STRINGSTRING
IRF1 IRF1 FOXM1 FOXM1 DEPDC1B DEPDC1B FOXO3 FOXO3 ASCC3 ASCC3 GABPA GABPA ASMT ASMT ASMTL ASMTL E2F6 E2F6 ETV6 ETV6 E2F3 E2F3 IRF7 IRF7 PSMD12 PSMD12 FOXE3 FOXE3 FOXP1 FOXP1 FOXA2 FOXA2 FOXL2 FOXL2 ELL2 ELL2 CUL1 CUL1 SPI1 SPI1 ERG ERG HIST1H103 HIST1H103 PA2G4 PA2G4 IRF5 IRF5 FOXA1 FOXA1 FLI1 FLI1 EIF3E EIF3E H1-10 H1-10 DEPDC6 DEPDC6 ETV1 ETV1 RAD21 RAD21 RAPGEF4 RAPGEF4 PSMD13 PSMD13 FOXG1 FOXG1 ELL ELL IRF2 IRF2 HIST1H110 HIST1H110 HSF3 HSF3 ELK3 ELK3 RGS7 RGS7 HIST1H101 HIST1H101 HSF1 HSF1 COPS3 COPS3 DEPDC1 DEPDC1 SPIC SPIC ETS2 ETS2 CDC6 CDC6 ADAR ADAR HSF2 HSF2 RFX3 RFX3 COPS2 COPS2 RPA2 RPA2 ETS1 ETS1 SNF8 SNF8 DVL1 DVL1 E2F4 E2F4 E2F1 E2F1 FOXN4 FOXN4 IRF8 IRF8 ETV5 ETV5 DEPTOR DEPTOR BLM BLM PIKFYVE PIKFYVE FOXN2 FOXN2 PLEK2 PLEK2 HP1BP3 HP1BP3 GTF2E2 GTF2E2 COPS4 COPS4 METAP2 METAP2 HISTH1 HISTH1 HIST1H111L HIST1H111L LARP7 LARP7 EIF3M EIF3M IRF4 IRF4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IRF1Interferon regulatory factor 1; Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and activates those genes. Acts as a tumor suppressor (By similarity); Belongs to the IRF family. (414 aa)
FOXM1Fork-head domain-containing protein. (795 aa)
DEPDC1BDEP domain-containing protein 1B. (563 aa)
FOXO3Forkhead box O3. (660 aa)
ASCC3Activating signal cointegrator 1 complex subunit 3; 3'-5' DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3, enabling ALKBH3 to process alkylated N3-methylcytosine (3mC) within double-stranded regions. (2211 aa)
GABPAUncharacterized protein. (455 aa)
ASMTAcetylserotonin O-methyltransferase; Catalyzes the transfer of a methyl group onto N- acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine). Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family. (346 aa)
ASMTLAcetylserotonin O-methyltransferase like. (634 aa)
E2F6E2F_TDP domain-containing protein. (252 aa)
ETV6Uncharacterized protein. (451 aa)
E2F3E2F transcription factor 3. (341 aa)
IRF7Interferon regulatory factor 3; Key transcriptional regulator of type I interferon (IFN)- dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN- stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. May activate transcription by complex formation with other transcriptional factors, possibly members of the STAT family. Binds specifically to the IFN-stimulated response element (ISRE) but not to the [...] (491 aa)
PSMD12PCI domain-containing protein. (456 aa)
FOXE3Forkhead box protein D3; Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri- implantation stages of embryogenesis. (386 aa)
FOXP1Forkhead box protein P1; Transcriptional repressor. (686 aa)
FOXA2Fork-head domain-containing protein. (438 aa)
FOXL2Transcription factor FOXL2. (305 aa)
ELL2Elongation factor for RNA polymerase II 2. (679 aa)
CUL1Cullin 1; Belongs to the cullin family. (776 aa)
SPI1ETS domain-containing protein. (266 aa)
ERGTranscriptional regulator Erg; Acts as a transcriptional activator. (485 aa)
HIST1H103Histone H1.03; Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. (224 aa)
PA2G4Peptidase_M24 domain-containing protein. (394 aa)
IRF5IRF tryptophan pentad repeat domain-containing protein. (472 aa)
FOXA1Forkhead box A1. (442 aa)
FLI1Uncharacterized protein. (432 aa)
EIF3EEukaryotic translation initiation factor 3 subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (462 aa)
H1-10H1 histone family member X. (215 aa)
DEPDC6Uncharacterized protein. (397 aa)
ETV1Ets domain protein. (477 aa)
RAD21Uncharacterized protein. (633 aa)
RAPGEF4Rap guanine nucleotide exchange factor 4. (1026 aa)
PSMD1326S proteasome non-ATPase regulatory subunit 13; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. (376 aa)
FOXG1Forkhead box protein G1; May determine the nasotemporal axis of the retina, and consequently specify the topographical projection of the retinal ganglion-cell axons to the tectum by controlling expression of their target genes. (451 aa)
ELLUncharacterized protein. (610 aa)
IRF2Interferon regulatory factor 2; Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation (By similarity). (414 aa)
HIST1H110Histone H1.10; Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. (220 aa)
