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SLCO1B1 SLCO1B1 CYP2D6 CYP2D6 UGT2A1 UGT2A1 NR1H4 NR1H4 ABCB11 ABCB11 HPGDS HPGDS ABCC2 ABCC2 NR2F2 NR2F2 INS INS CYP2C23b CYP2C23b UGT8L UGT8L CYP3A5 CYP3A5 CYP3A4 CYP3A4 HNF4A HNF4A UGT1A1 UGT1A1 STAT5A STAT5A NCOA6 NCOA6 NR1H3 NR1H3 VDR VDR NR3C1 NR3C1 CYP7A1 CYP7A1 ABCB1 ABCB1 RXRA RXRA CYP2C23a CYP2C23a ABCB1-2 ABCB1-2 OVAL OVAL NR2F1 NR2F1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SLCO1B1Solute carrier organic anion transporter family member. (705 aa)
CYP2D6Cytochrome P450 CYP2D49; Belongs to the cytochrome P450 family. (502 aa)
UGT2A1UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (529 aa)
NR1H4Farnesoid X receptor. (473 aa)
ABCB11ATP binding cassette subfamily B member 11. (1349 aa)
HPGDSHematopoietic prostaglandin D synthase; Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides, organic isothiocyanates and alpha,beta-unsaturated carbonyls. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide and t-butyl hydroperoxide. (199 aa)
ABCC2Uncharacterized protein. (1538 aa)
NR2F2COUP transcription factor 2; Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro) (By similarity). May be involved in motor neuron development. Belongs to the nuclear hormone receptor family. NR2 subfamily. (410 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (107 aa)
CYP2C23bCytochrome P450 2H2; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (491 aa)
UGT8LUDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (529 aa)
CYP3A5Uncharacterized protein. (508 aa)
CYP3A4Uncharacterized protein; Belongs to the cytochrome P450 family. (540 aa)
HNF4AUncharacterized protein. (466 aa)
UGT1A1UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (532 aa)
STAT5ASignal transducer and activator of transcription. (764 aa)
NCOA6Nuclear receptor coactivator 6. (2054 aa)
NR1H3Uncharacterized protein. (519 aa)
VDRVitamin D3 receptor; Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells. Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR. The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3- responsive target genes. Recruited to promoters via its interaction with BAZ1B/WSTF which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis. (608 aa)
NR3C1Uncharacterized protein. (837 aa)
CYP7A1Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (513 aa)
ABCB1ATP binding cassette subfamily B member 1. (1293 aa)
RXRARetinoid X receptor alpha. (467 aa)
CYP2C23aCytochrome P450 2H1; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (491 aa)
ABCB1-2Multidrug resistance protein 1. (1288 aa)
OVALOvalbumin; Non-inhibitory serpin. Storage protein of egg white. (386 aa)
NR2F1Nuclear receptor subfamily 2 group F member 1. (418 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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