9 items (Gallus gallus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	UBE2W	UBIQUITIN_CONJUGAT_2 domain-containing protein. (151 aa)
	FANCE	FA_FANCE domain-containing protein. (244 aa)
	FANCD2	Uncharacterized protein. (1510 aa)
	SKP1	S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1 (By similarity). (163 aa)
	FANCI	Uncharacterized protein. (1339 aa)
	RBX1	RING-type domain-containing protein. (108 aa)
	CUL1	Cullin 1; Belongs to the cullin family. (776 aa)
	CACUL1	Cullin domain-containing protein; Belongs to the cullin family. (377 aa)
	FANCM	Fanconi anemia group M protein; DNA-dependent ATPase component of the Fanconi anemia (FA) core complex (By similarity). Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double- stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates (By similarity). Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a mova [...] (2101 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CACUL1	RBX1	ENSGALP00000055119	ENSGALP00000019539	Cullin domain-containing protein; Belongs to the cullin family.	RING-type domain-containing protein.	0.709
CACUL1	SKP1	ENSGALP00000055119	ENSGALP00000010447	Cullin domain-containing protein; Belongs to the cullin family.	S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1 (By similarity).	0.817
CUL1	FANCM	ENSGALP00000046909	ENSGALP00000070244	Cullin 1; Belongs to the cullin family.	Fanconi anemia group M protein; DNA-dependent ATPase component of the Fanconi anemia (FA) core complex (By similarity). Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double- stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates (By similarity). Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a mova [...]	0.469
CUL1	RBX1	ENSGALP00000046909	ENSGALP00000019539	Cullin 1; Belongs to the cullin family.	RING-type domain-containing protein.	0.999
CUL1	SKP1	ENSGALP00000046909	ENSGALP00000010447	Cullin 1; Belongs to the cullin family.	S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1 (By similarity).	0.999
FANCD2	FANCE	ENSGALP00000005896	ENSGALP00000004037	Uncharacterized protein.	FA_FANCE domain-containing protein.	0.998
FANCD2	FANCI	ENSGALP00000005896	ENSGALP00000010756	Uncharacterized protein.	Uncharacterized protein.	0.999
FANCD2	FANCM	ENSGALP00000005896	ENSGALP00000070244	Uncharacterized protein.	Fanconi anemia group M protein; DNA-dependent ATPase component of the Fanconi anemia (FA) core complex (By similarity). Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double- stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates (By similarity). Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a mova [...]	0.999
FANCD2	UBE2W	ENSGALP00000005896	ENSGALP00000047483	Uncharacterized protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.644
FANCE	FANCD2	ENSGALP00000004037	ENSGALP00000005896	FA_FANCE domain-containing protein.	Uncharacterized protein.	0.998
FANCE	FANCI	ENSGALP00000004037	ENSGALP00000010756	FA_FANCE domain-containing protein.	Uncharacterized protein.	0.997
FANCE	FANCM	ENSGALP00000004037	ENSGALP00000070244	FA_FANCE domain-containing protein.	Fanconi anemia group M protein; DNA-dependent ATPase component of the Fanconi anemia (FA) core complex (By similarity). Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double- stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates (By similarity). Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a mova [...]	0.999
FANCE	UBE2W	ENSGALP00000004037	ENSGALP00000047483	FA_FANCE domain-containing protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.550
FANCI	FANCD2	ENSGALP00000010756	ENSGALP00000005896	Uncharacterized protein.	Uncharacterized protein.	0.999
FANCI	FANCE	ENSGALP00000010756	ENSGALP00000004037	Uncharacterized protein.	FA_FANCE domain-containing protein.	0.997
FANCI	FANCM	ENSGALP00000010756	ENSGALP00000070244	Uncharacterized protein.	Fanconi anemia group M protein; DNA-dependent ATPase component of the Fanconi anemia (FA) core complex (By similarity). Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double- stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates (By similarity). Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a mova [...]	0.999
FANCI	UBE2W	ENSGALP00000010756	ENSGALP00000047483	Uncharacterized protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.638
FANCM	CUL1	ENSGALP00000070244	ENSGALP00000046909	Fanconi anemia group M protein; DNA-dependent ATPase component of the Fanconi anemia (FA) core complex (By similarity). Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double- stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates (By similarity). Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a mova [...]	Cullin 1; Belongs to the cullin family.	0.469
FANCM	FANCD2	ENSGALP00000070244	ENSGALP00000005896	Fanconi anemia group M protein; DNA-dependent ATPase component of the Fanconi anemia (FA) core complex (By similarity). Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double- stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates (By similarity). Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a mova [...]	Uncharacterized protein.	0.999
FANCM	FANCE	ENSGALP00000070244	ENSGALP00000004037	Fanconi anemia group M protein; DNA-dependent ATPase component of the Fanconi anemia (FA) core complex (By similarity). Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double- stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates (By similarity). Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a mova [...]	FA_FANCE domain-containing protein.	0.999