17 items (Gallus gallus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	AHR	Uncharacterized protein. (877 aa)
	WNT2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (376 aa)
	CYP1A1	Cytochrome P450 1A4; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (530 aa)
	GCLC	Glutamate-cysteine ligase catalytic subunit. (636 aa)
	CRYZ	PKS_ER domain-containing protein. (331 aa)
	EIF2AK2	Uncharacterized protein. (550 aa)
	EPHX1	Epoxide hydrolase; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. Belongs to the peptidase S33 family. (464 aa)
	LOC100859347	Uncharacterized protein. (964 aa)
	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1277 aa)
	CYP1A2	Cytochrome P450 1A5; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (530 aa)
	RACK1	Receptor of activated protein C kinase 1; Involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes (By similarity). Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily. (317 aa)
	LCK	Proto-oncogene tyrosine-protein kinase LCK; Tyrosine kinase that plays an essential role for the selection and maturation of developing T-cell in the thymus and in mature T-cell function. Is constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors and plays a key role in T-cell antigen receptor(TCR)-linked signal transduction pathways (By similarity); Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. (508 aa)
	FYN	Tyrosine-protein kinase Fyn; Tyrosine-protein kinase implicated in the control of cell growth. Plays a role in the regulation of intracellular calcium levels. Required in brain development and mature brain function with important roles in the regulation of axon growth, axon guidance, and neurite extension. Role in CNTN1-mediated signaling. (589 aa)
	PTPRZ1	Protein-tyrosine-phosphatase. (2343 aa)
	MET	Uncharacterized protein. (1382 aa)
	PTGS2	Prostaglandin G/H synthase 2; Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays imp [...] (652 aa)
	CYP1B1	Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (536 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AHR	CYP1A1	ENSGALP00000047347	ENSGALP00000039219	Uncharacterized protein.	Cytochrome P450 1A4; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.	0.458
AHR	CYP1A2	ENSGALP00000047347	ENSGALP00000002016	Uncharacterized protein.	Cytochrome P450 1A5; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.	0.633
AHR	CYP1B1	ENSGALP00000047347	ENSGALP00000048510	Uncharacterized protein.	Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family.	0.636
AHR	LOC100859347	ENSGALP00000047347	ENSGALP00000006877	Uncharacterized protein.	Uncharacterized protein.	0.557
CRYZ	EPHX1	ENSGALP00000018510	ENSGALP00000015099	PKS_ER domain-containing protein.	Epoxide hydrolase; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. Belongs to the peptidase S33 family.	0.404
CRYZ	GCLC	ENSGALP00000018510	ENSGALP00000026270	PKS_ER domain-containing protein.	Glutamate-cysteine ligase catalytic subunit.	0.815
CYP1A1	AHR	ENSGALP00000039219	ENSGALP00000047347	Cytochrome P450 1A4; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.	Uncharacterized protein.	0.458
CYP1A1	CYP1A2	ENSGALP00000039219	ENSGALP00000002016	Cytochrome P450 1A4; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.	Cytochrome P450 1A5; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.	0.958
CYP1A1	CYP1B1	ENSGALP00000039219	ENSGALP00000048510	Cytochrome P450 1A4; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.	Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family.	0.932
CYP1A1	EPHX1	ENSGALP00000039219	ENSGALP00000015099	Cytochrome P450 1A4; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.	Epoxide hydrolase; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. Belongs to the peptidase S33 family.	0.972
CYP1A2	AHR	ENSGALP00000002016	ENSGALP00000047347	Cytochrome P450 1A5; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.	Uncharacterized protein.	0.633
CYP1A2	CYP1A1	ENSGALP00000002016	ENSGALP00000039219	Cytochrome P450 1A5; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.	Cytochrome P450 1A4; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.	0.958
CYP1A2	CYP1B1	ENSGALP00000002016	ENSGALP00000048510	Cytochrome P450 1A5; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.	Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family.	0.932
CYP1A2	EPHX1	ENSGALP00000002016	ENSGALP00000015099	Cytochrome P450 1A5; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.	Epoxide hydrolase; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. Belongs to the peptidase S33 family.	0.972
CYP1B1	AHR	ENSGALP00000048510	ENSGALP00000047347	Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family.	Uncharacterized protein.	0.636
CYP1B1	CYP1A1	ENSGALP00000048510	ENSGALP00000039219	Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family.	Cytochrome P450 1A4; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.	0.932
CYP1B1	CYP1A2	ENSGALP00000048510	ENSGALP00000002016	Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family.	Cytochrome P450 1A5; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.	0.932
CYP1B1	EPHX1	ENSGALP00000048510	ENSGALP00000015099	Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family.	Epoxide hydrolase; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. Belongs to the peptidase S33 family.	0.972
EPHX1	CRYZ	ENSGALP00000015099	ENSGALP00000018510	Epoxide hydrolase; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. Belongs to the peptidase S33 family.	PKS_ER domain-containing protein.	0.404
EPHX1	CYP1A1	ENSGALP00000015099	ENSGALP00000039219	Epoxide hydrolase; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. Belongs to the peptidase S33 family.	Cytochrome P450 1A4; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.	0.972