7 items (Gallus gallus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PAX6	Paired box protein Pax-6; May be a transcription factor with important functions in eye and nasal development. (500 aa)
	NEUROD1	Neurogenic differentiation factor 1; Acts as a transcriptional activator. Mediates transcriptional activation by binding to E box-containing promoter. Acts as a differentiation factor during neurogenesis. Induces photoreceptor cell overproduction in vivo and de novo generation in vitro. May play a role in photoreceptor cell production. Binds DNA on E-box consensus sequence 5'-CANNTG-3'. (357 aa)
	PAX2	Paired-box containing protein Pax-2. (394 aa)
	ASCL1	BHLH domain-containing protein. (219 aa)
	VSX2	Visual system homeobox 2; Acts as a transcriptional regulator (By similarity). Plays a significant role in the specification and morphogenesis of the sensory retina (By similarity). Mediates differentiation of V2a interneurons by repression of motor neuron gene transcription, via competitively binding to response elements that are activated by the ISL1-LHX3 complex. May also participate in the development of the cells of the inner nuclear layer, particularly bipolar cells (By similarity); Belongs to the paired homeobox family. (377 aa)
	NEUROG1	Neurogenin 1. (179 aa)
	CASP3	Caspase-3; Belongs to the peptidase C14A family. (283 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASCL1	NEUROD1	ENSGALP00000047577	ENSGALP00000014468	BHLH domain-containing protein.	Neurogenic differentiation factor 1; Acts as a transcriptional activator. Mediates transcriptional activation by binding to E box-containing promoter. Acts as a differentiation factor during neurogenesis. Induces photoreceptor cell overproduction in vivo and de novo generation in vitro. May play a role in photoreceptor cell production. Binds DNA on E-box consensus sequence 5'-CANNTG-3'.	0.484
ASCL1	NEUROG1	ENSGALP00000047577	ENSGALP00000057908	BHLH domain-containing protein.	Neurogenin 1.	0.872
ASCL1	PAX2	ENSGALP00000047577	ENSGALP00000045193	BHLH domain-containing protein.	Paired-box containing protein Pax-2.	0.553
ASCL1	PAX6	ENSGALP00000047577	ENSGALP00000070449	BHLH domain-containing protein.	Paired box protein Pax-6; May be a transcription factor with important functions in eye and nasal development.	0.854
ASCL1	VSX2	ENSGALP00000047577	ENSGALP00000048165	BHLH domain-containing protein.	Visual system homeobox 2; Acts as a transcriptional regulator (By similarity). Plays a significant role in the specification and morphogenesis of the sensory retina (By similarity). Mediates differentiation of V2a interneurons by repression of motor neuron gene transcription, via competitively binding to response elements that are activated by the ISL1-LHX3 complex. May also participate in the development of the cells of the inner nuclear layer, particularly bipolar cells (By similarity); Belongs to the paired homeobox family.	0.728
CASP3	NEUROD1	ENSGALP00000068843	ENSGALP00000014468	Caspase-3; Belongs to the peptidase C14A family.	Neurogenic differentiation factor 1; Acts as a transcriptional activator. Mediates transcriptional activation by binding to E box-containing promoter. Acts as a differentiation factor during neurogenesis. Induces photoreceptor cell overproduction in vivo and de novo generation in vitro. May play a role in photoreceptor cell production. Binds DNA on E-box consensus sequence 5'-CANNTG-3'.	0.441
CASP3	PAX2	ENSGALP00000068843	ENSGALP00000045193	Caspase-3; Belongs to the peptidase C14A family.	Paired-box containing protein Pax-2.	0.527
CASP3	PAX6	ENSGALP00000068843	ENSGALP00000070449	Caspase-3; Belongs to the peptidase C14A family.	Paired box protein Pax-6; May be a transcription factor with important functions in eye and nasal development.	0.770
CASP3	VSX2	ENSGALP00000068843	ENSGALP00000048165	Caspase-3; Belongs to the peptidase C14A family.	Visual system homeobox 2; Acts as a transcriptional regulator (By similarity). Plays a significant role in the specification and morphogenesis of the sensory retina (By similarity). Mediates differentiation of V2a interneurons by repression of motor neuron gene transcription, via competitively binding to response elements that are activated by the ISL1-LHX3 complex. May also participate in the development of the cells of the inner nuclear layer, particularly bipolar cells (By similarity); Belongs to the paired homeobox family.	0.432
