14 items (Gallus gallus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

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Predicted Interactions

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co-expression

protein homology

Your Input:
	BACH2	BTB domain and CNC homolog 2. (850 aa)
	RHOBTB1	Uncharacterized protein. (694 aa)
	BTBD1	BTB domain-containing protein. (376 aa)
	BTBD3	BTB domain containing 3. (520 aa)
	RBX1	RING-type domain-containing protein. (108 aa)
	RHOBTB3	Rho related BTB domain containing 3. (618 aa)
	CISH	Cytokine-inducible SH2-containing protein; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasom [...] (258 aa)
	BTBD6	BTB domain containing 6. (530 aa)
	CUL1	Cullin 1; Belongs to the cullin family. (776 aa)
	RHOBTB2	Rho related BTB domain containing 2. (362 aa)
	CUL2	CULLIN_2 domain-containing protein; Belongs to the cullin family. (774 aa)
	CACUL1	Cullin domain-containing protein; Belongs to the cullin family. (377 aa)
	TCEB1	Skp1_POZ domain-containing protein; Belongs to the SKP1 family. (112 aa)
	ZBTB7A	Zinc finger and BTB domain-containing protein 7A; Transcription factor that represses the transcription of a wide range of genes involved in cell proliferation and differentiation. Directly and specifically binds to the consensus sequence 5'- [GA][CA]GACCCCCCCCC-3' and represses transcription both by regulating the organization of chromatin and through the direct recruitment of transcription factors to gene regulatory regions (By similarity). May also play a role, independently of its transcriptional activity, in double-strand break repair via classical non-homologous end joining/cNHEJ [...] (753 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BTBD1	BTBD6	ENSGALP00000009678	ENSGALP00000043947	BTB domain-containing protein.	BTB domain containing 6.	0.486
BTBD1	CUL1	ENSGALP00000009678	ENSGALP00000046909	BTB domain-containing protein.	Cullin 1; Belongs to the cullin family.	0.545
BTBD1	CUL2	ENSGALP00000009678	ENSGALP00000050746	BTB domain-containing protein.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.517
BTBD1	RBX1	ENSGALP00000009678	ENSGALP00000019539	BTB domain-containing protein.	RING-type domain-containing protein.	0.493
BTBD1	TCEB1	ENSGALP00000009678	ENSGALP00000055188	BTB domain-containing protein.	Skp1_POZ domain-containing protein; Belongs to the SKP1 family.	0.505
BTBD6	BTBD1	ENSGALP00000043947	ENSGALP00000009678	BTB domain containing 6.	BTB domain-containing protein.	0.486
BTBD6	CUL2	ENSGALP00000043947	ENSGALP00000050746	BTB domain containing 6.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.589
BTBD6	RBX1	ENSGALP00000043947	ENSGALP00000019539	BTB domain containing 6.	RING-type domain-containing protein.	0.568
BTBD6	RHOBTB1	ENSGALP00000043947	ENSGALP00000004845	BTB domain containing 6.	Uncharacterized protein.	0.550
BTBD6	RHOBTB2	ENSGALP00000043947	ENSGALP00000049275	BTB domain containing 6.	Rho related BTB domain containing 2.	0.584
BTBD6	RHOBTB3	ENSGALP00000043947	ENSGALP00000023601	BTB domain containing 6.	Rho related BTB domain containing 3.	0.551
BTBD6	TCEB1	ENSGALP00000043947	ENSGALP00000055188	BTB domain containing 6.	Skp1_POZ domain-containing protein; Belongs to the SKP1 family.	0.610
BTBD6	ZBTB7A	ENSGALP00000043947	ENSGALP00000070348	BTB domain containing 6.	Zinc finger and BTB domain-containing protein 7A; Transcription factor that represses the transcription of a wide range of genes involved in cell proliferation and differentiation. Directly and specifically binds to the consensus sequence 5'- [GA][CA]GACCCCCCCCC-3' and represses transcription both by regulating the organization of chromatin and through the direct recruitment of transcription factors to gene regulatory regions (By similarity). May also play a role, independently of its transcriptional activity, in double-strand break repair via classical non-homologous end joining/cNHEJ [...]	0.436
CACUL1	RBX1	ENSGALP00000055119	ENSGALP00000019539	Cullin domain-containing protein; Belongs to the cullin family.	RING-type domain-containing protein.	0.709
CACUL1	TCEB1	ENSGALP00000055119	ENSGALP00000055188	Cullin domain-containing protein; Belongs to the cullin family.	Skp1_POZ domain-containing protein; Belongs to the SKP1 family.	0.487
CISH	CUL1	ENSGALP00000003536	ENSGALP00000046909	Cytokine-inducible SH2-containing protein; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasom [...]	Cullin 1; Belongs to the cullin family.	0.436
CISH	CUL2	ENSGALP00000003536	ENSGALP00000050746	Cytokine-inducible SH2-containing protein; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasom [...]	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.845
CISH	RBX1	ENSGALP00000003536	ENSGALP00000019539	Cytokine-inducible SH2-containing protein; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasom [...]	RING-type domain-containing protein.	0.647
CISH	TCEB1	ENSGALP00000003536	ENSGALP00000055188	Cytokine-inducible SH2-containing protein; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasom [...]	Skp1_POZ domain-containing protein; Belongs to the SKP1 family.	0.973
CUL1	BTBD1	ENSGALP00000046909	ENSGALP00000009678	Cullin 1; Belongs to the cullin family.	BTB domain-containing protein.	0.545