27 items (Gallus gallus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SLCO1B1	Solute carrier organic anion transporter family member. (705 aa)
	CYP2D6	Cytochrome P450 CYP2D49; Belongs to the cytochrome P450 family. (502 aa)
	UGT2A1	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (529 aa)
	NR1H4	Farnesoid X receptor. (473 aa)
	ABCB11	ATP binding cassette subfamily B member 11. (1349 aa)
	HPGDS	Hematopoietic prostaglandin D synthase; Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides, organic isothiocyanates and alpha,beta-unsaturated carbonyls. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide and t-butyl hydroperoxide. (199 aa)
	ABCC2	Uncharacterized protein. (1538 aa)
	NR2F2	COUP transcription factor 2; Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro) (By similarity). May be involved in motor neuron development. Belongs to the nuclear hormone receptor family. NR2 subfamily. (410 aa)
	INS	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (107 aa)
	CYP2C23b	Cytochrome P450 2H2; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (491 aa)
	UGT8L	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (529 aa)
	CYP3A5	Uncharacterized protein. (508 aa)
	CYP3A4	Uncharacterized protein; Belongs to the cytochrome P450 family. (540 aa)
	HNF4A	Uncharacterized protein. (466 aa)
	UGT1A1	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (532 aa)
	STAT5A	Signal transducer and activator of transcription. (764 aa)
	NCOA6	Nuclear receptor coactivator 6. (2054 aa)
	NR1H3	Uncharacterized protein. (519 aa)
	VDR	Vitamin D3 receptor; Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells. Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR. The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3- responsive target genes. Recruited to promoters via its interaction with BAZ1B/WSTF which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis. (608 aa)
	NR3C1	Uncharacterized protein. (837 aa)
	CYP7A1	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (513 aa)
	ABCB1	ATP binding cassette subfamily B member 1. (1293 aa)
	RXRA	Retinoid X receptor alpha. (467 aa)
	CYP2C23a	Cytochrome P450 2H1; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (491 aa)
	ABCB1-2	Multidrug resistance protein 1. (1288 aa)
	OVAL	Ovalbumin; Non-inhibitory serpin. Storage protein of egg white. (386 aa)
	NR2F1	Nuclear receptor subfamily 2 group F member 1. (418 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCB1	ABCC2	ENSGALP00000050400	ENSGALP00000011951	ATP binding cassette subfamily B member 1.	Uncharacterized protein.	0.553
ABCB1	CYP2C23a	ENSGALP00000050400	ENSGALP00000039271	ATP binding cassette subfamily B member 1.	Cytochrome P450 2H1; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.	0.501
ABCB1	CYP3A4	ENSGALP00000050400	ENSGALP00000007048	ATP binding cassette subfamily B member 1.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.634
ABCB1	CYP3A5	ENSGALP00000050400	ENSGALP00000007068	ATP binding cassette subfamily B member 1.	Uncharacterized protein.	0.489
ABCB1-2	ABCC2	ENSGALP00000037427	ENSGALP00000011951	Multidrug resistance protein 1.	Uncharacterized protein.	0.603
ABCB1-2	CYP2C23a	ENSGALP00000037427	ENSGALP00000039271	Multidrug resistance protein 1.	Cytochrome P450 2H1; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.	0.612
ABCB1-2	CYP2C23b	ENSGALP00000037427	ENSGALP00000009294	Multidrug resistance protein 1.	Cytochrome P450 2H2; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.	0.444
ABCB1-2	CYP3A4	ENSGALP00000037427	ENSGALP00000007048	Multidrug resistance protein 1.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.657
ABCB1-2	CYP3A5	ENSGALP00000037427	ENSGALP00000007068	Multidrug resistance protein 1.	Uncharacterized protein.	0.611
ABCB1-2	NR1H4	ENSGALP00000037427	ENSGALP00000018906	Multidrug resistance protein 1.	Farnesoid X receptor.	0.438
ABCB11	ABCC2	ENSGALP00000017690	ENSGALP00000011951	ATP binding cassette subfamily B member 11.	Uncharacterized protein.	0.561
ABCB11	CYP3A4	ENSGALP00000017690	ENSGALP00000007048	ATP binding cassette subfamily B member 11.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.428
ABCB11	CYP7A1	ENSGALP00000017690	ENSGALP00000054104	ATP binding cassette subfamily B member 11.	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family.	0.483
ABCB11	SLCO1B1	ENSGALP00000017690	ENSGALP00000021471	ATP binding cassette subfamily B member 11.	Solute carrier organic anion transporter family member.	0.552
ABCC2	ABCB1	ENSGALP00000011951	ENSGALP00000050400	Uncharacterized protein.	ATP binding cassette subfamily B member 1.	0.553
ABCC2	ABCB1-2	ENSGALP00000011951	ENSGALP00000037427	Uncharacterized protein.	Multidrug resistance protein 1.	0.603
ABCC2	ABCB11	ENSGALP00000011951	ENSGALP00000017690	Uncharacterized protein.	ATP binding cassette subfamily B member 11.	0.561
ABCC2	CYP2C23a	ENSGALP00000011951	ENSGALP00000039271	Uncharacterized protein.	Cytochrome P450 2H1; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.	0.537
ABCC2	CYP3A4	ENSGALP00000011951	ENSGALP00000007048	Uncharacterized protein.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.563
ABCC2	CYP3A5	ENSGALP00000011951	ENSGALP00000007068	Uncharacterized protein.	Uncharacterized protein.	0.591