STRINGSTRING
AUP1 AUP1 CISH CISH STAT5A STAT5A NEDD4 NEDD4 CUL3 CUL3 TSG101 TSG101 ATRX ATRX CDC20 CDC20 SEL1L SEL1L RBX1 RBX1 CDT1 CDT1 SYK SYK OCA2 OCA2 CUL4A CUL4A ATM ATM IRF7 IRF7 RAD50 RAD50 HIST1H2BO HIST1H2BO CUL5 CUL5 STAT1 STAT1 CUL1 CUL1 TOPBP1 TOPBP1 RELA RELA CD1C CD1C IRF5 IRF5 DDB1 DDB1 CUL2 CUL2 CANX CANX MAVS MAVS STAT2 STAT2 DCAF1 DCAF1 TRIM25 TRIM25 XRCC6 XRCC6 EGFR EGFR STAT4 STAT4 USP7 USP7 CACUL1 CACUL1 TCEB1 TCEB1 NEDD8 NEDD8 LOC107053803 LOC107053803 HIST1H2B8 HIST1H2B8 H2BE1 H2BE1 CD4 CD4 SIAH1 SIAH1 TRAF6 TRAF6 HIST1H2B5L HIST1H2B5L HIST1H2B5 HIST1H2B5 IFNA3 IFNA3 RNF20 RNF20
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AUP1AUP1 lipid droplet regulating VLDL assembly factor. (406 aa)
CISHCytokine-inducible SH2-containing protein; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasom [...] (258 aa)
STAT5ASignal transducer and activator of transcription. (764 aa)
NEDD4E3 ubiquitin-protein ligase. (932 aa)
CUL3Cullin 3; Belongs to the cullin family. (768 aa)
TSG101Uncharacterized protein. (390 aa)
ATRXATRX chromatin remodeler. (2420 aa)
CDC20WD_REPEATS_REGION domain-containing protein. (507 aa)
SEL1LSEL1L adaptor subunit of ERAD E3 ubiquitin ligase. (791 aa)
RBX1RING-type domain-containing protein. (108 aa)
CDT1Chromatin licensing and DNA replication factor 1. (745 aa)
SYKTyrosine-protein kinase SYK; Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the receptor can a [...] (636 aa)
OCA2OCA2 melanosomal transmembrane protein. (726 aa)
CUL4ACullin 4A; Belongs to the cullin family. (767 aa)
ATMNon-specific serine/threonine protein kinase. (3050 aa)
IRF7Interferon regulatory factor 3; Key transcriptional regulator of type I interferon (IFN)- dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN- stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. May activate transcription by complex formation with other transcriptional factors, possibly members of the STAT family. Binds specifically to the IFN-stimulated response element (ISRE) but not to the [...] (491 aa)
RAD50Zinc-hook domain-containing protein. (1313 aa)
HIST1H2BOHistone H2B 1/2/3/4/6; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (126 aa)
CUL5Cullin 5; Belongs to the cullin family. (662 aa)
STAT1Signal transducer and activator of transcription. (755 aa)
CUL1Cullin 1; Belongs to the cullin family. (776 aa)
TOPBP1DNA topoisomerase II binding protein 1. (1519 aa)
RELATranscription factor p65; NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain- containing proteins. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites tha [...] (559 aa)
CD1CIg-like domain-containing protein. (374 aa)
IRF5IRF tryptophan pentad repeat domain-containing protein. (472 aa)
DDB1DNA damage-binding protein 1; Required for DNA repair. Binds to DDB2 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair (By similarity). Also appears to function as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the DCX E3 ubiquitin-protein li [...] (1139 aa)
CUL2CULLIN_2 domain-containing protein; Belongs to the cullin family. (774 aa)
CANXUncharacterized protein. (601 aa)
MAVSCARD_2 domain-containing protein. (641 aa)
STAT2Signal transducer and activator of transcription. (961 aa)
DCAF1DDB1 and CUL4 associated factor 1. (1505 aa)
TRIM25Tripartite motif containing 25. (633 aa)
XRCC6X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic s [...] (647 aa)
EGFREpidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF and TGFA/TGF-alpha. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues (By similarity). The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades (By similarity). Activates at least 4 major downstream signaling cascades including [...] (1226 aa)
STAT4Signal transducer and activator of transcription. (749 aa)
USP7Ubiquitin carboxyl-terminal hydrolase 7; Hydrolase that deubiquitinates target proteins, such as p53/TP53. Deubiquitinates p53/TP53, and thereby modulates p53/TP53 stability, p53/TP53-dependent transcription regulation, cell growth repression and apoptosis. May be involved in cell proliferation during early embryonic development (By similarity). (1102 aa)
CACUL1Cullin domain-containing protein; Belongs to the cullin family. (377 aa)
TCEB1Skp1_POZ domain-containing protein; Belongs to the SKP1 family. (112 aa)
NEDD8NEDD8 ubiquitin like modifier. (85 aa)
LOC107053803Histone H2B 7; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (126 aa)
HIST1H2B8Histone H2B 8; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (126 aa)
H2BE1Histone H2B; Belongs to the histone H2B family. (118 aa)
CD4Uncharacterized protein. (487 aa)
SIAH1E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (282 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (545 aa)
HIST1H2B5LHistone H2B; Belongs to the histone H2B family. (126 aa)
HIST1H2B5Histone H2B 5; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (126 aa)
IFNA3Interferon. (193 aa)
RNF20E3 ubiquitin-protein ligase BRE1A; Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). (1028 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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