(22 nodes) (2011) CIN85 drives B cell responses by linking BCR signals to the canonical NF-kappaB pathway. network (Gallus gallus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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Predicted Interactions

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Your Input:
	LCP2	SH2 domain-containing protein. (550 aa)
	CD8A-3	Ig-like domain-containing protein. (318 aa)
	SH2D6	B-cell linker protein; Functions as a central linker protein, downstream of the B- cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR- mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-medi [...] (598 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (545 aa)
	CD4	Uncharacterized protein. (487 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are proba [...] (333 aa)
	CD8A-2	Ig-like domain-containing protein. (235 aa)
	CD5	Uncharacterized protein. (473 aa)
	RAG1	V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break b [...] (1041 aa)
	PXDNL	Uncharacterized protein. (1406 aa)
	EGF	Uncharacterized protein. (1283 aa)
	NFKBIA	NF-kappa-B inhibitor alpha; Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. May be involved in regulation of transcriptional responses to NF-kappa-B, including cell adhesion, immune and proinflammatory responses, apoptosis, differentiation and growth. Controlled by sequential serine-phosphorylation, ubiquitination and degradation. Tyrosine-phosphorylation could only lead to dissociation from NF-kappa- B (By similarity). (318 aa)
	IL4	Interleukin 4. (136 aa)
	CD40	Uncharacterized protein. (299 aa)
	CD86	Uncharacterized protein. (319 aa)
	CD2AP	Uncharacterized protein. (640 aa)
	TNFSF13B	TNF family B cell activation factor; Belongs to the tumor necrosis factor family. (288 aa)
	CARD11	Uncharacterized protein. (1170 aa)
	PXDN	Peroxidasin. (1611 aa)
	TAB2	TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (697 aa)
	CBL	Uncharacterized protein. (903 aa)
	SRC	Proto-oncogene tyrosine-protein kinase Src; Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy bet [...] (539 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CARD11	CD4	ENSGALP00000007002	ENSGALP00000065611	Uncharacterized protein.	Uncharacterized protein.	0.559
CARD11	CD40	ENSGALP00000007002	ENSGALP00000038316	Uncharacterized protein.	Uncharacterized protein.	0.518
CARD11	CD8A-2	ENSGALP00000007002	ENSGALP00000059832	Uncharacterized protein.	Ig-like domain-containing protein.	0.428
CARD11	CD8A-3	ENSGALP00000007002	ENSGALP00000071819	Uncharacterized protein.	Ig-like domain-containing protein.	0.428
CARD11	LCP2	ENSGALP00000007002	ENSGALP00000003296	Uncharacterized protein.	SH2 domain-containing protein.	0.716
CARD11	NFKBIA	ENSGALP00000007002	ENSGALP00000041417	Uncharacterized protein.	NF-kappa-B inhibitor alpha; Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. May be involved in regulation of transcriptional responses to NF-kappa-B, including cell adhesion, immune and proinflammatory responses, apoptosis, differentiation and growth. Controlled by sequential serine-phosphorylation, ubiquitination and degradation. Tyrosine-phosphorylation could only lead to dissociation from NF-kappa- B (By similarity).	0.607
CARD11	SH2D6	ENSGALP00000007002	ENSGALP00000070495	Uncharacterized protein.	B-cell linker protein; Functions as a central linker protein, downstream of the B- cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR- mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-medi [...]	0.643
CARD11	TAB2	ENSGALP00000007002	ENSGALP00000020155	Uncharacterized protein.	TGF-beta activated kinase 1 (MAP3K7) binding protein 2.	0.691
CARD11	TNFSF13B	ENSGALP00000007002	ENSGALP00000027177	Uncharacterized protein.	TNF family B cell activation factor; Belongs to the tumor necrosis factor family.	0.420
CARD11	TRAF6	ENSGALP00000007002	ENSGALP00000068399	Uncharacterized protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.842
CBL	CD2AP	ENSGALP00000010935	ENSGALP00000035888	Uncharacterized protein.	Uncharacterized protein.	0.719
CBL	EGF	ENSGALP00000010935	ENSGALP00000044972	Uncharacterized protein.	Uncharacterized protein.	0.647
CBL	LCP2	ENSGALP00000010935	ENSGALP00000003296	Uncharacterized protein.	SH2 domain-containing protein.	0.764
CBL	SH2D6	ENSGALP00000010935	ENSGALP00000070495	Uncharacterized protein.	B-cell linker protein; Functions as a central linker protein, downstream of the B- cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR- mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-medi [...]	0.644
CBL	SRC	ENSGALP00000010935	ENSGALP00000006117	Uncharacterized protein.	Proto-oncogene tyrosine-protein kinase Src; Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy bet [...]	0.912
CBL	TRAF6	ENSGALP00000010935	ENSGALP00000068399	Uncharacterized protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.938
CD2AP	CBL	ENSGALP00000035888	ENSGALP00000010935	Uncharacterized protein.	Uncharacterized protein.	0.719
CD2AP	SH2D6	ENSGALP00000035888	ENSGALP00000070495	Uncharacterized protein.	B-cell linker protein; Functions as a central linker protein, downstream of the B- cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR- mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-medi [...]	0.639
CD4	CARD11	ENSGALP00000065611	ENSGALP00000007002	Uncharacterized protein.	Uncharacterized protein.	0.559
CD4	CD40	ENSGALP00000065611	ENSGALP00000038316	Uncharacterized protein.	Uncharacterized protein.	0.960