STRINGSTRING
MYH15 MYH15 TMSB4X TMSB4X LMOD1 LMOD1 MYOT MYOT MYH10 MYH10 FLNB FLNB TNNT1 TNNT1 MYH7B MYH7B FHOD3 FHOD3 NEBL-2 NEBL-2 LOC776816 LOC776816 MYH7 MYH7 TPM2 TPM2 FLI1 FLI1 ACTA1 ACTA1 FMN1 FMN1 CNN2 CNN2 MYH9 MYH9 GSN GSN NEBL NEBL TPM1 TPM1 ACTB ACTB CNN3 CNN3 NEBL1 NEBL1 FLNA FLNA ACTA2 ACTA2 ACTG2 ACTG2 PFN2 PFN2 MYPN MYPN DSTN DSTN LMOD2 LMOD2 PFN3 PFN3 CFL2 CFL2 CAP2 CAP2 EDN1 EDN1 PFN4 PFN4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MYH15Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1937 aa)
TMSB4XThymosin beta; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family. (44 aa)
LMOD1Leiomodin 1. (624 aa)
MYOTMyotilin. (513 aa)
MYH10Myosin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2016 aa)
FLNBUncharacterized protein. (2652 aa)
TNNT1Uncharacterized protein. (272 aa)
MYH7BUncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1941 aa)
FHOD3Formin homology 2 domain containing 3. (1615 aa)
NEBL-2Uncharacterized protein. (334 aa)
LOC776816Actin, cytoplasmic 2, N-terminally processed; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells; Belongs to the actin family. (375 aa)
MYH7Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1931 aa)
TPM2Tropomyosin beta chain; Belongs to the tropomyosin family. (335 aa)
FLI1Uncharacterized protein. (432 aa)
ACTA1Actin, alpha skeletal muscle. (390 aa)
FMN1Formin; Is important for morphogenesis of limb and kidney and may be involved in determining dorsoventral neural tube polarity and motor neuron induction. It may also have a function in differentiated cells or be involved in maintaining specific differentiated states. (1437 aa)
CNN2Calponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. (305 aa)
MYH9Myosin-9; Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. (1960 aa)
GSNGelsolin; Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis (By similarity). (833 aa)
NEBLNebulette. (668 aa)
TPM1Tropomyosin alpha-1 chain; Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments; Belongs to the tropomyosin family. (321 aa)
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa)
CNN3Calponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. (331 aa)
NEBL1Uncharacterized protein. (2613 aa)
FLNAUncharacterized protein. (492 aa)
ACTA2Actin, aortic smooth muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells; Belongs to the actin family. (377 aa)
ACTG2Actin, gamma-enteric smooth muscle. (506 aa)
PFN2Profilin; Belongs to the profilin family. (140 aa)
MYPNMyopalladin. (991 aa)
DSTNDestrin; Actin-depolymerizing protein. Severs actin filaments (F- actin) and binds to actin monomers (G-actin). Acts in a pH-independent manner. (165 aa)
LMOD2Leiomodin-2; Mediates nucleation of actin filaments and thereby promotes actin polymerization (By similarity). Plays a role in the regulation of actin filament length. Required for normal sarcomere organization in the heart, and for normal heart function (By similarity); Belongs to the tropomodulin family. (552 aa)
PFN3Profilin; Belongs to the profilin family. (134 aa)
CFL2Cofilin-2; Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods; Belongs to the actin-binding proteins ADF family. (166 aa)
CAP2Adenylyl cyclase-associated protein; Belongs to the CAP family. (480 aa)
EDN1Endothelin 1. (194 aa)
PFN4Profilin; Belongs to the profilin family. (129 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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