HSF3Heat shock factor protein 3; DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. HSF3 binds DNA constitutively only when the C-terminal region is deleted; Belongs to the HSF family. (551 aa)
ELK3ETS domain-containing protein. (407 aa)
RGS7Uncharacterized protein. (506 aa)
HIST1H101Histone H1.01; Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. (220 aa)
HSF1Heat shock factor protein 1; Functions as a stress-inducible and DNA-binding transcription factor that plays a central role in the transcriptional activation of the heat shock response (HSR), leading to the expression of a large class of molecular chaperones heat shock proteins (HSPs) that protect cells from cellular insults' damage. In unstressed cells, is present in a HSP90-containing multichaperone complex that maintains it in a non-DNA-binding inactivated monomeric form. Upon exposure to heat and other stress stimuli, undergoes homotrimerization and activates HSP gene transcription [...] (343 aa)
COPS3COP9 signalosome complex subunit 3; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity (By similarity). (423 aa)
DEPDC1DEP domain-containing protein. (812 aa)
SPICSpi-C transcription factor. (251 aa)
ETS2Protein C-ets-2; Probable transcription factor; Belongs to the ETS family. (479 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (554 aa)
ADARRNA-specific Adenosine deaminase Transcript variant M. (1153 aa)
HSF2Heat shock factor protein 2; DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. HSF2 shows constitutive DNA binding activity, even without heat shock. (596 aa)
RFX3Regulatory factor X3. (749 aa)
COPS2PCI domain-containing protein. (443 aa)
RPA2RPA_C domain-containing protein. (267 aa)
ETS1Transforming protein p68/c-ets-1; Probable transcription factor. (497 aa)
SNF8Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family. (258 aa)
DVL1Dishevelled segment polarity protein 1. (529 aa)
E2F4E2F transcription factor 4. (414 aa)
E2F1Transcription factor E2F1; Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA bindi [...] (403 aa)
FOXN4Forkhead box N4. (513 aa)
IRF8Interferon regulatory factor 8; Plays a role as a transcriptional activator or repressor. Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a regulatory role in cells of the immune system (By similarity); Belongs to the IRF family. (425 aa)
ETV5ETS domain-containing protein. (507 aa)
DEPTORUncharacterized protein. (413 aa)
BLMBloom syndrome protein homolog; ATP-dependent DNA helicase that unwinds single- and double- stranded DNA in a 3'-5' direction. Participates in DNA replication and repair (By similarity). Involved in 5'-end resection of DNA during double-strand break (DSB) repair (By similarity). Negatively regulates sister chromatid exchange (SCE) (By similarity). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution (By similarity). Binds DNA. Binds single-stranded DNA (ssDNA), forked duplex DNA and DNA Holliday junction (By similarity). Belongs to the helicase family. R [...] (1380 aa)
PIKFYVEPhosphoinositide kinase, FYVE-type zinc finger containing. (2118 aa)
FOXN2Fork-head domain-containing protein. (438 aa)
PLEK2Uncharacterized protein. (355 aa)
HP1BP3Heterochromatin protein 1-binding protein 3; Component of heterochromatin that maintains heterochromatin integrity during G1/S progression and regulates the duration of G1 phase to critically influence cell proliferative capacity. (559 aa)
GTF2E2Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. (290 aa)
COPS4PCI domain-containing protein. (411 aa)
METAP2Methionine aminopeptidase 2; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily. (479 aa)
HISTH1Histone H1; Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. (305 aa)
HIST1H111LHistone H1.11R; Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. (219 aa)
LARP7La ribonucleoprotein domain family member 7. (647 aa)
EIF3MEukaryotic translation initiation factor 3 subunit M; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (374 aa)
IRF4Interferon regulatory factor 4. (445 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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