(11 nodes) (2001) Anaphase-promoting complexcyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint. network (Gallus gallus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	CDC27	Uncharacterized protein. (833 aa)
	CDC6	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (554 aa)
	CDK2	Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
	CACUL1	Cullin domain-containing protein; Belongs to the cullin family. (377 aa)
	CCNA1	Cyclin A1; Belongs to the cyclin family. (406 aa)
	CCNA2	Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. (395 aa)
	BUB1	Uncharacterized protein. (1087 aa)
	SKP1	S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1 (By similarity). (163 aa)
	CCNB1	G2/mitotic-specific cyclin-B2; Essential for the control of the cell cycle at the G2/M (mitosis) transition. (399 aa)
	CDK1	Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle (By similarity). It is required in higher cells for entry into S-phase and mitosis (By similarity). p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II (By similarity). May play a role in regulating the amplitude of the cyclic expression of circadian clock genes (By similarity). Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. (303 aa)
	PTTG2	Uncharacterized protein. (193 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BUB1	CCNA1	ENSGALP00000013385	ENSGALP00000027497	Uncharacterized protein.	Cyclin A1; Belongs to the cyclin family.	0.815
BUB1	CCNA2	ENSGALP00000013385	ENSGALP00000019361	Uncharacterized protein.	Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle.	0.933
BUB1	CCNB1	ENSGALP00000013385	ENSGALP00000006605	Uncharacterized protein.	G2/mitotic-specific cyclin-B2; Essential for the control of the cell cycle at the G2/M (mitosis) transition.	0.947
BUB1	CDC27	ENSGALP00000013385	ENSGALP00000000830	Uncharacterized protein.	Uncharacterized protein.	0.896
BUB1	CDC6	ENSGALP00000013385	ENSGALP00000067395	Uncharacterized protein.	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	0.710
BUB1	CDK1	ENSGALP00000013385	ENSGALP00000004867	Uncharacterized protein.	Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle (By similarity). It is required in higher cells for entry into S-phase and mitosis (By similarity). p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II (By similarity). May play a role in regulating the amplitude of the cyclic expression of circadian clock genes (By similarity). Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.	0.993
BUB1	CDK2	ENSGALP00000013385	ENSGALP00000056613	Uncharacterized protein.	Cyclin dependent kinase 2; Belongs to the protein kinase superfamily.	0.523
BUB1	PTTG2	ENSGALP00000013385	ENSGALP00000002289	Uncharacterized protein.	Uncharacterized protein.	0.909
CACUL1	CDC27	ENSGALP00000055119	ENSGALP00000000830	Cullin domain-containing protein; Belongs to the cullin family.	Uncharacterized protein.	0.684
CACUL1	SKP1	ENSGALP00000055119	ENSGALP00000010447	Cullin domain-containing protein; Belongs to the cullin family.	S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1 (By similarity).	0.817
CCNA1	BUB1	ENSGALP00000027497	ENSGALP00000013385	Cyclin A1; Belongs to the cyclin family.	Uncharacterized protein.	0.815
CCNA1	CCNA2	ENSGALP00000027497	ENSGALP00000019361	Cyclin A1; Belongs to the cyclin family.	Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle.	0.936
CCNA1	CCNB1	ENSGALP00000027497	ENSGALP00000006605	Cyclin A1; Belongs to the cyclin family.	G2/mitotic-specific cyclin-B2; Essential for the control of the cell cycle at the G2/M (mitosis) transition.	0.785
CCNA1	CDC27	ENSGALP00000027497	ENSGALP00000000830	Cyclin A1; Belongs to the cyclin family.	Uncharacterized protein.	0.891
CCNA1	CDC6	ENSGALP00000027497	ENSGALP00000067395	Cyclin A1; Belongs to the cyclin family.	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	0.995
CCNA1	CDK1	ENSGALP00000027497	ENSGALP00000004867	Cyclin A1; Belongs to the cyclin family.	Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle (By similarity). It is required in higher cells for entry into S-phase and mitosis (By similarity). p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II (By similarity). May play a role in regulating the amplitude of the cyclic expression of circadian clock genes (By similarity). Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.	0.998
CCNA1	CDK2	ENSGALP00000027497	ENSGALP00000056613	Cyclin A1; Belongs to the cyclin family.	Cyclin dependent kinase 2; Belongs to the protein kinase superfamily.	0.999
CCNA1	PTTG2	ENSGALP00000027497	ENSGALP00000002289	Cyclin A1; Belongs to the cyclin family.	Uncharacterized protein.	0.789
CCNA1	SKP1	ENSGALP00000027497	ENSGALP00000010447	Cyclin A1; Belongs to the cyclin family.	S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1 (By similarity).	0.930
CCNA2	BUB1	ENSGALP00000019361	ENSGALP00000013385	Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle.	Uncharacterized protein.	0.933