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CYP2AC7 CYP2AC7 CYP1A2 CYP1A2 DM5L DM5L MOXD1 MOXD1 CYP2W1-2 CYP2W1-2 CYP3A4 CYP3A4 CYP3A5 CYP3A5 CYP2C18 CYP2C18 CYP2C23b CYP2C23b CYP2R1 CYP2R1 COQ7 COQ7 KMO KMO CYP2AB2 CYP2AB2 CYP2AB1 CYP2AB1 COQ6 COQ6 CYP4B7 CYP4B7 CYP46A1 CYP46A1 CYP2J19 CYP2J19 CYP27C1 CYP27C1 CYP2D6 CYP2D6 CYP4V2 CYP4V2 CYP26B1 CYP26B1 CYP2AC1 CYP2AC1 TYR TYR DOHH DOHH CYP17A1 CYP17A1 TYRP1 TYRP1 CYP1A1 CYP1A1 CYP2C23a CYP2C23a CYP2U1 CYP2U1 CYP21A1 CYP21A1 CYP26A1 CYP26A1 CYP1B1 CYP1B1 CYP11A1 CYP11A1 FMO5 FMO5 PRRC2C-2 PRRC2C-2 FMO3 FMO3 RP11-400G3.5 RP11-400G3.5 CYP1C1 CYP1C1 LOC101749846 LOC101749846 CYP26C1 CYP26C1 CYP2J21 CYP2J21 CYP2W1 CYP2W1 CYP2J22 CYP2J22 CYP2J23 CYP2J23 TPH1 TPH1 CYP2AC2 CYP2AC2 CYP2AB3 CYP2AB3 CYP51A1 CYP51A1 CYP39A1 CYP39A1 CYP19A1 CYP19A1 TBXAS1 TBXAS1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CYP2AC7Uncharacterized protein; Belongs to the cytochrome P450 family. (501 aa)
CYP1A2Cytochrome P450 1A5; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (530 aa)
DM5LDimethylaniline monooxygenase [N-oxide-forming]. (535 aa)
MOXD1DBH-like monooxygenase protein 1. (614 aa)
CYP2W1-2Uncharacterized protein; Belongs to the cytochrome P450 family. (500 aa)
CYP3A4Uncharacterized protein; Belongs to the cytochrome P450 family. (540 aa)
CYP3A5Uncharacterized protein. (508 aa)
CYP2C18Uncharacterized protein; Belongs to the cytochrome P450 family. (494 aa)
CYP2C23bCytochrome P450 2H2; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (491 aa)
CYP2R1Cytochrome P450 family 2 subfamily R member 1; Belongs to the cytochrome P450 family. (646 aa)
COQ75-demethoxyubiquinone hydroxylase, mitochondrial; Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone- independent manner. (229 aa)
KMOKynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid. (486 aa)
CYP2AB2Uncharacterized protein; Belongs to the cytochrome P450 family. (488 aa)
CYP2AB1Uncharacterized protein; Belongs to the cytochrome P450 family. (489 aa)
COQ6Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. (486 aa)
CYP4B7Uncharacterized protein; Belongs to the cytochrome P450 family. (504 aa)
CYP46A1Uncharacterized protein; Belongs to the cytochrome P450 family. (499 aa)
CYP2J19Uncharacterized protein; Belongs to the cytochrome P450 family. (490 aa)
CYP27C1Cytochrome P450 family 27 subfamily C member 1; Belongs to the cytochrome P450 family. (416 aa)
CYP2D6Cytochrome P450 CYP2D49; Belongs to the cytochrome P450 family. (502 aa)
CYP4V2Uncharacterized protein; Belongs to the cytochrome P450 family. (530 aa)
CYP26B1Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (511 aa)
CYP2AC1Uncharacterized protein; Belongs to the cytochrome P450 family. (494 aa)
TYRTyrosinase; This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone. (537 aa)
DOHHDeoxyhypusine hydroxylase; Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L- lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF- 5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function. (299 aa)
CYP17A1Steroid 17-alpha-hydroxylase/17,20 lyase; Conversion of pregnenolone and progesterone to their 17- alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. (527 aa)
TYRP15,6-dihydroxyindole-2-carboxylic acid oxidase; Plays a role in melanin biosynthesis. Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6- quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized. Also to a lower extent, capable of hydroxylating tyrosine and producing melanin. (536 aa)
CYP1A1Cytochrome P450 1A4; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (530 aa)
CYP2C23aCytochrome P450 2H1; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (491 aa)
CYP2U1Cytochrome P450 family 2 subfamily U member 1; Belongs to the cytochrome P450 family. (524 aa)
CYP21A1Steroid 21-hydroxylase; Belongs to the cytochrome P450 family. (478 aa)
CYP26A1Cytochrome P450 26A1; A cytochrome P450 monooxygenase involved in the metabolism of all-trans retinoic acid (atRA), a signaling molecule that binds to retinoic acid receptors and regulates gene transcription. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds of atRA primarily at C-4. Has no activity toward 9-cis and 13-cis retinoic acid stereoisomer [...] (492 aa)
CYP1B1Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (536 aa)
CYP11A1Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] (508 aa)
FMO5Flavin-containing monooxygenase. (277 aa)
PRRC2C-2Flavin-containing monooxygenase. (126 aa)
FMO3Dimethylaniline monooxygenase [N-oxide-forming]. (530 aa)
RP11-400G3.5Uncharacterized protein; Belongs to the cytochrome P450 family. (494 aa)
CYP1C1Uncharacterized protein; Belongs to the cytochrome P450 family. (516 aa)
LOC101749846Uncharacterized protein; Belongs to the cytochrome P450 family. (668 aa)
CYP26C1Cytochrome P450 family 26 subfamily C member 1; Belongs to the cytochrome P450 family. (510 aa)
CYP2J21Uncharacterized protein; Belongs to the cytochrome P450 family. (558 aa)
CYP2W1Cytochrome P450 family 2 subfamily W member 1; Belongs to the cytochrome P450 family. (505 aa)
CYP2J22Uncharacterized protein; Belongs to the cytochrome P450 family. (491 aa)
CYP2J23Uncharacterized protein; Belongs to the cytochrome P450 family. (491 aa)
TPH1Tryptophan 5-hydroxylase 1; Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. (475 aa)
CYP2AC2Uncharacterized protein; Belongs to the cytochrome P450 family. (496 aa)
CYP2AB3Uncharacterized protein; Belongs to the cytochrome P450 family. (488 aa)
CYP51A1Uncharacterized protein; Belongs to the cytochrome P450 family. (496 aa)
CYP39A1Cytochrome P450 family 39 subfamily A member 1; Belongs to the cytochrome P450 family. (466 aa)
CYP19A1Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. (502 aa)
TBXAS1Thromboxane A synthase 1; Belongs to the cytochrome P450 family. (535 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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