24 items (Gallus gallus) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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Your Input:
	CISH	Cytokine-inducible SH2-containing protein; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasom [...] (258 aa)
	SIRT1	Deacetylase sirtuin-type domain-containing protein. (881 aa)
	NF1	Neurofibromin; Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity. (2865 aa)
	WSB1	SOCS box-containing WD protein SWiP-1. (421 aa)
	SHH	Sonic hedgehog protein N-product; [Sonic hedgehog protein]: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). (425 aa)
	SKP1	S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1 (By similarity). (163 aa)
	TRH	Pro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems; Belongs to the TRH family. (260 aa)
	SEC62	Translocation protein SEC62; Required for preprotein translocation. (398 aa)
	SECISBP2	SECIS binding protein 2. (929 aa)
	IHH	Indian hedgehog protein C-product; Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP); Belongs to the hedgehog family. (408 aa)
	HIF1A	Hypoxia-inducible factor 1-alpha; Functions as a master transcriptional regulator of the adaptive response to hypoxia. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Activation requires recruitment of transcriptional coactivators (By similarity). (811 aa)
	NR1H4	Farnesoid X receptor. (473 aa)
	RBX1	RING-type domain-containing protein. (108 aa)
	HIPK2	Homeodomain interacting protein kinase 2. (1206 aa)
	FOXO3	Forkhead box O3. (660 aa)
	IGF2	Insulin-like growth factor II; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Acts as a ligand for integrin which is required for IGF2 signaling. (187 aa)
	IDUA	Uncharacterized protein. (630 aa)
	TXN	Thioredoxin; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status [...] (105 aa)
	UCP3	Mitochondrial uncoupling protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (307 aa)
	MYOD1	Myoblast determination protein 1 homolog; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity). (299 aa)
	CUL5	Cullin 5; Belongs to the cullin family. (662 aa)
	PTHLH	Parathyroid hormone-related protein; Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport; Belongs to the parathyroid hormone family. (214 aa)
	CUL2	CULLIN_2 domain-containing protein; Belongs to the cullin family. (774 aa)
	USP20	Ubiquitin carboxyl-terminal hydrolase. (979 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CISH	CUL2	ENSGALP00000003536	ENSGALP00000050746	Cytokine-inducible SH2-containing protein; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasom [...]	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.845
CISH	CUL5	ENSGALP00000003536	ENSGALP00000045443	Cytokine-inducible SH2-containing protein; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasom [...]	Cullin 5; Belongs to the cullin family.	0.984
CISH	RBX1	ENSGALP00000003536	ENSGALP00000019539	Cytokine-inducible SH2-containing protein; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasom [...]	RING-type domain-containing protein.	0.647
CISH	WSB1	ENSGALP00000003536	ENSGALP00000009076	Cytokine-inducible SH2-containing protein; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasom [...]	SOCS box-containing WD protein SWiP-1.	0.817
CUL2	CISH	ENSGALP00000050746	ENSGALP00000003536	CULLIN_2 domain-containing protein; Belongs to the cullin family.	Cytokine-inducible SH2-containing protein; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasom [...]	0.845
CUL2	CUL5	ENSGALP00000050746	ENSGALP00000045443	CULLIN_2 domain-containing protein; Belongs to the cullin family.	Cullin 5; Belongs to the cullin family.	0.851
CUL2	HIF1A	ENSGALP00000050746	ENSGALP00000019338	CULLIN_2 domain-containing protein; Belongs to the cullin family.	Hypoxia-inducible factor 1-alpha; Functions as a master transcriptional regulator of the adaptive response to hypoxia. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Activation requires recruitment of transcriptional coactivators (By similarity).	0.803
CUL2	RBX1	ENSGALP00000050746	ENSGALP00000019539	CULLIN_2 domain-containing protein; Belongs to the cullin family.	RING-type domain-containing protein.	0.999
CUL2	SKP1	ENSGALP00000050746	ENSGALP00000010447	CULLIN_2 domain-containing protein; Belongs to the cullin family.	S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1 (By similarity).	0.908
CUL2	WSB1	ENSGALP00000050746	ENSGALP00000009076	CULLIN_2 domain-containing protein; Belongs to the cullin family.	SOCS box-containing WD protein SWiP-1.	0.503
CUL5	CISH	ENSGALP00000045443	ENSGALP00000003536	Cullin 5; Belongs to the cullin family.	Cytokine-inducible SH2-containing protein; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasom [...]	0.984
CUL5	CUL2	ENSGALP00000045443	ENSGALP00000050746	Cullin 5; Belongs to the cullin family.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.851
CUL5	RBX1	ENSGALP00000045443	ENSGALP00000019539	Cullin 5; Belongs to the cullin family.	RING-type domain-containing protein.	0.999
CUL5	SKP1	ENSGALP00000045443	ENSGALP00000010447	Cullin 5; Belongs to the cullin family.	S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1 (By similarity).	0.813
CUL5	USP20	ENSGALP00000045443	ENSGALP00000049159	Cullin 5; Belongs to the cullin family.	Ubiquitin carboxyl-terminal hydrolase.	0.614
CUL5	WSB1	ENSGALP00000045443	ENSGALP00000009076	Cullin 5; Belongs to the cullin family.	SOCS box-containing WD protein SWiP-1.	0.927
FOXO3	HIF1A	ENSGALP00000024641	ENSGALP00000019338	Forkhead box O3.	Hypoxia-inducible factor 1-alpha; Functions as a master transcriptional regulator of the adaptive response to hypoxia. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Activation requires recruitment of transcriptional coactivators (By similarity).	0.570
FOXO3	IGF2	ENSGALP00000024641	ENSGALP00000048743	Forkhead box O3.	Insulin-like growth factor II; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Acts as a ligand for integrin which is required for IGF2 signaling.	0.420
FOXO3	MYOD1	ENSGALP00000024641	ENSGALP00000038684	Forkhead box O3.	Myoblast determination protein 1 homolog; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity).	0.520
FOXO3	SIRT1	ENSGALP00000024641	ENSGALP00000004350	Forkhead box O3.	Deacetylase sirtuin-type domain-containing protein.	0.983