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TESC TESC ADAM22 ADAM22 CYP19A1 CYP19A1 CYP2J23 CYP2J23 CYP4B7 CYP4B7 CYP4A22 CYP4A22 CYP2D6 CYP2D6 CYP17A1 CYP17A1 CYP1A1 CYP1A1 HSD11B2 HSD11B2 CYP1B1 CYP1B1 RP11-400G3.5 RP11-400G3.5 CYP2J22 CYP2J22 CYP1A2 CYP1A2 RGS18 RGS18 STAR STAR CYP3A4 CYP3A4 CYP3A5 CYP3A5 CYP2C18 CYP2C18 ETV5 ETV5 TFRC TFRC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
TESCCalcineurin B homologous protein 3; Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Promotes the induction of hematopoietic stem cell differentiation toward megakaryocytic lineage. Essential for the coupling of ERK cascade activation with the expression of ETS family genes in megakaryocytic differentiation. Also involved in granulocytic differentiation in a ERK-dependent manner. Inhibits the phosphatase activity of calcineurin (By similarity). (214 aa)
ADAM22ADAM metallopeptidase domain 22. (967 aa)
CYP19A1Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. (502 aa)
CYP2J23Uncharacterized protein; Belongs to the cytochrome P450 family. (491 aa)
CYP4B7Uncharacterized protein; Belongs to the cytochrome P450 family. (504 aa)
CYP4A22Uncharacterized protein. (507 aa)
CYP2D6Cytochrome P450 CYP2D49; Belongs to the cytochrome P450 family. (502 aa)
CYP17A1Steroid 17-alpha-hydroxylase/17,20 lyase; Conversion of pregnenolone and progesterone to their 17- alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. (527 aa)
CYP1A1Cytochrome P450 1A4; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (530 aa)
HSD11B2Hydroxysteroid 11-beta dehydrogenase 2. (349 aa)
CYP1B1Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (536 aa)
RP11-400G3.5Uncharacterized protein; Belongs to the cytochrome P450 family. (494 aa)
CYP2J22Uncharacterized protein; Belongs to the cytochrome P450 family. (491 aa)
CYP1A2Cytochrome P450 1A5; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (530 aa)
RGS18RGS domain-containing protein. (235 aa)
STARSteroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone (By similarity). (281 aa)
CYP3A4Uncharacterized protein; Belongs to the cytochrome P450 family. (540 aa)
CYP3A5Uncharacterized protein. (508 aa)
CYP2C18Uncharacterized protein; Belongs to the cytochrome P450 family. (494 aa)
ETV5ETS domain-containing protein. (507 aa)
TFRCTransferrin receptor protein 1; Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Belongs to the peptidase M28 family. M28B subfamily. (776 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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