483 aa)
DCXRD-erythrulose reductase; Catalyzes the reduction of D-erythrulose to D-threitol with the concomitant oxidation of NAD(P)H to NAD(P)(+). NADH is less effective than NADPH. May also catalyze the reduction of L-xylulose; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (246 aa)
HSDL1Hydroxysteroid dehydrogenase-like protein 1; May catalyze the metabolism of steroid hormones and thus play an important role in sex differentiation, the emergence and maintenance of the secondary sexual characters, and the regulation of endocrine. Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily. (331 aa)
DHRS7BDehydrogenase/reductase 7B; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (324 aa)
WWOXWW domain-containing oxidoreductase; Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Required for normal bone development. Inhibits Wnt signaling (By similarity). Belongs to the short-chain dehydrogenases/reductases (SDR) family. (414 aa)
DHRS11Dehydrogenase/reductase SDR family member 11; Catalyzes the conversion of the 17-keto group of estrone, 4- and 5-androstenes and 5-alpha-androstanes into their 17-beta- hydroxyl metabolites and the conversion of the 3-keto group of 3-, 3,17- and 3,20- diketosteroids into their 3-hydroxyl metabolites. Exhibits reductive 3-beta-hydroxysteroid dehydrogenase activity toward 5-beta-androstanes, 5-beta-pregnanes, 4-pregnenes and bile acids. May also reduce endogenous and exogenous alpha-dicarbonyl compounds and xenobiotic alicyclic ketones. (255 aa)
BDH1AD-beta-hydroxybutyrate dehydrogenase, mitochondrial; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (343 aa)
SDR42E23Beta_HSD domain-containing protein. (454 aa)
SUCLG1Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. (331 aa)
HPGDUncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (265 aa)
NSDHLNAD(P) dependent steroid dehydrogenase-like; Belongs to the 3-beta-HSD family. (346 aa)
PTGR2PKS_ER domain-containing protein. (347 aa)
ERD2LUncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (305 aa)
KDSRUncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (224 aa)
LOC101748254Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (238 aa)
LDHAL-lactate dehydrogenase A chain; Belongs to the LDH/MDH superfamily. LDH family. (332 aa)
CTBPLUncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (440 aa)
MDH1BMalate dehydrogenase 1B. (476 aa)
MDH1Malate dehydrogenase, cytoplasmic. (535 aa)
STEAP2STEAP2 metalloreductase. (489 aa)
RDH11Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (326 aa)
SCCPDHSacchrp_dh_NADP domain-containing protein. (434 aa)
DHRS9Dehydrogenase/reductase 9; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (322 aa)
GPD1LGlycerol-3-phosphate dehydrogenase [NAD(+)]. (353 aa)
BDH23-hydroxybutyrate dehydrogenase 2. (245 aa)
GFOD1Glucose-fructose oxidoreductase domain containing 1. (390 aa)
HSDL2Hydroxysteroid dehydrogenase like 2. (413 aa)
TP53I3Tumor protein p53 inducible protein 3. (370 aa)
FAR1Fatty acyl-CoA reductase 1; Catalyzes the reduction of saturated and unsaturated C16 or C18 fatty acyl-CoA to fatty alcohols. It plays an essential role in the production of ether lipids/plasmalogens which synthesis requires fatty alcohols. In parallel, it is also required for wax monoesters production since fatty alcohols also constitute a substrate for their synthesis. (515 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
Server load: medium (52%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.