(6 nodes) Bcl-2, Bcl-2 homology region 1-3 network (Gallus gallus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	BOK	Bcl-2-related ovarian killer protein; May play a role in apoptosis; Belongs to the Bcl-2 family. (213 aa)
	BAK1	Uncharacterized protein. (216 aa)
	BCL2L1	Bcl-2-like protein 1; Dominant regulator of apoptotic cell death. The long form displays cell death repressor activity, whereas the short isoform promotes apoptosis. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis (By similarity). (229 aa)
	BCL2L10	Anti-apoptotic protein NR13; Shows anti-apoptotic properties. Counteract the pro-apoptotic activity of BAX; Belongs to the Bcl-2 family. (177 aa)
	BCL2	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). (233 aa)
	BCL2A1	Protein A1. (174 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BAK1	BCL2	ENSGALP00000055311	ENSGALP00000020984	Uncharacterized protein.	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).	0.985
BAK1	BCL2A1	ENSGALP00000055311	ENSGALP00000010509	Uncharacterized protein.	Protein A1.	0.937
BAK1	BCL2L1	ENSGALP00000055311	ENSGALP00000054103	Uncharacterized protein.	Bcl-2-like protein 1; Dominant regulator of apoptotic cell death. The long form displays cell death repressor activity, whereas the short isoform promotes apoptosis. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis (By similarity).	0.996
BAK1	BCL2L10	ENSGALP00000055311	ENSGALP00000053183	Uncharacterized protein.	Anti-apoptotic protein NR13; Shows anti-apoptotic properties. Counteract the pro-apoptotic activity of BAX; Belongs to the Bcl-2 family.	0.639
BCL2	BAK1	ENSGALP00000020984	ENSGALP00000055311	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).	Uncharacterized protein.	0.985
BCL2	BCL2L1	ENSGALP00000020984	ENSGALP00000054103	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).	Bcl-2-like protein 1; Dominant regulator of apoptotic cell death. The long form displays cell death repressor activity, whereas the short isoform promotes apoptosis. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis (By similarity).	0.972
BCL2	BCL2L10	ENSGALP00000020984	ENSGALP00000053183	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).	Anti-apoptotic protein NR13; Shows anti-apoptotic properties. Counteract the pro-apoptotic activity of BAX; Belongs to the Bcl-2 family.	0.566
BCL2	BOK	ENSGALP00000020984	ENSGALP00000071746	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).	Bcl-2-related ovarian killer protein; May play a role in apoptosis; Belongs to the Bcl-2 family.	0.628
BCL2A1	BAK1	ENSGALP00000010509	ENSGALP00000055311	Protein A1.	Uncharacterized protein.	0.937
BCL2A1	BCL2L10	ENSGALP00000010509	ENSGALP00000053183	Protein A1.	Anti-apoptotic protein NR13; Shows anti-apoptotic properties. Counteract the pro-apoptotic activity of BAX; Belongs to the Bcl-2 family.	0.495
BCL2L1	BAK1	ENSGALP00000054103	ENSGALP00000055311	Bcl-2-like protein 1; Dominant regulator of apoptotic cell death. The long form displays cell death repressor activity, whereas the short isoform promotes apoptosis. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis (By similarity).	Uncharacterized protein.	0.996
BCL2L1	BCL2	ENSGALP00000054103	ENSGALP00000020984	Bcl-2-like protein 1; Dominant regulator of apoptotic cell death. The long form displays cell death repressor activity, whereas the short isoform promotes apoptosis. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis (By similarity).	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).	0.972
BCL2L1	BCL2L10	ENSGALP00000054103	ENSGALP00000053183	Bcl-2-like protein 1; Dominant regulator of apoptotic cell death. The long form displays cell death repressor activity, whereas the short isoform promotes apoptosis. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis (By similarity).	Anti-apoptotic protein NR13; Shows anti-apoptotic properties. Counteract the pro-apoptotic activity of BAX; Belongs to the Bcl-2 family.	0.583
BCL2L10	BAK1	ENSGALP00000053183	ENSGALP00000055311	Anti-apoptotic protein NR13; Shows anti-apoptotic properties. Counteract the pro-apoptotic activity of BAX; Belongs to the Bcl-2 family.	Uncharacterized protein.	0.639
BCL2L10	BCL2	ENSGALP00000053183	ENSGALP00000020984	Anti-apoptotic protein NR13; Shows anti-apoptotic properties. Counteract the pro-apoptotic activity of BAX; Belongs to the Bcl-2 family.	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).	0.566
BCL2L10	BCL2A1	ENSGALP00000053183	ENSGALP00000010509	Anti-apoptotic protein NR13; Shows anti-apoptotic properties. Counteract the pro-apoptotic activity of BAX; Belongs to the Bcl-2 family.	Protein A1.	0.495
BCL2L10	BCL2L1	ENSGALP00000053183	ENSGALP00000054103	Anti-apoptotic protein NR13; Shows anti-apoptotic properties. Counteract the pro-apoptotic activity of BAX; Belongs to the Bcl-2 family.	Bcl-2-like protein 1; Dominant regulator of apoptotic cell death. The long form displays cell death repressor activity, whereas the short isoform promotes apoptosis. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis (By similarity).	0.583
BCL2L10	BOK	ENSGALP00000053183	ENSGALP00000071746	Anti-apoptotic protein NR13; Shows anti-apoptotic properties. Counteract the pro-apoptotic activity of BAX; Belongs to the Bcl-2 family.	Bcl-2-related ovarian killer protein; May play a role in apoptosis; Belongs to the Bcl-2 family.	0.511
BOK	BCL2	ENSGALP00000071746	ENSGALP00000020984	Bcl-2-related ovarian killer protein; May play a role in apoptosis; Belongs to the Bcl-2 family.	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).	0.628
BOK	BCL2L10	ENSGALP00000071746	ENSGALP00000053183	Bcl-2-related ovarian killer protein; May play a role in apoptosis; Belongs to the Bcl-2 family.	Anti-apoptotic protein NR13; Shows anti-apoptotic properties. Counteract the pro-apoptotic activity of BAX; Belongs to the Bcl-2 family.	0.511