NEUROD1	ASCL1	ENSGALP00000014468	ENSGALP00000047577	Neurogenic differentiation factor 1; Acts as a transcriptional activator. Mediates transcriptional activation by binding to E box-containing promoter. Acts as a differentiation factor during neurogenesis. Induces photoreceptor cell overproduction in vivo and de novo generation in vitro. May play a role in photoreceptor cell production. Binds DNA on E-box consensus sequence 5'-CANNTG-3'.	BHLH domain-containing protein.	0.484
NEUROD1	CASP3	ENSGALP00000014468	ENSGALP00000068843	Neurogenic differentiation factor 1; Acts as a transcriptional activator. Mediates transcriptional activation by binding to E box-containing promoter. Acts as a differentiation factor during neurogenesis. Induces photoreceptor cell overproduction in vivo and de novo generation in vitro. May play a role in photoreceptor cell production. Binds DNA on E-box consensus sequence 5'-CANNTG-3'.	Caspase-3; Belongs to the peptidase C14A family.	0.441
NEUROD1	PAX2	ENSGALP00000014468	ENSGALP00000045193	Neurogenic differentiation factor 1; Acts as a transcriptional activator. Mediates transcriptional activation by binding to E box-containing promoter. Acts as a differentiation factor during neurogenesis. Induces photoreceptor cell overproduction in vivo and de novo generation in vitro. May play a role in photoreceptor cell production. Binds DNA on E-box consensus sequence 5'-CANNTG-3'.	Paired-box containing protein Pax-2.	0.615
NEUROD1	PAX6	ENSGALP00000014468	ENSGALP00000070449	Neurogenic differentiation factor 1; Acts as a transcriptional activator. Mediates transcriptional activation by binding to E box-containing promoter. Acts as a differentiation factor during neurogenesis. Induces photoreceptor cell overproduction in vivo and de novo generation in vitro. May play a role in photoreceptor cell production. Binds DNA on E-box consensus sequence 5'-CANNTG-3'.	Paired box protein Pax-6; May be a transcription factor with important functions in eye and nasal development.	0.903
NEUROD1	VSX2	ENSGALP00000014468	ENSGALP00000048165	Neurogenic differentiation factor 1; Acts as a transcriptional activator. Mediates transcriptional activation by binding to E box-containing promoter. Acts as a differentiation factor during neurogenesis. Induces photoreceptor cell overproduction in vivo and de novo generation in vitro. May play a role in photoreceptor cell production. Binds DNA on E-box consensus sequence 5'-CANNTG-3'.	Visual system homeobox 2; Acts as a transcriptional regulator (By similarity). Plays a significant role in the specification and morphogenesis of the sensory retina (By similarity). Mediates differentiation of V2a interneurons by repression of motor neuron gene transcription, via competitively binding to response elements that are activated by the ISL1-LHX3 complex. May also participate in the development of the cells of the inner nuclear layer, particularly bipolar cells (By similarity); Belongs to the paired homeobox family.	0.725
NEUROG1	ASCL1	ENSGALP00000057908	ENSGALP00000047577	Neurogenin 1.	BHLH domain-containing protein.	0.872
NEUROG1	PAX2	ENSGALP00000057908	ENSGALP00000045193	Neurogenin 1.	Paired-box containing protein Pax-2.	0.751
NEUROG1	PAX6	ENSGALP00000057908	ENSGALP00000070449	Neurogenin 1.	Paired box protein Pax-6; May be a transcription factor with important functions in eye and nasal development.	0.804
NEUROG1	VSX2	ENSGALP00000057908	ENSGALP00000048165	Neurogenin 1.	Visual system homeobox 2; Acts as a transcriptional regulator (By similarity). Plays a significant role in the specification and morphogenesis of the sensory retina (By similarity). Mediates differentiation of V2a interneurons by repression of motor neuron gene transcription, via competitively binding to response elements that are activated by the ISL1-LHX3 complex. May also participate in the development of the cells of the inner nuclear layer, particularly bipolar cells (By similarity); Belongs to the paired homeobox family.	0.526
PAX2	ASCL1	ENSGALP00000045193	ENSGALP00000047577	Paired-box containing protein Pax-2.	BHLH domain-containing protein.	0.553
PAX2	CASP3	ENSGALP00000045193	ENSGALP00000068843	Paired-box containing protein Pax-2.	Caspase-3; Belongs to the peptidase C14A family.	0.527