31 items (Gallus gallus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	MLNR	Motilin receptor MTL-R/GPR38; Belongs to the G-protein coupled receptor 1 family. (349 aa)
	CCK	Cholecystokinin-70; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear (By similarity). It also decreases food intake and regulates gastrointestinal physiological processes. (130 aa)
	GAL	Galanin variant 1. (141 aa)
	GPR39	G-protein coupled receptor 39; Belongs to the G-protein coupled receptor 1 family. (462 aa)
	GH	Somatotropin; Growth hormone plays an important role in growth control. (216 aa)
	IL10	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (175 aa)
	AGRP	Agouti-related protein. (233 aa)
	SS2	Somatostatin II. (101 aa)
	ADIPOQ	C1q domain-containing protein. (244 aa)
	INS	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (107 aa)
	SST	Somatostatin-14; Somatostatin inhibits the release of somatotropin. (116 aa)
	FURIN	Trans Golgi network protease furin; Belongs to the peptidase S8 family. (789 aa)
	GHRL	Preproghrelin. (116 aa)
	LOC417800	Uncharacterized protein. (225 aa)
	NPY	C-flanking peptide of NPY; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone; Belongs to the NPY family. (97 aa)
	MBOAT4	Uncharacterized protein; Belongs to the membrane-bound acyltransferase family. (424 aa)
	PRL	Prolactin. (229 aa)
	AR	Uncharacterized protein. (703 aa)
	GCG	Glicentin-related polypeptide; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. (206 aa)
	ESR1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (651 aa)
	PIK3C3	Phosphatidylinositol 3-kinase catalytic subunit type 3. (944 aa)
	UCN	Urocortin. (100 aa)
	MLN	Motilin; Plays an important role in the regulation of interdigestive gastrointestinal motility and indirectly causes rhythmic contraction of duodenal and colonic smooth muscle; Belongs to the motilin family. (115 aa)
	CD36	Uncharacterized protein; Belongs to the CD36 family. (471 aa)
	LYPLA1	Lysophospholipase 1. (229 aa)
	POMC	Uncharacterized protein. (251 aa)
	NPW	Neuropeptide W. (139 aa)
	IGFBP1	Uncharacterized protein. (269 aa)
	IGFBP3	Uncharacterized protein. (337 aa)
	IL1B	Interleukin-1; Belongs to the IL-1 family. (267 aa)
	GHR	Growth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway; Belongs to the type I cytokine receptor family. Type 1 subfamily. (646 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADIPOQ	AGRP	ENSGALP00000008899	ENSGALP00000003505	C1q domain-containing protein.	Agouti-related protein.	0.603
ADIPOQ	CCK	ENSGALP00000008899	ENSGALP00000044506	C1q domain-containing protein.	Cholecystokinin-70; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear (By similarity). It also decreases food intake and regulates gastrointestinal physiological processes.	0.485
ADIPOQ	CD36	ENSGALP00000008899	ENSGALP00000068876	C1q domain-containing protein.	Uncharacterized protein; Belongs to the CD36 family.	0.758
ADIPOQ	GCG	ENSGALP00000008899	ENSGALP00000032494	C1q domain-containing protein.	Glicentin-related polypeptide; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis.	0.629
ADIPOQ	GHRL	ENSGALP00000008899	ENSGALP00000013685	C1q domain-containing protein.	Preproghrelin.	0.750
ADIPOQ	IL10	ENSGALP00000008899	ENSGALP00000001310	C1q domain-containing protein.	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	0.672
ADIPOQ	IL1B	ENSGALP00000008899	ENSGALP00000050171	C1q domain-containing protein.	Interleukin-1; Belongs to the IL-1 family.	0.744
ADIPOQ	INS	ENSGALP00000008899	ENSGALP00000010567	C1q domain-containing protein.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.958
ADIPOQ	NPY	ENSGALP00000008899	ENSGALP00000017870	C1q domain-containing protein.	C-flanking peptide of NPY; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone; Belongs to the NPY family.	0.523
ADIPOQ	POMC	ENSGALP00000008899	ENSGALP00000063133	C1q domain-containing protein.	Uncharacterized protein.	0.471
AGRP	ADIPOQ	ENSGALP00000003505	ENSGALP00000008899	Agouti-related protein.	C1q domain-containing protein.	0.603
AGRP	CCK	ENSGALP00000003505	ENSGALP00000044506	Agouti-related protein.	Cholecystokinin-70; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear (By similarity). It also decreases food intake and regulates gastrointestinal physiological processes.	0.861
AGRP	GAL	ENSGALP00000003505	ENSGALP00000042337	Agouti-related protein.	Galanin variant 1.	0.588
AGRP	GCG	ENSGALP00000003505	ENSGALP00000032494	Agouti-related protein.	Glicentin-related polypeptide; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis.	0.746
AGRP	GHRL	ENSGALP00000003505	ENSGALP00000013685	Agouti-related protein.	Preproghrelin.	0.982
AGRP	INS	ENSGALP00000003505	ENSGALP00000010567	Agouti-related protein.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.860
AGRP	LOC417800	ENSGALP00000003505	ENSGALP00000015633	Agouti-related protein.	Uncharacterized protein.	0.452
AGRP	MBOAT4	ENSGALP00000003505	ENSGALP00000018654	Agouti-related protein.	Uncharacterized protein; Belongs to the membrane-bound acyltransferase family.	0.519
AGRP	NPW	ENSGALP00000003505	ENSGALP00000059450	Agouti-related protein.	Neuropeptide W.	0.489
AGRP	NPY	ENSGALP00000003505	ENSGALP00000017870	Agouti-related protein.	C-flanking peptide of NPY; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone; Belongs to the NPY family.	0.984