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BCL2 | Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). (233 aa) | ||||
BCL2L1 | Bcl-2-like protein 1; Dominant regulator of apoptotic cell death. The long form displays cell death repressor activity, whereas the short isoform promotes apoptosis. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis (By similarity). (229 aa) | ||||
BOK | Bcl-2-related ovarian killer protein; May play a role in apoptosis; Belongs to the Bcl-2 family. (213 aa) | ||||
BAK1 | Uncharacterized protein. (216 aa) | ||||
BID | BH3-interacting domain death agonist; Induces caspases and apoptosis. Counters the protective effect of Bcl-2 (By similarity). (300 aa) | ||||
BCL2A1 | Protein A1. (174 aa) | ||||
BCL2L10 | Anti-apoptotic protein NR13; Shows anti-apoptotic properties. Counteract the pro-apoptotic activity of BAX; Belongs to the Bcl-2 family. (177 aa) |